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Karuna Therapeutics, little-known firm is yr's best US IPO with 420% surge

Early Karuna holders saw more than 420 per cent returns since the June IPO at $16 a share




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SBI Cards IPO: Price band fixed in the range of Rs 750 to Rs 755 per share

At issue size of Rs 10,355 cr, the offering will be Asia's biggest this year and fourth-largest domestically




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SBI Cards IPO: Why analysts suggest subscribing despite rich valuation

Siddharth Purohit of SMC Global Securities believes that given the stable RoE of 30% valuation, in terms of P/E ratio is likely to come down to 31x and 22x in FY21 and FY22, respectively from 43x.




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Equitas Small Finance Bank gets Sebi nod for IPO worth Rs 550 crore

JM Financial, Edelweiss Financial Services and IIFL Securities are managing the offer




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ESAF Small Finance Bank gets Sebi approval to float Rs 976 crore IPO

SEBI issued the final observations to the lenders proposal on March 20, 2020.




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Man held on charge of stabbing wife in Kolkata




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The American way: those above and those below / written by John Ridley ; pencils by Georges Jeanty ; inks by John Livesay [and 3 others] ; colors by Nick Filardi ; letters by Travis Lanham

Hayden Library - PN6728.A496 R54 2018




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Batman/The Shadow: the murder geniuses / story by Scott Snyder and Steve Orlando ; script by Steve Orlando ; art by Riley Rossmo ; colors by Ivan Plascencia ; letters by Clem Robins ; cover art and original series covers by Riley Rossmo

Barker Library - PN6728.B36 S674 2017




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Self/made / writer, Mat Groom ; artist, Eduardo Ferigato ; colorist, Marcelo Costa ; color flats, Mariana Calil ; letterer, A Larger World Studios' Troy Peteri ; editor, Kyle Higgins

Barker Library - PN6728.S437 G76 2019




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Battle angel Alita. presented by Yukito Kishiro ; lettering, Evan Hayden

Barker Library - PN6790.J34 G86613 2018




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My solo exchange diary / (true) story & art, Nagata Kabi ; translation, Jocelyne Allen ; adaptation, Lianne Sentar

Barker Library - PN6790.J33 N243413 2017




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Mister Miracle / Tom King, writer ; Mitch Gerads, artist and colorist ; Clayton Cowles, letterer ; Mitch Gerads, collection cover art ; Nick Derington, original series cover art

Barker Library - PN6728.M53 K56 2019




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Fruit of knowledge: the vulva vs. the patriarchy / Liv Strömquist ; [translator, Melissa Bowers]

Barker Library - PN6790.S883 S7513 2018




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A marvelous life: the amazing story of Stan Lee / Danny Fingeroth

Dewey Library - PN6727.L39 Z6455 2019




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Pound for pound / Natalie Chaidez, writer ; Andy Belanger, art ; Daniela Miwa, color art ; Serge LaPointe, letterer ; Sebastian Girner, editor

Barker Library - PN6727.P68 2019




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The Cambridge history of the graphic novel / edited by Jan Baetens, University of Leuven ; Hugo Frey, University of Chichester ; Stephen E. Tabachnick, University of Memphis

Hayden Library - PN6710.C34 2018




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Algernon Blackwood's The willows / written by Nathan Carson ; artwork by Sam Ford ; based on the novella by Algernon Blackwood ; lettered by Jason Fischer ; edited by Jason Leivian

Barker Library - PN6727.C386 A54 2019




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Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery

Biomater. Sci., 2020, 8,2274-2282
DOI: 10.1039/C9BM02036E, Paper
Yue Cai, Zhuomin Xu, Qi Shuai, Fangtao Zhu, Jiao Xu, Xin Gao, Xuanrong Sun
PEG-PLA micelles are modified with F3 peptides, thus endowing the micelles with active-targeting ability due to the nucleolin-binding ability of the F3 peptides.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ultra pH-sensitive polymeric nanovesicles co-deliver doxorubicin and navitoclax for synergetic therapy of endometrial carcinoma

