The invention relates to an arrangement for determining a position (x) of a stopper relative to a container in a drug delivery device, comprising an acoustic source configured to emit an acoustic signal and an acoustic sensor configured to detect an acoustic signal, a processing unit for controlling the acoustic source and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper. Furthermore, the invention relates to a method for determining a position (x) of a stopper relative to a container in a drug delivery device, the method comprising the steps of emitting an acoustic signal from an acoustic source, detecting an acoustic signal caused by the emitted acoustic signal by means of an acoustic sensor, and processing the detected acoustic signal for determining characteristics of the acoustic signal correlated with the position (x) of the stopper by means of a processing unit.

An introducer configured with a first curve having a first angle that traverses space of an atrial appendage, a central atrium, caudad to the coronary sinus, and a second curve that has an angle sufficient to align the introducer with an intrinsic curvature of the coronary sinus of a subject.

A drug delivery balloon apparatus is disclosed herein, comprising: (a) at least two lumens, comprising a first lumen and a second lumen, (b) a balloon inflation port in fluid communication with the first lumen, (c) a drug delivery port in fluid communication with the second lumen, (d) a guidewire port in fluid communication with the second lumen, wherein the second lumen is configured to receive both a guidewire and a drug solution, (e) an occlusion balloon, (I) a drug delivery balloon, where the occlusion balloon and the drug delivery balloon are in fluid communication with the first lumen, (g) one or more drug delivery channels extending the length of the second lumen, and (h) one or more drug delivery ducts extending from the one or more drug delivery channels to an exterior surface of the second lumen.

Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible. An automated, pre-programmable transdermal administration system is used to provide pulsed doses of medications, pharmaceuticals, hormones, neuropeptides, anorexigens, pro-drugs, stimulants, nutraceuticals, phytochemicals, phytonutrients, enzymes, antioxidants, essential oils, fatty acids, minerals, vitamins, amino acids, coenzymes, or other physiological active ingredient or precursor. The system can utilize a pump, pressurized reservoir, a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with porous membranes or micro-fabricated structures.

The invention relates to a method for analyzing the composition of a gaseous stream comprising at least two gaseous components, one of which is methane; and to a sensor array and a gas sensor comprising such sensor array. The method comprises contacting the gaseous mixture with a sensor, wherein the sensor comprises a sensor array comprising at least two sensor elements, wherein each of said sensor elements comprises a transducer coated with a coating comprising a polymeric material having at least one property that is responsive to one or more of said gaseous components when exposed thereto, wherein said sensor elements differ at least in the composition of the coating, providing an energy input to said transducers that is converted to output signals based on said property, and obtaining said output signals.

A sensing apparatus for characterizing current flow through a conductor includes a plurality of magnetic sensors. In some embodiments, the sensors are grouped in pairs to achieve common mode rejection of signals generated in response to magnetic fields not resulting from current flow through the conductor. Sensors having different levels of sensitivity are used to collect information regarding the magnetic field generated by the current flowing through the conductor, where such information is processed in order to characterize the magnetic field. In some cases the sensors are included on or in flexible material that can be wrapped around the conductor.

Precision AC and DC voltage, current, phase, power and energy measurements and calibrations with current ranges from 1 uA to 20 kA and voltage ranges from 1V to 1000 kV are now performed with accuracies of better than one part per million. Continued demand for improved accuracy has led the inventors to address remnant magetization within the current comparators that form the basis of the measuring process within many of the measurement instruments providing the precision AC and DC measurements and calibrations. Accordingly, the inventors present current comparator and measurement system architectures together with control protocols to provide for correction of this remnant magnetization.

Embodiments include apparatuses, systems, and methods including a switching converter having an output stage including a power switch or first switching device to convert an input switching signal to an output switching signal and a sensor stage including a second switching device and a third switching device. In embodiments, the sensor stage may be coupled to receive the output switching signal from the first switching device and to substantially replicate a condition of the first switching device to generate a continuous signal rather than a switched signal. In embodiments, the continuous signal may allow detection of a current level. In some embodiments, the current level may indicate an overcurrent event. A digital post-processing circuit may be coupled to the switching device to count a number of overcurrent events according to various embodiments. Other embodiments may also be described and claimed.

Various embodiments mitigate the risk of frequency-lock in systems having multiple resonators by dynamically changing the frequency at which at least one of the resonators is driven. More particularly, the drive frequency of at least one of the resonators is changed often enough that the multiple resonators do not have time to achieve frequency lock. Changes in the oscillation of the resonators may be analyzed to determine, for example, acceleration of such systems. Some embodiments implement self-test by assessing expected performance of a system with toggling drive frequencies. More particularly, some embodiments implement self-test by artificially inducing displacement of a movable member of a system.

A voltage of a first capacitor is compared with a threshold voltage and a signal corresponding to the comparison result is generated at each of a first timing during a period after the transfer of a positive charge has ended and before the transfer of a negative charge starts and a second timing during a period after the transfer of the negative charge has ended and before the transfer of the positive charge starts. In each of the case where a positive charge is transferred and the case where a negative charge is transferred, operations (digitization of an integrated value and a feedback operation) of a delta sigma modulator are performed.

An electronic arrangement and method for providing a signal characterized by reduced phase noise having a signal source for providing a stimulus signal, a modulator coupled to the signal source for generating a modulated signal as function of the stimulus signal and a local oscillator signal, and a mixer combining the stimulus and modulated signals to generate a mixed signal that includes a component characterized by a mathematical difference of the stimulus signal and the modulated signal. The modulated signal is substantially identical to the stimulus signal and offset by a frequency of the local oscillator signal, so that the difference component of the mixed signal results in a local oscillator signal wherein the stimulus signal phase noise generated by the signal source has been mathematically cancelled.

A method for preparing an object to be tested, having a given relative permittivity, intended to be illuminated by an incident electromagnetic wave. The method includes: providing a part including a cavity for housing the object and at least one extension element made from a material having a relative permittivity that is preferably equal to that of the object, the extension element at least partially delimiting the cavity and extending to either side of the cavity in a passage direction of the cavity, over a length at least equal, on either side of the cavity, to one third of the length of the cavity in the passage direction, and placing the object in the cavity, such that the object is in contact with the extension element in the passage direction.

The invention relates to a high-voltage dry apparatus having a semiconductor layer (2) covered by a metal screen (3), this screen (3) being eliminated so as to expose this semiconductor layer (2) over a length, this cable being connected to an element of equipment having an outer envelope (6) mechanically connected to said screen. According to the invention, an electronic monitoring arrangement (20) is contained within said envelope (6), this electronic arrangement (20) being electrically connected to an electrical power supply arrangement (21) surrounding said semiconductor layer (2) and to the metal screen (3) of said cable on either side of said length of the exposed semiconductor layer.

A method of detecting an electric arc in an electrical system from a signal originating from at least one sensor detecting acoustic waves in the system, including: a) calculating by means of a processing device, over a sliding window of signal samples, at least one statistical parameter selected from the skewness and the kurtosis of the signal; b) detecting a possible occurrence of an event by taking into account said at least one statistical parameter; and c) performing a frequency analysis of the signal enabling to identify an electric arc when an event is detected at step b).

A semiconductor device includes first and second semiconductor chips mounted on one package. In the first semiconductor chip, a current generation circuit generates a sense current in accordance with a load current and a fault current indicating that an abnormality detection circuit has detected an abnormality, and allows either one of the currents to flow through a current detecting resistor in accordance with presence or absence of detection of the abnormality. In the second semiconductor chip, a storage circuit stores a current value of the fault current obtained in an inspection process of the semiconductor device as a determination reference value. An arithmetic processing circuit sets a standard range based on the determination reference value, and determines presence or absence of detection of the abnormality based on whether or not a current value indicated by a digital signal of an analog-digital conversion circuit is included within the standard range.

A probe card, a wafer testing system and a wafer testing method are provided. The wafer testing system includes a wafer holder and a probe card. A wafer is held on the wafer holder, and testing pads are formed on the wafer, in which the testing pads are arranged along a test straight line. The probe card includes probes each of which includes an arm portion and a tip portion. An included angle between the test straight line and an extension of a projection line of the arm portion onto the wafer ranges from about 40 degrees to about 55 degrees.

A method and apparatus is provided the battery sensor for a large-scale battery system. More specifically, the present disclosure relates to the architecture and measurement scheme for a high-accuracy battery voltage sensor based on a calibration scheme. The present disclosure also related to the architecture and measurement method for a cell-level current sensor to effectively and reliably manage a battery pack.

Test measurements on a utility power device by a switch matrix apparatus and a common voltage source as separate devices is performed. Through the switch matrix apparatus, the common voltage source selectively sends a first high voltage signal via a first lead to a first terminal of the utility power device, measures a first corresponding signal returned via a second lead of the switch matrix apparatus from a second terminal of the utility power device. While the first lead and the second lead of the switch matrix apparatus remain electrically coupled to the first and the second terminal of the utility power device, a second high voltage signal is selectively sent via the second lead to the second terminal of the utility power device, and a second corresponding signal returned from the first terminal of the utility power device via the first lead of the switch matrix apparatus is measured.

A load testing apparatus includes: a resistor unit that has a resistor group including relays and resistors and is connected to a power source to be tested to perform a load test; a selection switch that is used to select whether to supply power from the power source to be tested to the resistor group; an electrical signal detection unit that detects at least one of a voltage applied to the resistor unit and a current flowing through the resistor unit; and a control unit. The relay operates in response to an on/off state of the selection switch to control power supply from the power source to be tested to the resistor group including the relay. The control unit performs determination on whether the relay normally operates based on detection information including a time-series change of at least one of the voltage and the current when the selection switch is operated, which is information from the electrical signal detection unit, and performs off control to stop power supply from the power source to be tested to the resistor unit.

A sensor apparatus adjusts output timings of a detection signal and a sensing signal for sensing an abnormality in the detection signal. Provided is a magnetic sensor apparatus comprising a magnetic sensor element, an amplifying section that amplifies and outputs an output of the magnetic sensor element, a plurality of comparing sections that compare the output of the magnetic sensor element or an output of the amplifying section to a threshold value, and a plurality of delaying sections that each delay and output a comparison result output by a corresponding comparing section among the plurality of comparing sections. Also provided is a current sensor apparatus including a current path through which a current serving as a measurement target flows and a magnetic sensor apparatus that is arranged corresponding to the current path and detects a magnetic field generated according to the current serving as the measurement target.

A magnetic field sensing apparatus and detection method thereof are provided. The magnetic field sensing apparatus includes an anisotropic magneto-resistive (AMR) magnetic field detector, a reference magnetic field detector, and a controller. The AMR magnetic field detector generates a first output voltage according to a detected magnetic field. The reference magnetic field detector generates a second output voltage according to the detected magnetic field. The controller identifies whether an absolute value of a field density of the detected magnetic field is larger or smaller than a predetermined value or not, and selects the first output voltage or a saturation voltage to be a magnetic field detection result accordingly.

According to one embodiment, magnetic resonance imaging apparatus includes a transmission coil, a plurality of reception channels, transmission/reception circuitry, and processing circuitry. The transmission coil transmits an RF wave to a subject. The reception channels receive MR signals generated from the subject. The transmission/reception circuitry controls the transmission coil to change the flip angle of a nucleus contained in the subject and excited by the transmitted RF wave. The processing circuitry determines whether the reception channels include an impaired channel, based on the comparison between the distributions of the signal values of the received MR signals with respect to the changing flip angles among the reception channels.

A universal, modular, temperature controlled MRI phantom for calibration and validation for anisotropic and isotropic imaging comprises an outer insulating shell configured to be received within an MRI chamber; an inner shell received within the outer insulating shell; a fluid conduits adjacent the inner shell for receiving temperature controlling fluid or gas cycling there-through; and a series of stacked layers of frames containing test points for the MRI phantom, each layer including at least one fiducial and including at least some anisotropic imaging test points in at least one frame and at least one isotropic imaging test point in at least one frame. The anisotropic imaging comprises hollow tubular textile fibers, wherein each hollow tubular fiber has an outer diameter of less than 50 microns and an inner diameter of less than 20 microns, wherein at least some hollow tubular fibers are filled with a fluid.

Acquiring seismic data using time-distributed sources and converting the acquired data into impulsive data using a multiple-frequency approach. The methods are performed in frequency-source location domain, frequency-wavenumber domain, or frequency-slowness domain. The methods are applicable to single source acquisition or simultaneous source acquisition.

A power control apparatus according to an embodiment includes an acquisition unit and a determination unit. The acquisition unit acquires information relating to a voltage and an electric current of a chargeable/dischargeable secondary battery during charging/discharging. The determination unit determines a maximum current of the secondary battery during charging on the basis of the information acquired by the acquisition unit so that the voltage of the secondary battery does not exceed a predetermined voltage.

A gyroscope includes a substrate, a first structure, a second structure and a third structure elastically coupled to the substrate and movable along a first axis. The first and second structure are arranged at opposite sides of the third structure with respect to the first axis A driving system is configured to oscillate the first and second structure along the first axis in phase with one another and in phase opposition with the third structure. The first, second and third structure are provided with respective sets of sensing electrodes, configured to be displaced along a second axis perpendicular to the first axis in response to rotations of the substrate about a third axis perpendicular to the first axis and to the second axis.

A force detector includes a first substrate, a second substrate, a circuit board provided between the first substrate and the second substrate, and an element mounted on the circuit board and outputting a signal in response to an external force, wherein a hole is formed in the circuit board at a location where the element is placed, and a first convex part inserted into the hole and protruding toward the element is provided on the first substrate. Further, the element is placed within a periphery of the first convex part as seen from a direction perpendicular to the first substrate.

A planet gear train based torque detector is provided with idler gears between an input shaft and an output shaft wherein a rotation of the input shaft rotates the idler gears which rotate the output shaft, and a force is applied to a tangent line between each idler gear and the input shaft; peripheral resilient members, each having a fixed first end and a second end for receiving force applied thereon by the revolution of idler gears; and at least one strain gauge, each attached on one resilient member for measuring a deformation at the resilient member due to the revolution of the idler gears. A torque between the input shaft and the output shaft is obtained by calculating the deformation. The resilient members parallel the input shaft.

A detecting element unit of a physical quantity detection apparatus includes a detection part and a supporting part. The detection part has a base part, a movable part coupled to the base part via a joint part, and a vibrator provided over the base part and the movable part, and the supporting part includes a fixing portion to be fixed to a base for supporting the base part. A processing unit of the physical quantity detection apparatus extracts vibration response signals at a resonance frequency of the detecting element unit from output of the vibrator.

A sensor arrangement with a sensor element for measuring at least one physical and/or chemical fluid characteristic in a turbomachine is provided. The sensor element detects the at least one fluid characteristic inside a non-contact seal, in particular a labyrinth seal, between a rotor stage and a stator stage, wherein during operation the sensor element is in contact with the fluid flow along the flow path inside the labyrinth seal.

A percolation network of functionalised reduced graphene oxide flakes, the percolation network configured to allow for hopping of charge carriers between adjacent reduced graphene oxide flakes to enable a flow of charge carriers through the percolation network, and wherein the reduced graphene oxide flakes are functionalised to facilitate detectable changes in the flow of charge carriers in response to a stimulus to the percolation network.

A mass sensor is provided for measuring a particle mass within an aerosol. The duration of a sensing cycle is set such that a pre-set change in mass resulting from particles deposited is caused. In the absence of cleaning, the lifetime of the sensor is dependent on the total mass deposited. As a result, the lifetime is made essentially constant by this approach, because each sensing operation is made to give rise to a constant amount of deposited particle mass. This means the lifetime can be predicted more accurately.

A photo acoustic non-destructive measurement apparatus and method for quantitatively measuring texture of a liquid. The apparatus includes a laser generating tool, an acoustic capturing device, and a data processing unit. The laser generating tool directs a laser towards a surface of a liquid contained in a container and creates pressure waves that propagate through the air and produce an acoustic signal. The acoustic capturing device records and forwards the signal to a data processing unit. The data processing unit further comprises a digital signal processing module that processes the received acoustic signal. A statistical processing module further filters the acoustic signal from the data processing unit and generates a quantitative acoustic model for texture attributes such as hardness and fracturability. The quantitative model is correlated with a qualitative texture measurement from a descriptive expert panel. Textures of liquids are quantitatively measured with the quantitative acoustic model.

A vacuum-assisted in-needle capillary adsorption trap (VA-INCAT) device for sampling and delivering materials to an analytical device is disclosed. A sorbent is multiwall carbon nanotube/polyaniline (PANI/MWCNT) nanocomposite and is coated within an interior space of the needle between the second end and the side aperture to entrap an analyte within a sample. The VA-INCAT device also includes a vacuum device configured to vacuum the vacuum flask to improve the extraction of the analytes vapors from the sample matrix to the sorbent bed.

The multi-parametric environmental diagnostics and monitoring sensor node (10) provides monitoring and diagnostics of a variety of different ambient environmental factors and is powered by multiple sources of renewable energy. The multi-parametric environmental diagnostics and monitoring sensor node (10) includes a base (38) and a plurality of environmental condition sensors (36a, 36b, 36c, 36d, 36e, 36f) mounted thereon. A controller (47) is also mounted on the base (38), the plurality of environmental condition sensors (36a, 36b, 36c, 36d, 36e, 36f) being in communication therewith. An external photovoltaic cell (18) is mounted to the base and an internal photovoltaic cell (34) is mounted in an opposed orientation on a cover (32). The external photovoltaic cell (18) and the internal photovoltaic cell (34) charge a power storage module (52), which powers the plurality of environmental condition sensors (36a, 36b, 36c, 36d, 36e, 36f) and the controller (47).

Described is a system which includes: a cable including: a first fiber optic interconnect to provide an input light; and a second fiber optic interconnect to provide an output light; and a first housing coupled to the cable, the first housing including: a first deflection circuit to deflect the input light received from the first fiber optic interconnect in response to a vibration or movement of the first housing; and a second housing coupled to the cable, the second housing including: a light source to generate the input light for transmission to the first deflection circuit via the first fiber optic interconnect; and a photo detector to receive the output light from the first deflection circuit via the second fiber optic interconnect.

A substrate for a sensor includes: a base section; a movable section connected to the base section; an arm portion as a support portion extending along the movable section from the base section; a first gap portion having a protrusion portion in which one of the movable section and the arm portion protrudes toward the other of the movable section and the arm portion, and having a predetermined gap between the protrusion portion on one side and the other of the movable section and the support portion; and a second gap portion which is located further toward the base section side than the first gap portion has a gap wider than the predetermined gap, in which in the first gap portion, one of the movable section and the arm portion has a ridge portion on the side facing the first gap portion.

A micro-electromechanical (MEMS) apparatus includes a substrate, two first anchors, a frame, and two elastic members. The substrate is provided with a reference point thereon. The frame surrounds the two first anchors, and each of the elastic members connects the corresponding first anchor and the frame. Each of the first anchors is disposed near the center of the MEMS apparatus to decrease an effect caused by warpage of the substrate. The MEMS apparatus can be applied to an MEMS sensor having a rotatable mass, such as a three-axis accelerometer or a magnetometer, to improve process yield, reliability, and measurement accuracy.

A vibration analyzing apparatus includes a vibration detecting unit set in a building where a person can reside and configured to detect vibration and output a detection signal based on the detected vibration, a mode determining unit configured to determine presence or absence of vibration of the building caused by an earthquake, and a control unit including a vibration analyzing unit configured to analyze the vibration on the basis of the detection signal, the control unit setting an analysis mode of the vibration analyzing unit. The control unit sets one of a normal time analysis mode for causing the vibration analyzing unit to analyze a vibration waveform indicated by the detection signal on the basis of a first condition and obtaining information concerning residence of the person and an earthquake analysis mode for obtaining information concerning deformation of the building.

An electronic circuit for amplifying signals with two components in phase quadrature, which includes: a feedback amplifier with a feedback capacitor; a switch that drives charging and discharging of the feedback capacitor; an additional capacitor; and a coupling circuit, which alternatively connects the additional capacitor in parallel to the feedback capacitor or else decouples the additional capacitor from the feedback capacitor. The switch opens at a first instant, where a first one of the two components assumes a first zero value; the coupling circuit decouples the additional capacitor from the feedback capacitor in a way synchronous with a second instant, where the first component assumes a second zero value.

The invention provides a method for acquiring fragment ion spectra of substances in complex substance mixtures wherein a trapped ion mobility spectrometer (“TIMS”) is used as the ion mobility separation device coupled to a triple quadrupole mass filter assembly. The fragment ion spectra may be used for the identification of high numbers of proteins in complex mixtures, or for a safe quantification of some substances, by their fragment ion mass spectra in a mass spectrometer with upstream substance separator. TIMS, in particular equipped with parallel accumulation, provides the unique possibility to prolong the ion accumulation duration to find more detectable ion species without decreasing the measuring capacity for fragment ion mass spectra. The high measurement capacity for fragment ion mass spectra permits the repeated measurement of low abundance ion species such as to improve the quality of the fragment ion spectra.

A sensing device includes an array of sensing elements. Each sensing element includes a photodiode, including a p-n junction, and a local biasing circuit, coupled to reverse-bias the p-n junction at a bias voltage greater than a breakdown voltage of the p-n junction by a margin sufficient so that a single photon incident on the p-n junction triggers an avalanche pulse output from the sensing element. A bias control circuit is coupled to set the bias voltage in different ones of the sensing elements to different, respective values that are greater than the breakdown voltage.

A laser beam having desired properties is output at desired timings. A laser apparatus is a laser apparatus for use with an extreme ultraviolet light generating apparatus that generates extreme ultraviolet light at a repetition frequency which is set in advance, and may be equipped with: a semiconductor laser that outputs a laser beam when a trigger signal is input thereto; an optical switch that switches between a state in which the laser beam passes therethrough and a state in which the laser beam does not pass therethrough, provided along the optical path of the laser beam; and a control unit configured to output the trigger signal to the semiconductor laser at a frequency which is an integer multiple of the repetition frequency, and to control the optical switch such that the laser beam passes therethrough at the repetition frequency.

The invention relates to a method for controlling the divergence of a jet of particles in vacuo with an aerodynamic lens, the aerodynamic lens including at least one chamber; a diaphragm, a so-called inlet diaphragm, intended to form an inlet of the aerodynamic lens for a jet of particles, the inlet diaphragm having a given diameter (d1); and another diaphragm, a so-called outlet diaphragm, intended to form an outlet of the aerodynamic lens for this jet of particles; the method including: a step for generating the jet of particles from the inlet to the outlet, in vacuo, of the aerodynamic lens; and a step for adjusting the diameter (ds) of the outlet diaphragm for controlling the divergence of the jet of particles.

The application provides a printed circuit board and an optical module so as to alleviate poor contact between the electro-conductive contact sheet group and the clamping piece due to the solder resist. The printed circuit board includes a substrate, and electro-conductive wirings and electro-conductive contact sheet group both laid on the surface of the substrate, where the substrate is overlaid with solder resist, and the solder resist has no contact with the electro-conductive contact sheet group.

Disclosed is an apparatus configured for collection and sterilization of expectorates. According to the embodiments of the invention, the apparatus includes a receptacle having an interior space defined by a bottom wall, and one or more side walls, an opening at a top portion for selectively receiving a separator for the expectorates to pass therethrough and be received at the interior space, and a power source, one or more light sources, such as ultraviolet (UV) light source radiating rays of sufficient wavelengths capable of sterilizing the expectorates received at the interior space, a reflective source surrounding the interior space of the receptacle for substantially reflecting the radiated rays throughout the interior space to effectively sterilize the expectorates received at the interior space, and a receptacle lid removably engaging the separator to close the opening at the top portion of the receptacle.

The present invention generally relates to fluorescent marking compositions and their use to determine whether a surface has been cleaned. More particularly, the marking compositions comprise fluorescent polymers.

An encoder, including: a scale that has a pattern and is mountable to a rotary member of an object to be measured; a main body including a detector that detects the pattern, the main body being mountable to a non-rotating portion of the object to be measured; and a holding member including: an abutment portion that is removably provided to the main body from outside the main body and passes through the main body to abut the scale; and a pushing portion that is capable of pushing the abutment portion toward the scale.

An optical circuit includes solid state photonics. The optical circuit includes a phased array of solid state waveguides that perform beamsteering on an optical signal. The optical circuit includes a modulator to modulate a bit sequence onto the carrier frequency of the optical signal, and the beamsteered signal includes the modulated bit sequence. The optical circuit includes a photodetector to detect a reflection of the beamsteered optical signal. The optical circuit autocorrelates the reflection signal with the bit sequence to generate a processed signal.

The present technology provides methods for increasing sensitivity of detection and/or quantification of a negatively charged analyte, e.g., an oligonucleotide, using an analytical system that comprises liquid chromatography and mass spectrometry. The methods comprise passing an acidic solution through the analytical system, i.e., through a fluidic path from the mobile phase reservoir to the detector to remove or displace, at least in part, metal ions adsorbed to charged sites in the fluidic path.