Interview with Dhruv S. Kazi, MD, MSc, MS, author of Cost-effectiveness of PCSK9 Inhibitor Therapy in Patients With Heterozygous Familial Hypercholesterolemia or Atherosclerotic Cardiovascular Disease

Introducing a new series of JAMA articles on professionalism, discussed from the perspective of how clinicians should address challenging clinical situations and adverse events in their medical practice. In the first episode of the accompanying podcast, JAMA Professionalism: Best Practice, we interview Wendy Levinson, MD, and Jensen Yeung, MD, authors of Disclosure of Medical Error, which appeared in the August 16, 2016 issue of JAMA, as well as Thomas H. Gallagher, MD.

Drug prices continue to rise in the US. Many solutions have been proposed but few have been implemented. Drs. Janet Woodcock from the FDA and Aaron Kesselheim, author of The High Cost of Prescription Drugs in the United States from the Harvard Medical School discuss the role of brand name drugs and generics and how they influence the cost of pharmaceuticals.

Also see The Cost of US Pharmaceutical Price Reductions: A Financial Simulation Model of R&D Decisions by Thomas A. Abbott and John A. Vernon.

Interview with Joel G. Ray, MD, MSc, FRCPC, author of Association Between MRI Exposure During Pregnancy and Fetal and Childhood Outcomes

In this episode of JAMA Professionalism: Best Practice, Edward H. Livingston, MD looks at the case of a physician requesting prescription medication from a colleague to examine professional boundaries between physicians and options for managing those boundaries. Shiphra Ginsburg, MD and Wendy Levinson, MD, authors of the related article, join Dr Livingston to discuss the best options for handling this challenging situation. Arthur S. Hengerer, MD, chair of the Federation of State Medical Boards discusses the legal and licensure ramifications of physicians prescribing for other clinicians and Kate E. Engelhardt, MD, and D. Brock Hewitt, MD, MPH, practicing physicians, relate their experience with other clinicians asking them to prescribe medications.

Interview with Douglas K. Owens, MD, MS, USPSTF Task Force member and coauthor of Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: US Preventive Services Task Force Recommendation Statement

Interview with Christopher JL. Murray, MD, DPhil, author of US County-Level Trends in Mortality Rates for Major Causes of Death, 1980-2014

Interview with Julie Rani Nangia, BA, MD, author of Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial, and Hope S. Rugo, MD, author of Association Between Use of a Scalp Cooling Device and Alopecia After Chemotherapy for Breast Cancer

Can testosterone gel improve memory, correct anemia, increase bone density or prevent the growth of coronary artery plaque in older men with low testosterone levels? Four new studies in JAMA and JAMA Internal Medicine found improvement in some of these measures.

Articles discussed in this episode:

• Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone

• Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment

• Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone: A Controlled Clinical Trial

• Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial

This podcast discusses the latest research into the workings of the lung microbiome and how it will affect future diagnosis and treatment of respiratory diseases. Related article: The Lung Microbiome: Key to Respiratory Ills?

Interview with Timothy E. McAlindon, MD,MPH, author of Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial

Interview with Ann C. McKee, M.D., author of Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football

Interview with Jeffrey Alan. Golden, MD, author of Deep Learning Algorithms for Detection of Lymph Node Metastases From Breast Cancer: Helping Artificial Intelligence Be Seen

Interview with Christopher JL. Murray, MD, DPhil, author of The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States

Interview with Neil Skolnik, M.D., author of Reexamining Recommendations for Treatment of Hypercholesterolemia in Older Adults

Interview with David A. Asch, MD, MBA, author of The Uncertain Effect of Financial Incentives to Improve Health Behaviors

Interview with Kevin A. Schulman, MD, author of The Implications of “Medicare for All” for US Hospitals

Interview with Benjamin Tolchin, MD, MS, author of Treatment of Patients With Psychogenic Nonepileptic Attacks

Interview with Robert M. Wachter, MD, author of Restricting the Number of Open Patient Records in the Electronic Health Record: Is the Record Half Open or Half Closed?

Interview with Andrew A. Nierenberg, MD, author of Evolving Issues in the Treatment of Depression

Interview with Anthony S. Fauci, MD, author of Durable Control of HIV Infection in the Absence of Antiretroviral Therapy: Opportunities and Obstacles

Interview with Marissa A. Hendrickson, MD, author of The Review of Systems, the Electronic Health Record, and Billing

Interview with John W Epling, MD, MSEd, Task Force member and co-author of Preexposure Prophylaxis for the Prevention of HIV Infection: US Preventive Services Task Force Recommendation Statement

Interview with Jennifer L. Swails, MD, author of The Conundrum of the United States Medical Licensing Examination Score Reporting Structure

Interview with Michael Nurok, MBChB, PhD, author of Relative Value Units and the Measurement of Physician Performance

Interview with Gary H. Gibbons, M.D., author of Accelerating the Science of SCD Therapies—Is a Cure Possible?

Interview with Alexandra K. Glazier, JD, MPH, author of Success of Opt-In Organ Donation Policy in the United States

Interview with Karina W. Davidson, PhD, MASc, author of Screening for Social Determinants of Health: The Known and Unknown

Interview with Michael J. Barry, MD, USPSTF member and coauthor of Medication Use to Reduce Risk of Breast Cancer: US Preventive Services Task Force Recommendation Statement

Interview with Yngvild Olsen, M.D., M.P.H., author of Lessons Learned From the Opioid Epidemic

Interview with Anna D. Sinaiko, Ph. D., author of What Is the Value of Market-Wide Health Care Price Transparency?

Interview with Frank B. Hu, MD, PhD, author of Can Plant-Based Meat Alternatives Be Part of a Healthy and Sustainable Diet?

Interview with S Claiborne Johnston, MD, PhD, author of The Risk and Cost of Limited Clinician and Patient Accountability in Health Care

Interview with Deborah Dowell, M.D., M.P.H., author of Patient-Centered Reduction or Discontinuation of Long-term Opioid Analgesics: The HHS Guide for Clinicians

Interview with John P. A. Ioannidis, MD, DSc, author of Neglecting Major Health Problems and Broadcasting Minor, Uncertain Issues in Lifestyle Science

Interview with Stephen Baldassarri, author of Vaping—Seeking Clarity in a Time of Uncertainty

Interview with Julia A. Segre, Ph.D., author of Manipulating the Human Microbiome to Manage Disease

Interview with I Glenn. Cohen, JD, author of Ethical and Legal Aspects of Ambient Intelligence in Hospitals

Interview with Jenny A. Doust, BMBS, author of Potential Consequences of Changing Disease Classifications

Interview with David Naylor, MD DPhil, author of The Evolution of Schools of Thought in Medicine: Healthy Tensions

Interview with Ezekiel J. Emanuel, M.D., Ph.D., author of The Inevitable Reimagining of Medical Education

Interview with Sandro Galea, MD, author of The Role of Physicians in Addressing Social Determinants of Health

Interview with Madison Kilbride, PhD, author of The Need to Improve the Clinical Utility of Direct-to-Consumer Genetic Tests: Either Too Narrow or Too Broad

Safianowicz, Katarzyna Marta, author

Hill, J., author