Systems, methods, and devices are disclosed for humidifying a breathing gas that reduces and/or eliminates the dangers and discomforts experienced by a patient. In one aspect, a system for humidifying gases includes a body, extending along a first axis from a first face to a second face, a first lumen at the first face, through which fluid enters the body, a second lumen at the first face through which fluid exits the body and a nonporous membrane located inside the body and extending from the first face to the second face wherein gas moving through the nonporous membrane is humidified by the fluid.

The invention relates to a method for automatically adjusting a plurality of tunable passive antennas, for instance a plurality of tunable passive antennas of a radio transceiver using several antennas simultaneously. The invention also relates to an automatically tunable antenna array using this method. An automatically tunable antenna array of the invention has 4 user ports, and comprises: 4 tunable passive antennas, the 4 tunable passive antennas operating simultaneously in a given frequency band and forming a multiport antenna array; 4 sensing units; 4 feeders; a signal processing unit delivering a tuning instruction; and a tuning control unit, the tuning control unit receiving the tuning instruction from the signal processing unit, the tuning control unit delivering tuning control signals to the tunable passive antennas, the tuning control signals being determined as a function of the tuning instruction.

A circuit board includes a substantially planar component carrier and a microstrip which is applied to a surface of the component carrier. The microstrip extends towards a connection transition which is arranged on a lateral edge of the component carrier. A waveguide portion of an antenna element which is produced by a 3D printing process is coupled to this connection transition.

Aspects of the subject disclosure may include, for example, an antenna structure having a feed point for coupling to a dielectric core of a cable that propagates electromagnetic waves without an electrical return path, and a dielectric antenna, substantially or entirely devoid of conductive external surfaces, coupled to the feed point, the dielectric antenna facilitating receipt, at the feed point, the electromagnetic waves for propagating the electromagnetic waves to an aperture of the dielectric antenna for radiating a wireless signal. Other embodiments are disclosed.

A 2×2 MIMO array antenna is provided which includes two separate radiating elements mounted to an antenna reflector. Each element is linear polarized with two orthogonal polarizations, one polarization excited by a transmit port and the other polarization receiving radiated signals destined for a receive port. The two elements are aligned that the polarizations excited by the transmit ports of the two elements are along a common axis, or the polarizations received by the receive ports of the two elements are along a common axis.

Antenna system for a georadar, comprising two plate like antenna devices, where said two antenna devices comprise at least one sender antenna (1) and at least one receiver antenna (2), respectively, as the antennas (1,2) in each antenna device comprise monopoles formed by applying to metal surfaces an electrically insulating plate base (3) located on the underside of a layer of radar absorbing material (4), where the top side of the material layer is covered by a metallic ground plane (5). The antenna device is also arranged to lay against the ground (10). A layer of radar absorbent material (4) is arranged on the top side of the ground planes (5), and the ground planes (5) are not connected electrically to each other.

The present invention relates to an RF tag comprising a magnetic antenna for transmitting and receiving information using an electromagnetic induction method, and an IC mounted to the magnetic antenna, wherein the magnetic antenna comprises a magnetic core and a plurality of coils formed on the magnetic core; the coils each have an inductance L1 satisfying the specific relational formula, and are connected in parallel to each other in an electric circuit and disposed in series on the magnetic core; and a combined inductance L0 of the magnetic antenna satisfies the specific relational formula. The RF tag of the present invention is used as a magnetic antenna for information communication using a magnetic field component which is capable of satisfying both reduction in size and improvement in communication sensitivity.

Various systems and methods for radiating RF transmissions outside of a portable electronic device with a conductive case. In an embodiment, this solution includes a conductive enclosure, a circuit board within the conductive enclosure, at least one non-conductive gap between the circuit board and the conductive enclosure, and a radio frequency (RF) connection between the circuit board and the conductive enclosure. The combination of enclosure and gaps can excite certain radiation modes at high frequency bands, such as a cavity-backed lambda-long slot radiation mode.

A transmission apparatus includes a first metal plate including a first surface, a second surface opposite to the first surface, and a first through hole penetrating from the first surface to the second surface, the first metal plate; a first board being disposed on the first surface side of the first metal plate, the first board including a first patch antenna positioned inside the first through hole; and a second board being disposed on the second surface side of the first metal plate, the second board including a second patch antenna positioned inside the first through hole and opposed to the first patch antenna, wherein an interval between the first patch antenna and the second patch antenna is set in accordance with a distance for wireless communicating between the first patch antenna and the second patch antenna in a near field.

Techniques and mechanisms to provide satellite communication functionality with an antenna assembly. In an embodiment, a communication device includes an antenna panel (comprising one or more holographic antenna elements), a housing and hardware interfaces which facilitate operation of the communication device has a module of the antenna display. A cross-sectional profile of the housing may conform to a polygon other than any rectangle. A configuration of the housing and hardware interfaces may facilitate the formation of an antenna assembly arrangement other than that of any rectilinear array. In another embodiment, communication devices of the antenna assembly each conform to a triangle or a hexagon.

In an on-vehicle radar device, a receiving antenna part includes a first antenna array with a plurality of receiving antennas arranged in a first direction perpendicular to a predetermined reference direction, and a second antenna array with three or more receiving antennas arranged in a second direction perpendicular to the reference direction and different from the first direction. A computing part computes the elevation angle of an object, using a first detection angle formed by the reference direction and a direction of the object acquired using the first antenna array in a plane parallel to the reference direction and the first direction, a second detection angle formed by the reference direction and a direction of the object acquired using the second antenna array in a plane parallel to the reference direction and the second direction, and a relative inclination angle formed by the first and second directions.

An antenna system including: a metal base plate; an antenna element arranged on and extending away from the front side of the base plate; a circuit board including a ground plane, adjacent to, and in thermal contact with the base plate; a plurality of electrical components on the circuit board including a power amplifier and an I/O connector; a metal support plate separated from, parallel to, and facing the base plate, with the circuit board located between the base and support plates; a plurality of thermally conductive standoffs thermally connecting the base plate to the support plate; and a master board including an I/O connector mating with the I/O connector on the circuit board and electrically connecting the circuit board to the master board, the master board located between the circuit board and the support plate and including signal paths for routing signals to the circuit board.

An antenna arrangement is provided. The antenna arrangement includes a first antenna element and a second antenna element. An inductance coil is coupled to the first antenna element and the second antenna element.

A folded planar antenna device for radio frequency identification (RFID) reading is provided. The folded planar antenna device includes an RFID chip, a conductor member comprising a binocular-shaped slot; and a substrate. The conductor member is mounted on the substrate and the substrate is connected to the RFID chip through the binocular-shaped slot. The folded planar antenna device can be mounted on different objects, such as metal, meat, or liquid container, without being completely de-tuned.

A waveguide device includes a first electrically conductive member having a first electrically conductive surface; a second electrically conductive member having a second electrically conductive surface which opposes the first electrically conductive surface; and a ridge-shaped waveguide member on the second electrically conductive member. The second electrically conductive member has a throughhole which splits the waveguide member into first and second ridges. The first and second ridges each have an electrically conductive end face, the end faces opposing each other via the throughhole. The opposing end faces and the throughhole together define a hollow waveguide. The hollow waveguide is connected to a first waveguide extending between the waveguide face of the first ridge and the first electrically conductive surface, and to a second waveguide extending between the waveguide face of the second ridge and the second electrically conductive surface.

A slot array antenna includes: a first conductive member having a first conductive surface and a plurality of slots therein, the slots being arrayed in a first direction and in a second direction which intersects the first direction; a second conductive member having a second conductive surface which opposes the first conductive surface; a plurality of waveguide members arrayed between the first and second conductive members along a direction which intersects the first direction, each waveguide member having an conductive waveguide face which extends along the first direction so as to oppose at least one of the slots; and an artificial magnetic conductor in a subregion which is within a region between the first and second conductive members but outside of a subregion containing the waveguide members. Neither an electric wall nor an artificial magnetic conductor exists in a space between two adjacent waveguide faces among the waveguide members.

A slot array antenna includes: an electrically conductive member having an electrically conductive surface and slots therein, the slots being arrayed in a first direction which extends along the conductive surface; a waveguide member having an electrically conductive waveguide face which opposes the slots and extends along the first direction; and an artificial magnetic conductor extending on both sides of the waveguide member. At least one of the conductive member and the waveguide member includes dents on the conductive surface and/or the waveguide face, the dents each serving to broaden a spacing between the conductive surface and the waveguide face relative to any adjacent site. The dents include a first, second, and third dents which are adjacent to one another and consecutively follow along the first direction. A distance between centers of the first and second dents is different from a distance between centers of the second and third dents.

