in Diagnostic Accuracy of PET Tracers for the Differentiation of Tumor Progression from Treatment-Related Changes in High-Grade Glioma: A Systematic Review and Metaanalysis By jnm.snmjournals.org Published On :: 2020-04-01T06:00:28-07:00 Posttreatment high-grade gliomas are usually monitored with contrast-enhanced MRI, but its diagnostic accuracy is limited as it cannot adequately distinguish between true tumor progression and treatment-related changes. According to recent Response Assessment in Neuro-Oncology recommendations, PET overcomes this limitation. However, it is currently unknown which tracer yields the best results. Therefore, a systematic review and metaanalysis were performed to compare the diagnostic accuracy of the different PET tracers in differentiating tumor progression from treatment-related changes in high-grade glioma patients. Methods: PubMed, Web of Science, and Embase were searched systematically. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Metaanalysis was performed using a bivariate random-effects model when at least 5 studies were included. Results: The systematic review included 39 studies (11 tracers). 18F-FDG (12 studies, 171 lesions) showed a pooled sensitivity and specificity of 84% (95% confidence interval, 72%–92%) and 84% (95% confidence interval, 69%–93%), respectively. O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) (7 studies, 172 lesions) demonstrated a sensitivity of 90% (95% confidence interval, 81%–95%) and specificity of 85% (95% confidence interval, 71%–93%). For S-11C-methyl)-l-methionine (11C-MET) (8 studies, 151 lesions), sensitivity was 93% (95% confidence interval, 80%–98%) and specificity was 82% (95% confidence interval, 68%–91%). The numbers of included studies for the other tracers were too low to combine, but sensitivity and specificity ranged between 93%–100% and 0%–100%, respectively, for 18F-FLT; 85%–100% and 72%–100%, respectively, for 3,4-dihydroxy-6-18F-fluoro-l-phenylalanine (18F-FDOPA); and 100% and 70%–88%, respectively, for 11C-choline. Conclusion: 18F-FET and 11C-MET, both amino-acid tracers, showed a comparably higher sensitivity than 18F-FDG in the differentiation between tumor progression and treatment-related changes in high-grade glioma patients. The evidence for other tracers is limited; thus, 18F-FET and 11C-MET are preferred when available. Our results support the incorporation of amino-acid PET tracers for the treatment evaluation of high-grade gliomas. Full Article
in Introduction to Radiomics By jnm.snmjournals.org Published On :: 2020-04-01T06:00:28-07:00 Radiomics is a rapidly evolving field of research concerned with the extraction of quantitative metrics—the so-called radiomic features—within medical images. Radiomic features capture tissue and lesion characteristics such as heterogeneity and shape and may, alone or in combination with demographic, histologic, genomic, or proteomic data, be used for clinical problem solving. The goal of this continuing education article is to provide an introduction to the field, covering the basic radiomics workflow: feature calculation and selection, dimensionality reduction, and data processing. Potential clinical applications in nuclear medicine that include PET radiomics-based prediction of treatment response and survival will be discussed. Current limitations of radiomics, such as sensitivity to acquisition parameter variations, and common pitfalls will also be covered. Full Article
in A Conversation with John Sunderland, Johannes Czernin, and Thomas Hope By jnm.snmjournals.org Published On :: 2020-04-01T06:00:28-07:00 Full Article
in Congressional Briefing: Diagnostic Imaging and Alzheimer Disease By jnm.snmjournals.org Published On :: 2020-04-01T06:00:28-07:00 Full Article
in SNMMI at NRC Commissioners Meeting By jnm.snmjournals.org Published On :: 2020-04-01T06:00:28-07:00 Full Article
in Fibrotic Encapsulation Is the Dominant Source of Continuous Glucose Monitor Delays By diabetes.diabetesjournals.org Published On :: 2019-09-20T12:00:23-07:00 Continuous glucose monitor (CGM) readings are delayed relative to blood glucose, and this delay is usually attributed to the latency of interstitial glucose levels. However, CGM-independent data suggest rapid equilibration of interstitial glucose. This study sought to determine the loci of CGM delays. Electrical current was measured directly from CGM electrodes to define sensor kinetics in the absence of smoothing algorithms. CGMs were implanted in mice, and sensor versus blood glucose responses were measured after an intravenous glucose challenge. Dispersion of a fluorescent glucose analog (2-NBDG) into the CGM microenvironment was observed in vivo using intravital microscopy. Tissue deposited on the sensor and nonimplanted subcutaneous adipose tissue was then collected for histological analysis. The time to half-maximum CGM response in vitro was 35 ± 2 s. In vivo, CGMs took 24 ± 7 min to reach maximum current versus 2 ± 1 min to maximum blood glucose (P = 0.0017). 2-NBDG took 21 ± 7 min to reach maximum fluorescence at the sensor versus 6 ± 6 min in adipose tissue (P = 0.0011). Collagen content was closely correlated with 2-NBDG latency (R = 0.96, P = 0.0004). Diffusion of glucose into the tissue deposited on a CGM is substantially delayed relative to interstitial fluid. A CGM that resists fibrous encapsulation would better approximate real-time deviations in blood glucose. Full Article
