ut Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00297K, Research ArticleBranislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea NikolićIn this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ut Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00562G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. StevensFlow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ut Recent advances from computer-aided drug design to artificial intelligence drug design By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00522H, Review ArticleKeran Wang, Yanwen Huang, Yan Wang, Qidong You, Lei WangCADD and AIDD contribute to the drug discovery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ut meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00601A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza GainaNew meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ut Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00553H, Research ArticleStefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro CosconatiNon-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ut Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00600C, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa LambertiBiological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ut 3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00597J, Research ArticleAlbert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken WittSomatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ut HC directs authorities to maintain park and ensure no encroachment By www.thehindu.com Published On :: Wed, 06 Nov 2024 21:09:52 +0530 Full Article Madurai
ut Deputy CM releases commemorative flag of Bharat Scouts and Guides By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:48:40 +0530 Full Article Tiruchirapalli
ut Ernakulam Express to stop at Muthupettai during Kandhoori festival By www.thehindu.com Published On :: Thu, 07 Nov 2024 18:51:18 +0530 Full Article Tiruchirapalli
ut Power shutdown in parts of Tiruchi on November 9 By www.thehindu.com Published On :: Fri, 08 Nov 2024 17:45:18 +0530 Full Article Tiruchirapalli
ut Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:25:49 +0530 Full Article Tiruchirapalli
ut Students cautioned against drug addiction By www.thehindu.com Published On :: Sat, 09 Nov 2024 22:12:06 +0530 Full Article Tiruchirapalli
ut 551: PlanetScale with Iheanyi Ekechukwu and Mike Coutermarsh By shoptalkshow.com Published On :: Mon, 06 Feb 2023 19:44:27 +0000 Iheanyi Ekechukwu and Mike Coutermarsh talk about PlanetScale, what Vitess is, if PlanetScale is for both side and big projects, what read only regions are, what schema changes are, and how PlanetScale compares to other projects. Full Article All Episodes database planetscale vitess
ut 562: Podcast Apps, Zaraz, Future CSS Thoughts, and Arc By shoptalkshow.com Published On :: Mon, 24 Apr 2023 08:01:44 +0000 What if Taylor Swift lyrics hold the answers to web dev questions? Podcast app thoughts, using Cloudflare Zaraz, what we're excited about with CSS, Arc browser updates, and are we even developers or are we specialized systems whisperers? Full Article All Episodes arc CSS zaraz
ut 570: Haircut Maintenance, Dave’s Bookshelf, Lazy Loading, and APIs By shoptalkshow.com Published On :: Mon, 19 Jun 2023 08:00:42 +0000 We're talking Dave's new haircut, playing Hondo, what Dave uses for images on his bookshelf page, lazy-loading thoughts, vh vw follow up, eyeball tracking updates, loading website with js, Vue transitions, charging for API access, and do you cross post, one post, or no post on social media in 2023? Full Article All Episodes api lazyloading transition
ut 596: The Year of AI, Arc, and Being Mad About the Right Thing By shoptalkshow.com Published On :: Mon, 18 Dec 2023 09:03:32 +0000 Looking back at the year of AI, using Arc on macOS and now Windows, dreaming of subscriptions, and knowing how to be mad about the right thing. Full Article All Episodes arc OpenAI web3
