Biomater. Sci., 2020, 8,2234-2244
DOI: 10.1039/C9BM01931F, Paper

Qiaojie Luo, Xiaojun Li, Ying Wang, Jianfang He, Qiao Zhang, Pengfei Ge, Xia Cai, Qiang Sun, Weipu Zhu, Zhiquan Shen, Xiaodong Li
A biodegradable CO₂-based polymeric nanodrug is obtained via a surfactant- and solvent-free miniemulsion preparation, which can be concentrated at tumor site by EPR and releases the encapsulated drug through pH responsiveness.
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Biomater. Sci., 2020, 8,2255-2263
DOI: 10.1039/D0BM00069H, Paper

Liting Zhang, Chengtao Jiang, Fanjun Zeng, Haiyu Zhou, Dongdong Li, Xinyu He, Song Shen, Xianzhu Yang, Jun Wang
The cell-penetrating function of R₉ peptide of DA@R₉-NP_DOX was masked in the blood circulation, while reactivated in tumor tissue for enhanced tumor cellular uptake.
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Biomater. Sci., 2020, 8,2264-2273
DOI: 10.1039/D0BM00112K, Paper

Jie Ding, Xu Zhang, Chuangqi Chen, Yuqiang Huang, Xingsu Yu, Xiaomao Li
An ultra pH-sensitive polymeric nanovesicle was constructed to co-deliver doxorubicin and navitoclax for highly efficient synergetic treatment of endometrial carcinoma.
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Biomater. Sci., 2020, 8,2283-2288
DOI: 10.1039/D0BM00088D, Paper

Guihong Lu, Liping Zuo, Jinfeng Zhang, Houshun Zhu, Wanru Zhuang, Wei Wei, Hai-Yan Xie
A highly efficient two-step targeting strategy integrating metabolic lipid-engineering with in situ click chemistry is developed, thus significantly improved the tumor theranostic performance of the red blood cells ghosts based drug delivery.
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Biomater. Sci., 2020, 8,2202-2211
DOI: 10.1039/C9BM01794A, Paper

Li Zhang, Shiyu Zhang, Huajian Chen, Yu Liang, Bingxia Zhao, Wanxian Luo, Qian Xiao, Jinheng Li, Junqiao Zhu, Chao Peng, Yaru Zhang, Zhe Hong, Ying Wang, Yingjia Li
Ultrasound-assisted fast extravasation and the following laser-triggered drug release of thermo-sensitive liposomes synergistically enhanced drug delivery in deep tumors.
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Biomater. Sci., 2020, 8,2074-2083
DOI: 10.1039/C9BM01928F, Review Article

Paul Mardling, Andrew Alderson, Nicola Jordan-Mahy, Christine Lyn Le Maitre
A number of biological tissues have been shown to behave in an auxetic manner, defined by having a negative poissons ratio. Thus mimicking this environment has a number of potential applications especially in tissue engineering.
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Biomater. Sci., 2020, 8,2318-2328
DOI: 10.1039/C9BM02000D, Paper

Bin Gao, Xiaoyu Wang, Meiyu Wang, Xiang-kui Ren, Jintang Guo, Shihai Xia, Wencheng Zhang, Yakai Feng
A dual-gene delivery system with coordinated expression function boosted the neovascularization.
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Biomater. Sci., 2020, 8,2245-2254
DOI: 10.1039/C9BM02010A, Paper

Gil Yeroslavsky, Masakazu Umezawa, Kyohei Okubo, Karina Nigoghossian, Doan Thi Kim Dung, Keiji Miyata, Masao Kamimura, Kohei Soga
Encapsulation of ICG and IR-1061 in PCL–PEG micelles producing agents with increased stability of ICG and tunable PTT and PDT activity. The micelles are also useful for NIR imaging and NIR nanothermometry.
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Biomater. Sci., 2020, 8,2300-2307
DOI: 10.1039/D0BM00276C, Paper

Ruru Li, Xiaoyu Huang, Guolin Lu, Chun Feng
A PEG₄₅-b-PVPOP₁₄ diblock copolymer with pendant levulinate-protected phenol groups exhibited a highly specific response toward sulfites.
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Biomater. Sci., 2020, 8,2120-2128
DOI: 10.1039/D0BM00242A, Paper