An antenna array includes a plurality of patch antennas including a plurality of layers. Each of the plurality of layers are separated by a distance and each support a portion of the plurality of patch antennas. A plurality of connectors are each associated with one of the plurality of layers and supply a signal for transmission by the associated layer. A feed network on each of the plurality of layers provides a connection between a connector associated with the layer and the portion of the patch antennas located on the layer. Each layer transmits a signal having a different orthogonal function applied thereto that multiplexes each of the signals having a different orthogonal function applied thereto onto a single transmission beam. A parabolic reflector reflects the single transmission beam from the plurality of layers of the antenna array.

A method of manufacturing a thin-film transistor includes forming an oxide semiconductor on a substrate, stacking an insulating layer and a metal layer on the substrate to cover the oxide semiconductor, forming a photosensitive pattern on the metal layer, forming a gate electrode by etching the metal layer using the photosensitive pattern as a mask, where a part of the gate electrode overlaps a first oxide semiconductor region of the oxide semiconductor, forming a gate insulating film by partially etching the insulating layer using the photosensitive pattern as a mask, where the gate insulating film includes a first insulating region with a first thickness under the photosensitive pattern and a second insulating region with a second thickness less than the first thickness, and performing plasma processing on the gate insulating film so that a second oxide semiconductor region of the oxide semiconductor under the second insulating region becomes conductive.

Disclosed is a retardation film which shows a high light selective absorbency to visible rays having short wavelengths near 400 nm to have a high light resistance, and which can give, when used in a display device, good display properties to the display device. This film is a retardation film, satisfying all of the following formulae (1) to (4): 2≦A(380) (1), 0.5≦A(400) (2), 0.4≧A(420)/A(400) (3), and 100 nm≦Re(550)≦170 nm (4), in which each A(λ) represents the absorbance of the film at a wavelength λ nm, and Re (550) represents the in-plane retardation value of the film to a light ray having a wavelength of 550 nm.

This disclosure relates to the technical field of display apparatus, and in particular to a display apparatus and a vehicle utilizing the same. The display apparatus comprises a transmitting device for forming privacy images on a front windshield of a vehicle body and polarized glasses for viewing the privacy images. In the above technical solutions, privacy images are formed on the front windshield of the vehicle body by the transmitting device, such that the formed images will not interfere with the driver's driving. Meanwhile, the passengers can view the images on the front windshield by wearing the polarized glasses. By using the above transmitting device to form privacy images on the front windshield, an area of display is enlarged to facilitate the passengers' viewing. Passengers sitting in the rear portion of the vehicle can clearly view the images, and the visual effect during the passengers' viewing is improved.

The disclosure provides a liquid crystal display panel, an array substrate and a manufacturing method thereof. In the method, controllable resistance spacer layers are formed on at least one of a source doped region and a drain doped region of a low temperature polysilicon active layer, wherein when a turn-on signal is not applied to the gate layer, the controllable resistance spacer layers serve as a blocking action for a flowing current, and when the turn-on signal is applied to the gate layer, the controllable resistance spacer layers serve as a conducting action for the flowing current, such that a contact region formed of the controllable resistance spacer layers is connected the corresponding source layer and the corresponding drain through the controllable resistance spacer layers. Therefore, the disclosure is capable of effectively decreasing a leakage of a thin film transistor.

A semiconductor device includes a substrate, a first thin film transistor supported on the substrate and having a first active layer that primarily contains a first oxide semiconductor, and second thin film transistor supported on the substrate and having a second active layer that primarily contains a second oxide semiconductor with a higher mobility than the first oxide semiconductor. The first active layer and the second active layer are positioned on the same insulating layer and contact the same insulating layer.

A display apparatus may include a display panel, a touch electrode, a connecting pad, a first inorganic insulation layer, and a second inorganic insulation layer. The display panel may display an image according to image data. The touch electrode and the connecting pad may be formed of the same conductive material and may be spaced from each other. The first inorganic insulation layer may be positioned between the display panel and the touch electrode and may directly contact each of the touch electrode and the connecting pad. The second inorganic insulation layer may directly contact each of the first inorganic insulation layer and the touch electrode. The touch electrode may be covered by the second inorganic insulation layer. The connecting pad may be positioned between two portions of the second inorganic insulation layer and have a side not covered by the second inorganic insulation layer.

