An apparatus and a method are provided for an application specific fuel filter that is configured to prevent particulates from entering the fuel system of a motor vehicle, the fuel filter comprising a hollow canister comprising a length and diameter; a first end comprising a fuel inlet; a second end comprising a fuel outlet; a filter element comprising a plurality of pleats; and a rolled seam.

Devices and methods for characterization of analyte mixtures are provided. Some methods described herein include performing enrichment steps on a device before expelling enriched analyte fractions from the device for subsequent analysis. Also included are devices for performing these enrichment steps.

An electrical sensor for sensing electromagnetic properties of process fluids in a dialysis machine or a similar medical device can include a probe for interfacing with the fluids that is made from electronic fabric materials. The electronic fabric probe can include one or more conductors embedded in a non-conductive fabric layer. The electronic fabric probe is accommodated an enclosure which establishes a flow path with respect to the probe to establish fluid contact between the process fluids and the conductors. The conductors can apply or sense current and/or voltage with respect to the fluid. A portion of the electronic fabric probe can be disposed externally of the enclosure to provide electronic communication externally of the enclosure.

Systems and methods for controlling fluid movement and volumes of fluid between a subject and a controlled compliant flow path. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the controlled compliant flow path. An extracorporeal flow path is in fluid communication with the controlled compliant flow path across a semi-permeable membrane where the extracorporeal flow path has a first terminal end and a second terminal end.

A blood purification apparatus capable of achieving a simplified configuration and switching between hemodialysis treatment (HD), hemofiltration treatment (HF), and hemodiafiltration treatment (HDF) as well as selecting from pre-dilution, post-dilution and pre and post-dilution easily and smoothly. The blood purification apparatus includes: a valve means 3 that is capable of closing and opening a dialysate introduction line and a dialysate supply line L3 in any manner, and a control unit 5 that operates the valve means 3 to allow any treatment to be performed selected from hemodialysis treatment in which the dialysate supply line L3 is closed while the dialysate introduction line L1 is opened, hemofiltration treatment in which the dialysate supply line L3 is opened while the dialysate introduction line L1 is closed, and hemodiafiltration treatment in which hemodialysis and hemofiltration are performed concurrently by alternately closing and opening the dialysate introduction line L1 and the dialysate supply line L3.

Blood separation systems and methods are provided for detecting lipids in plasma that has been separated from a plasma-containing fluid, such as blood. The system includes a fluid processing region in which a plasma-containing fluid is separated into plasma and other fluid components. A plasma flow path is associated with the fluid processing region for the flow of at least a portion of the separated plasma into or out of the region. A lipid detector shines blue and/or ultraviolet light through the separated plasma in the plasma line to optically detect the presence of lipids therein. The lipid detector may be used alone or in combination with a hemoglobin detector to reduce the number of false hemoglobin alarms or an interface detector for improved detection and correction of the location of an interface between separated fluid components in the fluid processing region.

A lattice and distribution network for a stackable chromatography cassette comprising: a peripheral seal;at least one screen forming the lattice surrounded by the peripheral seal, each at least one screen comprising a plurality of struts in a latticed arrangement;a first internal distribution network fluidly coupled to the lattice and surrounded by the peripheral seal;a second internal distribution network disposed opposite the first internal distribution network, fluidly coupled to the lattice and surrounded by the peripheral seal;wherein a direction of fluid flow is established from the first internal distribution network through the lattice to the second internal distribution network; andwherein preferential streamlines are minimized.

A slurry filtering device is provided, including a shell body, having a receiving space, an outlet portion and an inlet portion, the outlet portion and the inlet portion respectively communicating with the receiving space, the inlet portion and the outlet portion defining a flow passage therebetween; a first filter, received in the receiving space and connected to the inlet portion, the first filter laterally arranged in the flow passage; a second filter, received in the receiving space and connected to the outlet portion, the second filter laterally arranged in the flow passage.

a filtering method, with which a fluid to be filtered is led through a filter (4), the filter (4) is back-flushed at regular time intervals and a pre-treatment agent is added to the fluid at the entry side of the filter. A process variable which describes the efficiency of the filtration is continuously computed during the filtration, and a metering quantity of the pre-treatment agent is reset on the basis of the values for the process variable or a characteristic values derived from this.

A reverse osmosis (RO) water filtration device includes a body, a RO cartridge, a first cartridge, a second cartridge and a storage tank all mounted inside the body. Water to be filtered sequentially goes through a water inlet of the RO water filtration device, the first cartridge, the RO cartridge, the storage tank, the second cartridge, and a faucet to get the water filtered. The storage tank provides additional water supply when the pressure between the faucet and RO cartridge is below the water pressure inside the storage tank to increase water volume upon opening a faucet.

