ri Iran executes in public a serial rapist convicted in dozens of cases By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:43:02 +0530 Iran’s state media say authorities have executed in public a man convicted of raping dozens of women over two decades Full Article World
ri Lebanon media claims Israeli strike hit apartment south of Beirut By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:10:43 +0530 Israeli warplanes launched a strike at dawn targeting a residential apartment in a building in the Dawhet Full Article World
ri Sri Lanka to hold key parliamentary vote on November 14 By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:35:59 +0530 President Anura Kumara Dissanayake’s ruling alliance is looking to secure a majority in Parliament Full Article World
ri Indonesia and Australia hold joint military drills after signing a new defense agreement By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:32:15 +0530 The Indonesian and Australian militaries are holding joint combat drills off Indonesia’s main island of Java with about 2,000 troops training in air, maritime, amphibious and land operations Full Article World
ri In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ri Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3778-3794DOI: 10.1039/D4MD00281D, Research ArticleCarolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. PilliA novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ri Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3711-3727DOI: 10.1039/D4MD00584H, Research ArticleSara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-DiasA series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ri Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3652-3673DOI: 10.1039/D4MD00425F, Review ArticleSemim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra BorahMetabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ri Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3728-3745DOI: 10.1039/D4MD00476K, Research ArticleVincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien FortinNew water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ri Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ri Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ri Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ri Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:23:48 +0530 Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme Full Article Tamil Nadu
ri T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:15:58 +0530 It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students Full Article Tamil Nadu
ri Leaders of various parties condemn attack on govt. doctor By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:08:06 +0530 Full Article Tamil Nadu
ri Rival Zomato's CEO congratulates Swiggy on stock market listing By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:25:51 +0530 Swiggy got listed at ₹420, a jump of nearly 8% from the issue price on the NSE Full Article India
ri Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:16:07 +0530 Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year. Full Article Business
ri Godrej Industries Q2 net profit surges over three fold to ₹288 crore By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:47:28 +0530 Full Article Business
ri SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:49:14 +0530 Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities Full Article Mangaluru
ri Free and fair inquiry sought into death of snakebite victim in Srikakulam district By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:10:47 +0530 Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident Full Article Andhra Pradesh
ri New counters opened at Tirumala for issuing Srivani darshan tickets By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:45:53 +0530 Decision to open new counters taken following reports of devotees experiencing discomfort in queue at the previous counter, particularly during inclement weather, says TTD Additional EO Full Article Andhra Pradesh
ri Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:25:35 +0530 P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches Full Article Andhra Pradesh
ri New road proposed from IIT-Tirupati campus to Rachagunneri By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:18:24 +0530 Rachagunneri is home to the massive 400/220/132kV electrical substation and also a private steel plant Full Article Andhra Pradesh
ri Devotees offer special prayers at Sri Kalyana Venkateswara Swamy temple in Srikakulam By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:19:39 +0530 Full Article Andhra Pradesh
ri Andhra Pradesh govt. reaffirms commitment to ‘irrigating every acre of farmland’ in State through river-interlinking projects By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:43:13 +0530 Full Article Andhra Pradesh
ri Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:25:39 +0530 Full Article Andhra Pradesh
ri Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:31 +0530 Full Article Andhra Pradesh
ri Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:30:39 +0530 Full Article Andhra Pradesh
ri GlobalLogic opens delivery centre in Hyderabad to spread wings, ramp up hiring in Telangana By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:21:21 +0530 The company will consider spreading wings to one more such location, in addition to Mahbubnagar where it has about 350 employees Full Article Hyderabad
ri Ensuring full occupancy at IT towers in Tier-II cities focus: Telangana IT Minister By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:48:49 +0530 Godavarikhani near Ramagundam, Mancherial among locations likely to get facilities for IT firms Full Article Telangana
ri Prasar Bharati OTT launch, private FM stations for small towns on cards By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:29:11 +0530 Full Article Hyderabad
ri Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:50:51 +0530 GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations Full Article Health
ri Why are countries fighting over climate finance at COP29? By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:12:52 +0530 Here is what you need to know about the November 11-22 summit talks on finance. Full Article Environment
ri COP29: India, other developing countries demand fair climate finance commitments By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:33:21 +0530 India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments Full Article World
ri Millions of Nigerians go hungry as floods compound hardship By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:07:00 +0530 Torrential rains and floods in 29 of Nigeria's 36 states this year have destroyed more than 1.5 million hectares of cropland, affecting more than nine million people Full Article Environment
ri Uncontrolled diabetes increases risk of hearing loss; doctors call for more awareness, screening By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:04:48 +0530 Hearing loss occurs twice as frequently in patients with uncontrolled diabetes as compared to the non-diabetic population, doctors say, calling for screening to be included in routine diabetes care Full Article Health
ri Here are the big stories from Karnataka today By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:28:16 +0530 Welcome to the Karnataka Today newsletter, your guide from The Hindu on the major news stories to follow today. Curated and written by Nalme Nachiyar. Full Article Karnataka Today
ri Experimental Fortification Lab Centre opened at KLE By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:53:06 +0530 Full Article Karnataka
ri Illegal export of iron ore from Belekeri port: Karnataka High Court suspends sentence and grants bail to MLA Satish Sail and five other convicts By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:21:10 +0530 Full Article Karnataka
ri FIR registered against Snehamayi Krishna By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:21:22 +0530 Full Article Karnataka
ri After hosting World Cup, Qatar praised by U.N. rights body for labour law reforms but urged to do more By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:06:56 +0530 In Qatar, better labour law protections have been passed in recent years relating to a minimum wage, freedom to change employers and combating forced labor and trafficking Full Article World
ri Gambhir a prickly character, never took dig at Kohli: Ponting By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:15:43 +0530 Ponting said that his comments on Kohli were taken out of context Full Article Cricket
ri Pakistan should stop playing cricket with India, says Rashid Latif By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:49:54 +0530 The Pakistan Cricket Board (PCB) has written to ICC asking for written confirmation from the BCCI for India's inability to travel to Pakistan for the tournament Full Article Cricket
ri CRICKET | Tanmay’s 15th Ranji Trophy ton powers Hyderabad to position of strength By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:33:47 +0530 The opener makes Andhra pay a heavy price for a dropped catch early in his innings; off-spinner Vijay the pick of the bowlers with his three wickets Full Article Cricket
ri Sharandeep grinds out a half-century on a slow-moving opening day By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:43:55 +0530 The Jharkhand opener exhibits ample patience and a tight defence Full Article Cricket
ri Ennoventure bags $8.9 million in Series A led by Tanglin Venture Partners By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 10:50:10 +0530 The round included participation from existing investors, such as Fenice Investment Group and additional SAFE investors Full Article Companies
ri IL&FS debt resolution: NCLAT sets March 2025 deadline to lift moratorium on IL&FS entities By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 10:50:28 +0530 Some of the lenders had sought the tribunal’s approval to start proceedings under IBC for recovering dues from the 58 IL&FS entities Full Article Companies
ri Allison Transmission to double Chennai facility with $100 mn+ investment amid rising global demand By www.thehindubusinessline.com Published On :: Thu, 14 Nov 2024 07:33:39 +0530 The expansion aims to double the facility’s size, creating 167 new jobs, and enhance production capacity for automatic transmissions in response to growing global demand Full Article Companies
ri Death of woman after delivery at private hospital in Dharmapuri sparks row; RDO holds inquiry By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:12:49 +0530 Full Article Coimbatore
ri Permission of State govt. required for bringing elephants from outside: Kerala HC By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:23:10 +0530 Full Article Kochi