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[ASAP] Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode

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Published On :: Wed, 06 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00021

de

[ASAP] Design of Hydrazide-Bearing HDACIs Based on Panobinostat and Their p53 and FLT3-ITD Dependency in Antileukemia Activity

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Published On :: Wed, 06 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00442

de

[ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00337

de

[ASAP] Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00441

de

[ASAP] Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma

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Published On :: Mon, 30 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00601

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[ASAP] Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-<italic toggle="yes">a</italic>]pyridines against the 1A Family

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Published On :: Tue, 31 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00686

de

[ASAP] Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor

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Published On :: Wed, 01 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00665

de

[ASAP] Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00045

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[ASAP] Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00041

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[ASAP] Characterization of an Alginate Encapsulated LS180 Spheroid Model for Anti-colorectal Cancer Compound Screening

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Published On :: Fri, 03 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00076

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[ASAP] Structure Optimization of Gatastatin for the Development of ?-Tubulin-Specific Inhibitor

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Published On :: Mon, 06 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00526

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[ASAP] Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface

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Published On :: Tue, 07 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00111

de

[ASAP] Assembling Pharma Resources to Tackle Diseases of Underserved Populations

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Published On :: Wed, 08 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00051

de

[ASAP] Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents

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Published On :: Wed, 08 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00639

de

[ASAP] Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor

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Published On :: Thu, 09 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00681

de

[ASAP] Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00594

de

[ASAP] Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00574

de

[ASAP] Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors

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Published On :: Mon, 13 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00438

de

[ASAP] Artemisinin Derivatives with Antimelanoma Activity Show Inhibitory Effect against Human DNA Topoisomerase 1

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Published On :: Tue, 14 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00131

de

[ASAP] Sigma Receptor Ligands Carrying a Nitric Oxide Donor Nitrate Moiety: Synthesis, In Silico, and Biological Evaluation

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00661

de

[ASAP] Characterization of Specific <italic toggle="yes">N</italic>-a-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00029

de

[ASAP] Can Drug Repositioning Work as a Systematical Business Model?

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Published On :: Fri, 17 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00122

de

[ASAP] Update to Our Reader, Reviewer, and Author Communities—April 2020

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Published On :: Wed, 22 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00206

de

[ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00192

de

[ASAP] Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from <italic toggle="yes">Trypanosoma cruzi</italic>

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Published On :: Wed, 29 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00106

de

[ASAP] P2Y<sub>14</sub> Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00115

de

[ASAP] Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

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Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00025

de

[ASAP] Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase

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Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00092

de

[ASAP] Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 d Inhibitors

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Published On :: Mon, 04 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00028

de

[ASAP] Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture

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Published On :: Tue, 05 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00009

de

[ASAP] De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits

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Published On :: Tue, 05 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00022

de

[ASAP] Ligand Design for Cereblon Based Immunomodulatory Therapy

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Published On :: Fri, 08 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00214

de

China’s New Large Solar-Powered Drone Reaches 20,000 Meters in Altitude

By latestsolarnews.com
Published On :: Tue, 06 Jun 2017 16:29:43 +0000

China’s first domestically designed large solar-powered unmanned plane reached above 20,000 meters in altitude on its test flight in the country’s northwest regions recently. The drone was developed by the China Academy of Aerospace Aerodynamics (CAAA), it’s developers kept the exact size of the drone as a secret, but it is believed to be about 14 …

The post China’s New Large Solar-Powered Drone Reaches 20,000 Meters in Altitude appeared first on LatestSolarNews.

News

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Popular Design News of the Week: April 20, 2020 – April 26, 2020

By www.webdesignerdepot.com
Published On :: Sun, 26 Apr 2020 10:45:05 +0000

Every week users submit a lot of interesting stuff on our sister site Webdesigner News, highlighting great content from around the web that can be of interest to web designers. The best way to keep track of all the great stories and news being posted is simply to check out the Webdesigner News site, however, […]

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The Latest Research for Web Designers, April 2020

By www.webdesignerdepot.com
Published On :: Mon, 27 Apr 2020 10:45:10 +0000

Although life hasn’t returned to normal yet, the web design and marketing space doesn’t seem to have been too badly disrupted — at least not with all the new research and surveys floating around. And thank goodness for that. If we can maintain some semblance of normalcy, I think we’ll all get through this crisis in good shape.

