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A Mn(III)-catalyzed arylboronic acid-based cascade reaction via a nonclassical organometallic-radical mechanism

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00244J, Research Article
Hui-Min Qian, Jian-Dong Zhang, Shun-Jun Ji, Xiao-Ping Xu
An efficient Mn(III)-catalyzed cascade reaction of arylboronic acids, o-cyanoaryl isocyanides, and indoles was developed. The mechanism was fully investigated and elucidated.
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Diazenylation of active methyne compounds via arylazo sulfones

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00343H, Research Article
Ruiqing Wang, Lingkai Kong, Xinyu Zong, Minghui Zhang, Wenyi Chen, Yaxin Liu, Lingjuan Ma, Yulei Zhao
An interesting diazenylation reaction is demonstrated, which enables the efficient synthesis of hydrazones using active methyne compounds and arylazo sulfones.
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A Pd(II)-catalyzed denitrative alkyne annulation reaction for the synthesis of cyclopenta[b]chromanes

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00344F, Research Article
Pratiksha Bhorali, Deep J. Kalita, Babulal Das, Sanjib Gogoi
The first denitrative Pd(II)-catalyzed alkyne annulation reaction is reported for the synthesis of cyclopenta[b]chromanes.
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Organocatalyzed double dearomatization reaction of non-functionalized phenols and propargylic alcohols: the important regulating effect of steric hindrance

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00103F, Research Article
Xihong Liu, Boyan Zhu, Panpan Zhou, Jingying Zhang, Anqi Chu, Rui Wang
Steric hindrance-regulated double dearomatization reaction of non-functionalized phenols and propargylic alcohols for the efficient synthesis of polycyclic diketones is reported.
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DBU-catalyzed substitution-controlled synthesis of oxa[3.3.1] bridged ring and naphthylamine derivatives

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00012A, Research Article
Shiyu Xu, Zhihui Sun, Pengyutian Liu, Yuanlin Wei, Fan Sun, Man Zhao, Ying Wang, Ming Zhang, Guofeng Li, Hong Liang
A switchable cascade cyclization reaction of ortho-alkynyl arylketones with amines has been developed, where the different reaction pathways are controlled by the substituent on the α-carbon of in-situ-generated ortho-alkynyl arylaldimines.
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Photoredox catalyzed hydroazolylation of alkenes via phosphoranyl radicals

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00233D, Research Article
Fan Zhu, Zhi Qiao, Na He, Chunxiao Nong, Qiping He, Meilan Xi, Xizhong Song, Jun Lin, Jingbo Chen, Yi Jin
A general protocol for the hydroazolylation of alkenes with N-hydroxyl azoles is reported. These reactions proceed via a phosphoranyl radical, followed by radical coupling of the resulting azole radical to the alkene radical.
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Recent advances in the metal-catalyzed asymmetric alkene hydrogenation of cyclic conjugated carbonyl compounds

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00227J, Review Article
Min Tan, Bram B. C. Peters, Pher G. Andersson, Taigang Zhou
This review summarizes the recent advances (2016–2023) in the stereoselective metal-catalyzed hydrogenation of cyclic α,β-unsaturated ketones, lactams and lactones since considerable developments were made. Where possible the application of these methodologies in synthesis is outlined.
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Modular synthesis of C2-symmetric nitrogen-containing polyaromatics via visible light-enabled reductive aza-6π electrocyclization

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00140K, Research Article
Qun-Liang Zhang, Qing-Tian Fan, Yirong Zhou, Jingli Zhang, Fang-Lin Zhang
Here, an unprecedented one-step modular construction of C2-symmetric N-PACs through  reduction/aza-6π electrocyclization was reported and the resultant C2-symmetric N-PAC could be  converted into  a powerful organic photocatalyst.
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Palladium-catalyzed [4 + 4] cycloaddition of 2-pyrones with 2-alkylidenetrimethylene carbonates: access to bridged eight-membered oxygen heterocycles