ut 620: Cloudflare #HotDrama, Auth, and Prototyping Thoughts By shoptalkshow.com Published On :: Mon, 17 Jun 2024 08:27:24 +0000 Show DescriptionWe dive a bit deeper into the Cloudflare drama of the past couple of weeks, Instagram ads vs Cara art, what to do about Auth in your app, pre-negging any sponsorships, prototyping and feedback on projects, and ideas for future topics. Listen on Website →Links Cloudflare took down our website after trying to force […] Full Article All Episodes Cloudflare Prototyping Web Components
ut 638: Q&A About Copyright, Jekyll, Joomla, Statamic, and More! By shoptalkshow.com Published On :: Mon, 21 Oct 2024 08:38:43 +0000 Dave's designing a new tshirt, questions for lawyers about copyrights for code projects, what does the copyright in the footer actually do, what do Dave and Chris require for personal web projects, does Jekyll get updated anymore, the Bob from Hell UX pattern, viewing ads on CNN, what about Joomla or Statamic, and how do paid fonts on the web work? Full Article All Episodes CMS copyright Dark patterns Jekyll Joomla Statamic UX
ut Building practices for the future By www.thehindu.com Published On :: Fri, 05 Dec 2014 16:08:44 +0530 Sacred Groves in Auroville is being built using ecologically sensitive construction methods and material. Full Article Property Plus
ut Smart water solution By www.thehindu.com Published On :: Fri, 01 May 2015 16:18:06 +0530 A bunch of Chennai students are making Paani Genie, a 90-litre water container that can be rolled along. Full Article Design
ut Putting cholera back in focus By www.thehindubusinessline.com Published On :: Sun, 06 Oct 2024 22:22:57 +0530 Surge in cholera cases renews attention on the need to fortify public health Full Article Pulse
ut Flat organisation believers: Can you imagine a world without managers? By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:24:36 +0530 What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important? Full Article Corporate File
ut Outgunning fake drugmakers By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 21:00:00 +0530 Stringent steps needed to keep India label safe from fly-by-night operators Full Article Pulse
ut ‘Our goal is beauty for each,’ says L’Oréal India chief By www.thehindubusinessline.com Published On :: Sat, 26 Oct 2024 13:11:01 +0530 Aseem Kaushik, who leads the global beauty giant in India, says tech is playing a big part in its personalisation journey Full Article Corporate File
ut Royal Enfield Bear 650: Out of the woods By www.thehindubusinessline.com Published On :: Sat, 09 Nov 2024 08:22:00 +0530 The Interceptor-based Royal Enfield Bear 650 might’ve crawled out of the woods but it seems to be pretty much in its comfort zone Full Article Auto focus
ut Nvidia: The lynchpin of the AI revolution By www.thehindubusinessline.com Published On :: Sat, 09 Nov 2024 18:18:47 +0530 The meteoric rise of the Santa Clara-headquartered chipmaker is powered by bold innovation Full Article Corporate File
ut GalaxEye: A multi-sensor peek at earth from outer space By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 20:36:55 +0530 Startup sets out to fill a crucial gap in satellite imagery for real-world applications Full Article Emerging Entrepreneurs
ut Jamiat cautions NDA partners, says ‘crutches’ cannot escape responsibility for Waqf Bill By www.thehindu.com Published On :: Mon, 04 Nov 2024 21:07:19 +0530 The Jamiat Ulama-i-Hind urged NDA partners TDP and JD(U) to heed Muslim sentiments on the contentious issue surrounding the Waqf (Amendment) Bill, 2024 Full Article India
ut HC tells jail authority to decide plea on lack of facilities for visiting lawyers By www.thehindu.com Published On :: Tue, 05 Nov 2024 01:10:55 +0530 Full Article Delhi
ut Police rule out communal angle in clash near Jahangirpuri temple By www.thehindu.com Published On :: Wed, 06 Nov 2024 00:15:57 +0530 Full Article Delhi
ut Delhi’s air pollution: vehicular emissions top contributor, says study By www.thehindu.com Published On :: Thu, 07 Nov 2024 01:07:48 +0530 Full Article Delhi
ut Delhi govt tests drone-based mist spraying to combat pollution By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:39:59 +0530 Pollution levels are elevated at 13 hotspots across Delhi, and this pilot project allows us to test drone-based mist spraying in areas where conventional anti-smog guns can't reach Full Article Delhi
