ic Children’s Day: public meet, rally led by girls to be held in Thiruvananthapuram By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:41:04 +0530 25,000 students from 200 schools will be part of the rally Full Article Kerala
ic Try to stand on your own legs, Supreme Court tells NCP led by Ajit Pawar to stop using Sharad Pawar’s pictures, videos By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:49:46 +0530 The Bench asked the Ajit Pawar camp to circulate an online message among its leaders, party workers and representatives against using the pictures or video/audio clips of Sharad Pawar, whether old or new Full Article India
ic NIFT’s craft cluster projects enriching J&K’s artisans, crafts: L-G Manoj Sinha By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:46:32 +0530 He described J&K as “a repository of Indian creative traditions Full Article India
ic BJP’s win in recent polls is expression of people’s faith in govt. policies: Haryana Governor By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:50:35 +0530 Full Article Haryana
ic ED arrests four, including two Bangladeshi nationals, in human trafficking case By www.thehindu.com Published On :: Thu, 14 Nov 2024 07:52:22 +0530 Full Article India
ic Telangana BJP seeks judicial probe into Vikarabad incident By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:57:40 +0530 Full Article Telangana
ic Use fog safety devices to ensure punctuality and safety of trains in winters: SCR GM By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:13:21 +0530 Full Article Telangana
ic Nirmal Municipality junior assistant in ACB net By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:03:40 +0530 Full Article Telangana
ic Govt. charges BRS with hatching conspiracies to stall development projects for political gains By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:17:30 +0530 Dy CM says involvement of BRS leader in Lagacharla incident exposes the party’s intentions Full Article Telangana
ic India IT spending to reach USD 160 billion in 2025 fueled by application and infrastructure software market growth: Gartner By www.newkerala.com Published On :: Wed, 13 Nov 2024 17:38:01 +0530 Full Article
ic Google.org awards USD 1 mn grant to Karya to boost ai-based economic opportunities for low-income communities By www.newkerala.com Published On :: Wed, 13 Nov 2024 17:40:02 +0530 Full Article
ic Vegetable prices sky-rocket in October, food inflation at 10.87%, CPI at 6.21 % By www.newkerala.com Published On :: Wed, 13 Nov 2024 17:46:02 +0530 Full Article
ic Public Sector Banks records strong performance in 1st half of FY25 By www.newkerala.com Published On :: Wed, 13 Nov 2024 17:50:02 +0530 Full Article
ic India set to become 'major producer' of electric vehicles like China: Mark Mobius By www.newkerala.com Published On :: Wed, 13 Nov 2024 18:50:02 +0530 Full Article
ic An Efficient All-Visible Light-Activated Photoswitches Based on Diarylethenes and CdS Quantum Dots By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC06110A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Kezhou Chen, Jiayi Liu, Joakim Andréasson, Bo Albinsson, Tiegen Liu, Lili HouAll-visible light-activated diarylethene (DAE) photoswitches are highly attractive for applications in smart photoresponsive materials. Photocyclization of DAE via the low-lying excited triplet state through triplet energy transfer (TET) from a...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Photocatalytic 1,3-Oxyheteroarylation of Aryl Cyclopropanes with Azine N-oxides By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC06723A, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Doyoung Kim, Hyewon Ju, Wooseok Lee, Sungwoo HongCyclopropanes, valuable C3 building blocks in organic synthesis, possess high strain energy and inherent stability. We present an efficient, environmentally benign 1,3-oxyheteroarylation of aryl cyclopropanes using azine N-oxides as bifunctional...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic A multifunctional “three-in-one” fluorescent theranostic system for hepatic ischemia–reperfusion injury By pubs.rsc.org Published On :: Chem. Sci., 2024, Advance ArticleDOI: 10.1039/D4SC04962D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jihong Liu, Dongni Yin, Wen Zhang, Xin Wang, Tony D. James, Ping Li, Bo TangA single-component multifunctional fluorescent theranostic system (MB-Gly) for use during hepatic ischemia-reperfusion injury (HIRI) has been developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Phase transition induced hydrogen activation for enhanced furfural reductive amination over CoCu bimetallic catalyst By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC05885B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yilin Wei, Zixu Ma, Beibei Liu, Jialin Yang, Dan Wu, Yongsheng Zhang, Yuexing Zhang, Charles Chunbao Xu, Renfeng NieThe synthesis of primary amines from renewable biomass and its derivatives through reductive amination has garnered significant attention. How to construct efficient non-noble-metal catalysts that enable low-temperature catalysis still remains...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic TcESTIME: predicting high-temperature hydrogen-based superconductors By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC04465G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Trinidad Novoa, Matías E. di Mauro, Diego Inostroza, Kaoutar El Haloui, Nicolas Sisourat, Yvon Maday, Julia Contreras-GarcíaSuperconductivity can be considered among the most exciting discoveries in material science of the XXth century. However, the hard conditions for the synthesis and the difficult characterization, make the statement...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Gaining the Molecular Design Principles for Efficient Diarylethene Photoacid and Photohydride Generators Based on Photochemical Reaction Mechanism By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC06202G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yifan Su, Dexin Zheng, Lingfeng Ge, Le Yu, David Lee Phillips, Jiani Ma, Yu FangAbstract: Photoacid generators (PAGs) and photohydride generators (PHGs) are specific photolabile protecting groups that release acid and hydride, respectively. Over the past decade, great efforts have been devoted to developing...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic BRO rescues 20 vehicles stuck in snow in J-K's Bandipora By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:12:01 +0530 Full Article