in Immunomodulation Followed by Antigen-Specific Treg Infusion Controls Islet Autoimmunity By diabetes.diabetesjournals.org Published On :: 2020-01-20T12:00:26-08:00 Optimal immune-based therapies for type 1 diabetes (T1D) should restore self-tolerance without inducing chronic immunosuppression. CD4+Foxp3+ regulatory T cells (Tregs) are a key cell population capable of facilitating durable immune tolerance. However, clinical trials with expanded Tregs in T1D and solid-organ transplant recipients are limited by poor Treg engraftment without host manipulation. We showed that Treg engraftment and therapeutic benefit in nonautoimmune models required ablative host conditioning. Here, we evaluated Treg engraftment and therapeutic efficacy in the nonobese diabetic (NOD) mouse model of autoimmune diabetes using nonablative, combinatorial regimens involving the anti-CD3 (αCD3), cyclophosphamide (CyP), and IAC (IL-2/JES6–1) antibody complex. We demonstrate that αCD3 alone induced substantial T-cell depletion, impacting both conventional T cells (Tconv) and Tregs, subsequently followed by more rapid rebound of Tregs. Despite robust depletion of host Tconv and host Tregs, donor Tregs failed to engraft even with interleukin-2 (IL-2) support. A single dose of CyP after αCD3 depleted rebounding host Tregs and resulted in a 43-fold increase in donor Treg engraftment, yet polyclonal donor Tregs failed to reverse diabetes. However, infusion of autoantigen-specific Tregs after αCD3 alone resulted in robust Treg engraftment within the islets and induced remission in all mice. This novel combinatorial therapy promotes engraftment of autoantigen-specific donor Tregs and controls islet autoimmunity without long-term immunosuppression. Full Article
in Evidence of Tissue Repair in Human Donor Pancreas After Prolonged Duration of Stay in Intensive Care By diabetes.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 M2 macrophages play an important role in tissue repair and regeneration. They have also been found to modulate β-cell replication in mouse models of pancreatic injury and disease. We previously reported that β-cell replication is strongly increased in a subgroup of human organ donors characterized by prolonged duration of stay in an intensive care unit (ICU) and increased number of leukocytes in the pancreatic tissue. In the present study we investigated the relationship between duration of stay in the ICU, M2 macrophages, vascularization, and pancreatic cell replication. Pancreatic organs from 50 donors without diabetes with different durations of stay in the ICU were analyzed by immunostaining and digital image analysis. The number of CD68+CD206+ M2 macrophages increased three- to sixfold from ≥6 days’ duration of stay in the ICU onwards. This was accompanied by a threefold increased vascular density and a four- to ninefold increase in pancreatic cells positive for the replication marker Ki67. A strong correlation was observed between the number of M2 macrophages and β-cell replication. These results show that a prolonged duration of stay in the ICU is associated with an increased M2 macrophage number, increased vascular density, and an overall increase in replication of all pancreatic cell types. Our data show evidence of marked levels of tissue repair in the human donor pancreas. Full Article
in A Critical Insulin TCR Contact Residue Selects High-Affinity and Pathogenic Insulin-Specific T Cells By diabetes.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 Type 1 diabetes is an autoimmune-mediated disease that culminates in the targeted destruction of insulin-producing β-cells. CD4 responses in NOD mice are dominated by insulin epitope B:9-23 (InsB9-23) specificity, and mutation of the key T-cell receptor (TCR) contact residue within the epitope prevents diabetes development. However, it is not clear how insulin self-antigen controls the selection of autoimmune and regulatory T cells (Tregs). Here we demonstrate that mutation of insulin epitope results in escape of highly pathogenic T cells. We observe an increase in antigen reactivity, clonality, and pathogenicity of insulin-specific T cells that develop in the absence of cognate antigen. Using a single TCR system, we demonstrate that Treg development is greatly diminished in mice with the Y16A mutant epitope. Collectively, these results suggest that the tyrosine residue at position 16 is necessary to constrain TCR reactivity for InsB9-23 by both limiting the development of pathogenic T cells and supporting the selection of Tregs. Full Article