ut Kejriwal gives clarion call to sarpanchs in Punjab to wipe out curse of drugs By www.thehindu.com Published On :: Fri, 08 Nov 2024 20:56:50 +0530 Opposition says AAP government has ‘mishandled and mismanaged’ every aspect of State administration Full Article Punjab
ut Delhi L-G lied in Supreme Court about tree felling: Bharadwaj By www.thehindu.com Published On :: Sat, 09 Nov 2024 00:39:15 +0530 Full Article Delhi
ut Kejriwal sounds bugle, reaches out to AAP workers before Delhi Assembly poll By www.thehindu.com Published On :: Sat, 09 Nov 2024 00:49:39 +0530 AAP chief asks supporters to devote as much time as possible to help the party win upcoming Delhi Assembly election, launches mobile number, website to register volunteers; playing victim card: BJP Full Article Delhi
ut Demonising Constitutional institutions pastime for some: Vice-President Jagdeep Dhankhar By www.thehindu.com Published On :: Sat, 09 Nov 2024 15:45:09 +0530 Addressing an event of an educational institution in New Delhi, the Vice-President said it is time to "bid adieu to this" Full Article India
ut Delhi govt okays proposal, 10000 Civil Defence Volunteers to return for anti-pollution work: Atishi By www.thehindu.com Published On :: Sat, 09 Nov 2024 16:27:20 +0530 Within two-three days of the registration, the CDVs will be deployed on duties like management of pollution hotspots, preventing dust pollution and garbage burning, she said in a press briefing Full Article Delhi
ut One dead, one injured in two firing incidents in Delhi within 10 minutes By www.thehindu.com Published On :: Sat, 09 Nov 2024 16:49:04 +0530 The two incidents of firing in northeast Delhi leave one dead and one injured; three suspects apprehended by police Full Article Delhi
ut Security upped outside Canadian High Commission due to protest against temple attack By www.thehindu.com Published On :: Sun, 10 Nov 2024 16:13:43 +0530 The Hindu Sikh Global Forum members are marching towards the High Commission in the Chanakyapuri area Full Article Delhi
ut Delhi Transport Minister Kailash Gahlot announces two new bus routes for outer Delhi By www.thehindu.com Published On :: Mon, 11 Nov 2024 01:31:06 +0530 Full Article Delhi
ut ‘No religion encourages an activity that creates pollution: SC on firecrackers By www.thehindu.com Published On :: Mon, 11 Nov 2024 15:28:47 +0530 The Supreme Court wondered why the Delhi Government delayed imposition of the ban on firecrackers till October 14, when the order of ban was issued Full Article Delhi
ut DUSU polls: Delhi HC allows vote counting; student outfits welcome move By www.thehindu.com Published On :: Tue, 12 Nov 2024 00:57:29 +0530 Court asks university to conclude the counting process by November 26; DU Registrar says work to restore defaced properties is almost complete Full Article Delhi
ut BharatPe fraud case: Delhi HC quashes lookout circular against Ashneer Grover, wife By www.thehindu.com Published On :: Tue, 12 Nov 2024 16:17:13 +0530 Full Article Delhi
ut Living in a world without work By www.thehindubusinessline.com Published On :: Sun, 19 Jul 2020 19:41:49 +0530 Cohabitation with machines is an inevitable future that awaits us. But is it going to be easy? Full Article Books
ut Cashing out of a business, smartly By www.thehindubusinessline.com Published On :: Sun, 09 May 2021 20:04:10 +0530 The book draws upon diverse experiences of entrepreneurs to highlight the need for an exit strategy Full Article Books
ut How individuals shape institutions By www.thehindubusinessline.com Published On :: Sun, 04 Jul 2021 21:01:55 +0530 RK Talwar, SBI’s legendary Chairman, inspired an entire generation of bankers Full Article Books
ut Rushdie’s trysts with truth By www.thehindubusinessline.com Published On :: Sun, 04 Jul 2021 21:03:45 +0530 Essays in meditation on story, storytelling and storytellers Full Article Books
ut ‘India has carved out its own path in foreign policy’ By www.thehindubusinessline.com Published On :: Sun, 08 Aug 2021 20:14:35 +0530 In his new book, former diplomat Vijay Keshav Gokhale throws fresh light on India-China relations since Independence Full Article Books
ut Interesting, but only in parts By www.thehindubusinessline.com Published On :: Sun, 29 Aug 2021 20:33:39 +0530 The profiling of 25 BITSians follows a templated style Full Article Books