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Iran executes in public a serial rapist convicted in dozens of cases

Iran’s state media say authorities have executed in public a man convicted of raping dozens of women over two decades




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Lebanon media claims Israeli strike hit apartment south of Beirut

Israeli warplanes launched a strike at dawn targeting a residential apartment in a building in the Dawhet




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Sri Lanka to hold key parliamentary vote on November 14

President Anura Kumara Dissanayake’s ruling alliance is looking to secure a majority in Parliament




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Indonesia and Australia hold joint military drills after signing a new defense agreement

The Indonesian and Australian militaries are holding joint combat drills off Indonesia’s main island of Java with about 2,000 troops training in air, maritime, amphibious and land operations




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In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP

RSC Med. Chem., 2024, 15,3674-3694
DOI: 10.1039/D4MD00580E, Research Article
Jinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin Jin
Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation

RSC Med. Chem., 2024, 15,3778-3794
DOI: 10.1039/D4MD00281D, Research Article
Carolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. Pilli
A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity

RSC Med. Chem., 2024, 15,3711-3727
DOI: 10.1039/D4MD00584H, Research Article
Sara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-Dias
A series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction

RSC Med. Chem., 2024, 15,3652-3673
DOI: 10.1039/D4MD00425F, Review Article
Semim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra Borah
Metabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells

RSC Med. Chem., 2024, 15,3728-3745
DOI: 10.1039/D4MD00476K, Research Article
Vincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien Fortin
New water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3880-3888
DOI: 10.1039/D4MD00414K, Research Article
Phuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. Vo
Novel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00610K, Research Article
Open Access
Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
The content of this RSS Feed (c) The Royal Society of Chemistry




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Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers

Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme




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T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers

It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students




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Leaders of various parties condemn attack on govt. doctor




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Rival Zomato's CEO congratulates Swiggy on stock market listing

Swiggy got listed at ₹420, a jump of nearly 8% from the issue price on the NSE




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Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud

Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year.




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Godrej Industries Q2 net profit surges over three fold to ₹288 crore




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SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka

Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities




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Free and fair inquiry sought into death of snakebite victim in Srikakulam district

Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident




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New counters opened at Tirumala for issuing Srivani darshan tickets

Decision to open new counters taken following reports of devotees experiencing discomfort in queue at the previous counter, particularly during inclement weather, says TTD Additional EO




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Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector

P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches




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New road proposed from IIT-Tirupati campus to Rachagunneri

Rachagunneri is home to the massive 400/220/132kV electrical substation and also a private steel plant




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Devotees offer special prayers at Sri Kalyana Venkateswara Swamy temple in Srikakulam




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Andhra Pradesh govt. reaffirms commitment to ‘irrigating every acre of farmland’ in State through river-interlinking projects




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Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan




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Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam




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Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’




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GlobalLogic opens delivery centre in Hyderabad to spread wings, ramp up hiring in Telangana 

The company will consider spreading wings to one more such location, in addition to Mahbubnagar where it has about 350 employees




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Ensuring full occupancy at IT towers in Tier-II cities focus: Telangana IT Minister 

Godavarikhani near Ramagundam, Mancherial among locations likely to get facilities for IT firms 




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Prasar Bharati OTT launch, private FM stations for small towns on cards  




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Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar

GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations




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Why are countries fighting over climate finance at COP29?

Here is what you need to know about the November 11-22 summit talks on finance.




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COP29: India, other developing countries demand fair climate finance commitments

India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments




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Millions of Nigerians go hungry as floods compound hardship

Torrential rains and floods in 29 of Nigeria's 36 states this year have destroyed more than 1.5 million hectares of cropland, affecting more than nine million people




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Uncontrolled diabetes increases risk of hearing loss; doctors call for more awareness, screening

Hearing loss occurs twice as frequently in patients with uncontrolled diabetes as compared to the non-diabetic population, doctors say, calling for screening to be included in routine diabetes care




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Here are the big stories from Karnataka today

Welcome to the Karnataka Today newsletter, your guide from The Hindu on the major news stories to follow today. Curated and written by Nalme Nachiyar.




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Experimental Fortification Lab Centre opened at KLE




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Illegal export of iron ore from Belekeri port: Karnataka High Court suspends sentence and grants bail to MLA Satish Sail and five other convicts




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FIR registered against Snehamayi Krishna




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After hosting World Cup, Qatar praised by U.N. rights body for labour law reforms but urged to do more

In Qatar, better labour law protections have been passed in recent years relating to a minimum wage, freedom to change employers and combating forced labor and trafficking




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Gambhir a prickly character, never took dig at Kohli: Ponting

Ponting said that his comments on Kohli were taken out of context




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Pakistan should stop playing cricket with India, says Rashid Latif

The Pakistan Cricket Board (PCB) has written to ICC asking for written confirmation from the BCCI for India's inability to travel to Pakistan for the tournament




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CRICKET | Tanmay’s 15th Ranji Trophy ton powers Hyderabad to position of strength

The opener makes Andhra pay a heavy price for a dropped catch early in his innings; off-spinner Vijay the pick of the bowlers with his three wickets




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Sharandeep grinds out a half-century on a slow-moving opening day

The Jharkhand opener exhibits ample patience and a tight defence




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Ennoventure bags $8.9 million in Series A led by Tanglin Venture Partners

The round included participation from existing investors, such as Fenice Investment Group and additional SAFE investors




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IL&FS debt resolution: NCLAT sets March 2025 deadline to lift moratorium on IL&FS entities

Some of the lenders had sought the tribunal’s approval to start proceedings under IBC for recovering dues from the 58 IL&FS entities




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Allison Transmission to double Chennai facility with $100 mn+ investment amid rising global demand

The expansion aims to double the facility’s size, creating 167 new jobs, and enhance production capacity for automatic transmissions in response to growing global demand




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Death of woman after delivery at private hospital in Dharmapuri sparks row; RDO holds inquiry




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Permission of State govt. required for bringing elephants from outside: Kerala HC