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Variety corn line HID3483

The present invention provides an inbred corn line designated HID3483, methods for producing a corn plant by crossing plants of the inbred line HID3483 with plants of another corn plant. The invention further encompasses all parts of inbred corn line HID3483, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line HID3483, and plants produced according to these methods.




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Variety corn line KLI6131

The present invention provides an inbred corn line designated KLI6131, methods for producing a corn plant by crossing plants of the inbred line KLI6131 with plants of another corn plant. The invention further encompasses all parts of inbred corn line KLI6131, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line KLI6131, and plants produced according to these methods.




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Variety corn line KDL6289

The present invention provides an inbred corn line designated KDL6289, methods for producing a corn plant by crossing plants of the inbred line KDL6289 with plants of another corn plant. The invention further encompasses all parts of inbred corn line KDL6289, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line KDL6289, and plants produced according to these methods.




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Plants and seeds of corn variety CV052803

According to the invention, there is provided seed and plants of the corn variety designated CV052803. The invention thus relates to the plants, seeds and tissue cultures of the variety CV052803, and to methods for producing a corn plant produced by crossing a corn plant of variety CV052803 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV052803 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV052803.




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Plants and seeds of canola variety SCV435009

In an embodiment, the invention relates to the seeds, plants, and plant parts of canola variety SCV435009 and to methods for producing a canola plant produced by crossing canola variety SCV435009 with itself or with another canola variety. The invention also relates to methods for producing a canola plant containing in its genetic material one or more transgenes and to the transgenic canola plants and plant parts produced by those methods. This invention also relates to canola varieties or breeding lines and plant parts derived from canola variety SCV435009, to methods for producing other canola varieties, lines or plant parts derived from canola variety SCV435009 and to the canola plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid canola seeds, plants and plant parts produced by crossing the variety SCV435009 with another canola variety.




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Soybean variety A1035446

The invention relates to the soybean variety designated A1035446. Provided by the invention are the seeds, plants and derivatives of the soybean variety A1035446. Also provided by the invention are tissue cultures of the soybean variety A1035446 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety A1035446 with itself or another soybean variety and plants produced by such methods.




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Plants and seeds of hybrid corn variety CH715413

According to the invention, there is provided seed and plants of the hybrid corn variety designated CH715413. The invention thus relates to the plants, seeds and tissue cultures of the variety CH715413, and to methods for producing a corn plant produced by crossing a corn plant of variety CH715413 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH715413.




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Variety corn line FX8609

The present invention provides an inbred corn line designated FX8609, methods for producing a corn plant by crossing plants of the inbred line FX8609 with plants of another corn plant. The invention further encompasses all parts of inbred corn line FX8609, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line FX8609, and plants produced according to these methods.




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Variety corn line MFX7589

The present invention provides an inbred corn line designated MFX7589, methods for producing a corn plant by crossing plants of the inbred line MFX7589 with plants of another corn plant. The invention further encompasses all parts of inbred corn line MFX7589, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line MFX7589, and plants produced according to these methods.




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Wheat variety W030377L1

A wheat variety designated W030377L1, the plants and seeds of wheat variety W030377L1, methods for producing a wheat plant produced by crossing the variety W030377L1 with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety W030377L1 with another wheat line or plant, and the creation of variants by mutagenesis or transformation of variety W030377L1. This invention also relates to methods for producing other wheat varieties or breeding lines derived from wheat variety W030377L1 and to wheat varieties or breeding lines produced by those methods.




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Osteospermum and Dimorphoteca plants having an altered flower phenotype

The present invention relates to an Osteospermum and Dimorphoteca plant, seed, variety, and hybrid. Another aspect of the present invention relates to an Osteospermum and Dimorphoteca plant having a mutant allele designated KLEDF which results in an altered flower phenotype. The invention also relates to crossing Osteospermum and Dimorphoteca plants containing the KLEDF mutant allele with other Osteospermum and Dimorphoteca plants lacking the KLEDF mutant allele to produce intergeneric and interspecific hybrids. This invention further relates to specific lines of Osteospermum varieties exhibiting the altered-flowering phenotype. Furthermore, the invention relates to pollen, seed, and sexual, as well as asexual progeny of such plants with altered flowers. In addition, the invention relates to methods for propagating said plants and to uses of said plants.




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Lug type extruder screw

An extruder screw that enables mixing of viscous materials, such as rubber mixtures and thermoplastic materials, is disclosed. The screw includes a core extending from a sealing end to a nose cone end. At least one flight extends radially from the core in a quasi-helical pattern, wherein flights adjacent one another form channels therebetween. A plurality of elongate lugs extend radially from the core and are disposed in the channels. The shape as well as the number of lugs can be varied to ensure the requirements for a thorough and turbulent deflection and mixing of the material stream.