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00329B, Research Article
Huawei Lin, Biming Mao, Bing Han, Jiayi Luo, Yanqing Ge, Xuerui Zhang, Chang Wang, Hongchao Guo, Chunhao Yuan
A novel palladium-catalyzed [4 + 4] cycloaddition of 2-pyrones with 2-alkylidenetrimethylene carbonates has been developed for the synthesis of bridged eight-membered oxygen heterocycles in good yields and with excellent stereoselectivities.
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Computational insights into the synergistic interplay of ligand and fluorine effects in palladium-catalyzed regiodivergent decarboxylative allylic alkylation

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00147H, Research Article
Shiyu Wang, Hongli Wu, Xiangyang Tang, Genping Huang
DFT calculations were performed to investigate palladium-catalyzed decarboxylative allylic alkylation of allyl difluoro-β-ketoesters. The synergistic effects of ligand and fluorine substituents on regioselectivity were uncovered.
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Chiral guanidine catalyzed cyclization reactions of 1,3-enynes for lactone synthesis: switchable H-bond catalysis

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00374H, Research Article
Yongyan Zhang, Lichao Ning, Tianxin Zhu, Zheng Xie, Shunxi Dong, Xiaoming Feng, Xiaohua Liu
Cyclization and 1,4-conjugate addition/cyclization between 2-activated 1,3-enynes and azlactones were achieved with chiral guanidine-amides for enol-type activation to yield a range of δ-lactone derivatives.
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Synthesis of a helical boron-doped PAH by post-functionalization of 3,9-diboraperylene

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00421C, Research Article
Carina Mützel, Kazutaka Shoyama, Ana-Maria Krause, Frank Würthner
A doubly helical boron-doped polycyclic aromatic hydrocarbon was synthesized, which showed a low LUMO level, a high absorption coefficient and fluorescence (ΦF = 0.73), combined with a one-dimensional π–π stacking interaction in the solid state.
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Asymmetric [3 + 2] cycloaddition of donor–acceptor cyclopropanes with azadienes enabled by Brønsted base catalysis

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00002A, Research Article
Shu Li, Zhi-Hong Dong, Si-Yu Dan, Mei-Jun Zheng, Teng Long, Jie Zhan, Qing Zhou, Wen-Dao Chu, Quan-Zhong Liu
A chiral bifunctional Brønsted base-catalyzed enantioselective [3 + 2] cycloaddition of D–A cyclopropanes and azadienes is reported. The protocol features broad substrate scope, mild reaction conditions and high functional group tolerance.
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Stereodivergent synthesis of chiral spiropyrazolones through Pd-catalyzed asymmetric sequential hydroalkylation of 1,3-enynes: unusual solvent effects on the enantioselectivity

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00358F, Research Article
Shan Wang, Long Li, Yifei Zheng, Luqing Li, Yingcheng Wang, Fangzhi Peng, Zhihui Shao
Chiral spiropyrazolones were constructed through Pd-catalyzed asymmetric sequential hydroalkylation of 1,3-enynes. Four stereoisomers could be obtained through substrate control and chiral ligand control.
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Blue light-mediated carbene transfer reaction of thioesters with diazoesters: efficient synthesis of tetrasubstituted Z-enol esters

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00265B, Research Article
Shuncheng Wang, Hua Zhang, Jin Yang, Dongfang Zhang, Xin-Ping Hui
An efficient metal-free, blue light-mediated carbene transfer reaction of thioesters with diazoesters has been achieved. This protocol produced tetrasubstituted Z-enol esters containing arylsulfur groups in good yields under mild conditions.
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Triazatriangulenium salts – hosts and guests in supramolecular assemblies in solution

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00500G, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sayan Sarkar, Michael Böck, Agnes Uhl, Aleksandr Agafontsev, Jürgen Schatz, Evgeny A. Kataev
Self-assembly of triangulenium dyes bearing C3-C8 substituents and their interaction with aromatic compounds and cyclophanes were studied in solution.
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Cyclization reactions of 1,6-dienes and 1,6-enynes by dual cobalt photocatalysis

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00311J, Research Article
Pei-Ting Li, Zi-Fa Shi, Wei Yu
Two triphenylamine-derived organophotocatalysts were developed. Their photocatalytic capacity was exploited to enable the [CoIII]-H-mediated cycloisomerization of 1,6-dienes and reductive cyclization of 1,6-enynes under visible light irradiation.
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Iodine-catalyzed intermolecular 1,2-thio (seleno)amination of alkenes with 1,2,3-triazoles and disulfides (diselenides) in air

