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5-axis CNC micro-milling machine for three-dimensional microfluidics

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00496E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mitchell Modarelli, Devin Kot-Thompson, Kazunori Hoshino
The gold standard of microfluidic fabrication techniques, SU-8 patterning, requires photolithography equipment and facilities and is not suitable for 3D microfluidics. A 3D printer is more convenient and may achieve...
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idi

3D-printed microfluidic–microwave device for droplet network formation and characterisation

Lab Chip, 2024, 24,5101-5112
DOI: 10.1039/D4LC00387J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kai Silver, Jin Li, Adrian Porch, William David Jamieson, Oliver Castell, Pantelitsa Dimitriou, Colin Kallnik, David Barrow
A 3D-printed microwave–microfluidic device using a liquid metal resonator for droplet network formation and characterisation.
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idi

Real-time monitoring of a 3D blood–brain barrier model maturation and integrity with a sensorized microfluidic device

Lab Chip, 2024, 24,5085-5100
DOI: 10.1039/D4LC00633J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Ceccarelli, Marie Celine Lefevre, Attilio Marino, Francesca Pignatelli, Katarzyna Krukiewicz, Matteo Battaglini, Gianni Ciofani
A new in vitro sensorized model of the blood–brain barrier has been developed and characterized.
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idi

Discretised microfluidics for noninvasive health monitoring using sweat sensing

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00763H, Paper
Open Access
Emma J. M. Moonen, Walther Verberne, Eduard Pelssers, Jason Heikenfeld, Jaap M. J. den Toonder
We present the first wearable device with integrated electrowetting, which collects and transports sweat from single glands and measures sweat rate for extremely low sweat rate. This enables non-invasive biomarker monitoring of hospitalized patients.
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idi

An imaging scheme to study the flow dynamics of co-flow regimes in microfluidics: implications for nanoprecipitation

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00652F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Wali Inam, Anton Vladyka, Joanna W. Pylvänäinen, Junel Solis, Dado Tokic, Pasi Kankaanpää, Hongbo Zhang
Herein, by presenting a novel imaging-based scheme for analyzing fluid interactions in co-flow regimes, we identify oscillatory and chaotic flow behaviors to optimize nanoprecipitation through controlled fluid manipulation.
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idi

SERS-based pump-free microfluidic chip sensor for highly sensitive competitive immunoassay of cortisol in human sweat

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00858H, Paper
Siyue Xiong, Chushu Zhu, Chengxuan Wang, Peitao Dong, Xuezhong Wu
Cortisol, known as the "stress hormone," is secreted by the adrenal cortex. Measuring cortisol levels in body fluids is essential for evaluating stress levels, adrenal function, hormone imbalances, and psychological...
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idi

Golden Warrior for the Multidimensional Trophy




idi

King’s Battalion bags the Multidimensional Trophy




idi

CBIC issues valuation norms for foreign company supplies to Indian subsidiaries

Additionally, CBIC clarified that for calculating the time limit to avail ITC under the Reverse Charge Mechanism, the relevant financial year will be when the recipient issues the invoice




idi

Family pension in case of two widows to be paid after deciding legality of second marriage

Existing rule says ‘widow’ or ‘widower’ shall mean a spouse, legally wedded to deceased government servant or pensioners.




idi

Diwali 2024: How to get rid of acidity, bloating, constipation post Diwali binge?

Here are some natural ways to help ease digestive discomfort post-Diwali.




idi

Chess happened by accident but it was a happy accident: Vidit Gujrathi

It has not sunk in yet but I do know this achievement is going to stay with us for a long time, says Grandmaster Vidit Gujrathi




idi

Chennai Grandmasters | Arjun rallies to post a win over Vidit on opening day




idi

The application of a self-designed microfluidic lung chip in the assessment of different inhalable aerosols

Anal. Methods, 2024, 16,2111-2119
DOI: 10.1039/D4AY00017J, Paper
Zezhi Li, Xiang Li, Boyang Feng, Junwei Zhao, Kejian Liu, Fuwei Xie, Jianping Xie
Microfluidic-based assessment platforms have recently attracted considerable attention and have been widely used for evaluating in vitro toxic effects.
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idi

A novel multifunctional SERS microfluidic sensor based on ZnO/Ag nanoflower arrays for label-free ultrasensitive detection of bacteria

