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Why Art and Beauty Matter During a Pandemic

These theologians and artists found beauty in suffering.




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This Pandemic Hits Americans Where We’re Spiritually Weak

Our cultural values are making us sad: money, mortality, and fear of missing out.




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20 Prayers to Pray During This Pandemic

As COVID-19 sends the globe into crisis, it also sends us to our knees.




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Correct hardware design and verification methods [electronic resource] : 13th IFIP WG 10.5 advanced research working conference, CHARME 2005, Saarbrücken, Germany, October 3-6, 2005 : proceedings / Dominique Borrione, Wolfgang Paul (eds.)

Berlin ; New York : Springer, [2005]




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Continuous-time systems [electronic resource] / by Yuriy Shmaliy

Dordrecht, the Netherlands : Springer, [2007]




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Continuous system simulation [electronic resource] / François E. Cellier, Ernesto Kofman

New York : Springer Science+Business Media, [2006]




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Construction and analysis of safe, secure, and interoperable smart devices [electronic resource] : second international workshop, CASSIS 2005, Nice, France, March 8-11, 2005 : revised selected papers / Gilles Barthe [and others] (eds.)

Berlin ; New York : Springer, [2006]




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Construction and analysis of safe, secure, and interoperable smart devices [electronic resource] : international workshop, CASSIS 2004, Marseille, France, March 10-14, 2004 : revised selected papers / Gilles Barthe [and others] (eds.)

Berlin ; New York : Springer, [2005]




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Two, including cop, held with illicit liquor

The Ernakulam Excise Special Squad seized 14.50 litres of suspected illicit Indian Made Foreign Liquor and arrested two people, including a policeman,




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TONIGHT: Author John Barry on 1918 Pandemic

Tonight, April 7 at 8 p.m. (ET): John M. Barry, author of “The Great Influenza: The Story of the Deadliest Pandemic in History," talks with David Rubenstein about the 1918 influenza pandemic, how the world responded and what it can teach us about COVID-19. The program will repeat this Saturday, April 11, at 3 p.m. (ET) and will be available on the Facebook, YouTube and the Library of Congress website.




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TUNE IN: Understanding the Pandemic

To help with understanding of the current global pandemic, the Library of Congress National Book Festival Presents program is offering a virtual multipart series with authors who have written books about widespread diseases and the worldwide response to them. The talks will be available on social media channels such as Facebook and YouTube, on the Library's website, and in some cases on C-SPAN.

Two talks in this series "Understanding the Pandemic," are already available, and the third, "Spillover: Animal Infections and the Next Human Pandemic" premieres tonight, Thursday, April 30, at 7 pm ET. The full schedule:

“The Great Influenza: The Story of the Deadliest Pandemic in History." This 2004 bestseller has become a bestseller once again. John M. Barry talked with David Rubenstein, co-chair of the National Book Festival, on the 1918 influenza pandemic that ravaged the world even as World War I was being fought on the ground in Europe. Now available for viewing.

"No One Was Immune: Mapping the Great Pandemics from Columbus to COVID-19." The Library of Congress's John Hessler and Marie Arana discuss the sweep of history from the 1500s small pox pandemic that decimated the indigenous population of the Americas to the meticulous work that is being done now to map COVID-19. Now available for viewing.

"Spillover": Animal Infections and the Next Human Pandemic." Prize-winning science writer David Quammen discusses “Spillover,” in which he tracks the animal origins of human diseases through the centuries, with David Rubenstein. Premieres Thursday, April 30, 7 p.m. ET

"Once Upon a Time I Lived on Mars: Space, Exploration and Life on Earth." NASA astronaut and scientist Kate Greene went into the mouth of a volcano in a space capsule called Mars and spent several months in isolation, in the dark, doing research. She has a lot to say about the stress, loneliness and other challenges of sequestration -- and all from a very novel and unique perspective. Interview by the Library's Marie Arana. Premieres Thursday, May 14, 7 p.m. ET

"Why It's Hard to Know Things, Lately, and How COVID-19 Will Go Down in History." Bestselling historian and Harvard professor Jill Lepore discusses how the current pandemic, its effects and our reaction to them say something very real about America in this moment and in the historical record that will emerge from it. Interview by the Library's John Haskell. Premieres Thursday, May 21, 7 p.m. ET

All talks will be available on Library of Congress Facebook and YouTube channels, on the Library's website, and in some cases on C-SPAN.