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00246F, Research Article
Jian Ji, Xuwen Chen, Zongjing Hu, Cong Guan, Jinhua Liu, Yaqi Deng, Shunying Liu
Iodine-catalyzed 1,2-thio (seleno)amination of alkenes via direct N- and C-centered radical cross-coupling was established to elicit highly regioselective β-triazolized thioalkyl compounds.
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Nickel metallaphotoredox-catalyzed C–O bond activation/Csp2–Csp3 coupling enabled by phosphine

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00310A, Research Article
Jiaxi Fang, Ziheng Jian, Huan Liu, Yuting Wang, Xianbo Yu, Zehuai Mou, Huifei Wang
A novel and general nickel/photoredox dual catalysis platform for benzyl alcohol C–O bond activation/Csp2–Csp3 cross coupling of benzothiazolyl bromide and free alcohol, enabled by the catalytic generation of an alkyl radical, is reported.
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Three-component Friedel–Crafts-type difunctionalization of ynamides with (hetero)arenes and iodine(III) electrophile

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00489B, Research Article
Open Access
Jun Kikuchi, Toya Nagata, Shingo Ito, Naohiko Yoshikai
A three-component Friedel–Crafts type difunctionalization of ynamides with an iodine(III) electrophile and electron-rich (hetero)arenes has been developed, enabling regio- and stereoselective synthesis of densely functionalized enamides.
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Base-induced azofluoroalkylation of unactivated alkenes via halogen atom transfer

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Org. Chem. Front., 2024, 11,2161-2170
DOI: 10.1039/D3QO02114A, Research Article
Jing Zhang, Yanchuang Zhao, Yu-Yi Zhu, Peng Lei, Hanru Liu, Chang-Sheng Wang, Shuya Xing, Yong Liu, Shao-Fei Ni, Thomas Castanheiro, Li-Wen Xu, Xinxin Shao
A base-induced three-components coupling employing unactivated alkenes, fluoroalkyl iodides and diazonium salts under mild reaction conditions has been developed.
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Iron(III)/quinoxaline-derived N,N-ligand catalyzed oxygen transfer reaction of N-vinyl nitrones through selective 4π-electrocyclization and N–O bond cleavage

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Org. Chem. Front., 2024, 11,2277-2282
DOI: 10.1039/D3QO01999C, Research Article
Yan-Jiao Lu, Feng-Lan Lu, Jin-Qi Zhang, Chun-Hua Chen, Cui Liang, Xiao-Pan Ma, Dong-Liang Mo
We describe an iron(III)/quinoxaline-derived N,N-ligand promoted O-transfer reaction of N-vinyl nitrones through selective O-4π-electrocyclization and N–O bond cleavage to prepare a variety of 2,5-dihydrooxazoles in good yields.
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Synthesis of benzothiophenes via sulfonium-[3,3]-rearrangement of aryl sulfoxides with allenenitriles

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Org. Chem. Front., 2024, 11,2208-2214
DOI: 10.1039/D4QO00121D, Research Article
Lei Zhang, Kun Wan, Huanhuan Wang, Mengyao Wang, Ao Cui, Xin Huang, Bo Peng
A facile synthesis of benzothiophenes from readily available aryl sulfoxides and allenenitriles has been established through sulfonium-rearrangement triggered cyclization.
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Dynamic kinetic resolution of α-F-β-ketone amides (esters) via Ir/f-diaphos-catalyzed asymmetric hydrogenation

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Org. Chem. Front., 2024, 11,2201-2207
DOI: 10.1039/D4QO00125G, Research Article
Pengtao Yang, Dingguo Song, Lingxin Chen, Xianghua Zhao, Yirui Chen, Feiyang Shen, Fei Ling, Weihui Zhong
Highly reactive and highly stereoselective asymmetric hydrogenation of α-F-β-ketone amides (esters) via Ir/f-diaphos-catalyzed dynamic kinetic resolution is reported.
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A formal (3 + 2) annulation–Cannizzaro cascade of bifunctional peroxides for the synthesis of dihydrofurans