in A Hybrid Insulin Epitope Maintains High 2D Affinity for Diabetogenic T Cells in the Periphery By diabetes.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 β-Cell antigen recognition by autoreactive T cells is essential in type 1 diabetes (T1D) pathogenesis. Recently, insulin hybrid peptides (HIPs) were identified as strong agonists for CD4 diabetogenic T cells. Here, using BDC2.5 transgenic and NOD mice, we investigated T-cell recognition of the HIP2.5 epitope, which is a fusion of insulin C-peptide and chromogranin A (ChgA) fragments, and compared it with the WE14 and ChgA29–42 epitopes. We measured in situ two-dimensional affinity on individual live T cells from thymus, spleen, pancreatic lymph nodes, and islets before and after diabetes. Although preselection BDC2.5 thymocytes possess higher affinity than splenic BDC2.5 T cells for all three epitopes, peripheral splenic T cells maintained high affinity only to the HIP2.5 epitope. In polyclonal NOD mice, a high frequency (~40%) of HIP2.5-specific islet T cells were identified at both prediabetic and diabetic stages comprising two distinct high- and low-affinity populations that differed in affinity by 100-fold. This high frequency of high- and low-affinity HIP2.5 T cells in the islets potentially represents a major risk factor in diabetes pathogenesis. Full Article
in {beta}-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1 By diabetes.diabetesjournals.org Published On :: 2020-03-20T11:50:28-07:00 The signal peptide of preproinsulin is a major source for HLA class I autoantigen epitopes implicated in CD8 T cell (CTL)–mediated β-cell destruction in type 1 diabetes (T1D). Among them, the 10-mer epitope located at the C-terminal end of the signal peptide was found to be the most prevalent in patients with recent-onset T1D. While the combined action of signal peptide peptidase and endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) is required for processing of the signal peptide, the mechanisms controlling signal peptide trimming and the contribution of the T1D inflammatory milieu on these mechanisms are unknown. Here, we show in human β-cells that ER stress regulates ERAP1 gene expression at posttranscriptional level via the IRE1α/miR-17-5p axis and demonstrate that inhibition of the IRE1α activity impairs processing of preproinsulin signal peptide antigen and its recognition by specific autoreactive CTLs during inflammation. These results underscore the impact of ER stress in the increased visibility of β-cells to the immune system and position the IRE1α/miR-17 pathway as a central component in β-cell destruction processes and as a potential target for the treatment of autoimmune T1D. Full Article
in Maternal Type 1 Diabetes Reduces Autoantigen-Responsive CD4+ T Cells in Offspring By diabetes.diabetesjournals.org Published On :: 2020-03-20T11:50:28-07:00 Autoimmunity against pancreatic β-cell autoantigens is a characteristic of childhood type 1 diabetes (T1D). Autoimmunity usually appears in genetically susceptible children with the development of autoantibodies against (pro)insulin in early childhood. The offspring of mothers with T1D are protected from this process. The aim of this study was to determine whether the protection conferred by maternal T1D is associated with improved neonatal tolerance against (pro)insulin. Consistent with improved neonatal tolerance, the offspring of mothers with T1D had reduced cord blood CD4+ T-cell responses to proinsulin and insulin, a reduction in the inflammatory profile of their proinsulin-responsive CD4+ T cells, and improved regulation of CD4+ T cell responses to proinsulin at 9 months of age, as compared with offspring with a father or sibling with T1D. Maternal T1D was also associated with a modest reduction in CpG methylation of the INS gene in cord blood mononuclear cells from offspring with a susceptible INS genotype. Our findings support the concept that a maternal T1D environment improves neonatal immune tolerance against the autoantigen (pro)insulin. Full Article
in Artificial intelligence versus clinicians: systematic review of design, reporting standards, and claims of deep learning studies By feeds.bmj.com Published On :: Wednesday, March 25, 2020 - 22:30 Full Article
in Manual acupuncture versus sham acupuncture and usual care for prophylaxis of episodic migraine without aura: multicentre, randomised clinical trial By feeds.bmj.com Published On :: Wednesday, March 25, 2020 - 22:31 Full Article
in Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study By feeds.bmj.com Published On :: Thursday, March 26, 2020 - 10:55 Full Article
in Global, regional, and national burden of neck pain in the general population, 1990-2017: systematic analysis of the Global Burden of Disease Study 2017 By feeds.bmj.com Published On :: Thursday, March 26, 2020 - 19:10 Full Article
in Opioid agonist treatment and risk of mortality during opioid overdose public health emergency: population based retrospective cohort study By feeds.bmj.com Published On :: Tuesday, March 31, 2020 - 09:36 Full Article
in Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults: systematic review and network meta-analysis of randomised trials By feeds.bmj.com Published On :: Wednesday, April 1, 2020 - 22:31 Full Article
in Infectious diseases in children and adolescents in China: analysis of national surveillance data from 2008 to 2017 By feeds.bmj.com Published On :: Thursday, April 2, 2020 - 12:26 Full Article
in Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal By feeds.bmj.com Published On :: Tuesday, April 7, 2020 - 09:01 Full Article
in Use of electronic medical records in development and validation of risk prediction models of hospital readmission: systematic review By feeds.bmj.com Published On :: Wednesday, April 8, 2020 - 09:41 Full Article
