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Auto-affitech: an automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method

By feeds.rsc.org
Published On ::

Lab Chip, 2020, 20,1577-1585
DOI: 10.1039/D0LC00024H, Paper
Jingjing Guo, Li Lin, Kaifeng Zhao, Yanling Song, Mengjiao Huang, Zhi Zhu, Leiji Zhou, Chaoyong Yang
An automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method that reduces the bead loss.
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Microfluidic device to study flow-free chemotaxis of swimming cells

By feeds.rsc.org
Published On ::

Lab Chip, 2020, 20,1639-1647
DOI: 10.1039/D0LC00045K, Paper
Nicolas Garcia-Seyda, Laurene Aoun, Victoria Tishkova, Valentine Seveau, Martine Biarnes-Pelicot, Marc Bajénoff, Marie-Pierre Valignat, Olivier Theodoly
Permeable agarose barriers allow flow-free gradient generation, applicable to adherent and non-adherent (swimming) cells, as well as co-culture experiments.
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Quantitatively controllable fluid flows with ballpoint-pen-printed patterns for programmable photo-paper-based microfluidic devices

By feeds.rsc.org
Published On ::

Lab Chip, 2020, 20,1601-1611
DOI: 10.1039/D0LC00115E, Paper
Veasna Soum, Sooyong Park, Albertus Ivan Brilian, Jae-Youl Choi, Yongwoo Lee, Wonjung Kim, Oh-Sun Kwon, Kwanwoo Shin
A precise, simple, and inexpensive method for controlling fluid flow in a photo-paper-based microfluidic device was reported.
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Monitoring the two-dimensional concentration profile of toluene vapors by using polymer-stabilized nematic liquid crystals in microchannels

By feeds.rsc.org
Published On ::

Lab Chip, 2020, 20,1687-1693
DOI: 10.1039/C9LC01021A, Paper
Zongdai Liu, Dan Luo, Kun-Lin Yang
The concentration of toluene vapor is obtained based on polymer-stabilized liquid crystals by viewing a colourful gamut under a polarized optical microscope.
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Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery

By feeds.rsc.org
Published On ::

Lab Chip, 2020, 20,1562-1576
DOI: 10.1039/D0LC00121J, Paper
Open Access
Nicola Di Trani, Antonia Silvestri, Antons Sizovs, Yu Wang, Donald R. Erm, Danilo Demarchi, Xuewu Liu, Alessandro Grattoni
Control of molecular diffusion through nanofluidic channels using electrostatic gating.
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Hybrid paper and 3D-printed microfluidic device for electrochemical detection of Ag nanoparticle labels

By feeds.rsc.org
Published On ::

Lab Chip, 2020, 20,1648-1657
DOI: 10.1039/D0LC00276C, Paper
Charuksha Walgama, Michael P. Nguyen, Lisa M. Boatner, Ian Richards, Richard M. Crooks
A hybrid paper/plastic microfluidic device for detection of Ag nanoparticle labels at concentrations as low as 12 pM.
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A microfluidic platform for functional testing of cancer drugs on intact tumor slices

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Published On ::

Lab Chip, 2020, 20,1658-1675
DOI: 10.1039/C9LC00811J, Paper
A. D. Rodriguez, L. F. Horowitz, K. Castro, H. Kenerson, N. Bhattacharjee, G. Gandhe, A. Raman, R. J. Monnat, R. Yeung, R. C. Rostomily, A. Folch
We have developed a digitally-manufacturable microfluidic platform that allows for multiplexed drug testing of intact tumor slices.
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Selective cell propagation via micropatterning of a thermally-activated hydrogel

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Published On ::

Lab Chip, 2020, 20,1544-1553
DOI: 10.1039/C9LC01230C, Communication
Jeffrey C. Y. Chiu, Joyce A. Teodoro, Jeong Hyun Lee, Kerryn Matthews, Simon P. Duffy, Hongshen Ma
Inverse gelation of methylcellulose enables hydrogel micropatterning to selectively propagate cells identified by microscopy.
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In-flow measurement of cell–cell adhesion using oscillatory inertial microfluidics

