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Cyclic peptides targeting the SARS-CoV-2 programmed ribosomal frameshifting RNA from a multiplexed phage display library

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC04026K, Edge Article
Open Access
Jacob A. Iannuzzelli, Rachel Bonn, Andrew S. Hong, Abhijith Saseendran Anitha, Jermaine L. Jenkins, Joseph E. Wedekind, Rudi Fasan
Cyclopeptide agents targeted against the −1 programmed ribosomal frameshifting stimulatory sequence RNA pseudoknot of SARS-CoV-2 were discovered by screening a multiplexed phage display library of genetically encoded peptide macrocycles.
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An ultrasensitive 2,4,6-trinitrophenol nanofluidic sensor inspired by olfactory sensory neurons in sniffer dogs

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05493H, Edge Article
Open Access
Xin Li, Zhanfang Liu, Linsen Yang, Shengyang Zhou, Yongchao Qian, Yuge Wu, Zidi Yan, Zhehua Zhang, Tingyang Li, Qingchen Wang, Congcong Zhu, Xiang-Yu Kong, Liping Wen
Inspired by sniffer dog olfactory sensory neurons, an ultrasensitive TNP detection sensor was developed by in situ growing UiO-66-NH2 layers on AAO. It exhibits a limit of detection with 6.5 × 10−16 g mL−1, offering a new method for rapid detection.
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Strain-induced charge delocalization achieves ultralow exciton binding energy toward efficient photocatalysis

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05873A, Edge Article
Open Access
Junyuan Duan, Yinghe Zhao, Yu Wu, Youwen Liu, Junnian Chen, Ruoou Yang, Jiazhao Huang, Chuanqi Luo, Mao Wu, Xiaodong Zheng, Pengyu Li, Xueliang Jiang, Jianguo Guan, Tianyou Zhai
A novel approach of strain-induced charge delocalization is developed to significantly reduce the exciton binding energy of Ta2O5 nanorods to below ambient thermal energy, leading to a remarkable enhancement in photocatalytic hydrogen evolution.
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Deep Learning Enabled Ultra-high Quality NMR Chemical Shift Resolved Spectra

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC04742G, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhengxian Yang, Weigang Cai, Wen Zhu, Xiaoxu Zheng, Xiaoqi Shi, Mengjie Qiu, Zhong Chen, Maili Liu, Yanqin Lin
High quality chemical shift resolved spectra have long been pursued in nuclear magnetic resonance (NMR). In order to obtain chemical shift information with high resolution and sensitivity, a neural network...
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Simultaneous generation of hydroxyl and hydrogen radicals from H+/OH− pairs caused by water–solid contact electrification

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06227B, Edge Article
Open Access
Fengjie Chen, Jingde Wu, Dou Wang, Yu Xia, Qingyuan Song, Ying Liang, Pu Wang, Bolei Chen, Yong Liang, Yongguang Yin, Yawei Wang, Maoyong Song, Guibin Jiang
Water–solid contact electrification is a common physical phenomenon involving interfacial electron and ion transfer, recently discovered to trigger unique redox reactions.
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The Majrooh Sultanpuri of writers

Best known for musical blockbusters, legendary filmmaker Nasir Husain also wrote dialogues for his films. His words were true to the syntax of the timesthey were written in, whether it was forMunimjiorPaying Guestin the mid-1950s or forJo Jeeta Wohi Sikanderin the ’90s




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Of cultural vulnerabilities

A public adda withsix diverse voiceswill explore what happens when subculturesbecome part ofthe mainstream




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The pain and power of multiples

With as many as 14 Bollywood franchise films seeing the light of the day in 2016, we decode the phenomenon




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Counter culture queen

In an exclusive interview, Anushka Sharma opens up about shunning parties, her production company and her goals for the year




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Share Market Highlights 18 April 2024: Sensex falls 330 pts, Nifty at 22,000; media, metal stocks shine, FMCG, healthcare drag

Sensex, Nifty updates on 18th April 2024: Equity benchmarks BSE Sensex and NSE Nifty extended losses on Thursday. As per provisional figures, BSE Sensex fell 332.23 pts or 0.46 per cent to trade at 72,611.45 as of 3.35 pm and Nifty 50 declined 103.70 pts or 0.47 per cent to trade at 22,044.20., Bharti Airtel, Power Grid Corp, M&M, BPCL, and Tata Steel were the top gainers, while Nestle, Apollo Hospitals, Axis Bank, HCL Technologies, and ONGC were the major laggards. The stocks that hit a 52-week high on the NSE include AAA Tech (19.33 per cent), Just Dial (12.95 per cent), Indo Tech (10 per cent) and Hi-Tech Gear (10 per cent).