in Association between maternal and paternal mental illness and risk of injuries in children and adolescents: nationwide register based cohort study in Sweden By feeds.bmj.com Published On :: Wednesday, April 8, 2020 - 22:31 Full Article
in Prospective registration and reporting of trial number in randomised clinical trials: global cross sectional study of the adoption of ICMJE and Declaration of Helsinki recommendations By feeds.bmj.com Published On :: Tuesday, April 14, 2020 - 09:20 Full Article
in Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study By feeds.bmj.com Published On :: Tuesday, April 21, 2020 - 14:45 Full Article
in Estimated population wide benefits and risks in China of lowering sodium through potassium enriched salt substitution: modelling study By feeds.bmj.com Published On :: Wednesday, April 22, 2020 - 17:00 Full Article
in Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study By feeds.bmj.com Published On :: Tuesday, April 28, 2020 - 09:16 Full Article
in Use of sodium-glucose co-transporter 2 inhibitors and risk of serious renal events: Scandinavian cohort study By feeds.bmj.com Published On :: Wednesday, April 29, 2020 - 22:30 Full Article
in Occurrence, prevention, and management of the psychological effects of emerging virus outbreaks on healthcare workers: rapid review and meta-analysis By feeds.bmj.com Published On :: Tuesday, May 5, 2020 - 12:46 Full Article
in Association between tax on sugar sweetened beverages and soft drink consumption in adults in Mexico: open cohort longitudinal analysis of Health Workers Cohort Study By feeds.bmj.com Published On :: Wednesday, May 6, 2020 - 22:30 Full Article
in Prognosis of unrecognised myocardial infarction determined by electrocardiography or cardiac magnetic resonance imaging: systematic review and meta-analysis By feeds.bmj.com Published On :: Thursday, May 7, 2020 - 11:41 Full Article
in Guyana reports $60m in oil revenues By jamaica-gleaner.com Published On :: Tue, 05 May 2020 12:07:39 -0500 GEORGETOWN, Guyana (AP): Four months after Guyana became one of the world’s newest crude oil exporters, the South American country says it is already reaping the rewards with about $60 million in payments. The money is linked to Guyana’s... Full Article
in Stocks Round Up | JSE Combined Index advances marginally By jamaica-gleaner.com Published On :: Tue, 05 May 2020 17:09:59 -0500 The Jamaica Stock Exchange (JSE) Combined Index regained lost ground on Tuesday with an advance/decline ratio of 28/38 The JSE index advanced marginally 1,154.11 points or 0.32 per cent to close at 360,497.91. The JSE Main Market Index was up... Full Article
in Conrad George and André Sheckleford | Incorrect layoff procedures can lead to future liability By jamaica-gleaner.com Published On :: Wed, 06 May 2020 00:14:20 -0500 OP-CONTRIBUTION: EMPLOYMENT CONTRACTS The COVID-19 pandemic is hitting businesses and the economy in a manner perhaps not seen since the Second World War. This, of course, has affected the ability of employers to pay their employees. The COVID-19... Full Article
in Business Briefs By jamaica-gleaner.com Published On :: Wed, 06 May 2020 00:06:24 -0500 Branson Centre goes digital The Caribbean branch of Branson Centre of Entrepreneurship has shifted fully to online delivery of its services. This includes online training and support in three business development areas: finance, strategic... Full Article
in LNG complicates light bill savings By jamaica-gleaner.com Published On :: Wed, 06 May 2020 00:05:38 -0500 THE SWITCH towards liquefied natural gas, LNG, as fuel to produce power supplies for Jamaica has a downside for electricity customers, who are largely missing out on the big oil savings. The near two-thirds plunge in oil prices will have limited... Full Article
in Stocks Round Up | JSE Combined Index advances By jamaica-gleaner.com Published On :: Wed, 06 May 2020 17:17:24 -0500 The Jamaica Stock Exchange (JSE) Combined Index continued its mild rally on Wednesday with an advance/decline ratio of 34/29 The JSE index advanced marginally 1,983.51points or 0.55 per cent to close at 362,481.42. The JSE Main Market Index was up... Full Article
in US Treasury says April-June borrowing will be a record US$2.99t By jamaica-gleaner.com Published On :: Wed, 06 May 2020 23:07:24 -0500 THE ECONOMIC paralysis triggered by the coronavirus pandemic is forcing the United States Treasury to borrow far more than it ever has before – US$2.99 trillion in the current quarter alone. The amount is more than five times the government’s... Full Article
in To address AML oversight, BOJ creates sandbox for fintech applicants By jamaica-gleaner.com Published On :: Thu, 07 May 2020 15:55:34 -0500 FOUR MORE applicants are vying to provide mobile payment services in various formats, including one applicant seeking to use phone credit as a cash equivalent, but successful applicants will fall under a new framework the regulator calls its “... Full Article
in Stocks Round Up | 38 stocks advance, 27 decline and 8 trade firm By jamaica-gleaner.com Published On :: Thu, 07 May 2020 16:58:33 -0500 The Jamaica Stock Exchange (JSE) Combined Index continued its mild rally on Thursday with an advance/decline ratio of 38/27 The index advanced marginally 2,427.05 points or 0.67 per cent to close at 364,908.47. The JSE Main Market Index was up 2,... Full Article