Biomater. Sci., 2020, 8,2264-2273
DOI: 10.1039/D0BM00112K, Paper
Jie Ding, Xu Zhang, Chuangqi Chen, Yuqiang Huang, Xingsu Yu, Xiaomao Li
An ultra pH-sensitive polymeric nanovesicle was constructed to co-deliver doxorubicin and navitoclax for highly efficient synergetic treatment of endometrial carcinoma.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry

Biomater. Sci., 2020, 8,2283-2288
DOI: 10.1039/D0BM00088D, Paper
Guihong Lu, Liping Zuo, Jinfeng Zhang, Houshun Zhu, Wanru Zhuang, Wei Wei, Hai-Yan Xie
A highly efficient two-step targeting strategy integrating metabolic lipid-engineering with in situ click chemistry is developed, thus significantly improved the tumor theranostic performance of the red blood cells ghosts based drug delivery.
The content of this RSS Feed (c) The Royal Society of Chemistry




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MT1-MMP activatable fluorogenic probes with enhanced specificity via high-affinity peptide conjugation for tumor imaging

Biomater. Sci., 2020, 8,2308-2317
DOI: 10.1039/C9BM02007A, Paper
Xiuru Ji, Shuping Xie, Yan Jiao, Xiaojuan Zhang, Duxin Sun, Victor C. Yang, Mei Wang, Huining He, Lu Sun
A novel MT1-MMP activatable fluorogenic probe for tumor detection with enhanced specificity was developed via high-affinity and specific peptide conjugation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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From single to a dual-gene delivery nanosystem: coordinated expression matters for boosting the neovascularization in vivo

Biomater. Sci., 2020, 8,2318-2328
DOI: 10.1039/C9BM02000D, Paper
Bin Gao, Xiaoyu Wang, Meiyu Wang, Xiang-kui Ren, Jintang Guo, Shihai Xia, Wencheng Zhang, Yakai Feng
A dual-gene delivery system with coordinated expression function boosted the neovascularization.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Balancing the thickness of sensitizing and inert layers in neodymium-sensitized tetralayer nanoconstructs for optimal ultraviolet upconversion and near-infrared cross-linked hydrogel tissue sealants

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00453G, Paper
Zhongzheng Yu, Yong Yao Chun, Jingwen Xue, Jodie Zu Yi Tan, Wen Kiat Chan, Weizheng Cai, Yan Zhang, Timothy Thatt Yang Tan
Balancing the thickness of sensitizing and inert layers in neodymium-sensitized tetralayer nanoconstructs for optimal ultraviolet upconversion.
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Strategic reconstruction of macrophage-derived extracellular vesicles as a magnetic resonance imaging contrast agent

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00128G, Paper
Sagar Rayamajhi, Ramesh Marasini, Tuyen Duong Thanh Nguyen, Brandon L. Plattner, David Biller, Santosh Aryal
Reconstruction of extracellular vesicles with imaging agents allows precise downstream analysis using clinical imaging modalities, for example, MRI. This will further improve the biocompatibility of agents thereby enhancing clinical investigations.
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Osteopromotive carbon dots promote bone regeneration through the PERK-eIF2α-ATF4 pathway

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00424C, Paper
Nianqiang Jin, Nuo Jin, Zilin Wang, Lili Liu, Lin Meng, Daowei Li, Xing Li, Dabo Zhou, Jie Liu, Wenhuan Bu, Hongchen Sun, Bai Yang
Novel carbon dots induced ER stress and activated PERK-eIF2α-ATF4 pathway promote bone regeneration.
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A bioartificial liver support system integrated with a DLM/GelMA-based bioengineered whole liver for prevention of hepatic encephalopathy via enhanced ammonia reduction

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01879D, Paper
Guohua Wu, Di Wu, James Lo, Yimin Wang, Jianguo Wu, Siming Lu, Han Xu, Xin Zhao, Yong He, Jun Li, Utkan Demirci, Shuqi Wang
The developed bioartificial liver support system integrated with the decellularized liver matrix/GelMA-based bioengineered whole liver can potentially help elevate liver functions and prevent hepatic encephalopathy via enhanced ammonia reduction.
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Influence of the mechanical properties of biomaterials on degradability, cell behaviors and signaling pathways: current progress and challenges