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Method and apparatus for high intensity ultrasonic treatment of baking materials

The present invention discloses a high intensity ultrasonic treatment method and apparatus that is used in conjunction with an existing commercial dough or batter mixer to enhance the rheological, aeration and textural properties of the dough or batter. This change in properties is a result of the phenomenon of acoustic cavitation induced in the dough or batter by treatment with high intensity ultrasonic waves. The present invention discloses a mixing bowl (20) of an existing mixer system that is preloaded with dough or batter, the bowl (20) is located at the center of an ultrasonic bath tank (101) filled with a working fluid. The effect of ultra-sonic waves with power levels above 1 kW can be observed over the entire or partial mixing period of the dough or batter. The ultra-sonic waves of the present invention are generated by a plurality of ultrasonic wave generators (104A, 104B) and piezoelectric transducers (1) mounted on a stainless steel tank (101). The electrical energy received in each transducer (1) will be converted into appropriate mechanical expansion and contractions in the piezoelectric ceramics of the transducer (1) thus leading to pressure waves being transmitted to the dough or batter to be mixed. The generation and transmission of high intensity ultrasonic waves to the dough or batter affects its rheological, aeration and textural properties.




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Dinitroxide-type biradical compounds optimized for dynamic nuclear polarization (DNP)

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.




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Synthesis of MSE-framework type molecular sieves

A method of synthesizing a crystalline molecular sieve having an MSE framework type comprises crystallizing a reaction mixture comprising a source of water, a source of an oxide of a tetravalent element, Y, selected from at least one of silicon, tin, titanium, vanadium, and germanium, optionally a source of a trivalent element, X, a source of an alkali or alkaline earth metal, M, and a source of organic dications, Q, such as 3-hydroxy-1-(4-(1-methylpiperidin-1-ium-1-yl)butyl)quinuclidin-1-ium, 3-hydroxy-1-(5-(1-methylpiperidin-1-ium-1-yl)pentyl)quinuclidin-1-ium, 1,1'-(butane-1,4-diyl)bis(1-methylpiperidin-1-ium), 1,1'-(pentane-1,5-diyl)bis(1-methylpiperidin-1-ium), 1,1'-(hexane-1,6-diyl)bis(1-methylpiperidin-1-ium), and 1,1'-((3as,6as)-octahydropentalene-2,5-diyl)bis(1-methylpiperidin-1-ium).




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Compositions of protein receptor tyrosine kinase inhibitors

The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF receptor TrkA.




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Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators

The present disclosure relates to Oxime-Substituted Quinoxaline-Type Piperidine Compounds, such as those of Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R20, R21, Q, Y1, Z, A, B, and a are as defined herein; compositions comprising an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound.




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Phenoxyisobutyric acid compounds and method of synthesis

The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).




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Form tap having a plurality of lobes

A form tap for tapping an article may include a longitudinal shank having a mounting end opposite a tip, the shank having a shank length, and a thread portion with a plurality of threads for engaging a surface of the article. The thread portion includes a first region, a second region and a third region. The form tap includes a plurality of lobes extending though the first and second regions from the tip to the second region end, the lobes being spaced circumferentially around the shank and lying on a crest circumference. Each lobe may be disposed between respective first and second convex relief portions and each relief portion may be spaced radially inward from the crest circumference. Each lobe has a lobe width, the lobe width at the second region end being greater than the lobe width at the tip. The third region is free of lobes.




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High sensitivity eddy current monitoring system

A method of chemical mechanical polishing a substrate includes polishing a metal layer on the substrate at a polishing station, monitoring thickness of the metal layer during polishing at the polishing station with an eddy current monitoring system, and controlling pressures applied by a carrier head to the substrate during polishing of the metal layer at the polishing station based on thickness measurements of the metal layer from the eddy current monitoring system to reduce differences between an expected thickness profile of the metal layer and a target profile, wherein the metal layer has a resistivity greater than 700 ohm Angstroms.




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Lubricant base stocks with improved filterability

Provided for are lubricant base stocks with improved filterability. The lubricant base stock includes a bright stock and an effective amount of a heavy neutral. The filterability of the base stock as measured by the Membrane Filtration Method is less than or equal to 400 seconds. Also provided for are lubricating oils with improved filterability and methods of improving the filterability of lubricant base stocks.