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Org. Chem. Front., 2024, 11,2215-2219
DOI: 10.1039/D4QO00215F, Research Article
Yiwei Chen, Min Gao, Qianlan Xu, Jiumeng Zhang, Lin Hu
Tunable tandem processes of bifunctional peroxides allow the divergent construction of functionalized dihydrofurans and epoxides by simply changing the basic conditions.
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Synthesis of enantiopure 1,2,3-triazolylidene-type mesoionic carbene (MIC) conjugate acids featuring a rigid bicyclic scaffold

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Org. Chem. Front., 2024, 11,2178-2181
DOI: 10.1039/D4QO00269E, Research Article
Vojtěch Dočekal, Mohand Melaimi, Simona Petrželová, Jan Veselý, Xiaoyu Yan, Guy Bertrand
Chiral NHCs have found numerous applications as ligands for transition metals and in their own right for asymmetric catalysis. We report a synthetic route from L-malic acid to enantiopure 1,2,3-triazoliums with the chiral center in a fused ring.
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Iridium-catalyzed reductive γ-lactonization of ortho-acylbenzoic acids in water: sustainable access to phthalides

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Org. Chem. Front., 2024, 11,2220-2230
DOI: 10.1039/D3QO02019C, Research Article
Yang Chen, Jingyu Zhang, Hongguang Du, Renshi Luo, Jiaxi Xu, Zhanhui Yang
Iridium-catalyzed reductive γ-lactonization of ortho-acylbenzoic acids in water provides a practical and sustainable route to phthalides.
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Rhodium-catalyzed C–C bond alkenylation and arylation of α-branched N-sulfonyl amines

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Org. Chem. Front., 2024, 11,2182-2188
DOI: 10.1039/D3QO02140H, Research Article
Lun Xu, Yucheng Liu, Hang Shi, Lun Li
In this work, we described a rhodium-catalyzed C–C bond cleavage of α-branched amines via β-carbon elimination, then formed a five-membered rhodacycle intermediate, which can be captured by styrene(alkenylation) or silane(arylation).
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Electrode-switchable: exploring this new strategy to achieve regiodivergent azidoiodination of alkenes

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Org. Chem. Front., 2024, 11,2189-2194
DOI: 10.1039/D3QO01935G, Research Article
Xin-Lei Sun, Chen-Xi Xia, Yue Ren, Yu-Jin Li, Zhi-Qian Cao, Ling-Guo Meng
An “electrode-switchable” organic electrochemistry method for the azidoiodination of alkenes, where the choice of anode dictates the regiodivergent alkene azidoiodination, reveals a novel pathway for controlled regioisomers.
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Fe-catalyzed B–H and Si–H insertion reactions of gem-dihaloalkanes

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Org. Chem. Front., 2024, 11,2241-2248
DOI: 10.1039/D4QO00136B, Research Article
Xinyu Wang, Zhaobin Wang
We present an approach involving Fe-catalyzed B–H and Si–H insertion of gem-dichloroalkanes. In contrast to previous strategies, our method uses gem-dihaloalkanes as non-stabilized carbene precursors and operates through a radical reaction pathway.
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A dearomatization–rearomatization strategy for construction of 4H-quinolizin-4-ones via C–H bond functionalization of pyridines

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Org. Chem. Front., 2024, 11,2319-2325
DOI: 10.1039/D3QO01990J, Research Article
Dong Qiu, Yijin Su
Herein, the synthesis of 4H-quinolizin-4-ones from N-(2-methoxy-2-oxoethyl) pyridinium salts and alkenes through dearomative cycloaddition and rearomative ring expansion has been developed.
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Regioselective electrochemical cascade C–H sulfonylation–bromination of indolizines to access difunctionalized indolizines

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Org. Chem. Front., 2024, 11,2306-2312
DOI: 10.1039/D4QO00035H, Research Article
Wenxuan Jiang, Xiang Liu, Chuanying Zhu, Meiyi Chen, Weidan Li, Hua Cao
Regioselective electrochemical C–H sulfonylation–bromination between indolizines, sodium sulfinates, and KBr has been established in an undivided cell, in which KBr serves as both the brominating agent and electrolyte.
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Photoinduced alkylation of pyrazolones via β-scission of unstrained aliphatic alcohol derivatives