A blood filtration device comprising a generally cylindrical housing having an interior wall. An interior member is mounted interior of the housing and comprises an outer surface having a porous membrane disposed thereon. The housing and interior member are relatively rotatable and define an annular gap therebetween. The blood filtration device also comprises an inlet for directing fluid into the annular gap, a first outlet for exiting filtrate passing through the membrane, and a second outlet for directing from the annular gap the remaining retentate. The porous membrane comprises a first layer and a second layer.

Provided is an integral 3D graphene-carbon hybrid foam composed of multiple pores and pore walls, wherein the pore walls contain single-layer or few-layer graphene sheets chemically bonded by a carbon material having a carbon material-to-graphene weight ratio from 1/100 to 1/2, wherein the few-layer graphene sheets have 2-10 layers of stacked graphene planes having an inter-plane spacing d002 from 0.3354 nm to 0.40 nm and the graphene sheets contain a pristine graphene material having essentially zero % of non-carbon elements, or a non-pristine graphene material having 0.01% to 25% by weight of non-carbon elements wherein said non-pristine graphene is selected from graphene oxide, reduced graphene oxide, graphene fluoride, graphene chloride, graphene bromide, graphene iodide, hydrogenated graphene, nitrogenated graphene, doped graphene, chemically functionalized graphene, or a combination thereof. Also provided are a process for producing the hybrid form, products containing the hybrid foam, and its applications.

A brine filtration device disposable at a bottom portion of a brine storage tank has inner and outer tubes having a plurality of fine slits in order to mechanically trap any large undissolved salt crystals that may be entrained within a sodium chloride solution. A plurality of beads are disposed between the inner and outer tubes to cause the sodium chloride solution to change direction (i.e., cause turbulence) which further promotes or facilitates dissolution of any undissolved salt crystals entrained within the sodium chloride solution. The sodium chloride solution continues to flow through the slits of the inner tube which further traps or catches any undissolved salt crystals. Additional changes in flow direction of the sodium chloride solution are also contemplated to further increase or facilitate dissolution of undissolved salt crystals entrained in the sodium chloride solution.

A method for treating contaminated liquids in a flow by ozone, wherein the ozone is fed in gas form into the flow at one point and then is mixed into the flow in stages by mixers following one another in the flow direction, so that an absolute quantity of introduced ozone increases after each mixer until a feed efficiency of more than 95 percent is reached.

Plant for melting and cleaning of snow and ice, distinguished in that the plant comprises a means for melting using enthalpy of a water source in order to melt snow and ice, and a means for cleaning for cleaning out the pollution from the water phase that contains the melted snow and ice. Method for melting and cleaning of snow and ice, using the plant according to the invention.

The Bay Area Vibez festival landed at the Port of Oakland this past weekend, bringing world-renowned reggae, electronic, and hip-hop artists to Middle Harbor Shoreline Park — a vast, open space that overlooks the San Francisco skyline. In its first year, the event arrived with a seemingly enormous budget and star-studded lineup that included living legends Stephen Marley, Damian Marley, and Nas.

But despite the festival’s grandiosity, the event ultimately felt like a way to capitalize on people’s nostalgia for bygone eras, prioritizing artists who haven’t released new material in years or are descendants of celebrated musicians.…

First, a loud siren seared my ears. When I turned, I saw four men draped in bandages standing atop a white hearse.…

Jay Stone looked at home as he took the stage in a burgundy bathrobe last Thursday at The Night Light, a bar near Jack London Square.…

Despite some growing pains, the fest successfully expanded into a ten-day concert series that highlighted outstanding local talent. Jay Stone looked at home as he took the stage in a burgundy bathrobe last Thursday at The Night Light, a bar near Jack London Square. He was headlining the seventh night of Oakland Music Festival, which dominated the local concert calendar from September 30 to October 9 with shows taking place at different venues every night.…

Kamaiyah, Ice Cube, How to Dress Well, and Sigur Rós played in the rain despite the many delays, cancelations, and technical difficulties. Treasure Island promised one of its best lineups yet for its tenth anniversary, but severe weather literally rained on everyone's parade. Many performances were delayed or canceled, often with little communication to the public on Saturday.…

Including a photo slideshow. Even at 10 a.m. this past Saturday morning, hours before a throng of anti-fascists and Trump-supporting white nationalists overtook downtown Berkeley’s streets, it was clear that most of the attendees were less interested in speeches, protesting, and free speech — and were mostly there just to tee-off on each other. Before the brawling began, officers stationed themselves at the entrances to downtown's "Peace Park."…

ACT for America, which the Southern Poverty Law Center has designated as an anti-muslim hate group, showed up on Saturday morning in cities nationwide, dubbing its protest a "March Against Sharia." Berkeley was spared, but the group appeared in nearby Santa Clara, and in Roseville, a suburb of Sacramento.…