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Ethylene based copolymer compositions as viscosity modifiers and methods for making them

Polymeric compositions and methods for making and using the same are provided. The polymeric composition can include a first ethylene-based copolymer and a second ethylene-based copolymer. The first ethylene-based copolymer can have a weight percent of ethylene-derived units based on a weight of the polymeric composition (EA) ranging from about 35 wt % to about 52 wt % and a weight-average molecular weight (MwA) of less than or equal to 130,000. The second ethylene-based copolymer can have a weight percent of ethylene-derived units based on the weight of the polymeric composition (EB) ranging from about 65 wt % to about 85 wt % and a weight-average molecular weight (MwB) of less than 130,000.




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Process for producing ketones from fatty acids

The invention relates to a process for producing ketones or hydrocarbon base oil from fatty acids preferably derived from a biological origin or other renewable source. The process is directed at making an aliphatic ketone or a mixture of aliphatic ketones having 14 to 52 carbon atoms, comprising a ketonization reaction of a fatty acid in a vapor phase with a decarboxylation-coupling catalyst to provide ketones, which can be deoxygenated to give saturated hydrocarbons, unsaturated hydrocarbons, and mixtures thereof. Base oils and transportation fuels may be produced from the process herein.




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Chain-type tool magazine

A chain-type magazine includes a box, a chain-type conveyor and a spinning unit. The box includes a port defined therein. The chain-type conveyor includes links connected to one another so that each of the links can be pivoted relative to the other links about two axes in parallel to each other. A tool can be inserted in a holder inserted in each of the links. The spinning unit includes a mounting assembly, an elevating assembly, a rotary claw assembly and a connecting rod. The mounting assembly is connected to the box. The elevating assembly is movably connected to the mounting assembly. The rotary claw assembly is rotationally connected to the mounting assembly for catching a selected one of the links. The connecting rod connects the elevating assembly to the rotary claw assembly. The driving element drives the elevating assembly to spin the rotary claw assembly.




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Machine tool including a plurality of tool spindles and a frame shaped rack

The invention relates to a machine tool (1), comprising a plurality of fixed tool spindles (3) and such that can optionally be displaced from a retracted idle position to an extended working position and can be positioned at different positions in a frame-like rack (2), and a workpiece carrier (4) with at least one workpiece holder (5), with the workpiece (4) carrier being movable at least in several axes in a translational manner and preferably also in a rotational manner. In order to provide advantageous constructional conditions it is proposed that at least one of the tool spindles (3) is associated with a tool magazine (7) plus tool changer (8).




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Chain-type bit-storing apparatus

A machine tool is provided with a chain-type bit-storing apparatus which includes a frame, two sprockets, a chain and a pivoting unit. The frame includes a cutout. The sprockets are placed in the frame. The chain is driven by the sprockets. The chain includes links each including a socket for containing a bit, two plates for supporting the socket, first and second blocks placed between the plates, first and second bearing units for rotationally supporting the first and second blocks on the plates, and a connecting unit for pivotally connecting the first block thereof to the second block of an adjacent link. The pivoting unit is used to pivot the socket of a selected one of the links to move an open end of the socket out of the frame through the cutout.




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Optical network terminal management control interface-based passive optical network security enhancement

A network component comprising at least one processor coupled to a memory and configured to exchange security information using a plurality of attributes in a management entity (ME) in an optical network unit (ONU) via an ONU management control interface (OMCI) channel, wherein the attributes provide security features for the ONU and an optical line terminal (OLT). Also included is an apparatus comprising an ONU configured to couple to an OLT and comprising an OMCI ME, wherein the OMCI ME comprises a plurality of attributes that support a plurality of security features for transmissions between the ONU and the OLT, and wherein the attributes are communicated via an OMCI channel between the ONU and the OLT and provide the security features for the ONU and the OLT.




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Redundancy and interoperability in multi-channel optoelectronic devices

A multi-channel optoelectronic device is configured to establish a redundant status link with a remote device. The optoelectronic device can transmit N transmit optical signals to the remote device over a plurality of transmit channels and receive N receive optical signals from the remote device over a plurality of receive channels. The optoelectronic device includes one or more spare transmit and receive channels. When used with a remote device having spare transmit and receive channels, each device can establish a status link with the other and use the status link to switch out transmit and/or receive channels to identify and permanently switch out the worst transmit and/or receive channels. Alternately, the device can interoperate with a non-status-link enabled remote device by determining that the remote device is not status-link enabled, transitioning to a low transmit power mode, and transmitting and receiving over a plurality of default transmit and receive channels.