Click here for more information.




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Covid-19 hinterland digest: Rajasthan has 31 districts fighting disease

In less than a month, 20 districts reported new cases. Sri Ganganagar and Bondi are virus-free in Rajasthan




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Additional manpower may be sought from Centre to give police rest: Uddhav

Uddhav also admitted that while the spread of the virus has been contained, the state has not succeeded in breaking the chain of infection yet




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Karnataka govt allows restaurants, bars to sell liquor at retail prices

According to the latest update by the state health department, total number of coronavirus cases in Karnataka is 753




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Lockdown impact: Fuel demand in India plunged to historic lows in April

In its latest report, the International Energy Agency has said India's annual fuel consumption will decline 5.6 per cent in 2020




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Microfabricated electrochemical sensing devices

Lab Chip, 2020, 20,1358-1389
DOI: 10.1039/C9LC01112A, Critical Review
Fumihiro Sassa, Gokul Chandra Biswas, Hiroaki Suzuki
Electrochemistry provides possibilities to realize smart microdevices of the next generation with high functionalities.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Optically-controlled closable microvalves for polymeric centrifugal microfluidic devices

Lab Chip, 2020, 20,1426-1440
DOI: 10.1039/C9LC01187K, Paper
M. Shane Woolf, Leah M. Dignan, Hannah M. Lewis, Christopher J. Tomley, Aeren Q. Nauman, James P. Landers
Microvalving is a pivotal component in many microfluidic lab-on-a-chip platforms and micro-total analysis systems (μTAS).
The content of this RSS Feed (c) The Royal Society of Chemistry




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A liquid biopsy-guided drug release system for cancer theranostics: integrating rapid circulating tumor cell detection and precision tumor therapy

Lab Chip, 2020, 20,1418-1425
DOI: 10.1039/D0LC00149J, Paper
Chun-Miao Xu, Man Tang, Jiao Feng, Hou-Fu Xia, Ling-Ling Wu, Dai-Wen Pang, Gang Chen, Zhi-Ling Zhang
A system integrating diagnostic and therapeutic functions for cancer is presented using magnetically controlled microfluidics.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Colorimetric absorbance mapping and quantitation on paper-based analytical devices

Lab Chip, 2020, 20,1441-1448
DOI: 10.1039/D0LC00028K, Paper
Open Access
Yoshiki Soda, Kye J. Robinson, Thomas J. Cherubini, Eric Bakker
A pixel-level colorimetric absorbance analysis can measure the total quantity of dye on paper, irrespective of shape and size.
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Advanced 96-microtiter plate based bioelectrochemical platform reveals molecular short cut of electron flow in cytochrome P450 enzyme

Lab Chip, 2020, 20,1449-1460
DOI: 10.1039/C9LC01220F, Paper
Ronny Frank, Christoph Prönnecke, Ronny Azendorf, Heinz-Georg Jahnke, Annette G. Beck-Sickinger, Andrea A. Robitzki
We developed a novel 96-well microtiter plate based bioelectrochemical platform with a vertical divided cell three-electrode architecture and a 96-multipotentiostat to perform fully parallelised bioelectrocatalytic screenings on redox enzymes.
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An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery

Lab Chip, 2020, 20,1390-1397
DOI: 10.1039/D0LC00021C, Communication
Bo Wang, Ximiao Wen, Yan Cao, Shan Huang, Hoa A. Lam, Tingyi “Leo” Liu, Pei-Shan Chung, Harold G. Monbouquette, Pei-Yu Chiou, Nigel T. Maidment
PDMS thin-film transfer and enzyme microstamping enabled 3-in-1 Si/PDMS hybrid chemtrode for multi-analyte sensing and chemical delivery in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Scalable microfluidic droplet on-demand generator for non-steady operation of droplet-based assays

