Rudolph Tanzi, PhD, of Harvard University, and Berislav Zlokovic, MD, PhD, of the University of Southern California, discuss what the future holds for Alzheimer Disease research and treatment.

Can testosterone gel improve memory, correct anemia, increase bone density or prevent the growth of coronary artery plaque in older men with low testosterone levels? Four new studies in JAMA and JAMA Internal Medicine found improvement in some of these measures.

Articles discussed in this episode:

• Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone

• Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment

• Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone: A Controlled Clinical Trial

• Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial

Interview with Freddie C. Hamdy, MD, FRCSEd(Urol), and Jenny L Donovan, PhD, FMedSci, authors of Patient-Reported Outcomes Following Treatment for Localized Prostate Cancer: Helping Decision Making for Patients and Their Physicians

Interview with Alex H Krist, MD, MPH, Task Force member and co-author of Screening for Celiac Disease: US Preventive Services Task Force Recommendation Statement

This Medical News podcast features an interview with Barry Marshall, MD, who codiscovered the stomach bug H pylori in 1982.

This podcast discusses the latest research into the workings of the lung microbiome and how it will affect future diagnosis and treatment of respiratory diseases. Related article: The Lung Microbiome: Key to Respiratory Ills?

Whole-genome sequencing is now easily done for very little cost. It is not known how to interpret the results of this testing. Healthy individuals should not have this performed. If someone has a reason to suspect a particular disease with a known genetic association, then whole-genome or targeted sequencing is reasonable to pursue.

Interview with Jeffrey Alan. Golden, MD, author of Deep Learning Algorithms for Detection of Lymph Node Metastases From Breast Cancer: Helping Artificial Intelligence Be Seen

Interview with Dr. Ashish Jha, MD, MPH, about his study using Organization for Economic Cooperation and Development (OECD) data to compare health care infrastructure, outcomes, and prices in the US and other high-income countries to identify the sources of spending that make US health care so expensive.

Interview with Christopher JL. Murray, MD, DPhil, author of The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States

Interview with Seth Landefeld, MD, Task Force member and co-author of Screening for Cardiovascular Disease Risk With Electrocardiography: US Preventive Services Task Force Recommendation Statement

Interview with Michael J. Barry, MD, Task Force member and co-author of Screening for Peripheral Artery Disease and Cardiovascular Disease Risk Assessment With the Ankle-Brachial Index: US Preventive Services Task Force Recommendation Statement

Interview with Susan J. Curry, PhD, author of Screening and Behavioral Counseling Interventions to Reduce Unhealthy Alcohol Use in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement

Interview with Alex R Kemper, MD, MPH, MS, Task Force member and co-author of Interventions to Prevent Child Maltreatment: US Preventive Services Task Force Recommendation Statement

Interview with Ezekiel J. Emanuel, M.D., Ph.D., author of Next Phase in Effective Cost Control in Health Care

Interview with Neil Skolnik, M.D., author of Reexamining Recommendations for Treatment of Hypercholesterolemia in Older Adults

Interview with David A. Asch, MD, MBA, author of The Uncertain Effect of Financial Incentives to Improve Health Behaviors

Interview with Michael Silverstein, MD, MPH, USPSTF member and coauthor of Screening for Elevated Blood Lead Levels in Children and Pregnant Women: US Preventive Services Task Force Recommendation Statement

Interview with Robert M. Califf, MD, author of Lowering Cost and Increasing Access to Drugs Without Jeopardizing Innovation

Interview with Benjamin Tolchin, MD, MS, author of Treatment of Patients With Psychogenic Nonepileptic Attacks

Interview with Nancy L. Keating, MD, MPH, author of New Federal Requirements to Inform Patients About Breast Density: Will They Help Patients?

Interview with David M. Cutler, PhD, author of Life and Death in Norway and the United States

Interview with Robert M. Wachter, MD, author of Restricting the Number of Open Patient Records in the Electronic Health Record: Is the Record Half Open or Half Closed?