By feeds.rsc.org
Published On ::

Lab Chip, 2020, 20,1612-1620
DOI: 10.1039/D0LC00089B, Paper
Baris R. Mutlu, Taronish Dubash, Claudius Dietsche, Avanish Mishra, Arzu Ozbey, Kevin Keim, Jon F. Edd, Daniel A. Haber, Shyamala Maheswaran, Mehmet Toner
Cell–cell adhesion strength of freely suspended cell clusters can be measured using an oscillatory inertial microfluidic system.
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3-Step flow focusing enables multidirectional imaging of bioparticles for imaging flow cytometry

By feeds.rsc.org
Published On ::

Lab Chip, 2020, 20,1676-1686
DOI: 10.1039/D0LC00244E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Andreas Kleiber, Anuradha Ramoji, Günter Mayer, Ute Neugebauer, Jürgen Popp, Thomas Henkel
The control of the focus plane allows multi-directional imaging flow cytometry.
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Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment

By feeds.rsc.org
Published On ::

Lab Chip, 2020, 20,1586-1600
DOI: 10.1039/D0LC00099J, Paper
Karina M. Lugo-Cintrón, José M. Ayuso, Bridget R. White, Paul M. Harari, Suzanne M. Ponik, David J. Beebe, Max M. Gong, María Virumbrales-Muñoz
Lymphatic organotypic in vitro model allows the examination of components of the tumor microenvironment (e.g., ECM density, cancer cells) in lymphatic vessel biology in the context of cancer, providing insights into potential therapeutic targets.
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High-sensitivity microliter blood pressure sensors based on patterned micro-nanostructure arrays

By feeds.rsc.org
Published On ::

Lab Chip, 2020, 20,1554-1561
DOI: 10.1039/D0LC00063A, Communication
Nianzuo Yu, Yongshun Liu, Bai Ji, Shuli Wang, Yunyun Chen, Tianmeng Sun, Junhu Zhang, Bai Yang
Blood pressure sensors are proposed to measure the value of central venous pressure, and diagnose the severity of hypertension, hypotension and arterial thrombosis.
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Acoustic erythrocytometer for mechanically probing cell viscoelasticity

By feeds.rsc.org
Published On ::

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC00999J, Paper
Open Access
A. Link, T. Franke
Novel microfluidic platform to determine the viscoelastic fingerprint of a red blood cell population using surface acoustic waves.
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Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

By feeds.rsc.org
Published On ::

Lab Chip, 2020, 20,1621-1627
DOI: 10.1039/D0LC00304B, Paper
Fu Sun, Anurup Ganguli, Judy Nguyen, Ryan Brisbin, Krithika Shanmugam, David L. Hirschberg, Matthew B. Wheeler, Rashid Bashir, David M. Nash, Brian T. Cunningham
A 30-minute nucleic acid test for equine respiratory virus from nasal swab material, detected with a smartphone.
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Microfluidic assessment of red blood cell mediated microvascular occlusion

By feeds.rsc.org
Published On ::

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00112K, Paper
Yuncheng Man, Erdem Kucukal, Ran An, Quentin Watson, Jürgen Bosch, Peter A. Zimmerman, Jane A Little, Umut A. Gurkan
Abnormal red blood cells (RBC) deformability contributes to hemolysis, thrombophilia, inflammation, and microvascular occlusion in various circulatory diseases. A quantitative and objective assessment of microvascular occlusion mediated by RBCs with...
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Particle/cell separation using sheath-free deterministic lateral displacement arrays with inertially focused single straight input

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Published On ::

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00354A, Paper
Naotomo Tottori, Takasi Nisisako
We propose sheath-free microfluidic deterministic lateral displacement devices with inertially focused single straight input.
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A high-throughput system combining microfluidic hydrogel droplets with deep learning for screening the antisolvent-crystallization conditions of active pharmaceutical ingredient