Lab Chip, 2020, 20,1398-1409
DOI: 10.1039/C9LC01103J, Paper
Open Access
Kartik Totlani, Jan-Willem Hurkmans, Walter M. van Gulik, Michiel T. Kreutzer, Volkert van Steijn
We developed a microfluidic droplet on-demand (DoD) generator that enables the production of droplets with a volume solely governed by the geometry of the generator for a range of operating conditions.
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Rapid lipolytic oscillations in ex vivo adipose tissue explants revealed through microfluidic droplet sampling at high temporal resolution

Lab Chip, 2020, 20,1503-1512
DOI: 10.1039/D0LC00103A, Paper
Juan Hu, Xiangpeng Li, Robert L. Judd, Christopher J. Easley
High temporal resolution sampling and quantitative detection of glycerol secretion dynamics from adipose tissue using our automated, droplet-based microfluidic system.
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Applications of the microphysiology systems database for experimental ADME-Tox and disease models

Lab Chip, 2020, 20,1472-1492
DOI: 10.1039/C9LC01047E, Paper
Open Access
Mark Schurdak, Lawrence Vernetti, Luke Bergenthal, Quinn K. Wolter, Tong Ying Shun, Sandra Karcher, D. Lansing Taylor, Albert Gough
The Microphysiology Systems Database (MPS) is a critical tool for the design, management, analysis, and sharing of MPS study data.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Mathematical modeling and computational analysis of centrifugal microfluidic platforms: a review

Lab Chip, 2020, 20,1318-1357
DOI: 10.1039/C9LC00775J, Critical Review
Open Access
Masoud Madadelahi, Luis F. Acosta-Soto, Samira Hosseini, Sergio O. Martinez-Chapa, Marc J. Madou
This paper focuses on theory and computational modelling of lab-on-a-disc devices of relevance for novel applications discovery and optimal designs.
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Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00051E, Paper
Jinxin Zhang, Jessica H. Hartman, Chuyi Chen, Shujie Yang, Qi Li, Zhenhua Tian, Po-Hsun Huang, Lin Wang, Joel N. Meyer, Tony Jun Huang
Acoustofluidic sorting of Caenorhabditis elegans in a high throughput manner.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Nanoplasmon-enhanced drop-screen for high throughput single-cell nucleocytoplasmic miRNA profiling

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01226E, Paper
Jia Liu, Guoyun Sun, Shih-Chung Wei, Song Guo, Weikang Nicholas Lin, Chia-Hung Chen
Nanoplasmon-enhanced drop screen is developed to measure single-cell multiple miRNAs with high sensitivity of 0.1 nM, addressing cell nucleocytoplasmic profile in a throughput ∼100 cells per minute.
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Stretching DNA to twice the normal length with single-molecule hydrodynamic trapping

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01028A, Paper
Open Access
Yan Jiang, Theodore Feldman, Julia A. M. Bakx, Darren Yang, Wesley P. Wong
High-speed hydrodynamic trapping enables combined surface-free force spectroscopy and fluorescence imaging of single DNA molecules at extreme forces.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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ECM-based microchannel for culturing in vitro vascular tissues with simultaneous perfusion and stretch

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00254B, Paper
Azusa Shimizu, Wei Huang Goh, Shun Itai, Michinao Hashimoto, Shigenori Miura, Hiroaki Onoe
A perfusable and stretchable gelatin-based microfluidic system that can apply both simultaneous fluidic shear stress and stretch stress to in vitro endothelial 3D tissues is presented.
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Development of two-photon polymerised scaffolds for optical interrogation and neurite guidance of human iPSC-derived cortical neuronal networks