Anal. Methods, 2024, 16,2085-2092
DOI: 10.1039/D4AY00018H, Paper
Yue Liu, Guanwen Su, Wei Wang, Hongyuan Wei, Leping Dang
Design and working principle of bacterial capture and identification using a ZnO/Ag microfluidic SERS sensor array.
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idi

PCB-C4D coupled with paper-based microfluidic sampling for the rapid detection of liquid conductivity

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00198B, Paper
Mingpeng Yang, Mingyi Cao, Zhixuan Zhang, Chaofan Wang
A solution conductivity detection method, using PCB-C4D coupled with paper-based microfluidic sampling, has been proposed for the rapid and in situ analysis of raw solution with particle filtration, improving detection consistency and reliability.
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idi

Dual-mode detection of 2,6-pyridinedicarboxylic acid based on the enhanced peroxidase-like activity and fluorescence property of novel Eu-MOFs

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00331D, Paper
Jintao Yi, Xianqin Han, Jiahao Jian, Yayan Lai, Jun Lu, Lei Peng, Zhongkai Liu, Jun Xue, Hui Zhou, Xun Li
The dual-mode fluorescence and colorimetric detection of 2,6-pyridinedicarboxylic acid (DPA) based on the enhanced peroxidase-like activity and fluorescence property of a novel MOF.
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idi

Ag-coated tetrapod gold nanostars (Au@AgNSs) for acetamiprid determination in tea using SERS combined with microfluidics

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00297K, Paper
Qian Ke, Limei Yin, Heera Jayan, Hesham R. El-Seedi, Xiaobo Zou, Zhiming Guo
The combination of highly sensitive SERS substrate core–shell Au@AgNSs and microfluidic chip featuring four circular split hybrid structures were used for quantitative detection of acetamiprid in tea. The LOD of acetamiprid was 0.048 ng mL−1.
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idi

Dual-functional porphyrinic zirconium-based metal–organic framework for the fluorescent sensing of histidine enantiomers and Hg2+

Anal. Methods, 2024, 16,2386-2399
DOI: 10.1039/D3AY02241B, Paper
Shili Qin, Fanshu Meng, Fenglong Jin, Xidi Xu, Ming Zhao, Hongtao Chu, Lidi Gao, Shuren Liu
L-Cys/PCN-222 as a novel and dual-functional fluorescent sensor was developed. It not only showed a higher chiral fluorescent recognition of L-histidine but also performed as a visual sensor for Hg2+ in actual surface water.
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idi

On-chip light sheet illumination for nanoparticle tracking in microfluidic channels

Anal. Methods, 2024, 16,2229-2240
DOI: 10.1039/D3AY02290K, Communication
Théo Travers, Gaétan Delhaye, Martinus H. V. Werts, Denis Gindre, Matthieu Loumaigne
A simple and inexpensive method is presented to efficiently integrate light sheet illumination in a microfluidic chip for dark-field microscopic tracking and sizing of nanoparticles.
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idi

Proximity hybridization based “turn-on” DNA tweezer for accurate and enzyme-free small extracellular vesicles analysis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00487F, Paper
Jinlin Wu, Xi Mei, Xiaoqin Zhan, Fang Liu, Dongfang Liu
Small extracellular vesicles (sEVs) are a type of extracellular vesicles that carry many types of molecular information. The identification of sEVs is essential for the non-invasive detection and treatment of...
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idi

A colorimetric tandem combination of CRISPR/Cas12a with dual functional hybridization chain reaction for ultra-sensitive detection of mycobacterium bovis

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02200E, Paper
Qiong Liu, Mei Yang, He Zhang, Wenjie Ma, Xin Fu, Huiqing Li, Sainan Gao
Tuberculosis caused by Mycobacterium bovis poses a global infectious threat to humans and animals. Therefore, there is an urgent need to develop a sensitive, precise, and easy-to-readout strategy. Here, a...
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idi

Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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idi

Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists

RSC Med. Chem., 2024, 15,3477-3484
DOI: 10.1039/D4MD00266K, Research Article
Raitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps Jaudzems
The aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.
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idi

A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00632A, Review Article
Ashish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder Kumar
The present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.
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idi

S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00619D, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott
25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.
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idi

Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00663A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin Krátký
Linking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.
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idi

Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article
Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
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idi

