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Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00297K, Research Article
Branislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea Nikolić
In this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.
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Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00562G, Research Article
Open Access
Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. Stevens
Flow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.
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Recent advances from computer-aided drug design to artificial intelligence drug design

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00522H, Review Article
Keran Wang, Yanwen Huang, Yan Wang, Qidong You, Lei Wang
CADD and AIDD contribute to the drug discovery.
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meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
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Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
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3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00597J, Research Article
Albert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken Witt
Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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HC directs authorities to maintain park and ensure no encroachment




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Deputy CM releases commemorative flag of Bharat Scouts and Guides




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Ernakulam Express to stop at Muthupettai during Kandhoori festival




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Power shutdown in parts of Tiruchi on November 9




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Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation




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Students cautioned against drug addiction




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551: PlanetScale with Iheanyi Ekechukwu and Mike Coutermarsh

Iheanyi Ekechukwu and Mike Coutermarsh talk about PlanetScale, what Vitess is, if PlanetScale is for both side and big projects, what read only regions are, what schema changes are, and how PlanetScale compares to other projects.




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562: Podcast Apps, Zaraz, Future CSS Thoughts, and Arc

What if Taylor Swift lyrics hold the answers to web dev questions? Podcast app thoughts, using Cloudflare Zaraz, what we're excited about with CSS, Arc browser updates, and are we even developers or are we specialized systems whisperers?




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570: Haircut Maintenance, Dave’s Bookshelf, Lazy Loading, and APIs

We're talking Dave's new haircut, playing Hondo, what Dave uses for images on his bookshelf page, lazy-loading thoughts, vh vw follow up, eyeball tracking updates, loading website with js, Vue transitions, charging for API access, and do you cross post, one post, or no post on social media in 2023?




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596: The Year of AI, Arc, and Being Mad About the Right Thing

Looking back at the year of AI, using Arc on macOS and now Windows, dreaming of subscriptions, and knowing how to be mad about the right thing.




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620: Cloudflare #HotDrama, Auth, and Prototyping Thoughts

Show DescriptionWe dive a bit deeper into the Cloudflare drama of the past couple of weeks, Instagram ads vs Cara art, what to do about Auth in your app, pre-negging any sponsorships, prototyping and feedback on projects, and ideas for future topics. Listen on Website →Links Cloudflare took down our website after trying to force […]




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638: Q&A About Copyright, Jekyll, Joomla, Statamic, and More!

Dave's designing a new tshirt, questions for lawyers about copyrights for code projects, what does the copyright in the footer actually do, what do Dave and Chris require for personal web projects, does Jekyll get updated anymore, the Bob from Hell UX pattern, viewing ads on CNN, what about Joomla or Statamic, and how do paid fonts on the web work?




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Building practices for the future

Sacred Groves in Auroville is being built using ecologically sensitive construction methods and material.




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Smart water solution

A bunch of Chennai students are making Paani Genie, a 90-litre water container that can be rolled along.




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Putting cholera back in focus

Surge in cholera cases renews attention on the need to fortify public health




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Flat organisation believers: Can you imagine a world without managers?

What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important?




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Outgunning fake drugmakers

Stringent steps needed to keep India label safe from fly-by-night operators




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‘Our goal is beauty for each,’ says L’Oréal India chief

Aseem Kaushik, who leads the global beauty giant in India, says tech is playing a big part in its personalisation journey




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Royal Enfield Bear 650: Out of the woods

The Interceptor-based Royal Enfield Bear 650 might’ve crawled out of the woods but it seems to be pretty much in its comfort zone




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Nvidia: The lynchpin of the AI revolution

The meteoric rise of the Santa Clara-headquartered chipmaker is powered by bold innovation




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GalaxEye: A multi-sensor peek at earth from outer space

Startup sets out to fill a crucial gap in satellite imagery for real-world applications




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Jamiat cautions NDA partners, says ‘crutches’ cannot escape responsibility for Waqf Bill

The Jamiat Ulama-i-Hind urged NDA partners TDP and JD(U) to heed Muslim sentiments on the contentious issue surrounding the Waqf (Amendment) Bill, 2024




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HC tells jail authority to decide plea on lack of facilities for visiting lawyers




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Police rule out communal angle in clash near Jahangirpuri temple




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Delhi’s air pollution: vehicular emissions top contributor, says study  




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Delhi govt tests drone-based mist spraying to combat pollution

Pollution levels are elevated at 13 hotspots across Delhi, and this pilot project allows us to test drone-based mist spraying in areas where conventional anti-smog guns can't reach




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Kejriwal gives clarion call to sarpanchs in Punjab to wipe out curse of drugs

Opposition says AAP government has ‘mishandled and mismanaged’ every aspect of State administration




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Delhi L-G lied in Supreme Court about tree felling: Bharadwaj




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Kejriwal sounds bugle, reaches out to AAP workers before Delhi Assembly poll

AAP chief asks supporters to devote as much time as possible to help the party win upcoming Delhi Assembly election, launches mobile number, website to register volunteers; playing victim card: BJP




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Demonising Constitutional institutions pastime for some: Vice-President Jagdeep Dhankhar

Addressing an event of an educational institution in New Delhi, the Vice-President said it is time to "bid adieu to this"




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Delhi govt okays proposal, 10000 Civil Defence Volunteers to return for anti-pollution work: Atishi

Within two-three days of the registration, the CDVs will be deployed on duties like management of pollution hotspots, preventing dust pollution and garbage burning, she said in a press briefing




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One dead, one injured in two firing incidents in Delhi within 10 minutes

The two incidents of firing in northeast Delhi leave one dead and one injured; three suspects apprehended by police




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Security upped outside Canadian High Commission due to protest against temple attack

The Hindu Sikh Global Forum members are marching towards the High Commission in the Chanakyapuri area




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Delhi Transport Minister Kailash Gahlot announces two new bus routes for outer Delhi




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‘No religion encourages an activity that creates pollution: SC on firecrackers

The Supreme Court wondered why the Delhi Government delayed imposition of the ban on firecrackers till October 14, when the order of ban was issued




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DUSU polls: Delhi HC allows vote counting; student outfits welcome move

Court asks university to conclude the counting process by November 26; DU Registrar says work to restore defaced properties is almost complete




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BharatPe fraud case: Delhi HC quashes lookout circular against Ashneer Grover, wife




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Living in a world without work

Cohabitation with machines is an inevitable future that awaits us. But is it going to be easy?




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Cashing out of a business, smartly

The book draws upon diverse experiences of entrepreneurs to highlight the need for an exit strategy




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How individuals shape institutions

RK Talwar, SBI’s legendary Chairman, inspired an entire generation of bankers




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Rushdie’s trysts with truth

Essays in meditation on story, storytelling and storytellers




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‘India has carved out its own path in foreign policy’

In his new book, former diplomat Vijay Keshav Gokhale throws fresh light on India-China relations since Independence




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Interesting, but only in parts

The profiling of 25 BITSians follows a templated style