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01209E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
J. A. Crowe, A. El-Tamer, D. Nagel, A. V. Koroleva, J. Madrid-Wolff, O. E. Olarte, S. Sokolovsky, E. Estevez-Priego, A.-A. Ludl, J. Soriano, P. Loza-Alvarez, B. N. Chichkov, E. J. Hill, H. R. Parri, E. U. Rafailov
We identified photopolymers for 2-photon polymerisation with biocompatibility for human iPSC-derived neural network development. Generation of microscale scaffold topologies enabled neurite guidance, demonstrating use in reproducing aligned networks.
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Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01192G, Paper
Roman Mikhaylov, Fangda Wu, Hanlin Wang, Aled Clayton, Chao Sun, Zhihua Xie, Dongfang Liang, Yinhua Dong, Fan Yuan, Despina Moschou, Zhenlin Wu, Ming Hong Shen, Jian Yang, Yongqing Fu, Zhiyong Yang, Christian Burton, Rachel J. Errington, Marie Wiltshire, Xin Yang
We demonstrate a novel SAW device fabrication technique by mechanically clamping interdigital electrodes (IDEs) on the printed circuit board (PCB) to a LiNbO3 wafer. The novel PCB-SAW device is capable of performing all the functions of standard SAW devices.
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A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00263A, Paper
Jaime L. Korner, Elanna B. Stephenson, Katherine S. Elvira
A new type of pharmacokinetic compartment model using artificial cell membranes that predicts intestinal absorption three times more accurately than the current state of the art.
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Seeded droplet microfluidic system for small molecule crystallization

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00122H, Paper
N. Garg, R. Tona, P. Martin, P. M. Martin-Soladana, G. Ward, N. Douillet, D. Lai
A microfluidic approach to seeded crystallization has been demonstrated using abacavir hemisulfate, a nucleoside analog reverse transcriptase inhibitor, in droplet reactors to control polymorphism and produce particles with a low particle size distribution.
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A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00059K, Paper
Open Access
Christian G. M. van Dijk, Maarten M. Brandt, Nikolaos Poulis, Jonas Anten, Matthijs van der Moolen, Liana Kramer, Erik F. G. A. Homburg, Laura Louzao-Martinez, Jiayi Pei, Merle M. Krebber, Bas W. M. van Balkom, Petra de Graaf, Dirk J. Duncker, Marianne C. Verhaar, Regina Luttge, Caroline Cheng
We present a microfluidic vascular device. Vascular cells in a 3D-ECM environment support hemodynamic flow and enable monocyte interaction.
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Current commercialization status of electrowetting-on-dielectric (EWOD) digital microfluidics

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00144A, Critical Review
Jia Li, Chang-Jin “CJ” Kim
Electrowetting on EWOD surface: a droplet beading or spreading (left) or translating (right) by electric signals. The EWOD technology made the once-obscure electrowetting phenomenon practical, leading to the host of commercial products today.
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Microfluidic device for high-throughput affinity-based isolation of extracellular vesicles

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01190K, Paper
Ting-Wen Lo, Ziwen Zhu, Emma Purcell, Daniel Watza, Joyful Wang, Yoon-Tae Kang, Shruti Jolly, Deepak Nagrath, Sunitha Nagrath
Immunoaffinity based EV isolation technologies use antibodies targeting surface markers on EVs to provide higher isolation specificity and purity compared to existing approaches.
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Direct loading of blood for plasma separation and diagnostic assays on a digital microfluidic device

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00302F, Paper
Christopher Dixon, Julian Lamanna, Aaron R. Wheeler
The integration of 3D porous membranes in a digital microfluidic device enables the generation of cell-free plasma from finger-stick volumes of blood with in-line, on-chip analysis.
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In situ generation of plasma-activated aerosols via surface acoustic wave nebulization for portable spray-based surface bacterial inactivation

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00001A, Paper
Kiing S. Wong, William T. H. Lim, Chien W. Ooi, Leslie Y. Yeo, Ming K. Tan
We demonstrate an efficient technique for in situ production and application of plasma-activated aerosols for surface disinfection.
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Correction: Deformability-induced lift force in spiral microchannels for cell separation

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC90036B, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ewa Guzniczak, Oliver Otto, Graeme Whyte, Nicholas Willoughby, Melanie Jimenez, Helen Bridle
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A new polymer lab-on-a-chip (LOC) based on a microfluidic capillary flow assay (MCFA) for detecting unbound cortisol in saliva

