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[ASAP] Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00045




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[ASAP] Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00041




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[ASAP] Assembling Pharma Resources to Tackle Diseases of Underserved Populations

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00051




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[ASAP] Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00639




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[ASAP] Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR?t Inverse Agonist

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00063




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[ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00129




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[ASAP] Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00574




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[ASAP] Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00131




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[ASAP] Characterization of Specific <italic toggle="yes">N</italic>-a-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00029




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[ASAP] Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00095




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[ASAP] Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00155




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[ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00192




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[ASAP] Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from <italic toggle="yes">Trypanosoma cruzi</italic>

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00106




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[ASAP] P2Y<sub>14</sub> Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00115




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[ASAP] Discovery of RO7185876, a Highly Potent ?-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00109




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[ASAP] Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00092




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[ASAP] Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 d Inhibitors

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00028




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[ASAP] Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00009




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[ASAP] Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00085




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[ASAP] De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00022




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[ASAP] Ligand Design for Cereblon Based Immunomodulatory Therapy

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00214




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Germany Facing Mass Blackouts Because The Wind And Solar Won’t Cooperate

Germany’s energy network nearly broken down in January because of poor execution from wind turbines and sun based boards, as indicated by information from a noteworthy exchange union. Wind and sunlight based power plants failed to meet expectations in January, 2017, as a result of shady climate with almost no wind, setting the phase for …

The post Germany Facing Mass Blackouts Because The Wind And Solar Won’t Cooperate appeared first on LatestSolarNews.




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Tanzania turns to solar power to increase electricity connectivity

As many as 60 percent of the Kenyan population now has access to electricity according to official data. But in neighbouring Tanzania, the penetration rate is less than half of that and sparsely populated rural communities are especially neglected.  

The post Tanzania turns to solar power to increase electricity connectivity appeared first on LatestSolarNews.




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Ugly Duckling Presse




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The Latest Research for Web Designers, April 2020

Although life hasn’t returned to normal yet, the web design and marketing space doesn’t seem to have been too badly disrupted — at least not with all the new research and surveys floating around. And thank goodness for that. If we can maintain some semblance of normalcy, I think we’ll all get through this crisis in good shape.




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Email Personalization: Your Secret To Better Engagement

One of the struggles that marketers face is how to send the right message at exactly the right time to target people in a way that will appeal to them. To solve the problem, businesses need to get themselves acquainted with new technologies and the power of personalization. In the past few years, digital marketing […]




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3 Essential Design Trends, May 2020

The state of the world around us can greatly impact website design. From emotional changes that correlate to the feel of a design to information and data to deliver, the impact of the worldwide COVID-19 pandemic is making its way into projects (intentionally or not). Here’s what’s trending in design this month. 1. “Unbalanced” Use […]




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8 of the Top WP Multipurpose Themes That You Can Use

More than a few multipurpose WordPress themes have become big sellers in recent years, and for a reason. Actually, for several reasons. One reason is they serve as excellent toolkits for web designers who have large and varied clienteles. The best multipurpose themes, like those presented here, are popular for other reasons as well. They […]




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Women’s squad raises ₹20 lakh

The Indian women’s hockey team’s efforts to crowd-fund support for poor and migrant workers has raised ₹20,01,130 through an 18-day online challenge.T




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Legacy of the masters: painting and calligraphy of the Islamic world from the Shavleyan family collection / Will Kwiatkowski ; with contributions by John Seyller

Rotch Library - N6260.K87 2019




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Arnaud Vasseux: pièces non balayées.

Rotch Library - NB553.V37 A4 2018




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The shrinking universe: Ireland at Venice 2019 / Eva Rothschild

Rotch Library - N6488.I8 V433 2019 I73




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Gordon Parks: the new tide, early work, 1940-1950 / Philip Brookman ; with essays by Maurice Berger, Sarah Lewis, Richard J. Powell, Deborah Willis ; series editor, Peter W. Kunhardt, Jr

Rotch Library - TR647.P37 2018




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Herbst im paradies: The autumn of paradise / Jean-Luc Mylayne

Rotch Library - TR729.B5 H47 2018




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Land, sand, strand: activation manual / drawings by Suki Seokyeong Kang

Rotch Library - N6488.I8 V433 2019 K6




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Panos Charalambous, Eva Stefani, Zafos Xagoraris / curated by Katerina Tselou

Rotch Library - N6488.I8 V433 2019 G8




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Neuer Norden Zürich: ein Kunstprojekt im öffentlichen Raum, 9. Juni-2. September 2018 = New north Zurich: a public art project, 9th of June-2nd of September 2018 / herausgegeben von Christoph Doswald ; fotografiert von Pierluigi Macor ; Übe

Rotch Library - N6496.3.S9 Z876 2018




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Fogo Island arts: what do we know? What do we have? What do we miss? What do we love? / Brigitte Oetker, Nicolaus Schafhausen (eds.)

Rotch Library - N6546.N6 F64 2019




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Touch me / Johannes Frandsen ; text, Mattias Lundblad

Rotch Library - TR650.F73 2018




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Le modèle noir: de Géricault à Matisse: Musée d'Orsay / [éditeur, Claude Pommereau]

Rotch Library - N8232.M6325 2019




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Raoul de Keyser: oeuvre / editors, Martin Germann and Bernhart Schwenk

Rotch Library - ND673.K396 A4 2019




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Performance now / RoseLee Goldberg

Rotch Library - NX460.5.P47 G65 2018




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Exercises in freedom: polnische Konzeptkunst, 1968-1981 = Polish conceptualism, 1968-1981 / Herausgeber = editor, Staatliche Kunstsammlungen Dresden, Kupferstich-Kabinett, Björn Egging

Rotch Library - N7255.P6 E88 2018




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The stronger we become: the South African pavilion / Dineo Seshee Bopape, Tracey Rose, Mawande Ka Zenzile ; curated by Nkule Mabaso, Nomusa Makhubu

Rotch Library - N6488.I8 V433 2019 S6




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Unfinished conversations on the weight of absence: Belu-Simion Făinaru, Dan Mihălțianu, Miklós Onucsán / curator, Cristian Nae

Rotch Library - N6488.I8 V433 2019 R6




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Biennale Arte 2019: may you live in interesting times: 11.05-24.11 Venezia Giardini/Arsenale

Rotch Library - N6488.I8 V433 2019 A1




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History has failed us, but no matter: siren eun young jung, Jane Jin Kaisen, Hwayeon Nam

Rotch Library - N6488.I8 V433 2019 K6b




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Socially engaged art and the neoliberal city / Cecilie Sachs Olsen

Rotch Library - N72.A76 O47 2019




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Reading closed books / Sam Winston

Rotch Library - N7433.4.W56 R4 2018




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Sergei Romanov / edited by Oksana Salamatina ; essay by Lyle Rexer

Rotch Library - TR655.R66 2018