By feeds.rsc.org
Published On ::

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00153H, Paper
Zhening Su, Jinxu He, Peipei Zhou, Lu Huang, Jianhua Zhou
Crystallization of active pharmaceutical ingredients (APIs) is a crucial process in the pharmaceutical industry due to its great impact in drug efficacy. However, conventional approaches for screening the optimal crystallization...
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Evaluation of intercellular communication between breast cancer cells and adipose-derived stem cells via passive diffusion in a two-layer microfluidic device

By feeds.rsc.org
Published On ::

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00142B, Paper
Sharif M. Rahman, Joshua M. Campbell, Rachael N. Coates, Katie M. Render, C. Ethan Byrne, Elizabeth C. Martin, Adam T. Melvin
Breast cancer cells co-cultured with adipose-derived stem cells (ASCs) in a microfluidic device exhibited enhanced growth, a more aggressive morphology and polarization towards the ASCs, and increased drug resistance.
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Liquid-liquid-liquid three-phase microsystem: hybrid slug flow-laminar flow

By feeds.rsc.org
Published On ::

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00292E, Communication
Tao Wang, Cong Xu
Liquid-liquid-liquid three-phase microfluidics provides abundant flow patterns and attractive characteristics that substantially extend the applications of liquid-liquid two-phase microfluidics. Although the manipulation of stable interfaces between adjacent liquid phases is...
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Picoliter Agar Droplet Breakup in Microfluidics Meets Microbiology Application: Numerical and Experimental Approaches

By feeds.rsc.org
Published On ::

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00300J, Paper
Asmaa Khater, Osama Abdelrehim, Mehdi Mohammadi, Milad Azarmanesh, Mohsen Jonmaleki, Razieh Salahandish, AbdulMajeed Mohamad, Amir Sanati Nezhad
Droplet microfluidics has provided lab-on-a-chip platforms with the capability of bacteria encapsulation in biomaterials, controlled culture environment, and live monitoring of growth and proliferation. The droplets are mainly generated from...
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Express newslist: Updates on Draft National Encryption Policy, beef ban and other stories

By indianexpress.com
Published On :: Mon, 21 Sep 2015 05:51:55 +0000


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Express newslist: Secret letter on Netaji, Bombay HC verdict on sedition and other updates

By indianexpress.com
Published On :: Tue, 22 Sep 2015 04:26:18 +0000


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7/11 Mumbai train blasts: 6 of the 12 convicts profiled

By indianexpress.com
Published On :: Wed, 30 Sep 2015 10:38:08 +0000


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Express Newslist: Mumbai blasts convict’s confession, India’s reply to Pak at UN, Mahesh Sharma on Dadri lynching

By indianexpress.com
Published On :: Thu, 01 Oct 2015 09:16:12 +0000


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Dadri lynching: Akhlaq’s son fights for life, Muslims live in fear, politicians home in

By indianexpress.com
Published On :: Fri, 02 Oct 2015 05:22:05 +0000


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[ASAP] Comparing Cryo-EM Reconstructions and Validating Atomic Model Fit Using Difference Maps

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Published On :: Tue, 11 Feb 2020 05:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01103


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[ASAP] Computational Protocol for Assessing the Optimal Pixel Size to Improve the Accuracy of Single-particle Cryo-electron Microscopy Maps

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Published On :: Fri, 14 Feb 2020 05:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01107


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[ASAP] SPREAD: A Fully Automated Toolkit for Single-Particle Cryogenic Electron Microscopy Data 3D Reconstruction with Image-Network-Aided Orientation Assignment

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Published On :: Wed, 19 Feb 2020 05:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01099


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[ASAP] What Will Computational Modeling Approaches Have to Say in the Era of Atomistic Cryo-EM Data?

