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Chemo- and regioselective click reactions through nickel-catalyzed azide–alkyne cycloaddition

Org. Biomol. Chem., 2020, 18,3374-3381
DOI: 10.1039/D0OB00579G, Paper
Woo Gyum Kim, Seung-yeol Baek, Seo Yeong Jeong, Dongsik Nam, Ji Hwan Jeon, Wonyoung Choe, Mu-Hyun Baik, Sung You Hong
Nickel-catalyzed [3 + 2] cycloaddition reactions of unsymmetrical alkynes and organic azides afford substituted 1,2,3-triazoles with high levels of chemo- and regioselectivity.
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Chiral bifunctional sulfide-catalyzed asymmetric bromoaminocyclizations

Org. Biomol. Chem., 2020, 18,3367-3373
DOI: 10.1039/D0OB00459F, Paper
Takumi Nakamura, Ken Okuno, Kazuma Kaneko, Masahiro Yamanaka, Seiji Shirakawa
A chiral bifunctional sulfide catalyst bearing a urea moiety promotes the enantioselective bromoaminocyclization of 2-allylanilines to produce optically active 2-substituted indolines.
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O-Cyclopropyl hydroxylamines: gram-scale synthesis and utility as precursors for N-heterocycles

Org. Biomol. Chem., 2020, 18,3281-3287
DOI: 10.1039/D0OB00611D, Paper
Kaitlyn Lovato, Urmibhusan Bhakta, Yi Pin Ng, László Kürti
A novel and scalable synthesis of O-cyclopropyl hydroxylamines is reported. These compounds are bench-stable and have been shown to be practical precursors for the synthesis of N-heterocycles via a di-heteroatom [3,3]-sigmatropic rearrangement.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: Synthetic-biology-based discovery of a fungal macrolide from Macrophomina phaseolina

Org. Biomol. Chem., 2020, 18,3392-3392
DOI: 10.1039/D0OB90051F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yohei Morishita, Terutaka Sonohara, Tohru Taniguchi, Kiyohiro Adachi, Makoto Fujita, Teigo Asai
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Controlling the liberation rate of the in situ release of a chemical fuel for the operationally autonomous motions of molecular machines

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00669F, Paper
Chiara Biagini, Giorgio Capocasa, Daniele Del Giudice, Valerio Cataldi, Luigi Mandolini, Stefano Di Stefano
Aminolysis of the anhydride of 2-cyano-2-phenylpropanoic acid can be employed to conveniently regulate the liberation rate of the related acid which, in turn, can be used as a fuel for acid–base operated molecular machines.
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Gold(III)-catalyzed azide-yne cyclization/O–H insertion cascade reaction for the expeditious construction of 3-alkoxy-4-quinolinone frameworks

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00745E, Paper
Jingjing Huang, Han Su, Ming Bao, Lihua Qiu, Yuanqing Zhang, Xinfang Xu
A gold-catalyzed cascade reaction has been developed, and it provides an expeditious access to 3-alkoxy-4-quinolines and applications in alkaloid synthesis.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Late-stage synthesis and application of photoreactive probes derived from direct benzoylation of heteroaromatic C–H bonds

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00336K, Communication
Kevin D. Hesp, Jun Xiao, Graham M. West
A synthetically-driven, late-stage C–H benzoylation strategy for the expedited preparation and evaluation of heterocyclic alternatives to more classical benzophenone photoreactive probes is reported.
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Dienaminodioate based multicomponent reactions with post-benzylic oxidative transformations mediated by DDQ

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00721H, Paper
Jaice Ravindran, Velickakathu Yadhukrishnan, Reghuvaran Asha , Ravi Shankar Lankalapalli
Multicomponent reactions (MCRs) using dienaminodioate with post-benzylic oxidative transformation by DDQ that afforded a diverse array of products is described. An unprecedented rearrangement of 1,2-dihydropyridines (1,2-DHPs), 3CR products, to 2-pyridones...
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Synthesis of gem-difluoroalkenes via nickel-catalyzed allylic defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00535E, Communication
Xiao-Yu Lu, Run-Chuang Jiang, Jia-Mei Li, Chuang-Chuang Liu, Qing-Qing Wang, Hai-Pin Zhou
A nickel-catalyzed defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides has been developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Highly modified steroids from Inonotus obliquus

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00474J, Paper
Chun-Xin Zou, Zilin Hou, Ming Bai, Rui Guo, Bin Lin, Xiaobo Wang, Xiaoxiao Huang, Shaojiang Song
Six undescribed steroids were isolated from the fungus Inonotus obliquus. Notably, compounds 1 and 2 represented the first example of 8, 14-seco-4-methylpregnane. By spectroscopic data analyses, quantum chemical calculations and...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Efficient synthesis of a galectin inhibitor clinical candidate (TD139) using a Payne rearrangement/azidation reaction cascade

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00910E, Paper
Jacob St-Gelais, Vincent Denavit, Denis Giguère
Selective galectin inhibitors are valuable research tools and could also be used as drug candidates. In that context, TD139, a thiodigalactoside galectin-3 inhibitor, is currently being evaluated clinically for the...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Fire arm, opening an eatery: get licence application forms online

Now, getting a licence for a fire-arm or operating an eatery will be easy with Delhi Police on Tuesday launching a dedicated website for its Licencing Branch.




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Aspiring actor-cum-model arrested for killing IT professional

A 20-year-old aspiring actor- cum-model was arrested in the national capital for allegedly murdering a young woman IT professional a week ago after she refused to heed to his demand for money.




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DMRC delays inauguration of Yamuna Bank-Noida line

Delhi Metro has delayed the inauguration of the Yamuna Bank-Noida line by a month.




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Six held for forceful religious conversion

The arrests came soon after tribals demanded the arrest of those involved in the activity.




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People look at fairy tales in a limited way: Hudson Asia MD Tulika Tripathi

Tulika Tripathi is the managing director of a global talents solutions company, Hudson Asia.




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Climbing Everest, I've proved a tribal girl can do something: Malavath Poorna

At just 13 years, Malavath Poorna from Telangana has become the youngest female climber in the world to scale Mount Everest. Speaking with Rohit E David, Poorna discussed how she has emerged from a family of agricultural labourers to become a mountaineer, the difficulties she faced while navigating Mount Everest, the one thought that kept her going — and how she wants to climb many more mountains now.




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Cos use foreign money for political funding. Isn’t that influencing polls?

A recent Intelligence Bureau (IB) report has claimed that some well-known NGOs are working to stall economic development at the behest of their foreign donors. Activists and rights groups have been up in arms ever since the report was leaked.




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Pak politicians want to resolve Kashmir — military won't allow this: Arif Jamal

Arif Jamal is a Pakistani journalist and South Asia expert based in America.




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​'Advertising's art of persuasion — political ads will grow': Prasoon Joshi

Author and advertising authority headed the Titanium Lions jury at 2014's Cannes International Advertising Festival.




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There’s no power politics, customer is king, Piyush Goyal says

The responsibility of lighting up the country today rests on Piyush Goyal’s shoulders. Just a month into his new job, the minister for power, coal and renewable energy has set an electric pace to energize the sector.




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Australia-India cricket rivalry has even bettered Ashes: John Harnden

CEO of the ICC World Cup 2015 John Harnden spoke with Amin Ali about ensuring excitement in cricket's mega-tournament, clamping down on racism, managing 'minnows' matches — and how Australia is sizing up India as a rival for the trophy.




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A strong and vibrant India is important for peace and stability in Asia: K Shanmugam, Singapore's foreign minister

Singapore is one of India's closest partners in Asia. In his first visit to meet PM Narendra Modi after the formation of the NDA government, K Shanmugam, Singapore's foreign minister, tells Indrani Bagchi they would build some of India's new smart cities and involve themselves in skill development programmes in India.




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The BJP-PDP government is a people’s alliance: Mehbooba Mufti

PDP president Mehbooba Mufti is seen as the power behind the new PDP-BJP government in Jammu & Kashmir.




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Indian girl raped, murdered and stuffed inside suitcase in Australia

24-year-old Tosha Thakkar was last seen alive on March 9 in Sydney. Her alleged attacker, Daniel Stani-Reginald, has been denied bail.




