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Genocea's mark on malaria

Genocea has identified an immunological imprint in patients with malaria and is using a $1.2 million grant from the Gates Foundation to turn the findings into a vaccine.




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SciBX: Science-Business eXchange




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Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




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In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states




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FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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In vivo antitumor activity by dual stromal and tumor-targeted oncolytic measles viruses




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




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Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40




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Cancer Gene Therapy




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Machine intelligence lights up imaging




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Two-dimensional optical edge detection




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Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy




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Feeding back on ingestion




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Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities




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Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity




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New insights into K<sub>ATP</sub> channel gene mutations and neonatal diabetes mellitus




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Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis




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Nonoperative treatment of traumatic spinal injuries in Tanzania: who is not undergoing surgery and why?




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Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus




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Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder




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Age influences structural brain restoration during weight gain therapy in anorexia nervosa




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Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human




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Author Correction: “Dysfunctions” induced by Roux-en-Y gastric bypass surgery are concomitant with metabolic improvement independent of weight loss




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Efficient generation of mouse models with the prime editing system




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Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing




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Mendelian neurodegenerative disease genes involved in autophagy




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Activation and targeting of ATG8 protein lipidation




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Expert opinion—management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors




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Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea




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Anger and shock may follow tooth loss




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Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke




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An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders




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Monogenic small vessel diseases — rare but still important




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Treatment and management of cognitive dysfunction in patients with multiple sclerosis




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Predicting brain-disorder risk genes




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Get The Best Minds on Board, Hindustan Times

Years ago, working in the archives in New Delhi, I came across a brief, handwritten, letter from Jawaharlal Nehru to C. Rajagopalachari. It was dated 30th July 1947, and it read: ‘My dear Rajaji, This is to remind you that you have to approach Shanmukham Chetty—this must be done soon. I have seen Ambedkar and [...]




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Surgeon’s protection during ophthalmic surgery in the Covid-19 era: a novel fitted drape for ophthalmic operating microscopes




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Evaluation of an AI system for the detection of diabetic retinopathy from images captured with a handheld portable fundus camera: the MAILOR AI study




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Generational trends in US opioid-overdose deaths




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Age and generational patterns of overdose death risk from opioids and other drugs




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No, the Coronavirus Will Not Change the Global Order

Joseph Nye advises skepticism toward claims that the pandemic changes everything. China won't benefit, and the United States will remain preeminent.




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Getting Smart on Pandemics: Intelligence in the Wake of COVID-19

This episode of Horns of a Dilemma touches on whether the failure to properly anticipate and warn about the novel coronavirus constitutes an intelligence failure, what changes might be required in the intelligence community in the wake of the pandemic, and what type of investigation or inquiry might be appropriate in order to learn lessons and incorporate changes for both the intelligence community and the whole of government moving forward.




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There's No Such Thing as Good Liberal Hegemony

Stephen Walt argues that as democracies falter, it's worth considering whether the United States made the right call in attempting to create a liberal world order.




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Why Bernie Sanders Will Win in 2020, No Matter Who Gets Elected

Stephen Walt writes that even though Bernie Sanders is out of the presidential race, the time has come for many of the policies that he promoted: Universal Healthcare; Democratic Socialism; Income Redistribution; and Foreign Policy.




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Oil's Collapse Is a Geopolitical Reset In Disguise

The world is on the cusp of a geopolitical reset. The global pandemic could well undermine international institutions, reinforce nationalism and spur de-globalization. But far-sighted leadership could also rekindle cooperation, glimmers of which appeared in the G-20’s offer of debt relief for some of the world’s poorest countries, a joint plea from more than 200 former national leaders for a more coordinated pandemic response and an unprecedented multinational pact to arrest the crash in oil markets.  




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Promoting healthy lifestyle in Chinese college students: evaluation of a social media-based intervention applying the RE-AIM framework




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Comments on “The role of appetite-related hormones, adaptive thermogenesis, perceived hunger and stress in long-term weight-loss maintenance: a mixed-methods study”




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U.S. and Iranian Choices Are Getting Dangerously Narrow

The smoke is still clearing from the drone strike that killed Quds Force commander Qassem Suleimani, and from the Iranian retaliation against U.S. bases in Iraq, and any conclusions have to be tentative ones. But the history of U.S.-Iran conflict points to a narrow, and possibly dangerous, set of choices ahead.