z Iran executes in public a serial rapist convicted in dozens of cases By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:43:02 +0530 Iran’s state media say authorities have executed in public a man convicted of raping dozens of women over two decades Full Article World
z Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3728-3745DOI: 10.1039/D4MD00476K, Research ArticleVincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien FortinNew water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
z Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3837-3852DOI: 10.1039/D4MD00426D, Research ArticleAbdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. BednarskiStructure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safetyThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
z Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
z Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
z Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
z Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
z Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
z Rival Zomato's CEO congratulates Swiggy on stock market listing By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:25:51 +0530 Swiggy got listed at ₹420, a jump of nearly 8% from the issue price on the NSE Full Article India
z Sakhi centre inaugurated at Vizianagaram Collectorate By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:11:36 +0530 Full Article Andhra Pradesh
z Centre’s nod sought for Vizag Metro, MA&UD Minister informs A.P. Assembly By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:55:45 +0530 The revised cost estimate stands at ₹17,232 crore; the project is initially proposed to come up in two phases with four corridors spanning a total length of 76 km Full Article Andhra Pradesh
z Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 11:31:53 +0530 The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling Full Article News
z India's middle class tightens its belt, squeezed by food inflation By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:50:09 +0530 Slowing urban spending over the past three to four months has not only hurt the earnings of largest consumer goods firms Full Article Economy
z ‘Freelance journalist’ held for extortion in Rein Bazaar By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:21:15 +0530 Full Article Telangana
z Stale food seized at Kakkanad By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:40:24 +0530 Full Article Kochi
z Pro Kabaddi League: Gujarat Giants return to winning ways with big win over Bengal Warriorz By www.thehindu.com Published On :: Thu, 14 Nov 2024 06:39:17 +0530 In the second match of the night, Haryana Steelers moved to the top of the table and extended their winning run to four games after defeating the Patna Pirates 37-32 Full Article Sport
z How the Supreme Court clamped down on ‘bulldozer’ demolition drives | Explained By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:32:43 +0530 The top court has issued a slew of guidelines aimed at ensuring institutional accountability to curb retributive demolitions by state authorities Full Article India
z Photographer from Gaza Strip among winners at top photography award in UAE By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:19:09 +0530 The Hamdan bin Mohammed bin Rashid Al Maktoum International Photography Award (HIPA) is the richest photography competition in the world. Full Article World
z Kozhikode Corporation to rehabilitate traders evicted from shop rooms below CH Flyover By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:31:59 +0530 Around 40% of evicted traders find alternative locations; Deputy Mayor urges others to wait for funds to be allocated, while traders offer to build shops themselves Full Article Kerala
z No roadmap yet for better traffic signage system in Kozhikode city By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:33:12 +0530 Emergency signboards and lane markings near roundabouts have not yet been introduced to streamline the traffic management Full Article Kerala
z ‘Welcome’ that ‘drink’ with caution, say doctors as hepatitis A cases go up in Kozhikode By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:34:17 +0530 At least five to six cases of the infection being reported every day at the Government Medical College Hospital in recent weeks Full Article Kerala
z ‘Revathi Pattathanam’ held at Tali temple in Kozhikode By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:35:58 +0530 Full Article Kerala
z Pedal boating begins at Sarovaram Biopark in Kozhikode By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:37:01 +0530 Full Article Kerala
z ED seizes ₹8.36 cr. from premises linked to OPG Group By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:56:23 +0530 Full Article Tamil Nadu
z Trump names firebrand lawmaker Matt Gaetz U.S. Attorney General By www.thehindu.com Published On :: Thu, 14 Nov 2024 02:50:05 +0530 Donald Trump posted on social media that Matt Gaetz will end Weaponized Government Full Article World
z This week's sponsor: ZARGET By synd.co Published On :: 2016-12-14T17:36:00+00:00 ZARGET: Analytics Tool for designers. Capture exactly how users experience your website. Settle design debates with data. Full Article
z Complete laying of roads and repair works in Zone II, GVMC Commissioner directs officials in Visakhapatnam By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:38:50 +0530 Full Article Visakhapatnam
z Swiggy vs Zomato: which is a better choice for investment? By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 14:43:20 +0530 Investors keenly comparing Swiggy to its main competitor, Zomato, which has already experienced two years in the stock markets Full Article Companies
z Elon Musk, Vivek Ramaswamy to lead DOGE in bid to dismantle Govt Bureaucracy, says US Prez-elect Trump By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 16:00:00 +0530 Full Article Video