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Indian-origin model accuses Aus modelling agency of racism

According to a report in the local daily, Kema Rajandran was told by a Parth-based modelling agency that her work chances were "limited" in the country because she was not Caucasian.




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Five-year-old Indian becomes millionaire

A five-year-old Indian boy has become a millionaire overnight after winning a lottery at a national bond draw here.




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Australia's Victoria police inducts first turban wearing Sikh

Police in Australia's Victoria state today inducted its first officer from Sikh community who will wear a newly designed police turban, a media report said today.




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Indian-origin Canadian gets life term for killing wife

A Canadian court has sentenced an Indian-origin man to life in prison for murdering his pregnant wife in 2006.




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Indian connection to prince William and Kate Middleton's wedding cake

Had it not been for the encouragement of her Gujarati husband Kishore Patel, Fiona Cairns may have never made the leap from graphic design to luxury baking.




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Maharashtra: Major train accident averted on Urali-Loni route

The driver applied the emergency brakes after spotting around 20 people, including women sitting on a track, and some of them even walking with their luggage on the tracks.




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E-tokens fail to take off; liquor shops see rush

Booze lovers continued to throng liquor shops in the city, even as the e-token system introduced by the Delhi government could not fully take off due to heavy traffic on the designated website.




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Fake sites offer liquor at doorstep in Delhi

The excise department has filed a complaint with Crime Branch of Delhi Police against fake websites claiming to deliver liquor at people's doorsteps. The websites became active a day after Delhi government announced an e-token delivery system to avoid chaos at liquor shops.




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Temp likely to touch 40°C in Delhi today

The temperature in Delhi is likely to touch 40 degrees Celsius on Saturday, followed by two cloudy days, Met official said on Friday.




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Delhi: Liquor hunt shifts online, site crashes

The Delhi government's initiative to reduce crowding outside liquor stores by issuing e-tokens - one could book a time slot to buy the tipple without getting into long queues - failed to work as the excise department website crashed due to heavy rush late Thursday.




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Tears of relief at IGI arrival and departure

At 12.05pm on Friday, Air India flight AI-381 made a smooth landing at Indira Gandhi International Airport. Though half an hour late in arriving, the 234 passengers from Singapore were delighted to step on home soil after two months of anxiety and uncertainty. Their relatives weren’t allowed to meet them, and yet the relief of being back in India made them grin, wave their hands and give the thumbs up sign.




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Plea on metro card-address proof linking declined




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62-yr-old becomes 2nd corona fatality in Noida

A 62-year-old man died due to coronavirus in Noida, becoming the second Covid-19 fatality in Uttar Pradesh's Gautam Buddh Nagar district, officials said on Saturday.




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Coronavirus Pandemic: WhatsApp limits forwarding to one chat at a time to curb fake news

WhatsApp is also working directly with NGOs and governments, including the WHO and over 20 national health ministries, to help connect people with accurate information.




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Astronomers detect gravitational waves when Black Holes with asymmetric masses collided

The detection of Gravitational-wave in a collision between two black holes of substantially different masses has made astronomers excited.




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Motorola Edge, Motorola Edge+ launched: Here are the specifications, price, availability

Motorola is back in the flagship game with premium Edge series.




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YouTube sensation PewDiePie signs exclusive live-streaming deal with the video-sharing platform

In the month of Jan, he announced a break from YouTube but continued posting his regular videos after his break.




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The BEST MOMENTS of Aahana Kumra's Life

"From a very early age, I imagined myself playing powerful characters," she says, and she proves it with her filmography.






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'All of us need counselling at some point'

'People will be entertained by the Singhams and the Simmbas but they will still not respect cops. Batla House is an opportunity for us to show the true side of policemen and their sacrifices.'




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'I can't imagine how A-list actors manage their lives'

'Sometimes, I wish someone would tell me that this will happen at this point in time, so I know how my life will be. I don't know what my evening is like. I don't know what my tomorrow will be like. The uncertainty sometimes takes a toll on me.'




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'I can't believe there are two Constitutions in India'

'India is called the largest democracy in the world, and one cannot believe that there are two Constitutions, two penal codes and two sets of laws.'





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'Every actor would wish to do film like this'

'The script, the way it has been written, the relationships, the intensity... everything was so powerful.'