Yan Fang Cheng, Dicky Pranantyo, Gopinath Kasi, Zhi Song Lu, Chang Ming Li, Li Qun Xu
An amino-containing tannic acid derivative was self-polymerized to form colorless and uniform coatings on various substrate surfaces, and the resultant coatings can be further utilized to construct bioactive, antifouling and antibacterial surfaces.
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Biomater. Sci., 2020, 8,2102-2110
DOI: 10.1039/D0BM00027B, Minireview

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

T. Ahlfeld, V. Guduric, S. Duin, A. R. Akkineni, K. Schütz, D. Kilian, J. Emmermacher, N. Cubo-Mateo, S. Dani, M. v. Witzleben, J. Spangenberg, R. Abdelgaber, R. F. Richter, A. Lode, M. Gelinsky
This minireview highlights the use of the polysaccharide methylcellulose for biofabrication applications. Its properties are useful for printing of dissolvable support structures as well as the development of novel bioinks.
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Biomater. Sci., 2020, 8,2129-2142
DOI: 10.1039/D0BM00171F, Paper

Xiaoshuang Guo, Zihan Yuan, Yang Xu, Minyan Wei, Zhiwei Fang, Wei-En Yuan
RNAi technology targeting HIF-1α could benefit hemangioma therapy effectively and FPEI polyplexes which could inhibit the expression of HIF-1α at the translational level can provide a practicable strategy for clinical hemangioma treatment in the future.
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Biomater. Sci., 2020, 8,2143-2155
DOI: 10.1039/C9BM01691K, Paper

Open Access

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Katharina Schuhladen, Lena Stich, Jochen Schmidt, Alexander Steinkasserer, Aldo R. Boccaccini, Elisabeth Zinser
Bioactive borate glasses additionally doped with copper and/or zinc have enthralling immune-modulatory effects on immune cells.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00128G, Paper

Sagar Rayamajhi, Ramesh Marasini, Tuyen Duong Thanh Nguyen, Brandon L. Plattner, David Biller, Santosh Aryal
Reconstruction of extracellular vesicles with imaging agents allows precise downstream analysis using clinical imaging modalities, for example, MRI. This will further improve the biocompatibility of agents thereby enhancing clinical investigations.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00269K, Review Article

Lu Wang, Cunyang Wang, Shuai Wu, Yubo Fan, Xiaoming Li
We have clarified the influence of the mechanical properties of biomaterials on degradability and cell response, and also mechanical design targets and approaches.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00323A, Paper

Bunty Sharma, Gurpreet Kaur, Ganga Ram Chaudhary, Santosh L. Gawali, P. A. Hassan
Developments in the field of photodynamic therapy (PDT) are being made by investigating appropriate photosensitizers (PSs) and enhancing the penetration effect of light by developing new metallocatanionic vesicles.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM02056J, Paper

Yadu N. Vakkipurath Kodakkadan, Kristyna Idzakovicova, Josef Sepitka, Daniël ten Napel, Eric Safai, Petr Cigler, Frantisek Štěpánek, Ivan Rehor
We introduce a method for photolithographic synthesis of arbitrarily shaped microgels composed purely of a biopolymer of choice.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00083C, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Irene Anton-Sales, Justin Christopher D'Antin, Jorge Fernández-Engroba, Victor Charoenrook, Anna Laromaine, Anna Roig, Ralph Michael
Bacterial nanocellulose exhibits valuable properties to act as a corneal bandage material in terms of conformability, suturability, durability and ease of manipulation in ophthalmological environments.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00015A, Paper

Manisha Ahir, Priyanka Upadhyay, Avijit Ghosh, Sushmita Sarker, Saurav Bhattacharya, Payal Gupta, Swatilekha Ghosh, Sreya Chattopadhyay, Arghya Adhikary
Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual miRNA loading, efficient delivery and significantly inhibited tumor growth as well as retarded metastasis in triple-negative breast cancer.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01809C, Review Article

Jiajun Zhong, Yuexiong Yang, Liqiong Liao, Chao Zhang
The microenvironments that cells encounter with in vitro.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00372G, Paper

Yongbin Cao, Boshu Ouyang, Xiaowei Yang, Qin Jiang, Lin Yu, Shun Shen, Jiandong Ding, Wuli Yang
Tumors were effectively destroyed by a mild photothermal effect and the subsequent gas mechanical damage triggered by NIR-II light.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM90037K, Correction

Open Access

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Zhilin Liu, Na Shen, Zhaohui Tang, Dawei Zhang, Lili Ma, Chenguang Yang, Xuesi Chen
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00427H, Paper