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Tata Nifty Realty Index Fund NFO: Should you invest?

Does the strong revival in demand across realty segments signal an investing opportunity? Read on to take an informed call




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Why this consistent ultra short-term fund is a worthy debt investment

ICICI Prudential Ultra Short-Term fund can make the most of persistently high short-term interest rates




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Picking a pharma and healthcare fund post-Covid

Despite the run-up in valuations, the healthcare sector does have a strong investment case




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Navi Nifty 500 Multicap 50:25:25 Index Fund: Should you subscribe?

The only fund tracking the Nifty 500 Multicap 50:25:25 Index till date. But does it offer some unique value proposition?




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ICICI Pru Equity & Debt Fund review: A slight tilt to safety

Broad portfolio of holdings in equity and debt to limit portfolio downside during corrections from the peaks




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Franklin Templeton India makes a debt fund comeback: Should you invest in its ultra short duration NFO?

The ultra short duration scheme is a new offering from the fund house after a long gap




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Chinmaya Mission takes up growing challenges of mental health




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A paper-in-polymer-pond (PiPP) hybrid microfluidic microplate for multiplexed ultrasensitive detection of cancer biomarkers

Lab Chip, 2024, 24,4962-4973
DOI: 10.1039/D4LC00485J, Paper
Sanjay S. Timilsina, XiuJun Li
A reusable and cost-effective paper-in-polymer-pond (PiPP) hybrid microfluidic microplate with unique features for ultrasensitive and high-throughput multiplexed detection of disease biomarkers within an hour without using specialized instruments.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Compact lens-free imager using a thin-film transistor for long-term quantitative monitoring of stem cell culture and cardiomyocyte production

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00528G, Paper
Open Access
Taishi Kakizuka, Tohru Natsume, Takeharu Nagai
A novel compact lens-free imager achieved high-throughput long-term monitoring within an incubator, demonstrating the quantification of the confluency of human iPS cells, epithelial-to-mesenchymal transition, and cardiomyocyte beating dynamics.
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Self-actuated microfluidic chiplet for two-stage multiplex nucleic acid amplification assay

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00752B, Paper
Open Access
Felix Ansah, Marziyeh Hajialyani, Fatemeh Ahmadi, Yuming Gu, Ergün Alperay Tarım, Michael G. Mauk, Gordon A. Awandare, Haim H. Bau
Self-actuated chiplet for Penn-RAMP assay.
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Dual-drive acoustic micromixer for rapid nucleation and ultrafast growth of perovskite nanoparticles

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00721B, Paper
Zhifang Liu, Yuwen Lu, Wei Tan, Guorui Zhu
An acoustic micromixer driven by bubbles and sharp edges, controlling the nucleation and growth of perovskite nanoparticles.
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Discretised microfluidics for noninvasive health monitoring using sweat sensing

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00763H, Paper
Open Access
Emma J. M. Moonen, Walther Verberne, Eduard Pelssers, Jason Heikenfeld, Jaap M. J. den Toonder
We present the first wearable device with integrated electrowetting, which collects and transports sweat from single glands and measures sweat rate for extremely low sweat rate. This enables non-invasive biomarker monitoring of hospitalized patients.
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Multiple factors remain a hurdle in setting up centralised sewer networks, Kerala govt. informs NGT

Faecal sludge treatment plants proposed in a radius of 15 km on cluster basis in urban and rural local bodies




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Tooth-brushing event held to create awareness about oral health among children




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A champion pole-vaulter aims to bow out on a high




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Hits below the belt

"John le Carré's conduct in your pages is like ... that of a man who, having relieved himself in his own hat, makes haste to clamp the brimming chapeau on his head."