in Dwayne Devonish | Smart virus testing necessary for economic reboot By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:13:10 -0500 OP-ED CONTRIBUTION: COVID-19 AND THE ECONOMY FOR MOST countries in the Caribbean, the current testing for COVID-19 has not reached levels suitable for ascertaining an accurate picture of the state of outbreak and spread of the infection. This... Full Article
in FTC puts Total gas market share at 30% - Sees no threat to competition from Epping deal By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:08:14 -0500 THE ACQUISITION of Epping resulted in Total Jamaica controlling nearly a third of the retail gasolene market, but that’s not enough to lessen competition, the Fair Trading Commission, FTC, has found. “The acquisition is unlikely to have either the... Full Article
in SVL ramping up online games By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:18:10 -0500 SUPREME VENTURES Limited, SVL, has locked down its Acropolis gaming lounge since March 18, when the Government mandated the closure of all lounges and bars. Sports wagering has fallen precipitously, concomitant with the suspension of sporting... Full Article
in Digital Jamaica throws sales lifeline to furniture companies By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:18:42 -0500 DESPITE TUMBLING sales and challenges with hire-purchase accounts, two of the largest retailers of home furniture and appliances, Courts Jamaica and Singer Jamaica, have found glimmers of hope during the COVID-19 pandemic. That’s because work-from... Full Article
in Facing forex shortage, productive sector appeals to BOJ for help By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:17:12 -0500 WITH THE productive sector experiencing a shortage of foreign exchange for the past two months, the Jamaican Manufacturers and Exporters Association, JMEA, says it has appealed to the Bank of Jamaica, BOJ, for direct access to US currency for three... Full Article
in Why We Build Walls: 30 Years After the Fall of the Berlin Wall By feedproxy.google.com Published On :: Fri, 08 Nov 2019 11:11:56 +0000 8 November 2019 Robin Niblett Director and Chief Executive, Chatham House @RobinNiblett Gitika Bhardwaj Editor, Communications & Publishing, Chatham House @GitikaBhardwaj LinkedIn Robin Niblett talks to Gitika Bhardwaj about the physical and psychological significance of border walls and their role in politics today. GettyImages-1184642325.jpg Part of the Berlin Wall still standing today. 9 November marks the 30th anniversary of the fall of the Berlin Wall that soon led to the collapse of the communist East German government. Photo: Getty Images. This year marks the 30th anniversary of the fall of the Berlin Wall. The wall, which stood between 1961 to 1989, came to symbolize the ‘Iron Curtain’ – the ideological split between East and West – that existed across Europe and between the two superpowers, the US and the Soviet Union, and their allies, during the Cold War. How significant was the Berlin Wall during the Cold War – was it more important physically or psychologically? The Berlin Wall was important physically, as well as psychologically, because Berlin was the only city that was divided physically by the Cold War between the Soviet Union and its allies in the Eastern Bloc and the West.Given the disparity that quickly emerged between the two sides in economic wealth, freedom of expression and so on, the fear was that, without that wall, there would've been a unification of Berlin in a way that the Soviet side would have lost.But it was also very important psychologically because it became the symbol of the division between two ideologies that saw each other as inimical to each other.That meant that if you wanted to visualize the Cold War, and the separation between the capitalist, democratic system of the West and the communist, command-and-control system of the East, Berlin offered a place where you could physically walk from one world, through a checkpoint, into the other. The whole Cold War could be reduced to this one nexus point.Because of its psychological as well as its physical significance, the fall of the Berlin Wall quickly became the symbol of the collapse of the communist ideology it had shielded.Since the fall of the Berlin Wall, European countries have reportedly built over 1,000 kilometres of walls – the equivalent of more than six times the total length of the Berlin Wall – along their borders. Why has Europe been building more walls and how effective have they been? Have they been used more as symbols to appeal to political bases, and if so, has it worked with voters?The walls that have been built in Europe recently have been for a very specific reason. This was the huge influx of migrants and refugees to Europe in 2015, through what was called the ‘eastern Mediterranean’ or ‘western Balkan route’, from Turkey to Greece and on through the Balkans, Serbia and Hungary to northern Europe – in what was Europe's biggest migrant and refugee crisis since the Second World War.What’s interesting is that for Viktor Orbán and the Hungarian government, which was on the frontline of the flow of migrants and refugees, building a wall was a way of reasserting its sovereignty. Like many other countries along the ‘migrant