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00269K, Review Article
Lu Wang, Cunyang Wang, Shuai Wu, Yubo Fan, Xiaoming Li
We have clarified the influence of the mechanical properties of biomaterials on degradability and cell response, and also mechanical design targets and approaches.
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Arbitrarily-shaped microgels composed of chemically unmodified biopolymers

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM02056J, Paper
Yadu N. Vakkipurath Kodakkadan, Kristyna Idzakovicova, Josef Sepitka, Daniël ten Napel, Eric Safai, Petr Cigler, Frantisek Štěpánek, Ivan Rehor
We introduce a method for photolithographic synthesis of arbitrarily shaped microgels composed purely of a biopolymer of choice.
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Nanozyme-catalyzed oxygen release from calcium peroxide nanoparticles for accelerated hypoxia relief and image-guided super-efficient photodynamic therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00187B, Paper
Yuping Hu, Xuechun Wang, Peng Zhao, Hao Wang, Wei Gu, Ling Ye
The accelerated O2 release from CaO2 catalyzed by MnO2 nanozyme leads to a rapid and efficient hypoxia relief, an increased yield of 1O2, a down-regulated HIF-1α and VEGF, and eventually a super-efficient PDT.
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Bacterial nanocellulose as a corneal bandage material: a comparison with amniotic membrane

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00083C, Paper
Open Access
Irene Anton-Sales, Justin Christopher D'Antin, Jorge Fernández-Engroba, Victor Charoenrook, Anna Laromaine, Anna Roig, Ralph Michael
Bacterial nanocellulose exhibits valuable properties to act as a corneal bandage material in terms of conformability, suturability, durability and ease of manipulation in ophthalmological environments.
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Delivery of dual miRNA through CD44-targeted mesoporous silica nanoparticles for enhanced and effective triple-negative breast cancer therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00015A, Paper
Manisha Ahir, Priyanka Upadhyay, Avijit Ghosh, Sushmita Sarker, Saurav Bhattacharya, Payal Gupta, Swatilekha Ghosh, Sreya Chattopadhyay, Arghya Adhikary
Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual miRNA loading, efficient delivery and significantly inhibited tumor growth as well as retarded metastasis in triple-negative breast cancer.
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Development of new self-assembled cationic amino liposomes for efficient gene delivery

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00331J, Communication
Yihang Wu, Yue Xiong, Ling Wang, Quanming Zhou, Linxian Li, Pavel A. Levkin, Gary Davidson, Liqian Gao, Wenbin Deng
A library of lipidoids self-assembling to liposomes exhibits excellent transfection efficiency in HEK 293T cells and mESCs with low cytotoxicity.
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Fixed-point “blasting” triggered by second near-infrared window light for augmented interventional photothermal therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00372G, Paper
Yongbin Cao, Boshu Ouyang, Xiaowei Yang, Qin Jiang, Lin Yu, Shun Shen, Jiandong Ding, Wuli Yang
Tumors were effectively destroyed by a mild photothermal effect and the subsequent gas mechanical damage triggered by NIR-II light.
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Polydopamine-assisted one-step modification of nanofiber surfaces with adenosine to tune the osteogenic differentiation of mesenchymal stem cells and the maturation of osteoclasts

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01990A, Paper
Taufiq Ahmad, Hayeon Byun, Hyeok Jun Shin, Jinkyu Lee, Sajeesh Kumar Madhurakkat Perikamana, Eun Mi Kim, Young Min Shin, Heungsoo Shin
Adenosine and its receptors have emerged as alternative targets to control cellular functions for bone healing.
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An engineered exosome for delivering sgRNA:Cas9 ribonucleoprotein complex and genome editing in recipient cells