Nvidia: The lynchpin of the AI revolution

The meteoric rise of the Santa Clara-headquartered chipmaker is powered by bold innovation




idi

Fertilizer subsidies to come down, Mandaviya says

The Minister said the Centre increased subsidy to protect farmers interest, and added that it is likely to come down




idi

Chittoor farmers worried about frequent crop-raiding by jumbos

A herd of 16 elephants raided the paddy and tomato fields at Irikipenta village of Somala mandal on Saturday




idi

Microrheology of gemini surfactants at interfaces and in solutions in the dilute and semidilute regimes

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00860J, Paper
Mayssa Medfai, Antonio Stocco, Christophe Blanc, Maurizio Nobili, Martin In
The interface of semidilute Gemini surfactant solutions remains fluid and is less viscous than the bulk. Depletion of the viscosity near the interface plays a key role in microrheology.
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idi

Long-lived unidirectional flow of active particles within long narrow channels

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00879K, Paper
Man Xu, Ying Lan, Yuehua Yang, Hongyuan Jiang
We present the dynamics of particles in a device divided into two chambers by V-shaped barriers and connected by a narrow channel. Here three distinct movement modes occur, including stochastic movement, oscillation and unidirectional flows.
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idi

Aging iridium oxide catalyst inks: a formulation strategy to enhance ink processability for polymer electrolyte membrane water electrolyzers

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00987H, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sunilkumar Khandavalli, Jae Hyung Park, Robin Rice, Diana Y. Zhang, Sarah A. Berlinger, Guido Bender, Deborah J. Myers, Michael Ulsh, Scott A. Mauger
Steady-shear rheology showing evolution of the microstructure of iridium oxide catalyst inks of PEM water electrolyzers with aging time.
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idi

Pairing-specific microstructure in depletion gels of bidisperse colloids

Soft Matter, 2024, Advance Article
DOI: 10.1039/D4SM00811A, Paper
Open Access
Rony A. Waheibi, Lilian C. Hsiao
We report the ensemble-averaged and pairing-specific network microstructure formed by short-range depletion attractions in bidisperse hard sphere-like colloidal systems.
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idi

Bangalore University makes U-turn on 50% seats for locals condition for providing seven additional acres to NLSIU

The condition of reserving seats for students from Karnataka has been left to the discretion of the government




idi

Why was the validity of Uttar Pradesh’s madrasa law upheld by the Supreme Court? | Explained

How do madrasas operate? Why did the Allahabad High Court strike down the law? What were the top Court’s findings? What are the potential implications?




idi

HSAB theory guiding electrophilic substitution reactions of o-carborane

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01546K, Research Article
Yan Wang, Yi-Ge Li, Feijing Chen, Yan-Na Ma, Xuenian Chen
Herein, we systematically compared the reactivity of o-carborane and benzene toward different electrophiles and explained the results with the HSAB principle.
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idi

Iridium/palladium dual photocatalysis for oxidative decarboxylative esterification of alcohols using α-keto acids

Org. Chem. Front., 2024, 11,6367-6379
DOI: 10.1039/D4QO01452A, Research Article
Subal Mondal, Soumya Mondal, Debabrata Halder, Siba P. Midya, Ankan Paul, Pradyut Ghosh
Herein, we report an unprecedented oxidative decarboxylative C–O cross-coupling reaction for the esterification of feedstock α-keto carboxylic acids and alcohols under mild conditions.
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idi

Well-defined chiral dinuclear copper-catalyzed tandem asymmetric propargylic amination–carboxylative cyclization sequence toward chiral 2-oxazolidinone derivatives

Org. Chem. Front., 2024, 11,6319-6326
DOI: 10.1039/D4QO01368A, Research Article
Yu Lan, Peng Liu, Zekai Fang, Lili Shao, Qilong Cai, Xiaoming Wang
A variety of chiral 2-oxazolidinones was obtained via a dinuclear copper-catalyzed asymmetric propargylic amination–carboxylative cyclization sequence of propargylic esters with alkyl amine hydrochlorides and CO2.
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idi

Design, synthesis and application of bipyridine-N,N'-dioxide catalysts in asymmetric synthesis of chiral cyclopropanes