z Zinc futures show bearish bias By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 16:10:41 +0530 The November contract can decline to ₹255 Full Article Commodity Calls
z Saatvik Green Energy enters solar pump biz with order from Maharashtra By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 19:34:19 +0530 Saatvik Green Energy partners with Maharashtra State Electricity Distribution Company to supply solar submersible pumps, supporting sustainable irrigation solutions. Full Article Companies
z Bulldozer demolition chilling sight, executive cannot replace judiciary: SC By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 22:34:50 +0530 Destroying family homes, leaving entire families homeless, amount to anarchy: Justice Gavai Full Article News
z Nazara teams up with ONDC to launch in-game shopping platform By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 11:23:55 +0530 gCommerce, the new in-game platform, aims to help game developers overcome low in-app purchase conversion rates by creating additional revenue streams through affiliate marketing Full Article Stocks
z On ‘bulldozer justice’ Supreme Court sends a message. Will it be heard? By indianexpress.com Published On :: Wed, 13 Nov 2024 19:11:04 +0000 Full Article Editorials Opinion
z The Third Edit: In Samantha Harvey’s Booker Prize win, outer space and inner lives By indianexpress.com Published On :: Wed, 13 Nov 2024 20:54:24 +0000 Full Article Editorials Opinion
z Taapsee Would Like A Rose, Har Roz! By www.rediff.com Published On :: Wed, 13 Nov 2024 10:25:27 +0530 Taapsee Pannu's off-screen style too reflects her eye for detail, making her a fashionista worth following. Full Article
z Fritz fizzles out, Sinner cruises to victory By www.rediff.com Published On :: Wed, 13 Nov 2024 10:28:34 +0530 Jannik Sinner made it two wins out of two at the ATP Finals as he fought off Taylor Fritz in a high-octane clash inside the Inalpi Arena on Tuesday. Full Article
z Sick Alcaraz struggles: Can he recover in time? By www.rediff.com Published On :: Wed, 13 Nov 2024 11:04:00 +0530 An off-colour Alcaraz lost 6-1, 7-5 to Norway's Casper Ruud in his opening match on Monday and the 21-year-old cancelled a public training session the following day. Full Article
z ATP Finals: Ailing Alcaraz outclasses Rublev By www.rediff.com Published On :: Wed, 13 Nov 2024 21:02:39 +0530 Spain's Carlos Alcaraz made light of feeling under the weather as he dispatched Russia's Andrey Rublev in impressive fashion to revive his ATP Finals hopes on Wednesday. Full Article
z Tata Chess: Uzbek Abdusattorov emerges as early leader By www.rediff.com Published On :: Wed, 13 Nov 2024 21:29:55 +0530 Uzbekistan's young grandmaster Abdusattorov Nodirbek emerged sole leader in the open section of the Tata Steel Chess India Rapid tournament in Kolkata on Wednesday. Full Article
z Rule of law citizens' umbrella against State's power: SC By www.rediff.com Published On :: Wed, 13 Nov 2024 21:40:04 +0530 It said the law must be just and fair and should protect the human rights and dignity of all members of society. Full Article
z Pushpa 2 first review: Rashmika Mandanna says Allu Arjun movie is 'freaking amazing' By www.dnaindia.com Published On :: Wed, 13 Nov 2024 18:00:22 GMT Ahead of the mega trailer launch, Rashmika Mandanna shared her thoughts after watching Allu Arjun in Pushpa 2: The Rule. Full Article Entertainment
z Trump nominates Florida's Rep. Matt Gaetz to serve as attorney general By www.washingtontimes.com Published On :: Wed, 13 Nov 2024 15:42:07 -0500 President-elect Donald Trump announced Wednesday that he will nominate Rep. Matt Gaetz of Florida, who has clashed with Republican leaders in the House and served as a lightning rod against Democrats, to serve as attorney general in his incoming administration. Full Article
z White supremacists protest Michigan performance of Anne Frank play with Nazi flags By www.washingtontimes.com Published On :: Wed, 13 Nov 2024 16:41:48 -0500 A group of White supremacist demonstrators protested a performance of the play "The Diary of Anne Frank" in Howell, Michigan, by waving Nazi flags across the street from the venue. Full Article
z Bob Menendez trial jurors were given evidence that judge had excluded, prosecutors say By www.washingtontimes.com Published On :: Wed, 13 Nov 2024 17:05:36 -0500 Some evidence that a federal judge had excluded from the bribery trial of former New Jersey Sen. Bob Menendez was inadvertently put on a computer given to jurors, federal prosecutors revealed Wednesday, though they insisted it should have no effect on the Democrat's conviction. Full Article
z "We Need Everyone": New Award Recognizes the Importance of Scientific Community By www.newswise.com Published On :: Wed, 13 Nov 2024 13:30:03 EST In the lab of Minna Roh-Johnson, PhD, great science and great mentorship are inextricable. Now, up to $250,000 in federal funding from the National Cancer Institute has made that philosophy concrete by advancing cancer research and building scientific community. Full Article
z Olaf From The Movie Frozen By www.thecollectionshop.com Published On :: 5/14/2014 Olaf From The Movie Frozen by Trevor Mezak is a(n) Limited Edition. The Edition is Limited to Limited Edition Of 95 pcs Full Article
z ZIPPO THE FIRE-EATER By www.thecollectionshop.com Published On :: 10/27/2010 ZIPPO THE FIRE-EATER by Will Bullas is a(n) Open Edition. The Edition is Limited to Open Edition pcs Full Article
z the Lizard Lounge LIMITED EDITION CANVAS By www.thecollectionshop.com Published On :: 3/27/2008 the Lizard Lounge LIMITED EDITION CANVAS by Will Bullas is a(n) Limited Edition. The Edition is Limited to Limited to 75 pcs Full Article
z the Lizard Lounge MASTERWORK CANVAS EDITION By www.thecollectionshop.com Published On :: 3/27/2008 the Lizard Lounge MASTERWORK CANVAS EDITION by Will Bullas is a(n) Limited Edition. The Edition is Limited to Limited to 25 pcs Full Article