Interview with Alan Leshner, PhD, author of Medication-Based Treatment to Address Opioid Use Disorder

Interview with Marissa A. Hendrickson, MD, author of The Review of Systems, the Electronic Health Record, and Billing

Interview with Michael Nurok, MBChB, PhD, author of Relative Value Units and the Measurement of Physician Performance

Interview with Chyke A Doubeni, MD, MPH, USPSTF member and coauthor of Screening for Pancreatic Cancer: US Preventive Services Task Force Reaffirmation Recommendation Statement

Interview with Gary H. Gibbons, M.D., author of Accelerating the Science of SCD Therapies—Is a Cure Possible?

Interview with Daniel Brodie, MD, author of Extracorporeal Life Support for Adults With Respiratory Failure and Related Indications: A Review

Interview with Karina W. Davidson, PhD, MASc, author of Screening for Social Determinants of Health: The Known and Unknown

Interview with Michael J. Barry, MD, USPSTF member and coauthor of Medication Use to Reduce Risk of Breast Cancer: US Preventive Services Task Force Recommendation Statement

Interview with Anna D. Sinaiko, Ph. D., author of What Is the Value of Market-Wide Health Care Price Transparency?

Interview with Benjamin Daniel Sommers, MD, PhD, author of Medicaid Expansion and Health: Assessing the Evidence After Five Years

Interview with Frank B. Hu, MD, PhD, author of Can Plant-Based Meat Alternatives Be Part of a Healthy and Sustainable Diet?

Interview with Francisco G. Cigarroa, MD, author of The Advancing American Kidney Health Executive Order: An Opportunity to Enhance Organ Donation

Interview with S Claiborne Johnston, MD, PhD, author of The Risk and Cost of Limited Clinician and Patient Accountability in Health Care

Interview with William H. Shrank, MD, MSHS, author of Waste in the US Health Care System: Estimated Costs and Potential for Savings

Interview with John P. A. Ioannidis, MD, DSc, author of Neglecting Major Health Problems and Broadcasting Minor, Uncertain Issues in Lifestyle Science

Interview with Amol S. Navathe, MD, PhD, author of Addressing Bias in Artificial Intelligence in Health Care

Interview with Mercedes R. Carnethon, PhD, author of Disparities Research, Disparities Researchers, and Health Equity

Interview with Julia A. Segre, Ph.D., author of Manipulating the Human Microbiome to Manage Disease

Interview with Claire J. Creutzfeldt, MD, author of Treatment Decisions for a Future Self: Ethical Obligations to Guide Truly Informed Choices

In February 2020 the nature of the 2019-nCoV outbreak is still slowly coming into focus but it appears to be acting more like bad pandemic influenza (efficient spread, overall lower mortality) than like SARS (less efficient spread, overall higher mortality). Anthony Fauci, MD, of the US National Institute of Allergy and Infectious Diseases (NIAID) discusses the latest developments with JAMA Editor in Chief Howard Bauchner.

Coronavirus Resource Center

Interview with Jenny A. Doust, BMBS, author of Potential Consequences of Changing Disease Classifications

Interview with David Naylor, MD DPhil, author of The Evolution of Schools of Thought in Medicine: Healthy Tensions

Interview with Jonathan A. Patz, MD, MPH, author of A Low-Carbon Future Could Improve Global Health and Achieve Economic Benefits

The strategy for managing the COVID-19 pandemic has shifted from containment to mitigation. What does that mean for US hospitals and health systems? Kaiser Permanente Executive Vice President Stephen M. Parodi, MD, discusses telemedicine, protecting health care workers, equipment allocation planning, and more.

How does the current pandemic compare to historical infectious outbreaks and what can we expect in summer and fall of 2020? Nicholas Christakis, MD, PhD, MPH, director of the Human Nature Lab, Co-director of the Institute of Network Science, and Sterling Professor of Social and Natural Science at Yale University, discusses the epidemiology of COVID-19.

Interview with Sandro Galea, MD, author of The Role of Physicians in Addressing Social Determinants of Health

Infectious epidemics have always driven change and triggered discrimination in human societies. Frank Snowden, DPhil, Professor Emeritus of History and History of Medicine at Yale University and author of Epidemics and Society: From the Black Death to the Present (Yale University Press, 2019), puts the COVID-19 pandemic in historical context.