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Synthesis of methylene cyclopropane-fused chromenes and dihydroquinolines by sequential [4 + 2]- and [1 + 2]-annulation

Org. Biomol. Chem., 2020, 18,3303-3311
DOI: 10.1039/D0OB00389A, Paper
Tianyu Lu, Xuange Zhang, Zhiwei Miao
A base promoted sequential [4 + 2]- and [1 + 2]-annulation of 2-hydroxychalcones or 2-tosylaminochalcones with prop-2-ynylsulfonium salts was developed.
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A visible-light-induced “on–off” one-pot synthesis of 3-arylacetylene coumarins with AIE properties

Org. Biomol. Chem., 2020, 18,3346-3353
DOI: 10.1039/D0OB00479K, Paper
Xinjie Wu, Ming Jia, Mengmeng Huang, Jung Keun Kim, Zheng Zhao, Junkai Liu, Jinhu Xi, Yabo Li, Yangjie Wu
A mild one-pot approach to 3-arylacetylene coumarins with potential AIE activities was developed via photosensitizer-free photocatalysis and thermocatalysis.
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Base-promoted 1,6-conjugate addition of alkylazaarenes to para-quinone methides

Org. Biomol. Chem., 2020, 18,3354-3359
DOI: 10.1039/D0OB00419G, Paper
Amritha Rayaroth, Rajat Kumar Singh, Kalyanakrishnan A. V., Krishna Hari, Alagiri Kaliyamoorthy
1,1,2-Triarylethanes embedded with an azaarene unit were prepared in a single step at ambient temperature via the sodium hexamethyldisilazide mediated 1,6-conjugate addition of unactivated alkylazaarenes on para-quinone methides (p-QMs).
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Synthesis of phenanthridines by I2-mediated sp3 C–H amination

Org. Biomol. Chem., 2020, 18,3312-3323
DOI: 10.1039/D0OB00433B, Paper
Benyao Fang, Jiao Hou, Jinyue Tian, Wenquan Yu, Junbiao Chang
An I2-mediated transition-metal-free sp3 C–H amination reaction is established for phenanthridine synthesis in an efficient and scalable manner.
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Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines

Org. Biomol. Chem., 2020, 18,3263-3268
DOI: 10.1039/D0OB00491J, Communication
Hua Yao, Bo Xie, Xiaoyang Zhong, Shengzhou Jin, Sen Lin, Zhaohua Yan
A new synthetic method toward direct C–N bond formation through saturated C–H amination of benzylic hydrocarbons and inactive aliphatic alkanes with primary aromatic amines under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed.
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Synthesis of α-CF3-substituted E-dehydroornithine derivatives via copper(I)-catalyzed hydroamination of allenes

Org. Biomol. Chem., 2020, 18,3274-3280
DOI: 10.1039/D0OB00580K, Paper
Anna N. Philippova, Daria V. Vorobyeva, Florian Monnier, Sergey N. Osipov
Novel α-CF3-substituted E-dehydroornithine derivatives have been synthesized via the Cu(I)-catalyzed hydroamination of α-CF3-α-allenyl-α-aminocarboxylates/phosphonates with different amines.
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Dipyrazolodioxadiazocines as shelf-stable “ready-to-use” precursors for an in situ generation of enolate-iminium 1,4-dipoles: a straightforward atom-economical approach to pyrazolo[5,1-d][1,3,5]dioxazines

Org. Biomol. Chem., 2020, 18,3382-3391
DOI: 10.1039/D0OB00451K, Paper
Vladimir E. Zhulanov, Valeria A. Vigovskaya, Maksim V. Dmitriev, Pavel S. Silaichev, Andrey N. Maslivets, Michael Rubin
Generation of cyclic enolate-iminium 1,4-dipoles via thermolysis of dipyrazolodioxadiazocines in the presence of ketones allowed for efficient preparation of pyrazolo[5,1-d][1,3,5]dioxazines.
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Late-stage synthesis and application of photoreactive probes derived from direct benzoylation of heteroaromatic C–H bonds