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Org. Chem. Front., 2024, 11,2289-2296
DOI: 10.1039/D4QO00077C, Research Article
Xinxin Geng, Pan Tao, Yujun Li, Ke Zheng
An efficient radical approach was reported for the transformation of unstrained aliphatic alcohols through the β-scission of alkoxyl radicals.
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Nickel/photoredox-catalyzed carbonylative transformations of α-phosphorus-, α-sulfur-, and α-boron-substituted alkyl halides

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Org. Chem. Front., 2024, 11,2297-2305
DOI: 10.1039/D4QO00167B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Le-Cheng Wang, Xiao-Feng Wu
A novel dual nickel/photoredox catalyzed direct amino- and alkoxycarbonylation of α-heteroatom substituted organohalides has been developed.
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Prins cyclization of 1,3-dioxinone: synthesis of 11-epi-badkhysin

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Org. Chem. Front., 2024, 11,2332-2338
DOI: 10.1039/D4QO00162A, Research Article
Xiaoliang Xu, Ping Hua, Yiren Xu, Baoqing He, Jingfeng Zhao, Liang Li, Wen Chen, Hongbin Zhang
The asymmetric synthesis of highly functional 11-epi-badkhysin has been accomplished using a structure-unit based approach.
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Palladium-catalyzed asymmetric [4 + 3] cycloaddition of acyclic α,β-unsaturated imines with trimethylenemethane donors: access to chiral non-fused azepines

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Org. Chem. Front., 2024, 11,2326-2331
DOI: 10.1039/D4QO00064A, Research Article
Ting-Peng Li, Shuixiu Su, Jia-Huan Shen, Meng Zang, Yang-Zi Liu, Quannan Wang, Wei-Ping Deng
An efficient approach for the construction of non-fused azepines in good yields with high enantioselectivity via Pd-catalyzed asymmetric [4 + 3] cycloaddition was developed.
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Advancement in the C–H bond alkylation of (hetero)arenes catalyzed by the most abundant transition metal–iron

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Org. Chem. Front., 2024, 11,2397-2417
DOI: 10.1039/D4QO00063C, Review Article
Chandini Pradhan, Benudhar Punji
Advancement in the direct C–H bond alkylation of arenes and heteroarenes using the catalysts based on the most abundant transition metal, iron, is summarized.
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Catalytic intermolecular hydrofunctionalizations of ynamides

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Org. Chem. Front., 2024, 11,2351-2374
DOI: 10.1039/D4QO00301B, Review Article
Ying-Ying Zhao, Yu-Jing Jia, Yan-Cheng Hu
This review carefully summarizes the advances achieved in catalytic hydrofunctionalization of ynamides and is categorized by the bond formation type including C−C, C−X, C−O, C−N, C−S, C−P, C−Si, and C−Ge bonds.
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Correction: Cu-catalyzed arylation of S-tosyl peptides with arylboronic acids

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Org. Chem. Front., 2024, 11,2418-2418
DOI: 10.1039/D4QO90029D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Junjie Ying, Jingrong Huang, Chenguang Liu, Fa-Jie Chen, Chunfa Xu, Fen-Er Chen
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NHC and photoredox catalysis dual-catalyzed 1,4-mono-/di-fluoromethylative acylation of 1,3-enynes

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00372A, Research Article
Jiuli Xia, Ruiyang Ma, Lihong Wang, Jiaqiong Sun, Guangfan Zheng, Qian Zhang
NHC and photocatalysis dual-catalyzed mono/difluoromethylative acylation of 1,3-enynes was realized, providing fluormethyl-substituted allenyl ketones. SO2 might play a critical role in achieving high reactivity and selectivity.
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Selective deletion of one carbon atom from C60 through benzylamine mediated reactions

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00449C, Research Article
Yaqiong Wang, Yiran Wu, Yuming Yu, Jie Su, Yi Qiu, Liangbing Gan
Benzylamine selectively adds to one of the two carbonyl groups on the 9-membered orifice to form an N,O-aminal moiety. Subsequent oxidation and hydrogen atom transfer lead to a decarboxylation process and formation of a nor [59]fullerene derivative.
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Cr-mediated Photocatalytic Decarboxylative Coupling of alpha-Oxo Acids with Benzylic Pyridinium Salts