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Published On :: Mon, 24 Feb 2020 05:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00123


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[ASAP] Need for Cross-Validation of Single Particle Cryo-EM

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Published On :: Wed, 26 Feb 2020 05:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01121


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[ASAP] Combining Docking Pose Rank and Structure with Deep Learning Improves Protein–Ligand Binding Mode Prediction over a Baseline Docking Approach

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Published On :: Tue, 03 Mar 2020 05:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b00927


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[ASAP] What Could Go Wrong? A Practical Guide to Single-Particle Cryo-EM: From Biochemistry to Atomic Models

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Published On :: Mon, 09 Mar 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01178


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[ASAP] Structural Biology in the Multi-Omics Era

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Published On :: Tue, 10 Mar 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01164


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[ASAP] Will Cryo-Electron Microscopy Shift the Current Paradigm in Protein Structure Prediction?

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Published On :: Wed, 18 Mar 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00177


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[ASAP] Retrospect and Prospect of Single Particle Cryo-Electron Microscopy: The Class of Integral Membrane Proteins as an Example

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Published On :: Fri, 20 Mar 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01015


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[ASAP] Development and Evaluation of MM/GBSA Based on a Variable Dielectric GB Model for Predicting Protein–Ligand Binding Affinities

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Published On :: Fri, 20 Mar 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00024


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[ASAP] Flexible Fitting of Small Molecules into Electron Microscopy Maps Using Molecular Dynamics Simulations with Neural Network Potentials

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Published On :: Mon, 30 Mar 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01167


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[ASAP] Simulation-Based Methods for Model Building and Refinement in Cryoelectron Microscopy

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Published On :: Tue, 31 Mar 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00087


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[ASAP] Cylindrical Similarity Measurement for Helices in Medium-Resolution Cryo-Electron Microscopy Density Maps

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Published On :: Tue, 07 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00010


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[ASAP] Cov_FB3D: A De Novo Covalent Drug Design Protocol Integrating the BA-SAMP Strategy and Machine-Learning-Based Synthetic Tractability Evaluation

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Published On :: Thu, 09 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01197


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[ASAP] Live Analysis and Reconstruction of Single-Particle Cryo-Electron Microscopy Data with CryoFLARE

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01102


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[ASAP] Mechanism-Based Rational Discovery and <italic toggle="yes">In Vitro</italic> Evaluation of Novel Microtubule Stabilizing Agents with Non-Taxol-Competitive Activity

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Published On :: Tue, 21 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01133


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[ASAP] Brick-CFCMC: Open Source Software for Monte Carlo Simulations of Phase and Reaction Equilibria Using the Continuous Fractional Component Method

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Published On :: Tue, 21 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00334


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[ASAP] Discovery of Ubiquitin-Specific Protease 7 (USP7) Inhibitors with Novel Scaffold Structures by Virtual Screening, Molecular Dynamics Simulation, and Biological Evaluation

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Published On :: Thu, 23 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00154


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[ASAP] Ranking Molecules with Vanishing Kernels and a Single Parameter: Active Applicability Domain <italic toggle="yes">Included</italic>

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Published On :: Thu, 23 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01075


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[ASAP] Evaluating Scalable Uncertainty Estimation Methods for Deep Learning-Based Molecular Property Prediction

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Published On :: Fri, 24 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b00975


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[ASAP] Context Aware Data-Driven Retrosynthetic Analysis

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Published On :: Fri, 24 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01141


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[ASAP] Prototype Selection Method Based on the Rivality and Reliability Indexes for the Improvement of the Classification Models and External Predictions

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Published On :: Sun, 26 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00176


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[ASAP] Nanomaterial Synthesis Insights from Machine Learning of Scientific Articles by Extracting, Structuring, and Visualizing Knowledge

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Published On :: Wed, 29 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00199


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[ASAP] Multisolvent Models for Solvation Free Energy Predictions Using 3D-RISM Hydration Thermodynamic Descriptors

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00065


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