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Iran executes in public a serial rapist convicted in dozens of cases

Iran’s state media say authorities have executed in public a man convicted of raping dozens of women over two decades




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Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells

RSC Med. Chem., 2024, 15,3728-3745
DOI: 10.1039/D4MD00476K, Research Article
Vincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien Fortin
New water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety

RSC Med. Chem., 2024, 15,3837-3852
DOI: 10.1039/D4MD00426D, Research Article
Abdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. Bednarski
Structure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safety
The content of this RSS Feed (c) The Royal Society of Chemistry




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Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3880-3888
DOI: 10.1039/D4MD00414K, Research Article
Phuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. Vo
Novel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

RSC Med. Chem., 2024, 15,3817-3836
DOI: 10.1039/D4MD00477A, Research Article
Maha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa Matboli
ZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00610K, Research Article
Open Access
Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rival Zomato's CEO congratulates Swiggy on stock market listing

Swiggy got listed at ₹420, a jump of nearly 8% from the issue price on the NSE




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Sakhi centre inaugurated at Vizianagaram Collectorate




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Centre’s nod sought for Vizag Metro, MA&UD Minister informs A.P. Assembly

The revised cost estimate stands at ₹17,232 crore; the project is initially proposed to come up in two phases with four corridors spanning a total length of 76 km




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Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional

The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling




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India's middle class tightens its belt, squeezed by food inflation

Slowing urban spending over the past three to four months has not only hurt the earnings of largest consumer goods firms




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‘Freelance journalist’ held for extortion in Rein Bazaar




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Stale food seized at Kakkanad




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Pro Kabaddi League: Gujarat Giants return to winning ways with big win over Bengal Warriorz

In the second match of the night, Haryana Steelers moved to the top of the table and extended their winning run to four games after defeating the Patna Pirates 37-32




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How the Supreme Court clamped down on ‘bulldozer’ demolition drives | Explained

The top court has issued a slew of guidelines aimed at ensuring institutional accountability to curb retributive demolitions by state authorities




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Photographer from Gaza Strip among winners at top photography award in UAE

The Hamdan bin Mohammed bin Rashid Al Maktoum International Photography Award (HIPA) is the richest photography competition in the world.




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Kozhikode Corporation to rehabilitate traders evicted from shop rooms below CH Flyover

Around 40% of evicted traders find alternative locations; Deputy Mayor urges others to wait for funds to be allocated, while traders offer to build shops themselves




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No roadmap yet for better traffic signage system in Kozhikode city

Emergency signboards and lane markings near roundabouts have not yet been introduced to streamline the traffic management




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‘Welcome’ that ‘drink’ with caution, say doctors as hepatitis A cases go up in Kozhikode

At least five to six cases of the infection being reported every day at the Government Medical College Hospital in recent weeks




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‘Revathi Pattathanam’ held at Tali temple in Kozhikode




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Pedal boating begins at Sarovaram Biopark in Kozhikode




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ED seizes ₹8.36 cr. from premises linked to OPG Group




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Trump names firebrand lawmaker Matt Gaetz U.S. Attorney General

Donald Trump posted on social media that Matt Gaetz will end Weaponized Government




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This week's sponsor: ZARGET

ZARGET: Analytics Tool for designers. Capture exactly how users experience your website. Settle design debates with data.




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Complete laying of roads and repair works in Zone II, GVMC Commissioner directs officials in Visakhapatnam




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Swiggy vs Zomato: which is a better choice for investment?

Investors keenly comparing Swiggy to its main competitor, Zomato, which has already experienced two years in the stock markets




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Elon Musk, Vivek Ramaswamy to lead DOGE in bid to dismantle Govt Bureaucracy, says US Prez-elect Trump




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Zinc futures show bearish bias

The November contract can decline to ₹255




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Saatvik Green Energy enters solar pump biz with order from Maharashtra

Saatvik Green Energy partners with Maharashtra State Electricity Distribution Company to supply solar submersible pumps, supporting sustainable irrigation solutions.