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Optical module having a plurality of optical sources

An optical module that outputs a wavelength multiplexed optical signal is disclosed. The optical module provides at least first to third optical source, a wavelength multiplexer, a polarization rotator, and a polarization multiplexer. The optical sources each outputting first to third optical signals with a wavelength different from others. The wavelength multiplexer multiplexes the first optical signal with the third optical signal. The polarization rotator rotates the polarization vector of one of the multiplexed first and third optical signals and the second signal by substantially 90°. The polarization multiplexer multiplexes the polarization rotated optical signal with the second optical signal.




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Cutting edge replacement type groove forming tool and end face groove forming method

A cutting insert (130) is formed to be rotationally symmetric with respect to an axis line (C3) of a height direction and to be planarly symmetric with respect to a virtual plane of the insert (VS1), an axis line (C2) of a traverse direction is gradually inclined toward the front of a rotational direction around which a workpiece (W) rotates moving toward a first traverse direction (C2A), an axis line (C1) of a longitudinal direction extends toward a lower surface side of an insert body (131) so as to approach a virtual plane of the tool moving toward a first longitudinal direction (C1A), and one corner portion (143C) in the other cutting edge (132B) is disposed further toward a first traverse direction (C2A) than one corner portion (143A) in one cutting edge (132A).




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Reflection type optical sensor and image generation apparatus

A reflection type optical sensor that detect a surface condition of a moving body and that is used for an image generation apparatus which forms images on a recording media includes a light-emitting device which has a plurality of light emitter systems including at least two light-emitting members and a light-emitting optical system having a plurality of light-emitting lenses corresponding to a plurality of the light emitter systems and guiding light emitted from the light emitter systems to the moving body and a light-receiving device which has a light receiver system including at least two light-receiving members and a light-receiving optical system having light-receiving lenses corresponding to the at least two light-receiving members and guiding light reflected by the moving body to the light receiver system. The image generation apparatus has further a surface condition judging device in addition to the reflection type optical sensor.




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Laminated plasmon generator with cavity process

A plasmon generator (PG) is disclosed with a laminated structure of non-planar X and Y layers formed between a waveguide and write pole. Each X layer is made of a noble metal such as Au while each Y layer is a non-noble metal or dielectric material to improve durability. As a result, the PG has a peg portion at an air bearing surface with improved reliability compared with pegs made entirely of a noble metal. Non-planarity of X and Y layers improves diffusion of Y material between X grains thereby minimizing X grain growth to enhance thermal stability. The laminated PG is formed by a process sequence that involves forming and filling a cavity, and concludes with a chemical mechanical polish process to form a planar top PG surface that faces a write pole leading side.




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Extendible tourniquet cuff with stabilizer for improved utility and safety

A surgical tourniquet cuff that includes a stabilizer component that facilitates application of an overlapping cuff around the limb of a patient. The stabilizer is fixed to the cuff, and requires no tying or similar user manipulation to secure the overlapping cuff in alignment with the underlying cuff. The stabilizer improves the stability of the inflated cuff to prevent sideways shifting motion of overlapping cuff portions as the cuff is applied to the limb. The stabilizer also provides a handle mechanism to enable the user to snugly apply the overlapping cuff around the patient's limb while the overlapping portions remain properly aligned along their long axes. The stabilizer is designed to also facilitate attaching together two tourniquet cuffs end-to-end, with respective bladders overlapping and in proper alignment so that those attached cuffs can be used as a single, extended surgical cuff applied around a patient's limb.




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Method for restoring activity to a spent hydroprocessing catalyst, a spent hydroprocessing catalyst having restored catalytic activity, and a hyrdoprocessing process

A regenerated spent hydroprocessing catalyst treated with a chelating agent and having incorporated therein a polar additive.




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Use of oils with high concentrations of polyunsaturated fatty acids in plastics and surface coatings

Oil compositions having a high concentration of polyunsaturated fatty acids are described for use in various applications including use as drying oils, in ink compositions and coating compositions. Oil compositions wherein the double bonds of the fatty acids are substantially epoxidized are described and used as plasticizers and thermal stabilizers for various halogenated polymer compositions.




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Ocular implants with asymmetric flexibility

An ocular implant having an inlet portion and a Schlemm's canal portion distal to the inlet portion, the inlet portion being disposed at a proximal end of the implant and sized and configured to be placed within an anterior chamber of a human eye, the Schlemm's canal portion being arranged and configured to be disposed within Schlemm's canal of the eye when the inlet portion is disposed in the anterior chamber.




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Method for the improvement of mesh implant biocompatibility

The present invention provides a method of fixating a mesh implant to a tissue of a subject comprising attaching said mesh implant to said tissue, covering said mesh implant by an antiadhesive barrier, wherein said antiadhesive barrier is attached to said mesh implant by a biocompatible adhesive.