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00427H, Paper
Yangyang Ye, Xiang Zhang, Fei Xie, Bin Xu, Ping Xie, Ting Yang, Qian Shi, Chen-Yu Zhang, Yujing Zhang, Jiangning Chen, Xiaohong Jiang, Jing Li
CRISPR-Cas9 components delivered by engineered exosomes achieve genome editing in recipient cells.
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Messenger RNA/polymeric carrier nanoparticles for delivery of heme oxygenase-1 gene in the post-ischemic brain

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00076K, Paper
Jungju Oh, Sang-Mi Kim, Eun-Hye Lee, Minkyung Kim, Youngki Lee, Seung Hwan Ko, Ji Hoon Jeong, Chang-Hwan Park, Minhyung Lee
Heme oxygenase-1 messenger RNA (HO1-mRNA) was delivered into the post-ischemic brain, using a polymeric carrier. Therapeutic efficacy of HO1-mRNA delivery was compared with that of HO1-plasmid DNA (HO1-pDNA) in ischemia-reperfusion rat models.
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Dendritic cells reprogrammed by CEA messenger RNA loaded multi-functional silica nanospheres for imaging-guided cancer immunotherapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00395F, Communication
Yue Hu, Yuyin Tang, Xiao-Jing Zhang, Xiao-Tong Yang, Ying-Ying Tang, Su Li, Linyu Hu, Peng Chen, Dong Zhu
Multi-functional and hierarchically structured silica nanospheres are rationally designed and fabricated, which encapsulate quantum dots to permit near infrared deep tissue imaging and are loaded with carcinoembryonic antigen messenger RNA (CEAmRNA) to enable stable and abundant antigen expression in DCs.
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A photothermal-hypoxia sequentially activatable phase-change nanoagent for mitochondria-targeting tumor synergistic therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00003E, Paper
Jia Qu, Dengke Teng, Guoqing Sui, Shihui Guan, Yang Wang, Qimeihui Wang, Yuanqiang Lin, Haitao Ran, Zhigang Wang, Hui Wang
The advantages of PCM@Lip/IT NPs include mitochondrial-targeting, on-demand drug release, and prodrug activation by hypoxia with guidance/monitoring by PA and FL imaging.
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Long-term delivery of alendronate through an injectable tetra-PEG hydrogel to promote osteoporosis therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00376J, Paper
Dawei Li, Jin Zhou, Mingming Zhang, Yuanzheng Ma, Yanyu Yang, Xue Han, Xing Wang
An alendronate-loaded tetra-PEG hydrogel, as an injectable and effective drug carrier, regulates the optimized release of therapeutic cargoes to promote osteoporosis therapy and bone regeneration.
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Protein cages and virus-like particles: from fundamental insight to biomimetic therapeutics

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00159G, Minireview
Nicole F. Steinmetz, Sierin Lim, Frank Sainsbury
Protein cages found in nature have evolved for a variety of purposes and this review focuses on how they are being co-opted for use in immunotherapy and therapeutic delivery.
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Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6Al4V for treating methicillin-resistant Staphylococcus aureus bone infection and enhancing osteogenesis in a rabbit tibia osteomyelitis model

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01968E, Paper
Teng Zhang, Qingguang Wei, Hua Zhou, Wenhao Zhou, Daoyang Fan, Xinhong Lin, Zehao Jing, Hong Cai, Yan Cheng, Xiaoguang Liu, Weishi Li, Chunli Song, Yun Tian, Nanfang Xu, Yufeng Zheng, Zhongjun Liu
Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6A14V for treating MRSA bone infection and enhancing osteogenesis.
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Self-assembled nucleo-tripeptide hydrogels provide local and sustained doxorubicin release

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00134A, Paper
Kiheon Baek, Alexander David Noblett, Pengyu Ren, Laura J. Suggs
Doxorubicin is intercalated within the nanofibril structure of self-assembled nucleo-peptide hydrogels and injection leads to decrease in tumor volume and greater concentration of chemotherapeutic relative to soluble form.
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19 F magnetic resonance imaging enabled real-time, non-invasive and precise localization and quantification of the degradation rate of hydrogel scaffolds in vivo

