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Millennial-scale hydroclimate control of tropical soil carbon storage




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Basement membrane remodelling regulates mouse embryogenesis




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Worm brain, ocean giant and soothing Jupiter — April’s best science images




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Smart-technology spies, a final warning on the environment, and the staggering costs of cancer: Books in brief




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The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice




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Therapeutic targeting of p300/CBP HAT domain for the treatment of NUT midline carcinoma




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Oncogene




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Blood pressure control and complex health conditions in older adults: impact of recent hypertension management guidelines




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Management of hypertension in the very old: aggressive reduction of blood pressure is harmful in most patients




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Flavin doesn’t put all oxygens in one basket




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CDK11 is required for transcription of replication-dependent histone genes




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Publisher Correction: High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble




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COVID-19 assistance needs to target energy insecurity




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Cyanobacterial in vivo solar hydrogen production using a photosystem I–hydrogenase (PsaD-HoxYH) fusion complex




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Hydrogen comes alive




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Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection




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Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation




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Monkeypox virus emergence in wild chimpanzees reveals distinct clinical outcomes and viral diversity




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Author Correction: Metabolic activity analyses demonstrate that Lokiarchaeon exhibits homoacetogenesis in sulfidic marine sediments




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Prize-Winning Images of the Brain

Check out this year's winners of the Art of Neuroscience competition




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Beyond Intelligence




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Why Hostility Can Bring People Closer Together

The surprising power of “hostile mediators”




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Principal Investigator/Professor Positions at Max-Planck Center for Tissue Stem Cell Research and Regenerative Medicine, GDL

With a generous support from the Guangzhou City Government and the Guangdong Provincial Government, Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL) was launched in 2017. GRMH-GDL aims to bring together multiple leading scientific research units from Guangdong, Hong Kong, Macao and well-known international research institutes to achieve the vital goal of "Healthy China" and to cooperatively tackle the scientific and technical problems and challenges. GRMH-GDL is focused…




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Clinical utility of serial analysis of circulating tumour cells for detection of minimal residual disease of metastatic nasopharyngeal carcinoma




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Nine-factor-based immunohistochemistry classifier predicts recurrence for early-stage hepatocellular carcinoma after curative resection




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Exogenous hormone use, reproductive factors and risk of intrahepatic cholangiocarcinoma among women: results from cohort studies in the Liver Cancer Pooling Project and the UK Biobank




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Nanopore sequencing and the Shasta toolkit enable efficient de novo assembly of eleven human genomes




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Author Correction: Genetic circuit design automation for the gut resident species <i>Bacteroides thetaiotaomicron</i>




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Androgen receptor phosphorylation at serine 81 and serine 213 in castrate-resistant prostate cancer




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Thermophysical properties of a Si<sub>50</sub>Ge<sub>50</sub> melt measured on board the International Space Station

npj Microgravity, Published online: 25 March 2020; doi:10.1038/s41526-020-0100-5

Thermophysical properties of a Si50Ge50 melt measured on board the International Space Station




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Protein structural changes on a CubeSat under rocket acceleration profile

npj Microgravity, Published online: 23 April 2020; doi:10.1038/s41526-020-0102-3

Protein structural changes on a CubeSat under rocket acceleration profile




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CRISPR off-target detection with DISCOVER-seq




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Cellular thermal shift assay for the identification of drug–target interactions in the <i>Plasmodium falciparum</i> proteome




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Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system




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Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in <i>Drosophila</i>




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Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration




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CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians




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Phase I trial of maintenance selinexor after allogeneic hematopoietic stem cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndrome




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Oral health in allogeneic hematopoietic stem cells transplantation survivors




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Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR




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Safety and efficacy of chimeric antigen receptor T-cell therapy in relapsed/refractory multiple myeloma with renal impairment




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The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors




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QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism




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NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas




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Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs

miRNA-targeted antimiRs conjugated to a peptide with a low pH–induced transmembrane structure (pHLIP) could help treat solid tumors.




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RNAi against therapeutic targets with short interfering ribonucleic neutrals (siRNNs)

siRNNs could enable RNAi knockdown of therapeutic targets in a broader range of cells and tissue types than siRNA.




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IgE

Mouse studies suggest enhancing persistent IgE responses could help prevent GI infection with parasitic worms.




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Globohexaosylceramide (globo-H); stage-specific embryonic antigen-3 (SSEA-3); SSEA-4

Mouse studies suggest chemically modified carbohydrate conjugates could be useful as antigens for the development of cancer vaccines.




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Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC)

In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins.




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Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K)

Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy.