ar Divergent syntheses of okaramines C, J, L, and S-U By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Accepted ManuscriptDOI: 10.1039/D0OB00587H, CommunicationXiao Wan Li, Tong xu Si, Ya-Ping Liu, Mingzhong Wang, Albert S. C. ChanThe total synthesis of six novel okaramines (C, J, L, and S-U) was accomplished with a precise synthesis scheme involving few steps and with practical yield of 6.7%-23.0%. The significance...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Synthesis of unsymmetrical benzils via palladium-catalysed α-arylation–oxidation of 2-hydroxyacetophenones with aryl bromides By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Advance ArticleDOI: 10.1039/D0OB00575D, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Takanori Matsuda, Souta OyamaUnsymmetrical benzils are synthesised by a one-pot tandem palladium-catalysed α-arylation and oxidation of 2-hydroxyacetophenones with aryl bromides.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Enantioselective Synthesis of Indanone Spiro-Isochromanone Derivatives via Dinuclear Zinc-Catalyzed Michael/Transesterification Tandem Reaction By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Accepted ManuscriptDOI: 10.1039/D0OB00541J, PaperXiao-Chao Yang, Meng Xu, Jin-Bao Wang, Meng-Meng Liu, Francois Mathey, Yuan-Zhao Hua, Mincan WangAn enantioselective Michael/transesterification tandem reaction of α-hydroxy indanones with ortho-ester chalcones was realized by dinuclear zinc catalysts. A series of enantiomerically pure spiro[indanone-2,3’-isochromane-1-one] derivatives were obtained in good yields with...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Insights into the secondary structures of lactam N-substituted stapled peptides By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Accepted ManuscriptDOI: 10.1039/D0OB00767F, CommunicationAldrin Vasco Vidal, Celia Gonzalez, Stefan Gröger, W Brandt, Jochen Balbach, Carlos Perez, Ludger A. Wessjohann, Daniel G. RiveraStapled peptides derived from the Ugi macrocyclization comprise a special class of cyclopeptides with an N-substituted lactam bridge cross-linking two amino acid side chains. Herein we report a comprehensive analysis...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3229-3233DOI: 10.1039/D0OB00265H, CommunicationYing Han, Yifan Da, Mingjia Yu, Yaping Cheng, Xin Wang, Jiale Xiong, Guoying Guo, Yan Li, Xianxing Jiang, Xiaoqing CaiAn anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motif via sortase-mediated ligation to enhance the clathrin-mediated endocytosis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic–inorganic inhibitors By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3288-3296DOI: 10.1039/C9OB02682G, PaperMatthew B. Minus, Haopei Wang, Jaime O. Munoz, Alexandra M. Stevens, Alicia E. Mangubat-Medina, Michael J. Krueger, Wei Liu, Moses M. Kasembeli, Julian C. Cooper, Mikhail I. Kolosov, David J. Tweardy, Michele S. Redell, Zachary T. BallRecurrence and drug resistance are major challenges in the treatment of acute myeloid leukemia (AML) that spur efforts to identify new clinical targets and active agents.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar The quasi-irreversible inactivation of cytochrome P450 enzymes by paroxetine: a computational approach By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3334-3345DOI: 10.1039/D0OB00529K, PaperEmadeldin M. Kamel, Al Mokhtar LamsabhiThe potency of paroxetine as a P450 inhibitor is mainly attributed to the availability of two active sites on its structure, its compatibility with P450's active site and the ease of its tight coordination to heme iron.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Direct recognition and sensitive detection of circular RNA with ligation-based PCR By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3269-3273DOI: 10.1039/D0OB00625D, CommunicationPengbo Zhang, Na Guo, Kejian Gao, Fengxia Su, Fangfang Wang, Zhengping LiA sensitive and specific method for circRNA detection is developed through the direct ligation of two ingeniously designed DNA probes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Visible light induced 3-position-selective addition of arylpropiolic acids with ethers via C(sp3)–H functionalization By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3258-3262DOI: 10.1039/D0OB00480D, CommunicationZi-juan Wan, Xiao-feng Yuan, Jun LuoAlthough the 2-position-selective decarboxylative coupling or addition of arylpropiolic acids with cyclic ethers has been intensively investigated, selective functionalization of arylpropiolic acids at the 3-position is still a big challenge.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Modular continuous flow synthesis of orthogonally protected 6-deoxy glucose glycals By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3254-3257DOI: 10.1039/D0OB00522C, CommunicationSubbarao Yalamanchili, Tu-Anh V. Nguyen, Nicola L. B. Pohl, Clay S. BennettThe use of a continuous flow platform for the rapid and highly efficient construction of differentially protected glycals from commercial sources is described.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar A visible-light-induced “on–off” one-pot synthesis of 3-arylacetylene coumarins with AIE properties By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3346-3353DOI: 10.1039/D0OB00479K, PaperXinjie Wu, Ming Jia, Mengmeng Huang, Jung Keun Kim, Zheng Zhao, Junkai Liu, Jinhu Xi, Yabo Li, Yangjie WuA mild one-pot approach to 3-arylacetylene coumarins with potential AIE activities was developed via photosensitizer-free photocatalysis and thermocatalysis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Base-promoted 1,6-conjugate addition of alkylazaarenes to para-quinone methides By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3354-3359DOI: 10.1039/D0OB00419G, PaperAmritha Rayaroth, Rajat Kumar Singh, Kalyanakrishnan A. V., Krishna Hari, Alagiri Kaliyamoorthy1,1,2-Triarylethanes embedded with an azaarene unit were prepared in a single step at ambient temperature via the sodium hexamethyldisilazide mediated 1,6-conjugate addition of unactivated alkylazaarenes on para-quinone methides (p-QMs).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Modular synthesis of oligoacetylacetones via site-selective silylation of acetylacetone derivatives By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3297-3302DOI: 10.1039/D0OB00501K, PaperParantap Sarkar, Yuya Inaba, Hayato Shirakura, Tomoki Yoneda, Yasuhide InokumaAliphatic oligoketones with tailored carbonyl and substituent sequences were modularly synthesized utilizing site-selective formation of enol silyl ethers. Their unique conformational preferences in solid-state were revealed by X-ray crystallography.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3263-3268DOI: 10.1039/D0OB00491J, CommunicationHua Yao, Bo Xie, Xiaoyang Zhong, Shengzhou Jin, Sen Lin, Zhaohua YanA new synthetic method toward direct C–N bond formation through saturated C–H amination of benzylic hydrocarbons and inactive aliphatic alkanes with primary aromatic amines under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3360-3366DOI: 10.1039/D0OB00494D, PaperZhen Yang, Jing He, Yueting Wei, Weiwei Li, Ping LiuA series of diverse fused [1,2,4]triazolo[3,4-c]quinoxalines was obtained by an efficient KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Dipyrazolodioxadiazocines as shelf-stable “ready-to-use” precursors for an in situ generation of enolate-iminium 1,4-dipoles: a straightforward atom-economical approach to pyrazolo[5,1-d][1,3,5]dioxazines By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, 18,3382-3391DOI: 10.1039/D0OB00451K, PaperVladimir E. Zhulanov, Valeria A. Vigovskaya, Maksim V. Dmitriev, Pavel S. Silaichev, Andrey N. Maslivets, Michael RubinGeneration of cyclic enolate-iminium 1,4-dipoles via thermolysis of dipyrazolodioxadiazocines in the presence of ketones allowed for efficient preparation of pyrazolo[5,1-d][1,3,5]dioxazines.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Controlling the liberation rate of the in situ release of a chemical fuel for the operationally autonomous motions of molecular machines By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Advance ArticleDOI: 10.1039/D0OB00669F, PaperChiara Biagini, Giorgio Capocasa, Daniele Del Giudice, Valerio Cataldi, Luigi Mandolini, Stefano Di StefanoAminolysis of the anhydride of 2-cyano-2-phenylpropanoic acid can be employed to conveniently regulate the liberation rate of the related acid which, in turn, can be used as a fuel for acid–base operated molecular machines.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Late-stage synthesis and application of photoreactive probes derived from direct benzoylation of heteroaromatic C–H bonds By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Advance ArticleDOI: 10.1039/D0OB00336K, CommunicationKevin D. Hesp, Jun Xiao, Graham M. WestA synthetically-driven, late-stage C–H benzoylation strategy for the expedited preparation and evaluation of heterocyclic alternatives to more classical benzophenone photoreactive probes is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Arylation of Indoles Using Cyclohexanones Dually-Catalyzed by Niobic Acid and Palladium-on-Carbons By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Accepted ManuscriptDOI: 10.1039/D0OB00702A, PaperKazuho Ban, Yuta Yamamoto, Hironao Sajiki, Yoshinari Sawama3-Arylindoles were easily constructed from indoles and cyclohexanone derivatives using a combination of catalytic niobic acid-on-carbon (Nb2O5/C) and palladium-on-carbon (Pd/C) under heating conditions without any oxidants. The Lewis acidic Nb2O5/C...