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00278J, Paper
Qinghua Li, Zujian Feng, Huijuan Song, Jianhua Zhang, Anjie Dong, Deling Kong, Weiwei Wang, Pingsheng Huang
19 F MRI is able to precisely monitor the localization and quantify the degradation rate of implantable/injectable hydrogels in real-time and noninvasive manner, with no interference of endogenous background signals and limitation of penetration depth.
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A Fe3+-crosslinked pyrogallol-tethered gelatin adhesive hydrogel with antibacterial activity for wound healing

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00188K, Paper
Ning Han, Ziyang Xu, Chunyan Cui, Yuan Li, Dongfei Zhang, Meng Xiao, Chuanchuan Fan, Tengling Wu, Jianhai Yang, Wenguang Liu
A tunicate-inspired gelatin-based hydrogel prepared by a simple mixing method, exhibits strong adhesion and antibacterial capacity, and facilitates wound healing.
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ZBTB20-mediated titanium particle-induced peri-implant osteolysis by promoting macrophage inflammatory responses

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00147C, Paper
Open Access
Junxiong Qiu, Peng Peng, Min Xin, Zhenkang Wen, Zhong Chen, Sipeng Lin, Manyuan Kuang, Yuan Fu, Guibin Fang, Shixun Li, Changchuan Li, Jiaji Mao, Ling Qin, Yue Ding
Aseptic loosening (AL) caused by wear particles released from implant surfaces is one of the main causes for the failure of artificial joints, which is initiated by macrophage inflammatory responses.
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Disulfiram-Gold-Nanorod Integrate for Effective Tumor Targeting and Photothermal-Chemical Synergistic Therapy

Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00062K, Paper
Chaoli Xu, Ting Zhang, Guangming Lu, Kun Chen, Jun Tao, Yunlei Zhang, Zhaogang Teng, Bin Yang
Herein, we successfully constructed a combined therapeutic nanoplatform with high tumor targeting for cancer treatment by integrating gold nanorods with disulfiram (denoted Au-DSF). The Au-DSF integrates possess a uniform length...
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Fluorescence Imaging-Guided Multifunctional Liposomes for Tumor-Specific Phototherapy for Laryngeal carcinoma

Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00249F, Paper
Di Wu, zheng zhao, nan wang, xinrui zhang, honghong yan, xiaoqi chen, yunyun fan, weiwei liu, xuekui liu
Reliable diagnosed and efficient targeted therapy regime is important and may in turn lead to more effective laryngeal carcinoma treatments. Multifunctional nano-theranostic agents demonstrate great potential in tumor theranostic applications....
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A disulfide based low molecular weight gel for the selective sustained release of biomolecules

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00508H, Paper
Nitin D. Bansode, Kotagudda Ranganath Sindhu, Chloe Morel, Murielle Rémy, Julien Verget, Claudine Boiziau, Philippe Barthélémy
Constructing biocompatible soft materials via supramolecular approaches remains an important challenge for in vivo applications.
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Oral biofilm elimination by combining iron-based nanozymes and hydrogen peroxide-producing bacteria

Biomater. Sci., 2020, 8,2447-2458
DOI: 10.1039/C9BM01889A, Paper
Yanqiu Wang, Xinyu Shen, Shang Ma, Qianqian Guo, Wei Zhang, Lu Cheng, Liming Ding, Zhuobin Xu, Jing Jiang, Lizeng Gao
Combining nanozymes and bacteria to eliminate dental biofilms in a mixed-species model.
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Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy

Biomater. Sci., 2020, 8,2472-2480
DOI: 10.1039/D0BM00172D, Paper
Haishi Qiao, Xingmei Chen, Qiming Wang, Junmei Zhang, Dechun Huang, Enping Chen, Hongliang Qian, Yinan Zhong, Qi Tang, Wei Chen
Illustration of pH-degradable microgels (MGs) for the simultaneous encapsulation of OA and JQ1 for an enhanced oncolytic viral treatment with JQ1-meidated boosting viral replication and PD-L1 suppression.
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