Yangyang Ye, Xiang Zhang, Fei Xie, Bin Xu, Ping Xie, Ting Yang, Qian Shi, Chen-Yu Zhang, Yujing Zhang, Jiangning Chen, Xiaohong Jiang, Jing Li
CRISPR-Cas9 components delivered by engineered exosomes achieve genome editing in recipient cells.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00076K, Paper

Jungju Oh, Sang-Mi Kim, Eun-Hye Lee, Minkyung Kim, Youngki Lee, Seung Hwan Ko, Ji Hoon Jeong, Chang-Hwan Park, Minhyung Lee
Heme oxygenase-1 messenger RNA (HO1-mRNA) was delivered into the post-ischemic brain, using a polymeric carrier. Therapeutic efficacy of HO1-mRNA delivery was compared with that of HO1-plasmid DNA (HO1-pDNA) in ischemia-reperfusion rat models.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00395F, Communication

Yue Hu, Yuyin Tang, Xiao-Jing Zhang, Xiao-Tong Yang, Ying-Ying Tang, Su Li, Linyu Hu, Peng Chen, Dong Zhu
Multi-functional and hierarchically structured silica nanospheres are rationally designed and fabricated, which encapsulate quantum dots to permit near infrared deep tissue imaging and are loaded with carcinoembryonic antigen messenger RNA (CEAmRNA) to enable stable and abundant antigen expression in DCs.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00003E, Paper

Jia Qu, Dengke Teng, Guoqing Sui, Shihui Guan, Yang Wang, Qimeihui Wang, Yuanqiang Lin, Haitao Ran, Zhigang Wang, Hui Wang
The advantages of PCM@Lip/IT NPs include mitochondrial-targeting, on-demand drug release, and prodrug activation by hypoxia with guidance/monitoring by PA and FL imaging.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01872G, Review Article

Ratchapol Jenjob, Treethip Phakkeeree, Daniel Crespy
Core–shell particles offer significant advantages in their use for bioimaging and biosensors.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01968E, Paper

Teng Zhang, Qingguang Wei, Hua Zhou, Wenhao Zhou, Daoyang Fan, Xinhong Lin, Zehao Jing, Hong Cai, Yan Cheng, Xiaoguang Liu, Weishi Li, Chunli Song, Yun Tian, Nanfang Xu, Yufeng Zheng, Zhongjun Liu
Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6A14V for treating MRSA bone infection and enhancing osteogenesis.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00134A, Paper

Kiheon Baek, Alexander David Noblett, Pengyu Ren, Laura J. Suggs
Doxorubicin is intercalated within the nanofibril structure of self-assembled nucleo-peptide hydrogels and injection leads to decrease in tumor volume and greater concentration of chemotherapeutic relative to soluble form.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00222D, Review Article

Natanael Fernandes, Carolina F. Rodrigues, André F. Moreira, Ilídio J. Correia
Cancer photothermal therapy (PTT) has captured the attention of researchers worldwide due to its localized and trigger-activated therapeutic effect.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00188K, Paper

Ning Han, Ziyang Xu, Chunyan Cui, Yuan Li, Dongfei Zhang, Meng Xiao, Chuanchuan Fan, Tengling Wu, Jianhai Yang, Wenguang Liu
A tunicate-inspired gelatin-based hydrogel prepared by a simple mixing method, exhibits strong adhesion and antibacterial capacity, and facilitates wound healing.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00147C, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Junxiong Qiu, Peng Peng, Min Xin, Zhenkang Wen, Zhong Chen, Sipeng Lin, Manyuan Kuang, Yuan Fu, Guibin Fang, Shixun Li, Changchuan Li, Jiaji Mao, Ling Qin, Yue Ding
Aseptic loosening (AL) caused by wear particles released from implant surfaces is one of the main causes for the failure of artificial joints, which is initiated by macrophage inflammatory responses.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM02012H, Paper

Boguang Yang, Fanglian Yao, Lei Ye, Tong Hao, Yabin Zhang, Lei Zhang, Dianyu Dong, Wancai Fang, Yan Wang, Xiaoyang Zhang, Changyong Wang, Junjie Li
The development of three-dimensional conductive scaffolds is vital to support the adhesion, proliferation and myocardial differentiation of stem cells in cardiac tissue engineering.
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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00370K, Paper