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Hierarchical Self-Assembly of Azobenzene Dyad with Inverted Amide Connection into Toroidal and Tubular Nanostructures By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Accepted ManuscriptDOI: 10.1039/D0OB00833H, CommunicationShiki Yagai, Takuho SaitoInversion of the connectivity of amide groups in foldable azobenzene dyads with chiral side chains, which can self-assemble into toroids and nanotubes, significantly increases the thermal stability of these aggregates....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Efficient synthesis of a galectin inhibitor clinical candidate (TD139) using a Payne rearrangement/azidation reaction cascade By feeds.rsc.org Published On :: Org. Biomol. Chem., 2020, Accepted ManuscriptDOI: 10.1039/D0OB00910E, PaperJacob St-Gelais, Vincent Denavit, Denis GiguèreSelective galectin inhibitors are valuable research tools and could also be used as drug candidates. In that context, TD139, a thiodigalactoside galectin-3 inhibitor, is currently being evaluated clinically for the...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ar Man arrested for molesting Finnish woman in Jaipur By archive.indianexpress.com Published On :: Tue, 04 Aug 2009 12:04:40 GMT A person has been arrested in Jaipur for allegedly robbing and molesting a Finnish woman at a bar cum restaurant, police said. Full Article
ar Fire arm, opening an eatery: get licence application forms online By archive.indianexpress.com Published On :: Tue, 04 Aug 2009 12:11:15 GMT Now, getting a licence for a fire-arm or operating an eatery will be easy with Delhi Police on Tuesday launching a dedicated website for its Licencing Branch. Full Article
ar 70 per cent of teachers in Delhi schools are obese: survey By archive.indianexpress.com Published On :: Tue, 04 Aug 2009 12:27:25 GMT Nearly 70 per cent of schoolteachers in the national capital are overweight and obese, a recent survey has claimed. Full Article
ar Aspiring actor-cum-model arrested for killing IT professional By archive.indianexpress.com Published On :: Thu, 06 Aug 2009 14:26:17 GMT A 20-year-old aspiring actor- cum-model was arrested in the national capital for allegedly murdering a young woman IT professional a week ago after she refused to heed to his demand for money. Full Article
ar Mumbaikars usher in Ganesh amidst flu scare By archive.indianexpress.com Published On :: Sun, 23 Aug 2009 12:40:04 GMT Terror alerts and swine flu scare did not dampen the spirit of Mumbaikars as they welcomed the elephant headed-god. Full Article
ar Five-year-old survives 40-feet fall with minor scratches By archive.indianexpress.com Published On :: Tue, 10 Aug 2010 14:04:36 GMT A five-year old boy here survived a 40-feet fall from a multi-storeyed building with minor scratches. Full Article
ar 'I'd have done anything else other than write this book': Akhil Sharma By timesofindia.indiatimes.com Published On :: Mon, 16 Jun 2014 00:08:33 IST New York-based writer Akhil Sharma 's novel Family Life has received rave reviews. The autobiographical book traces the journey of a family that moves to the US from India, its eldest son suddenly suffering a freak accident. Full Article
ar 'In Nepal, some street children are controlled by gangs' By timesofindia.indiatimes.com Published On :: Tue, 17 Jun 2014 17:27:12 IST An unwanted child, a street urchin, a knife-wielding gang member and a child labourer — Basu Rai endured the vicissitudes of fate. But after his rescue and rehab, he dedicated his life to saving other street children. Full Article
ar Pak politicians want to resolve Kashmir — military won't allow this: Arif Jamal By timesofindia.indiatimes.com Published On :: Sun, 22 Jun 2014 00:06:17 IST Arif Jamal is a Pakistani journalist and South Asia expert based in America. Full Article
ar 'Advertising's art of persuasion — political ads will grow': Prasoon Joshi By timesofindia.indiatimes.com Published On :: Wed, 25 Jun 2014 00:04:34 IST Author and advertising authority headed the Titanium Lions jury at 2014's Cannes International Advertising Festival. Full Article
ar Women suffer sanitation absence most — also impacts economy: Bindeshwar Pathak By timesofindia.indiatimes.com Published On :: Fri, 27 Jun 2014 00:06:33 IST One month after the horrific Badaun gang rape exposed how gravely at risk women and minors lacking domestic toilets are. Full Article
ar Australia-India cricket rivalry has even bettered Ashes: John Harnden By timesofindia.indiatimes.com Published On :: Mon, 30 Jun 2014 00:00:17 IST CEO of the ICC World Cup 2015 John Harnden spoke with Amin Ali about ensuring excitement in cricket's mega-tournament, clamping down on racism, managing 'minnows' matches — and how Australia is sizing up India as a rival for the trophy. Full Article
