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For healthy adults, taking multivitamins daily is not associated with a lower risk of death

A large analysis of data from nearly 400,000 healthy U.S. adults followed for more than 20 years has found no association between regular multivitamin use and lower risk of death.




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Ram temple sets off realty boom in Ayodhya

As Ayodhya town gears up for the consecration of the temple, land prices soar to an all-time high, especially in areas around the new structure




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Exploring India’s diverse cultural heritage through GI tags | Data

Over 500 products across all the States have been given GI tags so far




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Manipur Police accuse radical outfit Arambai Tengol of extortion, assault

Terming the abduction of an officer “unprecedented”, police in valley and hill districts ask for more forces of Assam Rifles, fearing a breach of peace due to the movement of armed civilians, underground outfits  




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Bengal CM Mamata Banerjee's 'insult' at NITI Aayog meeting doesn't suit democratic norms: Sanjay Raut

The money which is distributed by the Centre belongs to the people of India. What did Maharashtra get... Our Chief Minister came back empty-handed: Shiv Sena UBT leader Sanjay Raut




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Ultimate Table Tennis: a passion project in need of mainstream sizzle

Having joined a select list of franchise-based leagues to have completed five seasons, UTT has the substance — not to mention the promoters’ determination — to stay afloat. What must it do to draw more eyeballs and footfalls so it can take table tennis to the next level in India? 




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It felt nicer to deliver for the team: Divya Deshmukh

The 18-year-old from Nagpur played every 11 rounds at the Olympiad. And she remained unbeaten, winning eight games and drawing three.




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Global Chess League: Nihal’s draw stands, SG Pipers’ appeal to reverse result rejected




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This Bengaluru software professional covered 518 km in three days to win Ultraman India 2024

Bengaluru’s Jayanarayan Raja won Ultraman India 2024, conquering 518 km in three days with a grueling swim, bike, and run challenge




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Gukesh brooks no complacency as he readies forces for World title assault

The 18-year-old has an opportunity to become the youngest World chess champion, with many observers — including several top players — expecting him to defeat Ding Liren. But Gukesh isn’t taking the Chinese defending champion, whom he is yet to beat in a classical game, lightly




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Qatar halts its mediation efforts on Gaza, says the Hamas office ‘no longer serves its purpose’

In Washington, a U.S. official said the Biden administration informed Qatar two weeks ago that the Hamas office's continued operation in Doha was no longer useful and the Hamas delegation should be expelled




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Two strong earthquakes jolt Cuba




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China to unveil stealth fighter jet and attack drones at Zhuhai airshow

The country's close ties with Moscow will also be on display at Airshow China, which showcases Beijing's civil and military aerospace sector every two years in the southern city of Zhuhai




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Trump asks Mike Waltz, China hawk, to be national security adviser

There are concerns on Capitol Hill about Donald Trump tapping members of the House, where the final tally is still uncertain




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Sri Lanka’s multi-ethnic east reflects challenges facing Anura Kumara Dissanayake

Voters in Ampara district voice hope, skepticism ahead of November 14 parliamentary polls 




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Andhra Pradesh’s tumultuous road to statehood

The formation of Andhra Pradesh, the first linguistic State in India, which led to the formation of more States on a linguistic basis, is a story of great sacrifices made by those who were bound by a strong force—mother tongue




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A novel multifunctional SERS microfluidic sensor based on ZnO/Ag nanoflower arrays for label-free ultrasensitive detection of bacteria

Anal. Methods, 2024, 16,2085-2092
DOI: 10.1039/D4AY00018H, Paper
Yue Liu, Guanwen Su, Wei Wang, Hongyuan Wei, Leping Dang
Design and working principle of bacterial capture and identification using a ZnO/Ag microfluidic SERS sensor array.
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Nanocubic cobalt-containing Prussian blue analogue-derived carbon-coated CoFe alloy nanoparticles for noninvasive uric acid sensing

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00121D, Paper
Yunting Qin, Dan Xiao, Xilan Gao, Xicui Zhang, Yanxue Xu
This work describes an electrochemical sensor for the fast noninvasive detection of uric acid (UA) in saliva.
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A Multimode Biosensor Based on Prussian Blue Nanoparticle Loaded with Gold Nanoclusters for the Detection of Aflatoxin B1

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02330C, Paper
zhaodi Fu, juan Huang, Wei Wei, zhihui Wu, Xingbo Shi
Herein, a novel fluorescent/colorimetric/photothermal biosensor is proposed for aflatoxin B1 (AFB1) detection in food based on Prussian blue nanoparticles (PBNPs) (~50 nm), gold nanocluster (AuNCs) and aptamer (Apt) within three...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A simple, fast and inexpensive approach to quantify low concentrations of iron in biodiesel by voltammetry after extraction induced by microemulsion breaking

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00342J, Paper
Cristian Henrique Krause, Alexandre Batista Schneider, Leandro Kolling, Lauren Thauani Teixeira Oliveira, Márcia M. Silva
An alternative approach to assay iron (Fe) in biodiesel by differential pulse adsorptive cathodic stripping voltammetry (DPAdCSV) is presented herein. The sample treatment involved a simple, rapid, but effective extraction...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Converging optical and electrochemical detection strategies for multimodal hydrazine sensing: insights into substituent-driven diverse response

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00063C, Paper
Rikitha S. Fernandes, Sahil Deepak Vasistha, Ritesh Kumar Singh, Sanket Goel, Nilanjan Dey
A pair of pyrene-based chalcogen derivatives have been developed, which demonstrate multimodal ratiometric response towards hydrazine.
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Phenylboronic acid modification-based novel dumbbell-shaped Au–Ag nanorod SERS substrates for ultrasensitive detection of SO42−

