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Union Jal Shakti Minister CR Paatil chairs 13th high-powered review meeting of Brahmaputra Board




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AI and hi-tech technologies will be used in CCTV arrangements: UP DGP Prashant Kumar on Mahakumbh 2025 preparations




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Assam Governor attends Sainik school Goalpara's Diamond Jubilee celebrations




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HC modifies the status quo order on maintaining constructions for Tent City in two islands of Lakshadweep




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No gaps in management of biodegradable waste, Kerala tells NGT




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‘Anti-war’ comedy play riles Bulgarian nationalists

Last week’s premiere of Arms and the Man by renowned Irish-born playwright George Bernard Shaw sparked raucous protests by nationalist groups




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IndiGo, Air India cancel flights to Bali following volcanic eruption

The Mount Lewotobi Laki Laki volcano located in a remote island in East Nusa Tenggara province erupted earlier this month and has resulted in ash clouds




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Senior Russian naval officer killed in car bombing claimed by Kyiv

Russia's state Investigative Committee said in a statement that an improvised explosive device had detonated in an act of terrorism, killing a serviceman whom it did not identify




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In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP

RSC Med. Chem., 2024, 15,3674-3694
DOI: 10.1039/D4MD00580E, Research Article
Jinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin Jin
Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.
The content of this RSS Feed (c) The Royal Society of Chemistry




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New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3759-3777
DOI: 10.1039/D4MD00498A, Research Article
Lucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. Enriz
A diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation

RSC Med. Chem., 2024, 15,3778-3794
DOI: 10.1039/D4MD00281D, Research Article
Carolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. Pilli
A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site

RSC Med. Chem., 2024, 15,3704-3710
DOI: 10.1039/D4MD00552J, Research Article
Jaeyong Jung, Jeong Soo Sung, Soonil Kwon, Hyung Eun Bae, Min-Jung Kang, Joachim Jose, Misu Lee, Jae-Chul Pyun
Fv-antibodies targeting the PPC region of SARS-CoV-2 to prevent infection, screened from an Fv-antibody library (displayed on outer membrane of E. coli cell).
The content of this RSS Feed (c) The Royal Society of Chemistry




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Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction

RSC Med. Chem., 2024, 15,3652-3673
DOI: 10.1039/D4MD00425F, Review Article
Semim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra Borah
Metabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells

RSC Med. Chem., 2024, 15,3795-3799
DOI: 10.1039/D4MD00458B, Research Article
Kazuya Matsuo, Takashi Kikukawa, Tomonori Waku, Akio Kobori, Nobuyuki Tamaoki
A photoswitchable centromere-associated protein E (CENP-E) inhibitor based on the 4-methylaminoazobenzene photoswitch is reported, which is characterized with cistrans photoisomerization with blue-green light and fast thermal relaxation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells

RSC Med. Chem., 2024, 15,3728-3745
DOI: 10.1039/D4MD00476K, Research Article
Vincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien Fortin
New water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety

RSC Med. Chem., 2024, 15,3837-3852
DOI: 10.1039/D4MD00426D, Research Article
Abdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. Bednarski
Structure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safety
The content of this RSS Feed (c) The Royal Society of Chemistry




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Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3880-3888
DOI: 10.1039/D4MD00414K, Research Article
Phuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. Vo
Novel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer

RSC Med. Chem., 2024, 15,3853-3861
DOI: 10.1039/D4MD00165F, Research Article
Jiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang Liu
The synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

RSC Med. Chem., 2024, 15,3817-3836
DOI: 10.1039/D4MD00477A, Research Article
Maha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa Matboli
ZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers

Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme




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IIT-M students develop robot for O.P. Jindal university’s Constitution Museum

It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says




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Leaders of various parties condemn attack on govt. doctor




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Delhi AQI drops to 361 in ‘very poor’ category as smog engulfs national capital

Delhi recorded its first dense fog of the season on Wednesday as visibility dropped to 0 metres at 8 a.m.




