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One of the main mechanisms of azole resistance of Aspergillus fumigatus is thought to be a reduction in the drug’s affinity for the target molecule, Cyp51A, due to its amino acid mutation(s). It is known that the azole resistance pattern is closely related to the mutation site(s) of the molecule. In this study, we tried to develop a simple and rapid detection method for cyp51A mutations using the endonuclease Surveyor nuclease. The Surveyor nuclease assay was verified using several azole-resistant strains of A. fumigatus that possess point mutations in Cyp51A. For validation of the Surveyor nuclease assay, blind tests were conducted using 48 strains of A. fumigatus (17 azole-resistant and 31 azole-susceptible strains). The Surveyor nuclease assay could rapidly detect cyp51A mutations with one primer set. Also, all the tested strains harboring different cyp51A single point mutations could be clearly distinguished from the wild type. The Surveyor nuclease assay is a simple method that can detect cyp51A mutations rapidly.

This report outlines the progress made by banks in implementing the Basel Committee's Principles for effective risk data aggregation and risk reporting ("the Principles" or "BCBS 239")1 based on supervisors' assessments conducted in 2019.

FSI Briefs No 5, April 2020. In response to the Covid-19 pandemic, governments have launched guarantee programmes to support bank lending to companies, especially small and medium-sized enterprises. This is essential to avoid a sharp contraction in bank credit that would exacerbate the pandemic's adverse impact. The design of such programmes needs to strike a difficult balance between responding promptly to the pandemic and maintaining a sufficient level of prudence. Key features of a sample of programmes (eg target beneficiaries, coverage of the guarantee, loan terms, length of the programme) reflect this tension. Incentives were created for the banks to join these programmes by exploiting flexibility in existing prudential requirements, while central banks have often provided liquidity support. Programmes are, however, subject to operational challenges and, ultimately, fiscal capacity limits.

Banks globally entered the Covid-19 crisis with roughly US$ 5 trillion of capital above their Pillar 1 regulatory requirements. The amount of additional lending will depend on how hard banks' capital is hit by the crisis, on their willingness to use the buffers and on other policy support. In an adverse stress scenario such as the savings and loan crisis, banks' usable buffers would decline to US$ 800 billion, which could support US$ 5 trillion of additional loans (6% of total loans outstanding). Yet in a severely adverse scenario, similar to the Great Financial Crisis, the corresponding figures would be only US$ 270 billion and US$ 1 trillion (1.3% of total loans).

The semiannual OTC derivatives statistics provide data on notional amounts outstanding and gross market values for all types of over-the-counter derivatives contracts. They are reported by large dealers in 12 countries on a worldwide consolidated basis.

Daily data on effective exchange rate in nominal terms have been updated. Broad indices cover 60 economies, with data from 1996. Narrow indices cover 26 economies with data from 1983.

Daily data on exchange rates against the US dollar have been updated. This covers 81 economies with the earliest data starting in 1949.

Banks' performance on equity and debt markets since the Covid-19 outbreak has been on a par with that experienced after the collapse of Lehman Brothers in 2008. During the initial phase, the market sell-off swept over all banks, which underperformed significantly relative to other sectors. Still, markets showed some differentiation by bank nationality, and credit default swap (CDS) spreads rose the most for those banks that had entered the crisis with the highest level of credit risk. The subsequent stabilisation, brought about by forceful policy measures since mid-March, has favoured banks with higher profitability and healthier balance sheets. Less profitable banks saw their long-term rating outlooks revised to negative. And the CDS spreads of the riskiest banks continued increasing even through the stabilisation phase.

Opening remarks by Ms Christine Lagarde, President of the European Central Bank, at the Online Edition of The State of the Union conference organised by the European University Institute, 8 May 2020.

Are financial intermediaries inherently unstable and, if so, why? To address this, we analyse whether model economies with financial intermediation are particularly prone to multiple, cyclic or stochastic equilibria.

At a time of conflicting narratives, a range of markets from equities to energy to gold may persist in volatility until one narrative gains the upper hand.

Bank of Italy Working Papers by Andrea Gazzani and Alejandro Vicondoa

Bank for International Settlements BIS Working Papers by David Cook and Nikhil Patel

Bank of England Working Papers by Aydan Dogan and Ida Hjortsoe

Bank of England Working Papers by Cristiano Cantore, Filippo Ferroni and Miguel León-Ledesma

Bank of England Working Papers by Nicola Garbarino and Benjamin Guin

European Central Bank Working Papers by Marien Ferdinandusse, Maximilian Freier and Annukka Ristiniemi

European Systemic Risk Board Occasional Papers by Greg Ros

Bank of Spain Working Papers by Henrique S. Basso and Juan F. Jimeno

Central Bank of Chile Working Papers by Andrés Sagner

Central Bank of Chile Working Papers by Gee Hee Hong, Matthew Klepacz, Ernesto Pasten and Raphael Schoenle

More suffering is ahead for the developing world.

These causes will make great use of your money or your time.

“I just went down on my knees,” his mother recalled later. “I just implored God for mercy.”

Magical thinking won’t protect us.

The Kangaroo Privacy Camera is an affordable indoor home security camera that delivers sharp daytime footage and is equipped with a built-in privacy shield, but some features require a paid subscription and its nighttime video quality could be better.

Cord cutters have more choices than just Netflix and Hulu. We break down the best video streaming services for your money, whether you're looking to completely replace cable or watch the latest original content on-demand.

Whether you're a casual smartphone shooter or a professional using an SLR, software can get the most out of your images. We help you find the best photo editing software for your needs.

Penn State is implementing a new opt-in grading system for the spring 2020 semester that will give students flexibility, help preserve GPAs and minimize impacts to students’ transcripts during the academic challenges presented by the novel coronavirus public health crisis.

Amanda Moore, of Chambersburg, Pennsylvania, is on track to graduate from Penn State Mont Alto this May with a degree in psychology. She credits her academic success with Mont Alto's strong focus on research and varied program offerings.

Penn State Mont Alto recognizes and honors winners during awards ceremony

The Penn State Mont Alto campus held its annual Academic and Leadership Awards Ceremony online on Sunday, April 19. Eighty-eight students were recognized for their academic achievements and campus leadership during the 2019-20 academic year. Three faculty members and one staff member were also recognized for their above-and-beyond contributions to the learning environment at Penn State Mont Alto.

Staying active and maintaining physical fitness has many benefits to all elements of wellness, including mental and emotional well-being that may be taxed during social distancing. At Penn State Mont Alto, the athletic department has been releasing weekly at-home workout and challenge videos that are accessible on our Facebook and Instagram pages to keep our student-athletes engaged.

Authoritarian rule may be just around the corner.

On cronies, cranks and the coronavirus.

The only fiscal thing to fear is deficit fear itself.

What’s bad for America is sometimes good for the market.

Why won’t Republicans help Americans losing their jobs?

Balancing finicky kid appetites with proper nutrition can be a challenge in the best of times. But now, with the majority of schools and day cares closed across Pennsylvania, many parents working from home, and schedules thrown in disarray, it may seem downright impossible. A Penn State nutritionist offers tips for feeding kids during stressful times.

The 2020 "Expanding Empathy" lecture series has moved online and added a lecture on "The Altruistic Brain," as well as a panel discussion on empathy in the time of COVID-19, both to be held on April 29 via Zoom.