route’, they resented that the rules under which people could migrate into Europe were flouted by northern European governments which were willing to accept large numbers of migrants and refugees.By accepting them, they kept attracting more, and so Orbán was worried that, at some point, Germany might say ‘We can’t take anymore’ and they’d be left in Hungary.It’s important to remember that the communist states of central and eastern Europe were kept in aspic by the Soviet Union – they existed in a hermetically sealed environment without immigration. As a result, they didn’t experience the rise of multicultural societies of the sort that emerged in Britain, Belgium, France and Germany, where immigration persisted throughout the Cold War period.The countries of central and eastern Europe were delighted that the Berlin Wall collapsed because it allowed them to unify with western Europe. They had been vassal states of the Soviet Union during the Cold War, and by joining the EU, they re-discovered personal freedom and re-gained national sovereignty. They thought they had become masters of their own future again.But they suddenly found they were on the frontline of a new movement of people that wanted to get into the same world that they’d entered some 15 years earlier. And, as hundreds of thousands of migrants and refugees began arriving, they suddenly realised they were in a union that did not respect their sovereignty.So, for them, putting up walls was a sovereign act against a European Union that didn’t seem to take their sovereignty seriously.Has it worked? Definitely. The flow of migrants has been reduced drastically. This is partly because the EU paid Turkey to hold back the over three million migrants based there. But the walls also acted as a physical and psychological deterrent. It also worked politically. It allowed Viktor Orbán and other European parties that took the sovereigntist line to strengthen their appeal to voters – voters like to know that governments can do certain things like protecting them and their borders.What is hypocritical, however, is that many of the governments in western Europe which criticized the Hungarian government for building its wall have actually been rather grateful that they did so as it slowed down the flow of migrants to their countries.Then there’s the additional hypocrisy of the EU criticizing Donald Trump for building his wall with Mexico when Europeans are benefitting from theirs in Hungary.Two years before the fall of the Berlin Wall, former US president Ronald Reagan challenged Soviet leader Mikhail Gorbachev to ‘tear down this wall’ declaring ‘across Europe this wall will fall. For it cannot withstand [freedom].’ 32 years later, building a wall along the US–Mexico border has become a cornerstone of the current US administration under Donald Trump who has pledged to build a ‘big beautiful wall’. How does this reflect the political evolution of the US and what effect does that have across the rest of the world?President Reagan talked about tearing down the Berlin Wall as a symbol of the Cold War. He knew that the fall of the wall would undermine the Soviet Union. President Trump is way beyond the Cold War. Building a new wall is his response to the growing sense of economic dislocation that segments of America, like Britain and other parts of Europe and the developed world, have experienced on the back of the rise of globalization, which was partly the result of the end of the Cold War but also the rise of China.The spread of globalization, the declining earning power of many workers in the West, advances in technology which have taken away many high-earning jobs, the eight years of austerity after the global financial crisis – these are all factors driving Trump’s thinking. Have inflows of Mexican immigrants or immigrants through the Mexico border been the principal driver of economic insecurity? No. What you’ve got is Trump promising to build a wall as a symbol of his administration’s determination to protect Americans.So I’d say the US–Mexico wall is another symbolic – or psychological – wall. Trump’s wall is supposedly about stopping illegal immigration but there are still plenty of ways to come through the border posts. It’s principally an exercise in political theatre. Construction site for a secondary border fence, following the length of the current primary border fence, separating the US and Mexico in San Diego. Photo: Getty Images. From the Great Wall of China to Hadrian’s Wall, walls and fences of all sorts have been used throughout history for defence and security, but not all of them have been physical. So-called ‘maritime walls’, as well as ‘virtual walls’, are also increasingly being enforced which, today, includes border forces patrolling seas and oceans, such as in the Mediterranean Sea or off the coasts of Australia, and border control systems controlling the movement of people. Politically how do these types of barriers compare to physical ones? You could argue that the Mediterranean Sea, and the European border forces operating within it, still act as a physical wall because they constitute a physical obstacle to migrants being able to move from the South across the Mediterranean Sea into Europe. So I don’t see this maritime wall being much different to the