The organization sets up at 27th Street and Northgate Avenue and at 6th and Castro streets. Blair Hippolyte and Jannie Rutledge, two Oakland residents who are homeless, sat on the sidewalk of 27th Street.…

Once Were Brothers celebrates the timeless sound of The Band. Here's a quiz for roots music fans. Multiple choice.…

From plain cheese slices to pan pizza to slices drizzled with balsamic reduction, Graffiti Pizza has you covered. After the clock strikes midnight in Oakland, there's no shortage of tacos, burritos, or won ton noodle soup. But one of the most classic of late-night foods — pizza by the slice — was hard to find in Oakland during the wee hours.…

The Richmond pop-up is a new contender for best fried chicken sandwich. There's no shortage of smog check stations on Richmond's 23rd Street, but on a sunny Saturday afternoon, a steady stream of cars piled into Super Star Smog's tiny parking lot, causing a minor traffic jam on the adjacent side street. On a Wednesday afternoon, an otherwise quiet industrial and residential Richmond street filled with cars, and people hastily headed into what appeared to be a warehouse (but was actually a motorcycle club).…

The chamber of commerce is maintaining a list of local eateries still open for business. The Oakland Chamber of Commerce has compiled a list of more than 175 Oakland restaurants offering takeout or home delivery. The City of Alameda had a similar idea, and has created a website listing about 85 restaurants.…

The invention generally relates to assemblies for displacing droplets from a vessel that facilitate the collection and transfer of the droplets while minimizing sample loss. In certain aspects, the assembly includes at least one droplet formation module, in which the module is configured to form droplets surrounded by an immiscible fluid. The assembly also includes at least one chamber including an outlet, in which the chamber is configured to receive droplets and an immiscible fluid, and in which the outlet is configured to receive substantially only droplets. The assembly further includes a channel, configured such that the droplet formation module and the chamber are in fluid communication with each other via the channel. In other aspects, the assembly includes a plurality of hollow members, in which the hollow members are channels and in which the members are configured to interact with a vessel. The plurality of hollow members includes a first member configured to expel a fluid immiscible with droplets in the vessel and a second member configured to substantially only droplets from the vessel. The assembly also includes a main channel, in which the second member is in fluid communication with the main channel. The assembly also includes at least one analysis module connected to the main channel.

Provided herein are methods of reliably determining whether or not an individual is a user of tobacco.

The present invention refers to a process for classifying tumor samples of unknown and/or uncertain primary origin, specifically including the steps of obtaining patterns of biological activity modulation of tumor of unknown and/or uncertain primary origin and comparing them to an specific and unique group of biomarkers which determine the profiles of biological activity modulation of known origin tumors. The present invention belongs to the molecular biology and genetics field.

The present invention relates to methods for predicting the survival time of patients suffering from cancer. Said methods are based on the quantification and analysis of the cell free nucleic acids that are present in a sample from the patient and typically include the determination of the level of the mutant nucleic acid which contains a mutation of interest, the calculation of the mutation load for said mutation of interest, the calculation of the DNA integrity index or a combination thereof.

Compositions and methods for detecting Trichomonas vaginalis are provided.

A microbial gaseous-fluid sampler for collecting microbial particles from gaseous fluid includes a gaseous-fluid intake portion having a sample head with a plurality of holes. The gaseous-fluid intake portion further includes a collar configured to receive a Petri dish including agar. The plurality of holes define an exit plane that is positioned a distance from the agar within a range of 5.5 millimeters to 7.5 millimeters. The velocity of the air exiting the plurality to holes is within a range of 18.5 meters per second to 20.5 meters per second.

Highly efficient and rapid filtration-based concentration devices, systems and methods are disclosed with sample fluidic lines and a filter packaged in a disposable tip which concentrate biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. The concentrate is then dispensed from the disposable tip in a set volume of elution fluid. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria in the size range of approximately 0.001 micron to 20 microns diameter. Concentration of these particles is advantageous for detection of target particles in a dilute suspension, because concentrating them into a small volume makes them easier to detect. All conduits by which the disposable tip attaches to the instrument are combined into a single connection point on the upper end of the tip.

A system and method for concurrently and uniformly removing thermal energy from clustered specimen samples.

In flow cytometry, particles (2) can be distinguished between populations (8) by combining n-dimensional parameter data, which may be derived from signal data from a particle, to mathematically achieve numerical results representative of an alteration (48). An alteration may include a rotational alteration, a scaled alteration, or perhaps even a translational alteration. Alterations may enhance separation of data points which may provide real-time classification (49) of signal data corresponding to individual particles into one of at least two populations.