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Delhi airport sees seven flight diversions owing to bad weather

The IMD reported that very dense fog began forming at around 5.30 a.m., resulting in a thick haze over various parts of Delhi




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DUSU election results to be announced on November 21

The counting of votes for both the central panel and college representatives will begin at 8:30 a.m. on November 21 at the DU Conference Centre




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Argentine monthly inflation falls to three-year low




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Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud

Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year.




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Mangaluru Junction - CSMT Superfast Express to get LHB coaches in March 2025

Train No. 12133 Mumbai CSMT-Mangaluru Junction Superfast Express will get an LHB rake from March 1 while its pairing service, Train No. 12134 Mangaluru Junction-Mumbai CSMT Superfast Express, will get an LHB rake from March 2




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Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators

It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion




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Andhra Pradesh government deploys drones to detect ganja palnatations

State collaborates with NCB and Google to map and track cannabis plantations using satellite imagery technology




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RLDA invites bids for commercial land use in Tirupati railway station

The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side




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Andhra Pradesh Govt. weighing options on how to utilise Mahila Samrakshana Karyadarshis, says Home Minister 

Ambiguity in overall control of their duties and service matters resulted in immense distress for the MSKs, says Home Minister




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117 applications received at Kuppam’s first ‘Praja Darbar’




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Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’




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Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional

The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling




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Vikarabad attack: Former BRS MLA Narender Reddy taken into custody for questioning

He was picked up near his residence when he stepped out for a morning walk




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Hyderabad to get regional centre of Indian Institute of Creative Technology

All activities are going to start quickly. The facility in Hyderabad will be set up in the IMAGE Tower, said Secretary, Union Ministry of Information and Broadcasting




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Missile Exhibition Centre inaugurated at DRDL




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Hyderabad Airport wins global recognition for digital innovations




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Prasar Bharati OTT launch, private FM stations for small towns on cards  




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Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar

GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations




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Millions of Nigerians go hungry as floods compound hardship

Torrential rains and floods in 29 of Nigeria's 36 states this year have destroyed more than 1.5 million hectares of cropland, affecting more than nine million people




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29th Climate Conference (COP) tracker | Day 2 LIVE: Key speeches, UK NDC, and India’s reaction at 5 p.m. on November 13

Vibhuti Garg, an Associate and Senior Energy Specialist with over 13 years of experience in the energy sector, will guide us through the implications of these financial negotiations and the potential impacts on global energy transitions and climate commitments at 5 p.m. on November 13




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Synthesis and evaluation of photoaffinity labeling reagents for identifying binding sites of sulfated neurosteroids on NMDA and GABAA receptors

RSC Adv., 2024, 14,36352-36369
DOI: 10.1039/D4RA07074G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mingxing Qian, Yuanjian Xu, Hong-Jin Shu, Zi-Wei Chen, Lei Wang, Charles F. Zorumski, Alex S. Evers, Steven Mennerick, Douglas F. Covey
Photoaffinity labels (PALs) for sulfated steroid binding sites on GABAA and NMDA receptors. The PALs have varying profiles of positive and negative modulatory (PAM and NAM) actions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of MOF-supported Pt catalyst with high electrochemical oxidation activity for methanol oxidation

RSC Adv., 2024, 14,36370-36377
DOI: 10.1039/D4RA06393G, Paper
Open Access
Merve Akin, Hatice Kars, Muhammed Bekmezci, Aysenur Aygun, Mert Gul, Guray Kaya, Fatih Sen
In this study, Pt and Pt@Ti-MOF NPs catalysts were synthesized by chemical reduction method. Ti-MOF structure was synthesized using the solvothermal method, and the effect of Ti-MOF on methanol oxidation was investigated.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Karnataka High Court dismisses Union Bank of India’s petition seeking transfer of Valmiki corporation case to CBI

‘Banking Regulations Act does not empower banks to seek transfer of probe into criminal cases registered by States to agency of its choice’




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Watch | War over Waqf: Busting myth and misinformation

How did an incident in a small village in Vijayapura snowball into an issue of national interest?




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KEA opposes fee reduction for recruitment examinations in Karnataka

Points out that the government does not provide any grant for conducting recruitment examinations