physical walls that have been built to try to stop migrants – just like any other border patrol, the Italian navy is preventing NGO vessels carrying migrants, who have been stranded at sea from docking at Italian ports. In this sense, you could argue that the Mediterranean Sea is a larger version of the Rio Grande between the US and Mexico which also incorporates physical barriers along its shores.I think the more interesting walls that are being built today are virtual walls such as regulatory walls to trade, or with the internet, new barriers are being built to digital communication which affect your capacity to access information. In the end, all these walls are manifestations of national sovereignty through which a government demonstrates it can ‘protect’ its citizens – whether they are successful in this objective or not.The border between Ireland and Northern Ireland, and the presence of enforcement mechanisms along the border, has become a key issue in the Brexit negotiations. How much of the debate over this is about the symbolism of the border against its economic implications?The Irish border carries great symbolic importance because it reflects the reality of the separation of two sovereign states.On the island of Ireland, the British and Irish governments have wanted to minimize this reality to the greatest extent possible. They even went as far as removing all types of barriers as part of the Good Friday Agreement.This is the same sort of fiction the European Union created when it removed any physical manifestations of the existence of borders between those member states in its Schengen agreement on borderless travel.By removing physical manifestations of the border, the UK was able to reduce some of the popular support for Irish unification as well as support for the IRA’s campaign of violence and terrorism to try to force the same outcome. Brexit has thrown a huge spanner into this arrangement. If Brexit is going to mean the entire UK not being in the EU’s customs union then some sort of border would need to be reinstated.The British government proposed to do all the checks behind the border somewhere. The EU’s view was, ‘Well, that’s nice for you to say, but this border will become the EU’s only land border with the UK, and you cannot guarantee that people won’t be able to smuggle things through.’On the other hand, recreating a border of some sort, whether physical or not, would reignite the differentiation between the two nations – running counter to the spirit of the Good Friday Agreement.The only solution available to Prime Minister Boris Johnson has been to put the border down the Irish Sea. While this means that Northern Ireland will no longer be an obstacle to the UK signing new, post-Brexit, free trade agreements with other countries, it has betrayed the Conservative Party’s unionist allies, for whom it’s essential that the UK’s borders include and not exclude them. By the end of the Cold War there were just 15 walls and fences along borders around the world, but today, there are at least 70. How effective, do you think, building barriers are as a political and military strategy to defence and security issues given their financial – and human – cost?Physical barriers can be an effective form of protection – or imprisonment. The separation wall between Israel and the Palestinian territories has reduced the level of terrorist violence being perpetrated in Israel, but the cost has been the impoverishment of many Palestinians, and is another nail in the coffin of a two-state solution.Yet many Israelis are saying that, maybe, being entirely separate is the best way to achieve peace between the two sides.However, the walls around the Gaza Strip have not prevented, for various reasons, the Hamas government from developing rockets and firing them into Israel. You could argue that the border between China and North Korea, which is severely patrolled, has been a tool of continued political control protecting the Kim Jong-un regime from collapse – as has its virtual border preventing internet penetration.Similarly, the virtual border the Chinese government has created around its own internet, the ‘great firewall’, has been very effective both economically – allowing Chinese internet platforms to develop without the threat of competition – and also as a form of political control that helps the Chinese Communist Party retain its monopoly on power. So walls in all of their shapes and forms can work. They are like sanctions – sanctions are easy to impose but difficult to remove. Walls are easy to build but they’re difficult to break down. But my view would be that they still only work temporarily. In the end, walls serve their particular purpose for a particular period, like the Berlin Wall, they end up outliving their purpose.You have to be alive to the fact that, whether that purpose was a good or bad purpose, there will be a moment when walls end up protecting the interests of an ever-narrower number of people inside the wall, while they cease serving, if they ever did, the interests of the growing number on both sides. It’s ironic that the fall of the Berlin Wall in November 1989 was not the main marker of the end of the Cold War. It began earlier that year, with the intensification of people protesting in Poland, Hungary and Czechoslovakia.Once Hungarian troops dismantled the fence separating them from Austria in May 1989, thousands of Hungarian citizens simply walked out of their country, because by then, the wall between the East and West only existed in their minds.Then, once East Germans also realized that Mikhail Gorbachev and the Soviet regime had lost its willingness to defend the Berlin Wall, it collapsed. So it is interesting that we’re marking the end of the Cold War with this anniversary of the fall of the Berlin Wall, which of course, did divide two halves of one country, making its fall all the more poignant and powerful. But the end of the Cold War really began with the fall of the invisible wall in people’s minds. Full Article