Disclosed herein is a display panel in which a space between a color filter substrate and an array substrate is filled with liquid crystals. The cell gap between the color filter substrate and the array substrate is maintained by a column spacer and a filling pattern with which a contact hole is filled. Accordingly, it is possible to stress damage to an alignment film by the movement of the column spacer even if the display panel is deformed by external force. In addition, the contact hole is filled with the filling pattern, thereby suppressing overcoming the problem of insufficient or excessive amount of liquid crystals.

A circuit board is provided and the circuit board is used for being attached to a matching board. The circuit board includes a first circuit pattern and an attaching state inspection area, and the attaching state inspection area further includes a third circuit pattern. A liquid crystal display device is further provided, including the circuit board and the matching board, the matching board includes a second circuit pattern matching the circuit board. It is more accurate to judge the attaching state between the circuit board and the matching board by detecting the deformation state of the conductive particles in vacant areas at different locations after the circuit board is attached to the matching board.

A display apparatus includes a liquid crystal layer between first and second substrates. The first and second scan lines along a first direction are disposed adjacently above the first substrate. A first region defined by the first and second data/scan lines includes the first and second sub-pixel regions. The first sub-pixel region includes a first TFT (connected to the first scan line and the first data line) and a first electrode electrically connected to the first TFT. A first common electrode disposed above the first substrate includes the first and second portions connected to each other. The first portion is positioned between the first electrode and the first data line, and the second portion is positioned between the second electrode and the first data line, wherein a width of the first portion in the first direction is greater than a width of the second portion in the first direction.

An array substrate and a method of fabricating the same are disclosed. The method has the following steps of: fabricating a switch array layer on a substrate; forming a color resist layer having a red color filter, a green color filter and a blue color filter on the switch array layer, and a through hole in the color resist layer; forming a transparent conductive layer on the color resist layer; and forming a light shield layer on the transparent conductive layer.

Carbon allotropes, a thin-film transistor array substrate comprising the same, and a display device comprising the same are disclosed. The thin-film transistor array substrate comprising a substrate, a gate electrode on the substrate, a gate insulating film on the gate electrode, an active layer positioned on the gate insulating film and comprising a semiconductor material and a plurality of carbon allotropes, and a source electrode and a drain electrode that make contact with the active layer.

According to one embodiment, a laminated film includes a first adhesive layer, a first insulating layer which faces the first adhesive layer, a first metal layer which is located between the first adhesive layer and the first insulating layer, and a first porous layer which is located between the first adhesive layer and the first insulating layer and faces the first metal layer.

The purpose of the present invention is to provide an In—Cu alloy sputtering target member having high compositional homogeneity in the thickness direction. The present invention provides a sputtering target member having a composition containing from 1 to 70 at. % of Cu relative to a total number of atoms of In and Cu, the balance being In and inevitable impurities, wherein the target member fulfills 0.95≦A/B≦1, where A represents a Cu atomic concentration relative to the total number of atoms of In and Cu in one half of a thickness direction; B represents a Cu atomic concentration relative to the total number of atoms of In and Cu in the other half of the thickness direction; and B≧A; and wherein a number of pores having a size of 100 μm or more is less than 10/cm2 on average.

The invention discloses a composite material used for catalyzing and degrading nitrogen oxide and its preparation method and application thereof. The invention of the hollow g-C3N4 nanospheres/reduced graphene oxide composite-polymer carbonized nanofiber material is prepared as follow: 1) the preparation of silica nanospheres; 2) the preparation of hollow g-C3N4 nanospheres; 3) the preparation of graphene oxide; 4) the preparation of surface modified hollow g-C3N4 nanoparticles preparation; 5) the preparation of composites; 6) the preparation of composite-polymer carbon nanofiber material. The raw materials used in the process is low cost and easy to get; the operation of the invention is simple and convenient without the use of expensive equipment in the whole process; the composite has high adsorption efficiency of ppb level nitrogen oxide with good repeatability.

Microfluidic devices having an electrowetting configuration and an optimized droplet actuation surface are provided. The devices include a conductive substrate having a dielectric layer, a hydrophobic layer covalently bonded to the dielectric layer, and a first electrode electrically coupled to the dielectric layer and configured to be connected to a voltage source. The microfluidic devices also include a second electrode, optionally included in a cover, configured to be connected to the voltage source. The hydrophobic layer features self-associating molecules covalently bonded to a surface of the dielectric layer in a manner that produces a densely-packed monolayer that resists intercalation and or penetration by polar molecules or species. Also provided are microfluidic devices having an electrowetting configuration that further include a section or module having a dielectrophoresis configuration; systems that include any of the microfluidic devices in combination with an aqueous droplet and a fluidic medium immiscible with the medium of the aqueous droplet; related kits; and methods of manipulating droplets, optionally containing micro-objects such as biological cells, within the microfluidic devices.

Electrolytic liquid generating device (1) includes laminated body (41) in which conductive film (46) is laminated to be interposed between mutually adjacent electrodes (44, 45), and electrolytic part (40) which electrolyzes liquid. Furthermore, electrolytic liquid generating device (1) includes a passage having inflow port (71) in which liquid to be provided to electrolytic part (40) flows and outflow port (72) from which electrolytic liquid generated in electrolytic part (40) flows out. The passage is formed such that liquid flowing direction (X) crosses laminated direction (Z) of laminated body (41).

For coating substrates (S) having along their surfaces to be coated high aspect ratio vias, a sputtering system has a sputtering source arrangement, which includes a first DC pulse operated magnetron sub-source (1203) and a second frame-shaped magnetron sub-source (1213) which latter is arranged, in the system, between the substrate (S) and the first magnetron sub-source (1203). The second magnetron sub-source (1213) may be operated in DC, pulsed DC, thereby also HIPIMS mode. The first magnetron sub-source (1203) is advantageously also operated in HIPIMS mode. The substrate (S) is biased by an Rf power source (1253).

An Al—Te—Cu—Zr alloy sputtering target, comprising 20 at % to 40 at % of Te, 5 at % to 20 at % of Cu, 5 at % to 15 at % of Zr and the remainder of Al, wherein a Te phase, a Cu phase and a CuTe phase are not present in a structure of the target. An object of the present invention is to provide an Al—Te—Cu—Zr alloy sputtering target capable of effectively reducing particle generation, nodule formation and the like upon sputtering and further capable of reducing oxygen contained in the target.

A plating apparatus is described. The apparatus includes: a substrate holder configured to hold a substrate in a vertical position; at least one processing bath configured to process the substrate held by the substrate holder; a transporter configured to grip and horizontally transport the substrate holder; at least one lifter configured to receive the substrate holder from the transporter, lower the substrate holder to place the substrate holder in the processing bath, elevate the substrate holder from the processing bath after processing of the substrate, and transfer the substrate holder to the transporter; and a controller configured to control operations of the transporter and the lifter.

An electrochemical polishing apparatus is provided for polishing a workpiece having at least one sharp object. According to the present invention, the electrolyte is driven to flow to the sharp object and the electrochemical processing is performed for polishing the sharp object.

The present document describes an electrophoretic tissue clearing chamber comprising an electrophoresis channel, configured to receive a clarification fluid therethrough; a first clarification fluid inlet, in fluid communication with the electrophoresis channel, configured to be connected to a source of the clarification fluid; a tissue sample holder in fluid communication with the electrophoresis channel, configured to receive a tissue sample to be clarified, and pressurize and homogenously apply the clarification fluid onto the tissue sample; a clarification fluid outlet, in fluid communication with the tissue sample holder, for exit of the clarification fluid from the electrophoretic tissue clearing chamber; and first and a second electrode, opposite one another in the electrophoresis channel, for transmission of an electric field therethrough.

In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries.

The present disclosure relates, in some embodiments, to an apparatus for conducting a capillary electrophoresis assay. The apparatus can comprise a capillary array comprising an anode end and a cathode end, the capillary array provided in a housing further comprising a reservoir configured to house a separation medium and an anode buffer. The system can also comprise an injection mechanism configured to deliver sample to the cathode end of the capillary array, and a temperature control zone, wherein the temperature control zone is configured to control the temperature of the interior of the housing.

There is provided an insulator target which, when mounted on a sputtering apparatus and supplied with AC power, is capable of preventing the discharging from occurring in a clearance between a shield and the target. The insulator target for the sputtering apparatus according to this invention, around which is disposed a shield at the time of assembling the insulator target on the sputtering apparatus, is made up of: a plate-shaped target material to be enclosed by the shield; and, suppose that one surface of the target material is defined as a sputtering surface to be subjected to sputtering, an annular supporting material coupled to an outer peripheral portion of the opposite surface of the target material. The supporting material has an extended portion which is extended outward from a peripheral surface of the target material and which keeps a predetermined clearance to the shield.

A Cu—Ga alloy sputtering target includes, as a component composition, Ga: 0.1 to 40.0 at % and a balance including Cu and inevitable impurities, in which a porosity is 3.0% or lower, an average diameter of circumscribed circles of pores is 150 μm or less, and an average crystal grain size of Cu—Ga alloy particles is 50 μm or less.

Methods and apparatus for processing a substrate are disclosed herein. In some embodiments, a process chamber includes: a chamber body defining an interior volume; a substrate support to support a substrate within the interior volume; a plurality of cathodes coupled to the chamber body and having a corresponding plurality of targets to be sputtered onto the substrate; and a shield rotatably coupled to an upper portion of the chamber body and having at least one hole to expose at least one of the plurality of targets to be sputtered and at least one pocket disposed in a backside of the shield to accommodate and cover at least another one of the plurality of targets not to be sputtered, wherein the shield is configured to rotate about and linearly move along a central axis of the process chamber.

A sputtering system that includes a sputtering chamber having a target material serving as a cathode, and an anode and a work piece. A direct current (DC) power supply supplies electrical power to the anode and the cathode sufficient to generate a plasma within the sputtering chamber. A detection module detects the occurrence of an arc in the sputtering chamber by monitoring an electrical characteristic of the plasma. In one embodiment the electrical characteristic monitored is the impedance of the plasma. In another embodiment the electrical characteristic is the conductance of the plasma.

Methods and apparatus for processing substrates are provided herein. In some embodiments, a physical vapor deposition chamber includes a first RF power supply having a first base frequency and coupled to one of a target or a substrate support; and a second RF power supply having a second base frequency and coupled to one of the target or the substrate support, wherein the first and second base frequencies are integral multiples of each other, wherein the second base frequency is modified to an offset second base frequency that is not an integral multiple of the first base frequency.

A film formation apparatus and a film-formed workpiece manufacturing method which are capable of forming a film with a uniform thickness on a workpiece like a three-dimensional object that includes a plurality of surfaces by a simple structure are provided. A film formation apparatus includes a target 21 that is a film formation material including a plane SU3, a power supply unit 3 applying power to the target 21, a rotating unit 4 rotating a workpiece W that is a film formation object around a rotation axis AX1, and a revolving unit 5 revolving the rotating unit 4 around a revolution axis AX2 separate from the rotation axis AX1 to repeatedly make the workpiece W to come close to and move apart from the target 21.

In one illustrative embodiment, a test strip with a first planar substrate has coplanar electrodes on a first planar surface and a second planar substrate (which opposes the first surface of the first planar substrate) has coplanar electrodes on a second planar surface. The first planar surface of the first planar substrate having a first sensing area electrically connected to a first electrical contact. The second planar surface of the second planar substrate having a second electrical contact electrically connected to the first electrical contact via a conductive element, the conductive element extending between the first surface of the first planar substrate and the second surface of the second planar substrate without passing through the first planar substrate, the second planar substrate, or any intermediate layers.

Provided herein is an apparatus that includes a body with a top surface and a recess in the top surface. The top surface, excluding the recess, is substantially planar. The recess is confined to an area that is defined by an inner diameter of the top surface of the body.

Exemplary embodiments provide wearable automatic injection devices for providing an injection of a therapeutic agent into a patient. The wearable automatic injection device includes a housing having a patient contact portion securable to the patient, an injection needle for insertion into the patient, and a prefilled syringe assembly for holding the therapeutic agent. The prefilled syringe assembly includes a distal stopper and a proximal stopper penetrated by a penetrating needle. The penetrating needle is in fluid communication with the patient injection needle.