Business & Tech
cybersecurity
design research
ecommerce marketing
technical seo
web design facts
web design research

de

Popular Design News of the Week: April 27, 2020 – May 3, 2020

By www.webdesignerdepot.com
Published On :: Sun, 03 May 2020 10:45:45 +0000

Every week users submit a lot of interesting stuff on our sister site Webdesigner News, highlighting great content from around the web that can be of interest to web designers. The best way to keep track of all the great stories and news being posted is simply to check out the Webdesigner News site, however, […]

de

3 Essential Design Trends, May 2020

By www.webdesignerdepot.com
Published On :: Mon, 04 May 2020 10:45:56 +0000

The state of the world around us can greatly impact website design. From emotional changes that correlate to the feel of a design to information and data to deliver, the impact of the worldwide COVID-19 pandemic is making its way into projects (intentionally or not). Here’s what’s trending in design this month. 1. “Unbalanced” Use […]

Community & Inspiration
design inspiration
design trends
new design ideas
trending web design
web design trends

de

Design: the key concepts / D.J. Huppatz

By library.mit.edu
Published On :: Sun, 16 Feb 2020 06:00:01 EST

Barker Library - NK1510.H87 2019

de

How art can be thought: a handbook for change / Allan deSouza

By library.mit.edu
Published On :: Sun, 16 Feb 2020 06:00:01 EST

Rotch Library - N7425.D459 2018

de

Library of light: encounters with artists and designers / Jo Joelson

By library.mit.edu
Published On :: Sun, 16 Feb 2020 06:00:01 EST

Rotch Library - N8219.L5 J64 2019

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The women of Atelier 17: modernist printmaking in midcentury New York / Christina Weyl

By library.mit.edu
Published On :: Sun, 16 Feb 2020 06:00:01 EST

Rotch Library - NE538.N5 W49 2019

de

Mathias Goeritz: modernist art and architecture in Cold War Mexico / Jennifer Josten

By library.mit.edu
Published On :: Sun, 16 Feb 2020 06:00:01 EST

Rotch Library - N6559.G64 J67 2018

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El nombre de un país / Mariana Telleria ; curadora, Florencia Battiti

By library.mit.edu
Published On :: Sun, 23 Feb 2020 06:00:02 EST

Rotch Library - N6488.I8 V433 2019 A7

de

New design, neoplasticism: Nieuwe beelding / Piet Mondrian ; English translation by Harry Holtzman and Martin S. James

By library.mit.edu
Published On :: Sun, 23 Feb 2020 06:00:02 EST

Rotch Library - N6948.5.D42 M6613 2019

de

Inventing Boston: design, production, and consumption / Edward S. Cooke, Jr

By library.mit.edu
Published On :: Sun, 23 Feb 2020 06:00:02 EST

Rotch Library - NK838.B67 C66 2019

de

Gordon Parks: the new tide, early work, 1940-1950 / Philip Brookman ; with essays by Maurice Berger, Sarah Lewis, Richard J. Powell, Deborah Willis ; series editor, Peter W. Kunhardt, Jr

By library.mit.edu
Published On :: Sun, 23 Feb 2020 06:00:02 EST

Rotch Library - TR647.P37 2018

de

Fields of fungus and sunflowers / [edited and designed by Tammy Nguyen ; contributions by Lovely Umayam and Adriel Luis]

By library.mit.edu
Published On :: Sun, 23 Feb 2020 06:00:02 EST

Rotch Library - N7433.35.U6 M37 no.6

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On desire: BIII / Herausgeber, Bernd Kracke, Marc Ries

By library.mit.edu
Published On :: Sun, 23 Feb 2020 06:00:02 EST

Rotch Library - N6498.V53 B15 2018

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Altered states: Substanzen in der zeitgenössischen Kunst = substances in contemporary art / herausgegeben von = edited by Milena Mercer ; Texte = texts, Max Daly ... [and thirteen others]

By library.mit.edu
Published On :: Sun, 23 Feb 2020 06:00:02 EST

Rotch Library - N8251.S555 A48 2018

de

The shadow of dream cast upon Giardini della Biennale

By library.mit.edu
Published On :: Sun, 23 Feb 2020 06:00:02 EST

Rotch Library - N6488.I8 V433 2019 U38