se Acid–base titration using a microfluidic thread-based analytical device (μTAD) By feeds.rsc.org Published On :: Analyst, 2020, Advance ArticleDOI: 10.1039/D0AN00522C, PaperPurim Jarujamrus, Akarapong Prakobkij, Sodsai Puchum, Sawida Chaisamdaeng, Rattapol Meelapsom, Wipark Anutrasakda, Maliwan Amatatongchai, Sanoe Chairam, Daniel CitterioThis work presents a novel analytical approach for precise and quick (within 2 minutes) determination of acid and base concentrations (of very small amount) by titration using a microfluidic thread-based analytical device (μTAD).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
se Surface Polymer Imprinted Optical Fibre Sensor for Dose Detection of Dabrafenib By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00434K, PaperChenyang He , Ulises Hernandez Ledezma , Pratik Gurnani, Thais Fedatto Abelha, Kristofer James Thurecht, Ricardo Goncalves Correia , Steve Morgan, Poulam Patel, Cameron Alexander, Sergiy KorposhDabrafenib is one of the most widely used of the new generation of targeted anti-cancer drugs. However, its therapeutic window varies for different patients and so there is an unmet...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
se An efficient assay for identification and quantitative evaluation of potential polysialyltransferase inhibitors By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00721H, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Xiaoxiao Guo, Jodie R Malcolm, Marrwa M Ali, Goreti Ribeiro Morais, Steve Shnyder, Paul Loadman, L H Patterson, Robert Andrew FalconerThe polysialyltransferases (polySTs) catalyse the polymerisation of polysialic acid, which plays an important role in tumour metastasis. While assays are available to assess polyST enzyme activity, there is no methodology...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
se Phenyl doped graphitic carbon nitride nanosheets for sensing of copper ions in living cells By feeds.rsc.org Published On :: Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00795A, PaperZhiping Song, Yuanteng Xu, Liangqia GuoCopper (Cu) is a vital mental element for human and animals. Monitoring and evaluating the concentration level of Cu2+ in biological body is an effective way to prevent a variety...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
se [ASAP] Nucleic Acid Detection Using CRISPR/Cas Biosensing Technologies By feedproxy.google.com Published On :: Tue, 17 Mar 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00507 Full Article
se [ASAP] A Coculture Based Tyrosine-Tyrosinase Electrochemical Gene Circuit for Connecting Cellular Communication with Electronic Networks By feedproxy.google.com Published On :: Thu, 02 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00469 Full Article
se [ASAP] A Modular Method for Directing Protein Self-Assembly By feedproxy.google.com Published On :: Thu, 09 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00504 Full Article
se [ASAP] SCRaMbLEing of a Synthetic Yeast Chromosome with Clustered Essential Genes Reveals Synthetic Lethal Interactions By feedproxy.google.com Published On :: Fri, 17 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00059 Full Article
se [ASAP] Engineering Prokaryotic Transcriptional Activator XylR as a Xylose-Inducible Biosensor for Transcription Activation in Yeast By feedproxy.google.com Published On :: Fri, 17 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00122 Full Article
se [ASAP] Genome-Wide CRISPRi-Based Identification of Targets for Decoupling Growth from Production By feedproxy.google.com Published On :: Tue, 21 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00143 Full Article
se [ASAP] Engineering Stable <italic toggle="yes">Pseudomonas putida</italic> S12 by CRISPR for 2,5-Furandicarboxylic Acid (FDCA) Production By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00006 Full Article
se [ASAP] A Synthetic Genetic Circuit Enables Precise Quantification of Direct Repeat Deletion in Bacteria By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00256 Full Article
se [ASAP] Facilitating Protein Expression with Portable 5'-UTR Secondary Structures in <italic toggle="yes">Bacillus licheniformis</italic> By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00355 Full Article
se [ASAP] MAPPS: A Web-Based Tool for Metabolic Pathway Prediction and Network Analysis in the Postgenomic Era By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00397 Full Article
se [ASAP] Analyzing and Engineering the Product Selectivity of a 2-Methylenebornane Synthase By feedproxy.google.com Published On :: Mon, 04 May 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.9b00432 Full Article
se [ASAP] Translation Related Factors Improve the Productivity of a <italic toggle="yes">Streptomyces</italic>-Based Cell-Free Protein Synthesis System By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT ACS Synthetic BiologyDOI: 10.1021/acssynbio.0c00140 Full Article
se Our Suffering Servant By feeds.christianitytoday.com Published On :: The death and burial of Christ sets the stage for the true victory that every believer has in Christ. Full Article
se [ASAP] A Selective Modulator of Peroxisome Proliferator-Activated Receptor ? with an Unprecedented Binding Mode By feedproxy.google.com Published On :: Mon, 20 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01786 Full Article
se [ASAP] Molecule Property Analyses of Active Compounds for <italic toggle="yes">Mycobacterium tuberculosis</italic> By feedproxy.google.com Published On :: Mon, 20 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02075 Full Article
se [ASAP] Imidazo[1,2-<italic toggle="yes">a</italic>]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells By feedproxy.google.com Published On :: Mon, 20 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01910 Full Article