ic Indian Coast Guard evacuates critically ill fisherman off Diu coast By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:24:02 +0530 Full Article
ic HC quashes magistrate court’s directive to register FIR against police officers By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:36:51 +0530 Magistrate court’s order to file FIR against police officers, including IPS officer and former Malappuram Superintendent of Police Sujith Das, in connection with an alleged sexual assault case quashed Full Article Kerala
ic Iran executes in public a serial rapist convicted in dozens of cases By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:43:02 +0530 Iran’s state media say authorities have executed in public a man convicted of raping dozens of women over two decades Full Article World
ic IndiGo, Air India cancel flights to Bali following volcanic eruption By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:06 +0530 The Mount Lewotobi Laki Laki volcano located in a remote island in East Nusa Tenggara province erupted earlier this month and has resulted in ash clouds Full Article India
ic Senior Russian naval officer killed in car bombing claimed by Kyiv By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:48 +0530 Russia's state Investigative Committee said in a statement that an improvised explosive device had detonated in an act of terrorism, killing a serviceman whom it did not identify Full Article World
ic Chemical synthetic approaches to mimic the TRAIL: promising cancer therapeutics By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3639-3651DOI: 10.1039/D4MD00183D, Review ArticleAbdullah-Al Masum, Shin Aoki, Md. Mahbubur Rahman, Yosuke HisamatsuTRAIL induced apoptosis signalling by death receptors (DR4/DR5).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3759-3777DOI: 10.1039/D4MD00498A, Research ArticleLucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. EnrizA diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3778-3794DOI: 10.1039/D4MD00281D, Research ArticleCarolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. PilliA novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3711-3727DOI: 10.1039/D4MD00584H, Research ArticleSara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-DiasA series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3652-3673DOI: 10.1039/D4MD00425F, Review ArticleSemim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra BorahMetabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3795-3799DOI: 10.1039/D4MD00458B, Research ArticleKazuya Matsuo, Takashi Kikukawa, Tomonori Waku, Akio Kobori, Nobuyuki TamaokiA photoswitchable centromere-associated protein E (CENP-E) inhibitor based on the 4-methylaminoazobenzene photoswitch is reported, which is characterized with cis–trans photoisomerization with blue-green light and fast thermal relaxation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3728-3745DOI: 10.1039/D4MD00476K, Research ArticleVincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien FortinNew water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3837-3852DOI: 10.1039/D4MD00426D, Research ArticleAbdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. BednarskiStructure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safetyThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3853-3861DOI: 10.1039/D4MD00165F, Research ArticleJiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang LiuThe synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3695-3703DOI: 10.1039/D4MD00546E, Research ArticleMiyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke DemizuA novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ic SBI, HDFC Bank, ICICI Bank figure in RBI’s 2024 list of Domestic Systemically Important Banks (D-SIBs) By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:00:14 +0530 Higher D-SIB surcharge fixed for SBI and HDFC Bank, will be applicable from April 01, 2025 Full Article Business
ic U.S. oil industry urges Trump to ditch Biden climate policies By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:27:45 +0530 Full Article Business
ic SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:49:14 +0530 Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities Full Article Mangaluru
ic Free and fair inquiry sought into death of snakebite victim in Srikakulam district By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:10:47 +0530 Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident Full Article Andhra Pradesh
ic New counters opened at Tirumala for issuing Srivani darshan tickets By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:45:53 +0530 Decision to open new counters taken following reports of devotees experiencing discomfort in queue at the previous counter, particularly during inclement weather, says TTD Additional EO Full Article Andhra Pradesh
ic Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:25:35 +0530 P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches Full Article Andhra Pradesh
ic 117 applications received at Kuppam’s first ‘Praja Darbar’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:37:24 +0530 Full Article Andhra Pradesh
ic Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:25:39 +0530 Full Article Andhra Pradesh
ic Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:30:39 +0530 Full Article Andhra Pradesh