  • R K Nair

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Golden Warrior for the Multidimensional Trophy




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King’s Battalion bags the Multidimensional Trophy




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Seeking The Stars, Pink Jasmine, Still I Rise and Multiflora catch the eye




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Something Royal, Multiflora, Asio and Danny’s Girl excel




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Geographique should score a hat-trick in the Teena Katrak Memorial R.W.I.T.C. Ltd Trophy (Gr. 2)




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Geographique completes hat-trick by winning the Teena Katrak Memorial R.W.I.T.C. Ltd. Trophy




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Lt Gen Upendra Dwivedi appointed as next Chief of Army Staff

Lt. Gen Dwivedi brings extensive experience in military operations, technology integration, and strategic leadership, having served in various command and staff appointments throughout his illustrious 39-year career




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PM Modi pledges threefold effort and results in third term; appeals for responsible Opposition

Emphasising the increased responsibility following a significant electoral victory, Modi promised to work harder and achieve greater outcomes 




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Self-declaration for advertisers limited to food, health sectors

I&B Ministry stated that advertisements issued for products related to food and health sectors will be required to upload an annual self-certificate on the Broadcast Seva Portal and Press Council of India portal.  




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Health Ministry directs FSSAI to waive off registration fee for street food vendors

Union Health Minister, Jagat Prakash Nadda also stressed on providing ‘Street Safe’ Rapid Testing Kit to ensure safe food is used by street food vendors and highlighted the need to empower them by enrolling them on food delivery platforms




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Govt brings all citizens aged 70+ under Ayushman Bharat’s ₹5 lakh health scheme

India expands Ayushman Bharat to cover 6 crore senior citizens aged 70+ with ₹5 lakh free health insurance per family, at a total cost of ₹3,437 crore




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Ayushman Bharat scheme could see addition of more geriatric care packages: Health Ministry officials

Suggestions have been sought to increase the number of geriatric care packages under the health insurance scheme




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Government schemes catapulting India to become developed nation: Amit Shah

Modi government has ended “policy paralysis” and transformed India into an economic bright spot, says Union Home Minister Amit Shah




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GoM for freeing health insurance for senior citizens, all policies up to ₹5-lakh cover from GST burden

GoM suggests rate hike on high-end wrist watches, shoes; GST on packaged water to be cut




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CCI sharpens penalty recovery rules, seeks public input on new amendments

Stakeholders invited to share feedback by December 6 on proposed changes aimed at a more streamlined and effective penalty recovery process




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Tigor iCNG: Alt-Fuel

The Tata Tigor iCNG isn’t just inexpensive to run, it’s now easy on the left foot, too




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Audi RS5: Svelte demeanor, sporting intent

Power-packed: The Audi RS 5 Sportback packs more of a punch than its classy looks might suggest




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Tata Altroz teaser released ahead of launch 

Powering the car is going to be a Nexon-sourced 1.2-litre turbocharged petrol engine claimed to make 118 bhp and 17.33 kg-m.




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Renault Kiger 2024 Review: Compact SUV’s pricing, performance and features explained

Renault’s sub-four-metre Kiger is refreshed with added vigour for 2024




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TN Health Dept to launch 25 bike ambulances with Rs 1.60 crore allocation




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Cyclone Dana: Mangrove belt acting as natural speed breaker minimised impact in coastal Sundarbans




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Can air pollution make you fat? Know how high AQI impact your health

Studies indicate that extended exposure to pollutants like particulate matter (PM2.5), nitrogen dioxide, and carbon monoxide can lead to systemic inflammation and metabolic disruptions, both of which play a significant role in weight gain.




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Is kala namak really a detox? Shalini Passi swears by this simple health hack

Kala namak is believed to aid in digestion by helping regulate pH levels and providing essential electrolytes.




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New health directive in Tamil Nadu, Government declares THIS as notifiable disease

Tamil Nadu has declared THIS as a notifiable disease requiring hospitals to report cases and deaths to improve monitoring and treatment.