ar Swiss accounts are a diversion. Bulk of black money is right here in India By timesofindia.indiatimes.com Published On :: Sun, 06 Jul 2014 06:49:59 IST The scent of 'black money' is in the air again. At the Supreme Court's order, Modi sarkar has set up a Special Investigation Team to look into cases of illegal outflow of money to foreign havens. Full Article
ar Singapore appoints Sikh as Army chief By timesofindia.indiatimes.com Published On :: Sat, 05 Mar 2011 15:02:25 IST Singapore has appointed Brigadier General Ravinder Singh as its next army chief, the first Sikh in nearly 30 years to be given the force's baton. Full Article
ar Hindu guru gets 14 years prison for sexual molestation in US By timesofindia.indiatimes.com Published On :: Wed, 09 Mar 2011 16:58:45 IST Absconding Indian godman Prakashanand Saraswati, also known as Shree Swamiji, has been sentenced to 14 years in prison and fined USD 10,000. Full Article
ar NRI dentist in UK faces charges of seducing patient By timesofindia.indiatimes.com Published On :: Tue, 15 Mar 2011 18:09:24 IST An NRI dentist, once the face of Oral B toothpaste and appears on a British TV show, has been accused of seducing a patient on the couch of his dental clinic and marital home, a disciplinary hearing was told. Full Article
ar Five-year-old Indian becomes millionaire By timesofindia.indiatimes.com Published On :: Tue, 22 Mar 2011 11:39:40 IST A five-year-old Indian boy has become a millionaire overnight after winning a lottery at a national bond draw here. Full Article
ar Australia's Victoria police inducts first turban wearing Sikh By timesofindia.indiatimes.com Published On :: Tue, 22 Mar 2011 17:19:51 IST Police in Australia's Victoria state today inducted its first officer from Sikh community who will wear a newly designed police turban, a media report said today. Full Article
ar Gujarati icing on Will-Kat wedding cake! By timesofindia.indiatimes.com Published On :: Mon, 28 Mar 2011 06:29:34 IST The royal wedding cake is set to have a Gujarati connection. It has emerged that Prince William and Kate Middleton have chosen a cake company run by a Gujarati in Leicestershire. Full Article
ar Lucknow zoo animals are more active in lockdown By timesofindia.indiatimes.com Published On :: Fri, 08 May 2020 04:45:00 IST Full Article
ar Kanpur baraat stuck in Bihar for 45 days By timesofindia.indiatimes.com Published On :: Fri, 08 May 2020 12:31:53 IST Khushbu Khatoon of Begusarai in Bihar was a happy bride after her nikah was solemnised with Kanpur's Imtiyaz on March 21. Full Article
ar Two more areas turn hotspots after 3 test +ve By timesofindia.indiatimes.com Published On :: Sat, 09 May 2020 08:07:45 IST Full Article
ar Covid warriors in Lucknow put duty before family By timesofindia.indiatimes.com Published On :: Sat, 09 May 2020 10:32:09 IST Full Article
ar UP: 63 flee quarantine centre, all traced By timesofindia.indiatimes.com Published On :: Sat, 09 May 2020 10:47:47 IST Full Article
ar UP: Heritage tag for 100-year-old trees By timesofindia.indiatimes.com Published On :: Sat, 09 May 2020 04:51:00 IST Full Article
ar Maharashtra: Major train accident averted on Urali-Loni route By timesofindia.indiatimes.com Published On :: Sat, 09 May 2020 19:10:34 IST The driver applied the emergency brakes after spotting around 20 people, including women sitting on a track, and some of them even walking with their luggage on the tracks. Full Article
ar Delhi govt says it will pay train fare of migrants By timesofindia.indiatimes.com Published On :: Sat, 09 May 2020 05:47:39 IST Delhi government on Friday said it would bear the cost of train travel of migrant workers if their home states didn’t respond on the issue. Full Article
ar Funds for salaries late, inadequate: DU colleges By timesofindia.indiatimes.com Published On :: Sat, 09 May 2020 04:30:00 IST For the second time this year, Delhi government has allegedly released inadequate funds for the salaries of teaching and non-teaching staff of 12 Delhi University colleges, that too after a month-long delay. Full Article
ar Tears of relief at IGI arrival and departure By timesofindia.indiatimes.com Published On :: Sat, 09 May 2020 04:56:00 IST At 12.05pm on Friday, Air India flight AI-381 made a smooth landing at Indira Gandhi International Airport. Though half an hour late in arriving, the 234 passengers from Singapore were delighted to step on home soil after two months of anxiety and uncertainty. Their relatives weren’t allowed to meet them, and yet the relief of being back in India made them grin, wave their hands and give the thumbs up sign. Full Article