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Bulldozer demolition chilling sight, executive cannot replace judiciary: SC

Destroying family homes, leaving entire families homeless, amount to anarchy: Justice Gavai




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Nazara teams up with ONDC to launch in-game shopping platform 

gCommerce, the new in-game platform, aims to help game developers overcome low in-app purchase conversion rates by creating additional revenue streams through affiliate marketing




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On ‘bulldozer justice’ Supreme Court sends a message. Will it be heard?




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The Third Edit: In Samantha Harvey’s Booker Prize win, outer space and inner lives




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Taapsee Would Like A Rose, Har Roz!

Taapsee Pannu's off-screen style too reflects her eye for detail, making her a fashionista worth following.




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Fritz fizzles out, Sinner cruises to victory

Jannik Sinner made it two wins out of two at the ATP Finals as he fought off Taylor Fritz in a high-octane clash inside the Inalpi Arena on Tuesday.




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Sick Alcaraz struggles: Can he recover in time?

An off-colour Alcaraz lost 6-1, 7-5 to Norway's Casper Ruud in his opening match on Monday and the 21-year-old cancelled a public training session the following day.




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ATP Finals: Ailing Alcaraz outclasses Rublev

Spain's Carlos Alcaraz made light of feeling under the weather as he dispatched Russia's Andrey Rublev in impressive fashion to revive his ATP Finals hopes on Wednesday.




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Tata Chess: Uzbek Abdusattorov emerges as early leader

Uzbekistan's young grandmaster Abdusattorov Nodirbek emerged sole leader in the open section of the Tata Steel Chess India Rapid tournament in Kolkata on Wednesday.




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Rule of law citizens' umbrella against State's power: SC

It said the law must be just and fair and should protect the human rights and dignity of all members of society.




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Pushpa 2 first review: Rashmika Mandanna says Allu Arjun movie is 'freaking amazing'

Ahead of the mega trailer launch, Rashmika Mandanna shared her thoughts after watching Allu Arjun in Pushpa 2: The Rule.




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Trump nominates Florida's Rep. Matt Gaetz to serve as attorney general

President-elect Donald Trump announced Wednesday that he will nominate Rep. Matt Gaetz of Florida, who has clashed with Republican leaders in the House and served as a lightning rod against Democrats, to serve as attorney general in his incoming administration.




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White supremacists protest Michigan performance of Anne Frank play with Nazi flags

A group of White supremacist demonstrators protested a performance of the play "The Diary of Anne Frank" in Howell, Michigan, by waving Nazi flags across the street from the venue.




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Bob Menendez trial jurors were given evidence that judge had excluded, prosecutors say

Some evidence that a federal judge had excluded from the bribery trial of former New Jersey Sen. Bob Menendez was inadvertently put on a computer given to jurors, federal prosecutors revealed Wednesday, though they insisted it should have no effect on the Democrat's conviction.




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"We Need Everyone": New Award Recognizes the Importance of Scientific Community

In the lab of Minna Roh-Johnson, PhD, great science and great mentorship are inextricable. Now, up to $250,000 in federal funding from the National Cancer Institute has made that philosophy concrete by advancing cancer research and building scientific community.




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Olaf From The Movie Frozen

Olaf From The Movie Frozen by Trevor Mezak is a(n) Limited Edition. The Edition is Limited to Limited Edition Of 95 pcs




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ZIPPO THE FIRE-EATER

ZIPPO THE FIRE-EATER by Will Bullas is a(n) Open Edition. The Edition is Limited to Open Edition pcs




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the Lizard Lounge LIMITED EDITION CANVAS

the Lizard Lounge LIMITED EDITION CANVAS by Will Bullas is a(n) Limited Edition. The Edition is Limited to Limited to 75 pcs




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the Lizard Lounge MASTERWORK CANVAS EDITION

the Lizard Lounge MASTERWORK CANVAS EDITION by Will Bullas is a(n) Limited Edition. The Edition is Limited to Limited to 25 pcs