Org. Chem. Front., 2024, 11,6470-6476
DOI: 10.1039/D4QO01532K, Research Article
Xiaoying Cao, Xue Tian, Minmin Liu, Shi-Wu Li
A novel type of highly efficient chiral C2-symmetric bipyridine-N,N'-dioxide ligands was prepared and successfully applied in the synthesis of optically pure 1,2,3-trisubstituted cyclopropanes.
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Iridium-catalyzed asymmetric cascade allylation/lactonization of methyl salicylates: enantioselective construction of chiral benzodioxepinones

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01771D, Research Article
Bendu Pan, Yunru Wu, Yaqi Zhang, Xiaobo He, Long Jiang, Liqin Qiu
An efficient asymmetric cascade allylation/lactonization of methyl salicylates is achieved. The utilization of chiral-bridged biphenyl phosphoramidite ligand resulted in good results for the construction of a wide range of chiral benzodioxepinones.
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idi

Metal–ligand cooperation and synergistic palladium catalysis for the dual ligand system [2,2'-bipyridin]-6(1H)–one/PCy3: milder conditions for the undirected C–H arylation of arenes

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01877J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Cintya Pinilla, Mario García-Zarza, Ana C. Albéniz
The mixture of Pd(OAc)2 and two ligands segregate into distinct active species working synergistically for the C–H arylation of simple arenes.
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idi

Confusion remains over CET’s validity

Medical seat aspirants keeping their fingers crossed




idi

Graphene-supported organoiridium clusters catalyze N-alkylation of amines via hydrogen borrowing reaction

RSC Adv., 2024, 14,35163-35171
DOI: 10.1039/D4RA06595F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Tsun-Ren Chen, Siang-Yu Chiu, Wen-Jen Lee, Yi-Siou Tsai, Yu-Sheng Huang
Graphene-supported organic iridium clusters (GSOIC) exhibit excellent N-alkylation on various substrates under green processes.
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idi

Design, synthesis, and in vitro and in vivo biological evaluation of triazolopyrimidine hybrids as multitarget directed anticancer agents

RSC Adv., 2024, 14,35239-35254
DOI: 10.1039/D4RA06704E, Paper
Open Access
Heba A. Adawy, Samar S. Tawfik, Abdullah A. Elgazar, Khalid B. Selim, Fatma E. Goda
In response to the urgent need for new anti-proliferative agents, four novel series of triazolopyrimidine compounds (7a–e, 9a–d, 11a–f, and 13a–e) were synthesized and evaluated for in vitro and in vivo anticancer efficacy.
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idi

Complexes between 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) and cucurbit[n]uril hosts modulate the yield and fate of photolytically-generated AAPH radicals

RSC Adv., 2024, 14,35980-35991
DOI: 10.1039/D4RA07150F, Paper
Open Access
Angie C. Forero-Girón, Mauricio Oyarzún, Kevin Droguett, Denis Fuentealba, Soledad Gutiérrez-Oliva, Barbara Herrera, Alejandro Toro-Labbé, Eduardo Fuentes-Lemus, Michael J. Davies, Camilo López-Alarcón, Margarita E. Aliaga
AAPH-cucurbit[n]uril systems were experimentally and theoretically studied. Radical yields formed upon photolysis of AAPH were altered by complexation with CB[8] in a stoichiometry-dependent manner, however, radical yields were not changed by CB[6].
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idi

Distance-based paper microfluidic devices for rapid visual quantification of heavy metals in herbal supplements and cosmetics

RSC Adv., 2024, 14,36142-36151
DOI: 10.1039/D4RA05358C, Paper
Open Access
Yanawut Manmana, Mirek Macka, Nantana Nuchtavorn
The ion exchange paper shows strongly retain anionic metallochromic reagents, enabling clear endpoint detection on DμPADs. This method allows rapid heavy metal screening in real samples, with the predeposited reagents stable for at least 2 months.
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UN COP16 biodiversity summit agrees to establish Indigenous subsidiary body

The value of the traditional knowledge of indigenous peoples, Afro-descendants and local communities is recognised with this decision, says Susana Muhamad, Colombia’s environment minister and COP16 president




idi

Rational fabrication of an anionic zinc carboxylate framework as a fluorescent probe for 2,6-pyridinedicarboxylic acid

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02529F, Paper
Hui-Hui Xie, Hao Yu, Xiuling Xu, Si-Fu Tang
An anionic zinc carboxylate framework has been fabricated as a fluorescent sensor for the detection of 2,6-pyridinedicarboxylic acid (DPA).
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