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00336K, Communication
Kevin D. Hesp, Jun Xiao, Graham M. West
A synthetically-driven, late-stage C–H benzoylation strategy for the expedited preparation and evaluation of heterocyclic alternatives to more classical benzophenone photoreactive probes is reported.
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Dienaminodioate based multicomponent reactions with post-benzylic oxidative transformations mediated by DDQ

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00721H, Paper
Jaice Ravindran, Velickakathu Yadhukrishnan, Reghuvaran Asha , Ravi Shankar Lankalapalli
Multicomponent reactions (MCRs) using dienaminodioate with post-benzylic oxidative transformation by DDQ that afforded a diverse array of products is described. An unprecedented rearrangement of 1,2-dihydropyridines (1,2-DHPs), 3CR products, to 2-pyridones...
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Synthesis of gem-difluoroalkenes via nickel-catalyzed allylic defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00535E, Communication
Xiao-Yu Lu, Run-Chuang Jiang, Jia-Mei Li, Chuang-Chuang Liu, Qing-Qing Wang, Hai-Pin Zhou
A nickel-catalyzed defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides has been developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Hierarchical Self-Assembly of Azobenzene Dyad with Inverted Amide Connection into Toroidal and Tubular Nanostructures

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00833H, Communication
Shiki Yagai, Takuho Saito
Inversion of the connectivity of amide groups in foldable azobenzene dyads with chiral side chains, which can self-assemble into toroids and nanotubes, significantly increases the thermal stability of these aggregates....
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Correction: Nickel-catalyzed cyanation of phenol derivatives activated by 2,4,6-trichloro-1,3,5-triazine

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB90052D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Liang Wang, Yaoyao Wang, Jun Shen, Qun Chen, Ming-Yang He
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Efficient synthesis of a galectin inhibitor clinical candidate (TD139) using a Payne rearrangement/azidation reaction cascade

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00910E, Paper
Jacob St-Gelais, Vincent Denavit, Denis Giguère
Selective galectin inhibitors are valuable research tools and could also be used as drug candidates. In that context, TD139, a thiodigalactoside galectin-3 inhibitor, is currently being evaluated clinically for the...
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TN woman seeks Rs 1 cr compensation from AIDS society

A housewife has moved the Madras High Court seeking Rs 1 crore as compensation and a public apology from the Tamil Nadu AIDS Control Society.




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Fire arm, opening an eatery: get licence application forms online

Now, getting a licence for a fire-arm or operating an eatery will be easy with Delhi Police on Tuesday launching a dedicated website for its Licencing Branch.




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70 per cent of teachers in Delhi schools are obese: survey

Nearly 70 per cent of schoolteachers in the national capital are overweight and obese, a recent survey has claimed.




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Delhi: 2 schools closed after students test positive for H1N1 virus

Two city schools have been closed for a week from Monday after a student each from the educational institution tested positive for swine flu.




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'In Nepal, some street children are controlled by gangs'

An unwanted child, a street urchin, a knife-wielding gang member and a child labourer — Basu Rai endured the vicissitudes of fate. But after his rescue and rehab, he dedicated his life to saving other street children.




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Cos use foreign money for political funding. Isn’t that influencing polls?

A recent Intelligence Bureau (IB) report has claimed that some well-known NGOs are working to stall economic development at the behest of their foreign donors. Activists and rights groups have been up in arms ever since the report was leaked.




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Women suffer sanitation absence most — also impacts economy: Bindeshwar Pathak

One month after the horrific Badaun gang rape exposed how gravely at risk women and minors lacking domestic toilets are.




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Australia-India cricket rivalry has even bettered Ashes: John Harnden

CEO of the ICC World Cup 2015 John Harnden spoke with Amin Ali about ensuring excitement in cricket's mega-tournament, clamping down on racism, managing 'minnows' matches — and how Australia is sizing up India as a rival for the trophy.




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Officials to pay for illegal building: Venkaiah Naidu

The Centre will push for key reforms including the provision of incentivising civic agencies for good work & making officials concerned accountable for illegal construction or unauthorized development under their jurisdiction.