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Compact multifunctional ligand to enhance colloidal stability of nanoparticles

A ligand design allows compact nanoparticle materials, such as quantum dots (QDs), with excellent colloidal stability over a wide range of pH and under high salt concentrations. Self-assembled biomolecular conjugates with QDs can be obtained which are stable in biological environments. Energy transfer with these ligands is maximized by minimizing distances between QDs/nanoparticles and donors/acceptors directly attached to the ligands or assembled on their surfaces.




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Safety device for detecting electrode breakage

The invention relates to a safety device (1) for detecting electrode breakage in an electric arc furnace, wherein an electrode (6) is secured on an electrode support arm (4), and wherein a conduit is filled with a medium under a constant pressure and a pressure drop is produced at an electrode breakage, which is detected as an alarm signal. Here, the conduit (7a-d,3) is integrated in a protective component that is arranged beneath the electrode support arm (4) thereon, wherein in case of an electrode breakage, the conduit (7a-d,3) is damaged by a produce electric arc and the pressure drop takes place.




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Electronic circuit and method of supplying electricity

The invention relates to an electronic circuit and a method for feeding power to at least one electrode of an alternating-current electric-arc furnace, particularly for melting metal. Known circuits of this type typically comprise a series connection with a transformer for providing a supply voltage for the electric-arc furnace from a power grid (1) and a AC power controller (8) connected between the transformer (6) and the electrode (11) for regulating the current through the electrode (11). According to the invention, a further development for such electronic circuits is proposed, which development has a simple design, is inexpensive and prevents overload of the AC power controller (8) even in operating modes of the electric-arc furnaces at high electrode currents. This further development provides to bypass the AC power controller with a bypass switch (9) that is opened or closed with the help of a controller as a function of the amount of current flowing through the electrode (11).




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Constant velocity joint torsional damper

A constant velocity joint including an outer race having inner and outer surfaces, the inner surface including a plurality of outer bail tracks. The constant velocity joint also includes an inner race having a plurality of inner ball tracks which correspond to the outer ball tracks, a ball cage disposed between the outer race and the inner race, a plurality of balls arranged within the ball cage and contacting the outer ball tracks and the inner ball tracks. A damping assembly is connected to the outer race.




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Fixed-type constant velocity universal joint

A fixed type constant velocity universal joint has pairs of track grooves, each pair forming a wedge angle (α). The wedge angle (α) includes a wedge angle (α0) formed, when an operating angle is 0°, with respect to each of torque transmitting balls arranged in a joint center plane, and opening to the same side in an axial direction for all pairs of track grooves. Further, the pairs of track grooves are mirror-image symmetrical with each other when the operating angle is 0°.




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Low-cost, high-reliability controller for remotely operated robots

Provided is a device for wirelessly controlling robots suitable for competition or educational purposes, the device including: an input module configured to receive commands from a human user interface, the human user interface sending signals indicative of inputs by a user to control a robot; a protocol translator configured to translate the received commands into a protocol to which the robot is responsive; a wireless output module configured to wirelessly transmit the translated commands to the robot such that the robot executes the commands.




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Action detection and activity classification

Activities, actions and events during user performance of physical activity may be detected using various algorithms and templates. Templates may include an arrangement of one or more states that may identify particular event types and timing between events. Templates may be specific to a particular type of activity (e.g., types of sports, drills, events, etc.), user, terrain, time of day and the like.




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Pyridine-bis (oxazoline)(“pybox”) moiety as a chelator and sensitizer for lanthanide ion (Ln (III)) Luminescence

This invention relates to novel Ln(III) complexes of pybox, and methods of making the same. The present invention also relates to a method of use of pybox as a chelating moiety and sensitizer for Ln(III) ion luminescence. Derivatives of pybox and methods of making the same are also provided.




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Azo compounds reducing formation and toxicity of amyloid beta aggregation intermediates

The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.




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Method of differentially diagnosing different types of dementia

The present invention relates to a method of differentially diagnosing different types of dementia. In particular, the method relates to the use of specific SPECT tracers for differentially diagnosing Alzheimer's disease, Lewy-Body Dementia, and Frontotemporal Dementia.




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Polypeptides with permease activity

The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO: 55, and wherein the polypeptide has permease activity.




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Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids

Acylated insulins wherein an acyl moiety is attached to the parent insulin and wherein the acyl moiety comprises repeating units of alkylene glycol containing amino acids and wherein there is only one lysine residue (K & Lys) in the parent insulin, having satisfactory properties when administered pulmonary.




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Muteins of hNGAL and related proteins with affinity for a given target

The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.