se [ASAP] Discovery, Structure–Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP By feedproxy.google.com Published On :: Tue, 21 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02164 Full Article
se [ASAP] Pyridine-Embedded Phenothiazinium Dyes as Lysosome-Targeted Photosensitizers for Highly Efficient Photodynamic Antitumor Therapy By feedproxy.google.com Published On :: Tue, 21 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00280 Full Article
se [ASAP] Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties By feedproxy.google.com Published On :: Wed, 22 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00117 Full Article
se [ASAP] Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation By feedproxy.google.com Published On :: Wed, 22 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00035 Full Article
se [ASAP] Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands By feedproxy.google.com Published On :: Thu, 23 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01835 Full Article
se [ASAP] Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma By feedproxy.google.com Published On :: Thu, 23 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02161 Full Article
se [ASAP] Correction to Toggling Preassembly with Single-Site Mutation Switches the Cytotoxic Mechanism of Cationic Amphipathic Peptides By feedproxy.google.com Published On :: Fri, 24 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00608 Full Article
se [ASAP] Molecular Interactions of Pyrazine-Based Compounds to Proteins By feedproxy.google.com Published On :: Fri, 24 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02021 Full Article
se [ASAP] Discovery and Structure–Activity Relationship Study of (<italic toggle="yes">Z</italic>)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00227 Full Article
se [ASAP] Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase By feedproxy.google.com Published On :: Mon, 27 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02035 Full Article
se [ASAP] Correction to Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00599 Full Article
se [ASAP] Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology By feedproxy.google.com Published On :: Tue, 28 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01336 Full Article
se [ASAP] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies By feedproxy.google.com Published On :: Wed, 29 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00202 Full Article
se [ASAP] Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1 By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00101 Full Article
se [ASAP] Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy By feedproxy.google.com Published On :: Thu, 30 Apr 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00491 Full Article
se [ASAP] Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase By feedproxy.google.com Published On :: Mon, 04 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00339 Full Article
se [ASAP] Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma By feedproxy.google.com Published On :: Tue, 05 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00395 Full Article
se [ASAP] Both <sc>d</sc>- and <sc>l</sc>-Glucose Polyphosphates Mimic <sc>d</sc>-<italic toggle="yes">myo</italic>-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00215 Full Article
se [ASAP] Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00245 Full Article
se [ASAP] Design of Hydrazide-Bearing HDACIs Based on Panobinostat and Their p53 and FLT3-ITD Dependency in Antileukemia Activity By feedproxy.google.com Published On :: Wed, 06 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00442 Full Article
se [ASAP] Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to <italic toggle="yes">In Vivo</italic> Studies By feedproxy.google.com Published On :: Thu, 07 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00431 Full Article
se [ASAP] Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core By feedproxy.google.com Published On :: Fri, 08 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.0c00192 Full Article
se [ASAP] Drug Research Meets Network Science: Where Are We? By feedproxy.google.com Published On :: Fri, 08 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01989 Full Article
se [ASAP] Discovery and Optimization of Glucose Uptake Inhibitors By feedproxy.google.com Published On :: Fri, 08 May 2020 04:00:00 GMT Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02153 Full Article
se [ASAP] Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma By feedproxy.google.com Published On :: Mon, 30 Mar 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00601 Full Article
se [ASAP] Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-<italic toggle="yes">a</italic>]pyridines against the 1A Family By feedproxy.google.com Published On :: Tue, 31 Mar 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00686 Full Article
se [ASAP] Cancer Immunotherapy through the Inhibition of Diacylglycerol Kinases Alpha and Zeta By feedproxy.google.com Published On :: Wed, 01 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00118 Full Article
se [ASAP] Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor By feedproxy.google.com Published On :: Wed, 01 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00665 Full Article
se [ASAP] Peptoid NPhe<sup>4</sup> in AGRP-Based c[Pro<sup>1</sup>-Arg<sup>2</sup>-Phe<sup>3</sup>-Phe<sup>4</sup>-Xxx<sup>5</sup>-Ala<sup>6</sup>-Phe<sup>7</sup> By feedproxy.google.com Published On :: Wed, 01 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00641 Full Article
se [ASAP] Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants By feedproxy.google.com Published On :: Thu, 02 Apr 2020 04:00:00 GMT ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.0c00043 Full Article