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00071J, Paper
Vinitha T. U., Sthitodhi Ghosh, Alexander Milleman, Thinh Nguyen, Chong H. Ahn
A new polymer lab-on-a-chip with on-chip dried reagents for microfluidic capillary flow assay (MCFA) detection of unbound cortisol in saliva.
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Photonic crystal-based smart contact lens for continuous intraocular pressure monitoring

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01268K, Paper
Bohee Maeng, Hyung-kwan Chang, Jungyul Park
A powerless smart contact lens enabling to monitor intraocular pressure (IOP) by checking the visual color change in photonic crystal structure with a microhydraulic amplification system has been realized.
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Spatially isolated reactions in a complex array: using magnetic beads to purify and quantify nucleic acids with digital and quantitative real-time PCR in thousands of parallel microwells

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00069H, Paper
W. Hampton Henley, Nathan A. Siegfried, J. Michael Ramsey
Encoded beads carrying primer pairs for nucleic acid targets are used for sample preparation and multiplexed-in-space digital PCR quantification.
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Multiplexed homogeneous digital immunoassay based on single-particle motion analysis

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00079E, Paper
Kenji Akama, Hiroyuki Noji
Homogeneous digital immunoassay is a powerful analytical method for highly sensitive biomarker detection with a simple protocol. By using this method, we demonstrated the simultaneous multiple protein detection.
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Clip-to-release on amplification (CRoA): a novel DNA amplification enhancer on and off microfluidics

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00318B, Paper
Ren Shen, Yanwei Jia, Pui-In Mak, Rui P. Martins
A proposed DNA amplification enhancer with a “clip-to-release on amplification” mechanism reduces dye-mediated inhibition to amplification, increases fluorescence signal up to 10-fold, and eliminates false-negative results for on-chip PCR.
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Nanocrystal synthesis, μfluidic sample dilution and direct extraction of single emission linewidths in continuous flow

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00213E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ioannis Lignos, Hendrik Utzat, Moungi G. Bawendi, Klavs F. Jensen
We present a flow-based system coupled with an optical interferometry setup for the extraction of single nanocrystal properties.
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Acoustic separation of living and dead cells using high density medium

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00175A, Paper
Open Access
Karl Olofsson, Björn Hammarström, Martin Wiklund
A novel, simple and robust route for binary separation of viable and dead cells using a density modified medium which takes advantage of the compromised cell membrane of dead cells.
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Bioinspired reconfiguration of 3D printed microfluidic hydrogels via automated manipulation of magnetic inks

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00280A, Communication
Amin Mansoorifar, Anthony Tahayeri, Luiz E. Bertassoni
We proposed a novel concept for reconfiguration of hydrogel microfluidic devices, where multiple fluidic pathways could be generated via reversible manipulation of magnetic inks.
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Catalytic exchange of hydrogen isotopes intensified by two-phase stratified flow in wettability designable microchannels

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00250J, Paper
Yuexiao Song, Feng Xin, Yongsheng Xu
This work develops a reliable method to achieve stratified flow in squared cross-section microchannels by endowing the four channel walls with very different wettabilities. The gas–liquid flows are studied experimentally...
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PRESCIENT: platform for the rapid evaluation of antibody success using integrated microfluidics enabled technology

Lab Chip, 2020, 20,1628-1638
DOI: 10.1039/C9LC01165J, Paper
Jose A. Wippold, Han Wang, Joseph Tingling, Julian L. Leibowitz, Paul de Figueiredo, Arum Han
Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents.
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Multiscale brain research on a microfluidic chip

Lab Chip, 2020, 20,1531-1543
DOI: 10.1039/C9LC01010F, Critical Review
Yanan Zhao, Utkan Demirci, Yun Chen, Pu Chen
We report recent progress in applying innovative microfluidic chip-based neurotechnologies to promote multiscale brain research across the hierarchical organizations from the molecular, cellular, and tissue levels up to the whole organism level.
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