in Challenges and Opportunities in the Fight Against Corruption By feedproxy.google.com Published On :: Wed, 13 Nov 2019 15:40:01 +0000 Members Event 9 December 2019 - 6:30pm to 7:30pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Rory Stewart, Member of Parliament for Penrith and The Border (2010-19); Secretary of State for International Development (2019)Chair: Daniel Bruce, Chief Executive, Transparency International UK Drawing on his experience in government, Rory Stewart shares his observations into the impact corruption can have on society.This event is organized in association with Transparency International UK as part of Transparency International UK’s Annual Lecture series. Members Events Team Email Full Article
in Webinar: The UK's Unpredictable General Election? By feedproxy.google.com Published On :: Wed, 13 Nov 2019 17:00:01 +0000 Members Event Webinar 19 November 2019 - 11:30am to 12:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Professor Matthew Goodwin, Visiting Senior Fellow, Europe Programme, Chatham HouseProfessor David Cutts, Associate Fellow, Europe Programme, Chatham House On 12 December 2019, the United Kingdom will go to the polls in a fifth nationwide vote in only four years. This is expected to be one of the most unpredictable general elections in the nation’s post-war history with the anti-Brexit Liberal Democrats and Nigel Farage’s Eurosceptic Brexit Party both presenting a serious challenge to the UK’s established two-party system.This webinar will discuss the UK general election and will unpack some of the reasons behind its supposed unpredictability. To what extent will this be a Brexit election and what are the other issues at the forefront of voters’ minds? And will the outcome of the election give us a clear indication of the UK’s domestic, European and wider international political trajectory?Please note, this event is online only. Members can watch webinars from a computer or another internet-ready device and do not need to come to Chatham House to attend. Full Article
in EU–US Relations on Internet Governance By feedproxy.google.com Published On :: Thu, 14 Nov 2019 16:12:28 +0000 14 November 2019 As internet governance issues emerge in the wake of innovations such as the Internet of Things and advanced artificial intelligence, there is an urgent need for the EU and US to establish a common, positive multi-stakeholder vision for regulating and governing the internet. Read online Download PDF Emily Taylor Associate Fellow, International Security Programme @etaylaw LinkedIn Stacie Hoffmann Internet Policy and Cybersecurity Consultant, Oxford Information Labs 2019-11-14-EUUSInternet.jpg Server room network cables in New York City, November 2014. Photo: Michael Bocchieri/Staff/Getty. Political, economic, sociological and technological factors are poised to challenge EU and US ideological positions on internet governance, which will make it difficult to find consensus and common ground in the years to come.The EU and US share core values and perspectives relating to internet governance, such as openness, freedom and interoperability, as well as a human rights framework for cybersecurity. There have been many examples of successful multi-stakeholder cooperation between the EU and US, including the Internet Assigned Numbers Authority (IANA) transition and the European Dialogue on Internet Governance (EuroDIG).There are also subtle differences between the EU and US, and each has different reasons to support multi-stakeholderism. Cases that highlight growing tensions in EU–US coordination on internet governance include the controversies surrounding the EU General Data Protection Regulation (GDPR), the WHOIS system that governs domain name registration data, and the board of the Internet Corporation for Assigned Names and Numbers (ICANN), which undermined an independent cybersecurity review.Internet governance is becoming more complex, with a multiplicity of actors and no obvious authority for important emerging issues. Additionally, the rise of China and its authoritarian vision for the future of the internet is a threat to the current internet governance institutions that have been shaped by and reflect Western values.To bridge ideological gaps the EU and US should build capacity between likeminded stakeholders, create a taskforce on effective multi-stakeholder internet governance, and work through non-governmental stakeholders to improve participation. Department/project International Security Programme, Internet Governance Full Article