Maria Salem Ibrahim, Isadora Martini Garcia, Taissa Vila, Abdulrahman A. Balhaddad, Fabricio Mezzomo Collares, Michael D Weir, Huakun Xu, Mary Anne Melo
Dental caries in children is a leading worldwide concern for oral health. Combining antibacterial and remineralizing additives within dental sealants is a promising approach for caries prevention. Saliva contains oral...
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Biomater. Sci., 2020, 8,2447-2458
DOI: 10.1039/C9BM01889A, Paper

Yanqiu Wang, Xinyu Shen, Shang Ma, Qianqian Guo, Wei Zhang, Lu Cheng, Liming Ding, Zhuobin Xu, Jing Jiang, Lizeng Gao
Combining nanozymes and bacteria to eliminate dental biofilms in a mixed-species model.
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Biomater. Sci., 2020, 8,2481-2487
DOI: 10.1039/D0BM00021C, Paper

Zhen Ke, Aize Xie, Jianjiao Chen, Zhenyuan Zou, Lei Shen, Yansong Dai, Dengfeng Zou
Hypericin undergoing electron transfer can be used for type I PDT and PTT.
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Biomater. Sci., 2020, 8,2549-2563
DOI: 10.1039/C9BM01956A, Paper

Chungeng Liu, Weihua Qiao, Hong Cao, Jinchi Dai, Fei Li, Jiawei Shi, Nianguo Dong
Riboflavin–ultraviolet light A could effectively crosslink a decellularized heart valve to improve its biomechanical properties, stability and biocompatibility.
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Biomater. Sci., 2020, 8,2590-2599
DOI: 10.1039/D0BM00314J, Paper

Julie Tzu-Wen Wang, Umberto Martino, Rehan Khan, Maasoomeh Bazzar, Paul Southern, Dönüş Tuncel, Khuloud T. Al-Jamal
Self-red-emitting magnetic PLGA-PEG nanocapsules for optical imaging and magnetic tumour targeting.
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Biomater. Sci., 2020, 8,2420-2433
DOI: 10.1039/C9BM01905G, Paper

Vera L. Silva, Abdessamad Kaassis, Ashkan Dehsorkhi, Cédrik-Roland Koffi, Maja Severic, Moustafa Abdelhamid, Duuamene Nyimanu, Christopher J. Morris, Wafa’ T. Al-Jamal
Cu(TPZ)₂ complex as a promising hypoxia selective cytotoxin in prostate cancer.
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Biomater. Sci., 2020, 8,2577-2589
DOI: 10.1039/D0BM00087F, Paper

Marta R. Casanova, Catarina Oliveira, Emanuel M. Fernandes, Rui L. Reis, Tiago H. Silva, Albino Martins, Nuno M. Neves
An engineered biofunctional system comprises endogenous BMP-2 and VEGF bound in a parallel pattern. It successfully enabled obtaining the spatial osteogenic and angiogenic differentiation of human hBM-MSCs under basal culture conditions.
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Biomater. Sci., 2020, 8,2611-2626
DOI: 10.1039/C9BM01965K, Paper

Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

F. A. A. Ruiter, L. E. Sidney, K. L. Kiick, J. I. Segal, C. Alexander, F. R. A. J. Rose
The fabrication and application of a biocompatible peptide conjugated thermo-responsive fibrous scaffolds for cellular phenotype support and enzymatic-free passaging of mammalian cells.
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Biomater. Sci., 2020, 8,2394-2397
DOI: 10.1039/C9BM02019E, Communication

Peng-Hao Hsu, Carina Arboleda, Alexandra Stubelius, Ling-Wei Li, Jason Olejniczak, Adah Almutairi
Nanoparticles formulated from fast-degrading oxidation-responsive polycaprolactone are responsive to 50 μM of H₂O₂.
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Biomater. Sci., 2020, 8,2653-2665
DOI: 10.1039/D0BM00140F, Paper

Amit G. Krishnan, Raja Biswas, Deepthy Menon, Manitha B. Nair
The study shows the development of a biodegradable bi-functional composite scaffold that can reduce bacterial infection, while promotes bone regeneration in osteomyelitis, without the need for revision surgery.
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Biomater. Sci., 2020, 8,2434-2446
DOI: 10.1039/D0BM00182A, Paper

Jann Harberts, Undine Haferkamp, Stefanie Haugg, Cornelius Fendler, Dennis Lam, Robert Zierold, Ole Pless, Robert H. Blick
Nanostructured substrates such as nanowire arrays form a powerful tool for building next-generation medical devices.
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