Anal. Methods, 2024, 16,2311-2321
DOI: 10.1039/D3AY01831H, Paper
Kang Shen, Caili Bi, Haifan Yang, Miaowen Xu, Lili Huang, Youwei Wang
Based on the coordination principle of Lewis acids, a novel 4-MPBA-modified dumbbell-shaped Au–Ag nanorod (4-MPBA@DS Au–AgNR) SERS substrate was developed to realize the high sensitivity and specificity of SO42− detection.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A complementary method with PFBBr-derivatization based on a GC-EI-MS platform for the simultaneous quantitation of short-, medium- and long-chain fatty acids in murine plasma and feces samples

Anal. Methods, 2024, 16,2330-2339
DOI: 10.1039/D3AY02271D, Paper
Hong-Xu Zhou, Qing Jiang, Xin He, Xian Fu, Jun-Yan Liu
Fatty acids (FAs) are essential molecules in all organisms and are involved in various physiological and pathophysiological processes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Solvation effect enabled visualized discrimination of multiple metal ions

Anal. Methods, 2024, 16,2301-2310
DOI: 10.1039/D4AY00060A, Paper
Yang Cheng, Yuan Liu, Jiguang Li, Yudong Li, Da Lei, Dezhong Li, Xincun Dou
Highly efficient detection of environmental residual potentially toxic species is of concern worldwide as their presence in an excessive amount would greatly endanger the health of human beings as well as environmental sustainability.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A new colorimetric aptasensor for paraquat detection based on the designed aptamer with multiple paraquat binding sites in combination with gold nanoparticles

Anal. Methods, 2024, 16,2340-2348
DOI: 10.1039/D4AY00053F, Paper
Pakawat Kongpreecha, Sineenat Siri
Given paraquat's environmental health risks, there is a need for a fast and simple detection method. This study presents a novel colorimetric aptasensor with a tailored aptamer, boosting sensitivity by targeting multiple paraquat binding sites.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Online quantification of nicotine in e-cigarette aerosols by vacuum ultraviolet photoionization mass spectrometry

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00279B, Paper
Shaoxin Ye, Zuoying Wen, Kai Xie, Xuejun Gu, Jian Wang, Xiaofeng Tang, Weijun Zhang
A new method for quantifying nicotine in e-cigarette aerosols within a few seconds using a homemade VUV-AMS.
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Analysis of brominide disinfection by-products in aquaculture water using ultra-high-performance liquid chromatography–quadrupole–time-of-flight mass spectrometry

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00396A, Paper
Weimin Yang, Yi Zhang, Jilong Huang, Xing Yang, Ning Jiang
Background: Halogenic disinfectants have been shown to produce toxic and carcinogenic disinfection by-products (DBPs) during water disinfection. Dibromohydantoin (DBDMH) is a commonly used water disinfectant in aquaculture. Aquaculture water has...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A colorimetric tandem combination of CRISPR/Cas12a with dual functional hybridization chain reaction for ultra-sensitive detection of mycobacterium bovis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02200E, Paper
Qiong Liu, Mei Yang, He Zhang, Wenjie Ma, Xin Fu, Huiqing Li, Sainan Gao
Tuberculosis caused by Mycobacterium bovis poses a global infectious threat to humans and animals. Therefore, there is an urgent need to develop a sensitive, precise, and easy-to-readout strategy. Here, a...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Wrong notion: On simultaneous elections

The idea of simultaneous elections is inherently anti-federal




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Politicising the laddu: On the Tirupati laddu and its ‘adulteration’

The Tirupati laddu issue should be limited to one of quality control




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​Healthy sign: On the voting in the 2024 J&K Assembly elections

Turnout numbers in the Assembly elections show distinct patterns in south Kashmir




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​Inflection point: On the escalation in the multi-party West Asia conflict

West Asia needs the intervention of major world powers for peace 




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​Flipping scripts: On the Haryana and J&K election results  

BJP and INDIA bloc emerge clear winners in Haryana and Jammu & Kashmir




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Sweet and sour: On the laddu ‘adulteration’ case  

The inquiry into laddu adulteration must not be communalised




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Culture and society: On upholding Section 6A of the Citizenship Act

Supreme Court of India verdict on citizenship law for Assam helps avoid fresh problems




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Cost of Games: On the 2026 Commonwealth Games 

Taking out popular sports from the CWG is a short-term solution 




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What Makes <I>Andaz Apna Apna</I> Such Fun Even Today

Andaz Apna Apna is practically the most quoted film since Sholay, observes Sukanya Verma, as she celebrates 30 years of this cult classic movie.




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Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides

RSC Med. Chem., 2024, 15,3469-3476
DOI: 10.1039/D4MD00422A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
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Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00562G, Research Article
Open Access
Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. Stevens
Flow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.
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Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan

Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago




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Doctor assaulted inside Tiruchi ESI Hospital




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50 new primary health centres to be opened in State soon: Minister




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Three arrested for assaulting doctor in ESI hospital




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Urban Primary Health Centre stuck in cramped, temporary facility




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Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival

Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base




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Consultant to be appointed soon to design Kalaignar grand library in Tiruchi

The centre will offer translation, services for persons with disabilities and children, training and mentorship programmes, besides hosting monthly literary events




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Fishermen seek healthcare and cold storage facilities




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Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation