ca Colorimetric identification of lanthanide ions based on two carboxylic acids as an artificial tongue By feeds.rsc.org Published On :: Analyst, 2020, 145,3359-3363DOI: 10.1039/D0AN00357C, PaperChi Zhang, Juan Huang, Wei Wei, Zhengbo ChenWe report a colorimetric array, which consists of two carboxylic acids (quinolinic acid (QA), tannic acid (TCA)) as the sensor element and Eriochrome Black T (EBT) as the colorimetric signal readout.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Synthesis of a manganese dioxide nanorod-anchored graphene oxide composite for highly sensitive electrochemical sensing of dopamine By feeds.rsc.org Published On :: Analyst, 2020, 145,3283-3288DOI: 10.1039/D0AN00348D, PaperJuan Li, Huifang Shen, Suhua Yu, Geshan Zhang, Chuanli Ren, Xiaoya Hu, Zhanjun YangA novel manganese dioxide nanorod-anchored graphene oxide (MnO2 NRs/GO) composite was synthesized by a simple hydrothermal method for the development of a highly sensitive electrochemical sensor for dopamine.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Detection and classification of fentanyl and its precursors by surface-enhanced Raman spectroscopy By feeds.rsc.org Published On :: Analyst, 2020, 145,3440-3446DOI: 10.1039/C9AN02568E, PaperRustin Mirsafavi, Martin Moskovits, Carl MeinhartAn analytical technique combining partial least squares-discriminant analysis, surface-enhanced Raman spectroscopy (SERS), and microfluidics for the detection and classification of fentanyl and its chemical precursors.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Quantitative toxicological study of dose-dependent arsenic-induced cells via synchrotron-based STXM and FTIR measurement By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00346H, PaperHuiqiang Liu, Junshan Xiu, Yunyan Liu, Bengyi Wang, Yanling Xue, Min Chen, Te JiInorganic arsenic (iAs) is a well-known naturally occurring metalloid with abundant hazards in our environment, especially being a human carcinogen through arsenic contaminated drinking water. The iAs-related contamination is usually...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A highly efficient preconcentration route for rapid and sensitive detection of endotoxin based on an electrochemical biosensor By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00315H, PaperWenrui Ma, Lulu Liu, Yi Xu, Li Wang, Li Chen, Sheng Yan, Lingling Shui, Zhijun Wang, Shunbo LiAn impedimetric aptasensor for detection of endotoxin in a microfluidic chip was proposed, in which the Apt/AuNPs/SPCE sensing surface was fabricated in screen-printed electrode with good biological activity and stability....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Plasmonic Nanobiosensors for Detection of MicroRNA Cancer Biomarkers in Clinical Samples By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00193G, PaperBridget M Crawford, Hsin-Neng Wang, Christina Stolarchuk, Richard Von Furstenberg, Pietro Strobbia, dadong zhang, xiaodi qin, kouros owzar, katherine garman, Vo-Dinh TuanMicroRNA (miRNA) play an important role in the regulation of biological processes and have demonstrated great promise as biomarkers for the early detection of various diseases, including esophageal adenocarcinoma (EAC)...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Laser-induced graphene hybrid photoelectrode for enhanced photoelectrochemical detection of glucose By feeds.rsc.org Published On :: Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00252F, PaperHui Li, Chengxiang Guo, Changchun Liu, Lei Ge, Feng LiThe in situ and synchronous fabrication of Ni0/NiO–CdS–graphene hybrid photoelectrodes is developed using a facile and scalable direct-laser-writing method for photoelectrochemical detection of glucose.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca An electrochemical biosensor based on methylene blue-loaded nanocomposites as signal-amplifying tags to detect pathogenic bacteria By feeds.rsc.org Published On :: Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00470G, PaperShengjun Bu, Kuiyu Wang, Zhongyi Li, Chengyu Wang, Zhuo Hao, Wensen Liu, Jiayu WanSynthesis of new methylene blue–magainin I organic–inorganic nanocomposites as electrochemical signal labels for the detection of bacteria.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Liquid-crystal-based immunosensor for detection of cardiac troponin I By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00425A, PaperChunli Xia, dong Zhou, yueming Su, guangkai Zhou, Lishuang Yao, Weimin sun, yongjun LiuCardiac troponin I (cTnI) is one of the most sensitive and specific markers of myocardial cell injury, which can detect even minor myocardia damage. It is recognized as the main...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Driving Force to Detect Alzheimer's Disease Biomarkers: The Application Of A Thioflavine T@Er-MOF Ratiometric Fluorescent Sensor for Smart Detection of Presenilin 1, amyloid β-protein and Acetyl Choline By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00440E, PaperXing Ze Wang, jing du, Nannan Xiao, Yan Zhang, Ling Fei, Jed D. LaCoste, Zhuo Huang, Qian wang, Xin Rui Wang, Bin DingCurrently, the highly sensitive detection of Alzheimer's Disease (AD) biomarkers, namely presenilin 1, amyloid β-protein (Aβ), and acetylcholine (ACh), are vital to helping us prevent and diagnose AD. In this...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A homogeneous photoelectrochemical hydrogen sulfide sensor based on the electronic transfer mediated by tetrasulfophthalocyanine By feeds.rsc.org Published On :: Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00302F, PaperXinyang Wang, Huanan Zhao, Zhonghui Chen, Fang Luo, Longhua Guo, Bin Qiu, Zhenyu Lin, Jian WangA homogeneous photoelectrochemical sensor for H2S detection based on the electronic transfer mediated by [Fe(III)PcS4]+ was developed with an un-modified photoelectrode.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Tetrahedral DNA Nanostructure-decorated Electrochemical Platform for Simple and Ultrasensitive EGFR Genotyping of Plasma ctDNA By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00591F, PaperXuyao Wang, Jianping Wu, Weilin Mao, Xia He, Liming Ruan, Junlan Zhu, Peng Shu, Zhenqi Zhang, Bitao Jiang, Xingguo ZhangGenotyping of the epidermal growth factor receptor (EGFR) mutation status is of great importance in the screening of appropriate advanced non-small cell lung carcinoma (NSCLC) patients to receive superior tyrosine...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Biocompatible Alkyne arms containing Schiff base Fluorescence Indicator for Duel detection of CdII and PbII at Physiological pH and its Application to Live Cell Imaging By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00862A, PaperJebastin Andrews S.G, Benita Jeba Silviya S, Jeyanthi Dharmaraj, Winfred Jebaraj J, Sathya Devi E, C. BalakrishnanAn alkyne arms containing salen-type Schiff base ligand, 6,6'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(3-(prop-2-yn-1-yloxy)phenol) (H2L), is reported here as a dual chemosensor for CdII and PbII ions. The ligand, H2L was characterized by various spectral...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A paper-supported sandwich immunosensor based on upconversion luminescence resonance energy transfer for the visual and quantitative determination of a cancer biomarker in human serum By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/C9AN02307K, PaperMengyuan He, Ning Shang, Lin Shen, Zhi-hong LiuIn this paper, a paper-supported analytical device based on a sandwich immunoreaction and luminescence resonance energy transfer (LRET) was reported for the visual and quantitative determination of a cancer biomarker,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Acid–base titration using a microfluidic thread-based analytical device (μTAD) By feeds.rsc.org Published On :: Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00522C, PaperPurim Jarujamrus, Akarapong Prakobkij, Sodsai Puchum, Sawida Chaisamdaeng, Rattapol Meelapsom, Wipark Anutrasakda, Maliwan Amatatongchai, Sanoe Chairam, Daniel CitterioThis work presents a novel analytical approach for precise and quick (within 2 minutes) determination of acid and base concentrations (of very small amount) by titration using a microfluidic thread-based analytical device (μTAD).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A Simple and Ubiquitous Device for Picric Acid Detection in Latent Fingerprints using Carbon Dots By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00750A, PaperArunkumar Kathiravan, Annasamy Gowri, Srinivasan Venkatesan, Trevor Smith, Muthpandian Ashokkumar, Asha Jhonsi MariadossThis work addresses the synthetic optimization of carbon dots (CDs) and their application in sensing picric acid from latent fingerprint by exploiting a smartphone-based RGB tool. The optimization in the...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Surface Polymer Imprinted Optical Fibre Sensor for Dose Detection of Dabrafenib By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00434K, PaperChenyang He , Ulises Hernandez Ledezma , Pratik Gurnani, Thais Fedatto Abelha, Kristofer James Thurecht, Ricardo Goncalves Correia , Steve Morgan, Poulam Patel, Cameron Alexander, Sergiy KorposhDabrafenib is one of the most widely used of the new generation of targeted anti-cancer drugs. However, its therapeutic window varies for different patients and so there is an unmet...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00721H, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaoxiao Guo, Jodie R Malcolm, Marrwa M Ali, Goreti Ribeiro Morais, Steve Shnyder, Paul Loadman, L H Patterson, Robert Andrew FalconerThe polysialyltransferases (polySTs) catalyse the polymerisation of polysialic acid, which plays an important role in tumour metastasis. While assays are available to assess polyST enzyme activity, there is no methodology...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Phenyl doped graphitic carbon nitride nanosheets for sensing of copper ions in living cells By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00795A, PaperZhiping Song, Yuanteng Xu, Liangqia GuoCopper (Cu) is a vital mental element for human and animals. Monitoring and evaluating the concentration level of Cu2+ in biological body is an effective way to prevent a variety...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca [ASAP] Nucleic Acid Detection Using CRISPR/Cas Biosensing Technologies By feedproxy.google.com Published On :: Tue, 17 Mar 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00507 Full Article
ca [ASAP] A Coculture Based Tyrosine-Tyrosinase Electrochemical Gene Circuit for Connecting Cellular Communication with Electronic Networks By feedproxy.google.com Published On :: Thu, 02 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00469 Full Article
ca [ASAP] Genome-Wide CRISPRi-Based Identification of Targets for Decoupling Growth from Production By feedproxy.google.com Published On :: Tue, 21 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00143 Full Article
ca [ASAP] One-Day Construction of Multiplex Arrays to Harness Natural CRISPR-Cas Systems By feedproxy.google.com Published On :: Wed, 22 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00489 Full Article
ca [ASAP] Determinants for Efficient Editing with Cas9-Mediated Recombineering in <italic toggle="yes">Escherichia coli</italic> By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00440 Full Article
ca [ASAP] Engineering Stable <italic toggle="yes">Pseudomonas putida</italic> S12 by CRISPR for 2,5-Furandicarboxylic Acid (FDCA) Production By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00006 Full Article
ca [ASAP] A Synthetic Genetic Circuit Enables Precise Quantification of Direct Repeat Deletion in Bacteria By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00256 Full Article
ca [ASAP] Truncating the Structure of Lipopolysaccharide in <italic toggle="yes">Escherichia coli</italic> Can Effectively Improve Poly-3-hydroxybutyrate Production By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00071 Full Article
ca [ASAP] A Chemical Switch System to Modulate Chimeric Antigen Receptor T Cell Activity through Proteolysis-Targeting Chimaera Technology By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00476 Full Article
ca [ASAP] Multicomponent Microscale Biosynthesis of Unnatural Cyanobacterial Indole Alkaloids By feedproxy.google.com Published On :: Thu, 07 May 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00038 Full Article
ca [ASAP] Synthesis and Structure–Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy By feedproxy.google.com Published On :: Tue, 21 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01961 Full Article
ca [ASAP] Discovery, Structure–Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP By feedproxy.google.com Published On :: Tue, 21 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02164 Full Article
ca [ASAP] Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation By feedproxy.google.com Published On :: Wed, 22 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00035 Full Article
ca [ASAP] Correction to Toggling Preassembly with Single-Site Mutation Switches the Cytotoxic Mechanism of Cationic Amphipathic Peptides By feedproxy.google.com Published On :: Fri, 24 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00608 Full Article
ca [ASAP] Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design By feedproxy.google.com Published On :: Fri, 24 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02092 Full Article
ca [ASAP] Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02097 Full Article
ca [ASAP] Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02035 Full Article
ca [ASAP] Structure–Activity Relationship of SPOP Inhibitors against Kidney Cancer By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00161 Full Article
ca [ASAP] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00202 Full Article
ca [ASAP] Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00015 Full Article
ca [ASAP] Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00491 Full Article
ca [ASAP] A Chemical Switch for Transforming a Purine Agonist for Toll-like Receptor 7 to a Clinically Relevant Antagonist By feedproxy.google.com Published On :: Mon, 04 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00011 Full Article
ca [ASAP] p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02038 Full Article
ca [ASAP] Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00021 Full Article
ca [ASAP] Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme By feedproxy.google.com Published On :: Fri, 08 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00441 Full Article
ca [ASAP] Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma By feedproxy.google.com Published On :: Mon, 30 Mar 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00601 Full Article
ca [ASAP] Cancer Immunotherapy through the Inhibition of Diacylglycerol Kinases Alpha and Zeta By feedproxy.google.com Published On :: Wed, 01 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00118 Full Article
ca [ASAP] Inhibitors of Hypoxia-Inducible Factors as Treatment for Cancer By feedproxy.google.com Published On :: Wed, 01 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00116 Full Article
ca [ASAP] Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor By feedproxy.google.com Published On :: Wed, 01 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00665 Full Article
ca [ASAP] Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time By feedproxy.google.com Published On :: Thu, 02 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00045 Full Article
ca [ASAP] Escaping from Flatland: Substituted Bridged Pyrrolidine Fragments with Inherent Three-Dimensional Character By feedproxy.google.com Published On :: Thu, 02 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00039 Full Article