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India needn't follow West's energy model — have a new path: ​Sam Tranum

There's a fundamental mismatch between India's energy resources and the needs of its people and companies for energy.




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The BJP-PDP government is a people’s alliance: Mehbooba Mufti

PDP president Mehbooba Mufti is seen as the power behind the new PDP-BJP government in Jammu & Kashmir.




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Indian-American scientists develop alternative to radio tags

A team of Indian-American scientists has developed a smart tracking system, which could very well provide an honourable alternative to the radio tags.




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S African-Indian women get 3-yr jail for fraud

An Indian-origin woman and her mother were sentenced to three years in prison by a South African court, which found them guilty of arranging a fake certificate of marriage to inherit property of their landlord, who died of poisoning.




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NRI dentist in UK faces charges of seducing patient

An NRI dentist, once the face of Oral B toothpaste and appears on a British TV show, has been accused of seducing a patient on the couch of his dental clinic and marital home, a disciplinary hearing was told.




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Indian-origin model accuses Aus modelling agency of racism

According to a report in the local daily, Kema Rajandran was told by a Parth-based modelling agency that her work chances were "limited" in the country because she was not Caucasian.




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Indian dentists caught in UK red tape

Several dentists from India and other non-EU countries have been caught in bureaucratic wrangles between professional governing bodies in Britain, a leading migrants campaign group said today.




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UP: 1 dies, 6 hurt in three accidents on e-way

Three back-to-back road accidents on Agra-Lucknow Expressway on Friday left one dead and many injured.




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Denied treatment, woman gives birth on roadside

A woman delivered her child on the roadside after she was allegedly denied treatment by doctors here, police said on Friday. Kiran (35) delivered the baby at around 11 am on the roadside at Katra Bazar in Shikohabad area of the district, they said.




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UP: 63 flee quarantine centre, all traced




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Prayagraj: Two teenage girls drown in Ganga




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Maharashtra: Major train accident averted on Urali-Loni route

The driver applied the emergency brakes after spotting around 20 people, including women sitting on a track, and some of them even walking with their luggage on the tracks.




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E-tokens fail to take off; liquor shops see rush

Booze lovers continued to throng liquor shops in the city, even as the e-token system introduced by the Delhi government could not fully take off due to heavy traffic on the designated website.




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3 more Delhi pvt hosps to treat corona patients




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Indian researchers start working on genome sequencing of novel coronavirus

In the next 3-4 weeks researchers would be able to get at least 200-300 isolates and this information would help them to make some further conclusion about the behaviour of this virus.




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Govt invites startups, innovators to develop a world-class video conferencing solution

The winners will receive Rs 1 crore in the first year and additional support @ Rs 10 lakhs per year towards Operations & Maintenance.




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Astronomers detect gravitational waves when Black Holes with asymmetric masses collided

The detection of Gravitational-wave in a collision between two black holes of substantially different masses has made astronomers excited.




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USGS releases first comprehensive geological map of moon using Apollo data

The new map explains the 4.5-billion-year-old history of our neighbour in space.




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COVID-19 gene detected in air pollutants: Study

The study was led by led by Leonardo Setti of the University of Bologna in Italy.




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NASA's Hubble captures breakup of comet ATLAS into more than two dozen pieces

Hubble identified about 30 fragments on April 20, and 25 pieces on April 23.




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YouTube sensation PewDiePie signs exclusive live-streaming deal with the video-sharing platform

In the month of Jan, he announced a break from YouTube but continued posting his regular videos after his break.




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Astronomers discover closest black hole to earth, can be seen with naked eye

The finding was published in the journal Astronomy & Astrophysics.




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PUBG Mobile India Series 2020: Prize money, date of tournament and registration details

The tournament has a Rs 50 lakh prize pool.




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The BEST MOMENTS of Aahana Kumra's Life

"From a very early age, I imagined myself playing powerful characters," she says, and she proves it with her filmography.





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When McSher met Thor...

'When I met him, I was a behaving like a 16 year old!''He is incredible, very casual and chilled out.''He told me he would watch Gully Boy and then he said a dialogue from Gully Boy, 'Bahut hard!'.'