Aspects of the present disclosure include methods for processing a biological sample. Methods according to certain embodiments include contacting a biological sample having cells with an assay reagent that includes one or more analyte-specific binding members to produce a biological sample assay composition and introducing the biological assay composition into an inlet of a flow cytometer having an integrated acoustic separator. Systems, including a flow cytometer with integrated acoustic separator having one or more acoustic concentrator devices suitable for practicing the subject methods are also described.

The present invention provides a method for imaging microtentacles on isolated, living, non-adherent primary tumor cells from a cancer subject comprising: i) obtaining one or more living, non-adherent primary tumor cells that has been isolated from a solid tumor from the subject; and ii) imaging the one or more living, non-adherent primary tumor cells and detecting the microtentacles.

An assay and a method for identifying a prebiotic to treat a subject in need thereof to promote intestinal barrier integrity or to blunt an inflammatory response are provided.

Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.

Methods of screening for expression of an RNA associated with a post-kidney transplant complication include collecting vesicles from urine, isolating vesicle-associated RNA, and analyzing expression patterns. In particular, AIF1, BTN3A3, CCL5, CD48, HAVCR1, or SLC6A6 mRNA expression patterns are analyzed.

A sensing sensor includes a wiring board, a piezoelectric resonator, a channel forming member, a case body, and a regulating portion. The case body houses the wiring board, the piezoelectric resonator, and the channel forming member. The case body includes a window faced to a region including the output terminal on the another surface side of the wiring board and an injection port supplying a supply liquid to the one end side of the channel. The regulating portion is disposed in the case body. The regulating portion regulates the wiring board from the one surface side when the wiring board is pressed from the another surface side. The piezoelectric resonator is pressed against the surrounding portion by the output terminal being pressed from the another surface side.

An assay system and method for use in the field of chemical testing is disclosed. The assay system can be used for filtering whole blood for testing on an integrated circuit containing digital control functionality.

Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50×104-fold more sensitive for the detection of SNV. For both pathogens, the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1. The biosensor was able to detect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS). Further, in a proof-of-principle real world application, the SAW biosensor was capable of selectively detecting SNV agents in complex solutions, such as naturally occurring bodies of water (river, sewage effluent) without analyte pre-processing.

An antigenic characterization method using polyclonal antibody-based proximity ligation assays (polyPLA). Methods, kits, and other tools disclosed herein are useful in detecting microbial antigenic variants in samples, including clinical samples. The methods and kits have great utility in detecting antigenic variants for pathogenic microbes, including viruses, bacteria, and parasites.

This invention publicizes a chronic renal disease diagnostic kit, comprised of FGF23 monoclonal antibody, biotin labeling reagent Sulfo-NHS-LC-Biotin, PBS buffer solution (pH7.0, 0.1M), casein saline solution, streptomycin avidin and substrate TMB. The labeling condition is the weight ratio of FGF23 antibody and Sulfo-NHS-LC-Biotin, which is 1:5-1:12. The dilution ratio of streptomycin avidin is 1:3000. The lowest testing threshold limit value of FGF23 kit is 10 pg/ml, whose sensitivity is 10 times higher than that of common monoclonal antibody, which is very significant for early diagnose of chronic renal disease.

The present invention relates to an in vitro method of diagnosing chronic myelomonocytic leukemia (CMML) in a subject, said method comprising the steps of: a) Detecting a monocyte population in a biological sample from said subject; b) Quantifying the CD14+/CD16− monocytes in said biological sample; c) Comparing the value of step b) to a reference value; and d) Diagnosing CMML based on said comparison. Preferably, said detecting step a) is performed by an exclusion gating strategy by flow cytometry.

A method to detect prostate cancer comprising contacting a sample of prostate cells from the patient with a set of detectably labeled probes under hybridization conditions and determining the presence of chromosomal abnormalities in prostate tumor tissue, PIN (intra-epithelial neoplasia), histologically benign tissue and benign prostatic hyperplasia (BPH); a method to combine immunofluorescence and FISH (IF-FISH) to facilitate the assessment of chromosomal abnormalities; a set of probes; and a kit comprising the set of probes and instructions for diagnosing prostate cancer in a patient.

A population of bright and stable nanocrystals is provided. The nanocrystals include a semiconductor core and a thick semiconductor shell and can exhibit high extinction coefficients, high quantum yields, and limited or no detectable blinking.

The owners of Oakland's Homestead Restaurant have just debuted a new business concept that is meant to outlast the Covid-19 crisis.

Currently operating at the restaurant's 4029 Piedmont Ave. space Tuesdays through Saturdays from 10 a.m. to 6 p.m. via curbside pickup and Caviar or Doordash delivery, The Humble Sandwich comprises a selection of classic deli sandos made with the same high-quality ingredients for which the seven-year-old restaurant is revered.…