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00475B, Research Article
Jia Cao, Yan Liu, Zhixiang Wang, Le Liu
Herein, we report the chromium/photoredox dual catalytic synthesis of ketones using α-oxo acids with benzylic pyridinium salts. This reaction proceeded by photocatalytic generation of acyl radical from α-oxo acids and...
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Visible-light Induced [1, 3]-Brook Rearrangements of α-Ketoacylsilanes and Its Subsequent Trapping in a Tandem Annulation with 1, 3, 5-Triazinanes and Azomethine Imines

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00463A, Research Article
Zhong Zhang, Sirui Wu, Yuqiao Zhou, Bao-Lin Li, Siyue Xiao, Xiaohu Zhao, Zhipeng Yu
An unusual visible light-induced [1, 3]-Brook rearrangement of α-ketoacylsilanes for cascade cyclization with 1,3,5-triazinanes and C,N-cyclic azomethine imines has been developed under catalyst-free and mild reaction conditions. The strategy offers...
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Concise synthesis of succinimide-fused densely 1,3-cyclohexadienes via Co-catalyzed [2+2+2] cycloaddition of 1,6-diynes and maleimides

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00435C, Research Article
Jinhui Cai, Kaili Cen, Ziyi Zhai, Yuan Liu, Jiahao Wei, Mixia Ouyang, Guojun He, Shuyu Huang, Feng Zhao
Herein, we report a new route towards succinimide-fused densely 1,3-cyclohexadienes through the reaction of 1,6-diynes with electron-deficient alkenes under cobalt catalysis. This method shown high efficiency, wide substrate scope, good...
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Cobalt-catalysed Csp3–Csp3 cross-coupling of benzyl Katritzky pyridinium salts with Callyl–O electrophiles

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00402G, Research Article
Mengyu Gao, Corinne Gosmini
Different allylbenzyl derivatives are synthesized by Co-catalyzed reductive cross-coupling from functionalized benzyl Katritzky pyridinium salts and various allylic acetates, ethers or carbonates in moderate to good yields under mild conditions.
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Metal-free photoinduced denitrogenative alkylation of vinyl azides with alkyl radicals toward ketones

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00280F, Research Article
Hui Yin, Siqi Jian, Xiujuan Feng, Ming Bao, Xuan Zhang
A metal-free method for the synthesis of ketones via a visible-light induced denitrogenative alkylation of vinyl azides with alkyl radicals is presented.
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Copper-catalyzed oxidative sulfenylation and alkylation of indolin-2-ones for direct construction of sulfur-substituted quaternary carbons

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00491D, Research Article
Yun-Hao Zhang, Yi-Nuo Wang, Zi-Yu Liu, Si-Han Zheng, Guang-Lin Li, Dexin Feng, Da-Zhen Xu
A rapid and green one-pot access to S-substituted quaternary carbon centers from commercially available feedstock chemicals has been established, providing complex molecules with high chemoselectivity by the use of air as the terminal oxidant.
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Base- and metal-free visible-light driven site-selective α-C(sp3)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00425F, Research Article
Shiyun He, Hongying Fan, Xue Zhang, Meiling Ye, Jian Chen, Jinyu Hou, Tianle Huang, Li Guo, Guanghui Lv, Yong Wu
A visible-light-mediated radical–radical cross-coupling reaction between hydroxamic acid and N-phenyl glycine derivatives under base and metal free conditions is reported. A series of unnatural amino acids and peptides were obtained in good to excellent yields with good chemo-selectivity.
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A retro-Mannich mediated transformation of Morita–Baylis–Hillman ketones to saturated imidazo[1,2-a]pyridines

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00352G, Research Article
Sachin Sharma, Ajit Kumar Jha, Srinivasan Easwar
Two fruits felled with one stone! – a proof of mechanism and a synthetic method that delivers a privileged heterocyclic motif.
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Development of a photoenzymatic one-pot hybrid system for the direct synthesis of 3,3-disubstituted indole-2-ketones from N-methyl indoles

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00371C, Research Article
Yao Yao, Yuan Yu, Ming-Liang Shi, Xin-Yue Fan, Ru-De Lin, Kun Li, Wen-Dian Li, Fei-Yan Tao, Na Wang
The effective combination of photocatalysis and enzyme catalysis has been widely utilized for the synthesis of high-value-added products.
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