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A screening method for the quantitative determination of selective androgen receptor modulators (SARMs) in capsules by high resolution 19F- and 1H-NMR spectroscopy

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2135-2146
DOI: 10.1039/D4AY00188E, Paper
Alessandro Maccelli, Anna Borioni, Federica Aureli, Maria Cristina Gaudiano, Livia Manna, Mariangela Raimondo
A new method for rapid determination of selective androgenic receptor modulators (SARMs) andarine, cardarine, ligandrol, ostarine and S-23 in capsules by 1H- and 19F-high resolution NMR spectroscopy was described and validated.
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Electrochemical aptasensor based on silver-thiolated graphene for high-sensitive detection of Pb2+

By pubs.rsc.org
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00322E, Paper
Jie Zhou, Changchun Hu, Shuo Li, Chuanxiang Zhang, Yuan Liu, Zhu Chen, Song Li, Hui Chen, Yan Deng
The presence of lead ions (Pb2+) not only leads to environmental contamination but also poses a significant risk to public health through their migration into food and drinking water. Therefore,...
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Subtle adjustment of the cyclic potential on electro-activated glassy carbon electrodes for sensitive sensing of methyl parathion

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00079J, Paper
Yunyin Yang, Sian Chen, Changqiu Zhang, Yanqing Li, Xinrong Zong, Yitao Lv, Min Zhang
Upon experiencing a negligible change of 0.5 V which only takes 5 more seconds, the signal value of an e-GCE was efficiently enhanced from 2-fold to 30-fold compared with a bare GCE.
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Rapid and green quantification of phloridzin and trilobatin in Lithocarpus litseifolius (Hance) Chun (sweet tea) using an online pressurized liquid extraction high-performance liquid chromatography at equal absorption wavelength method

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00170B, Paper
Zhengming Qian, Qinggui Lei, Dan Tang, Guoying Tan, Qi Huang, Fucai Zhou, Wenhao Wang
Sweet tea is a functional herbal tea with anti-inflammatory, anti-diabetic, and other effects, in which phloridzin and trilobatin are two functional compounds.
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Aptamer aided plasmonic nano-urchin for reporter free surface-enhanced Raman spectroscopy analysis of cortisol

By pubs.rsc.org
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00401A, Paper
Chengyu Li, Jing Hu, Nan Hu, Jianjun Zhao, Qianwen Li, Yanhui Han, Yanxiong Liu, Xufang Hu, Liyan Zheng, Qiu-E Cao
Cortisol is a vital glucocorticoid hormone reflecting stress levels and related disease processes. We present an aptamer functionalized plasmonic nano-urchin (α-FeOOH@Au-aptamer) aided cortisol capturing and Surface-enhanced Raman spectroscopy (SERS) analysis...
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Direct detection of dithiocarbamate fungicides by SALDI/MS using porous TiC ceramic powder as a substrate

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY01533E, Paper
Hiroshi Moriwaki, Issey Osaka, Kotaro Hashimoto, Osamu Yamada
Direct detection of dithiocarbamate fungicides (DTCs) has been achieved by SALDI/MS using porous titanium carbide (TiC) ceramic powder as a substrate.
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Establishing a new methodology for determining the water absorbability of cellulose-derived materials via a vapor-monitoring headspace strategy

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02209A, Communication
Yi-Xian Gong, Wei-Qi Xie
In this research, for the first time, we introduce a vapor-monitoring headspace strategy to establish a new methodology for determining the water absorbability of cellulose-derived materials.
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The selective extraction of dietary polyamines from chicken breast using the application of a lab-on-a-chip electromembrane and dispersive liquid–liquid microextraction followed by gas chromatography-mass spectrometry

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02172F, Paper
Fatemeh Barzegar, Samaneh Nabizadeh, Marzieh Kamankesh, Jahan B. Ghasemi, Abdorreza Mohammadi
Excessive dietary polyamines (PAs), including putrescine (PUT), spermine (SPM), and spermidine (SPD), have become a worldwide concern due to their carcinogenicity and reduced shelf life.
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Near-infrared responsive gold nanorods for highly sensitive colorimetric and photothermal lateral flow immuno-detection of SARS-CoV-2

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00347K, Paper
Xiaohui Liu, Jingwen Li, Kun Wang, Xiang Li, Shenming Wang, Gengchen Guo, Qiaowen Zheng, Maosheng Zhang, Jingbin Zeng
We developed a colorimetric and photothermal dual-mode LFIA platform for sensitive and selective SARS-CoV-2 N protein detection based on gold nanorods.
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Discrimination of Diptera order insects based on their saturated cuticular hydrocarbon content using a new microextraction procedure and chromatographic analysis

By pubs.rsc.org
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00214H, Paper
Open Access
Lixy Olinda León-Morán, Marta Pastor-Belda, Pilar Viñas, Natalia Arroyo-Manzanares, María Dolores García, María Isabel Arnaldos, Natalia Campillo
The nature and proportions of hydrocarbons in the cuticle of insects is characteristic of the species and age. Chemical analysis of cuticular hydrocarbons allows species discrimination, which is of great...
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Caffeine quantification in dietary supplements using high-throughput on-line solid phase extraction coupled to Venturi easy ambient sonic-spray ionization mass spectrometry

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00333K, Paper
David Ulisses Tega, Luan Felipe Campos Oliveira, Patrick Cesar Ferreira, Bruna Beatriz Soldera, Heliara Dalva Lopes Nascimento, Marcos Nogueira Eberlin, Alessandra Sussulini
Optimization of a LC-V-EASI-MS system. Employment of LC-V-EASI-MS and online SPE to enhance analytical performance for caffeine determination reaching 90 s per sample.
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LAMP-based hydrogen ion selective electrochemical sensor for highly sensitive detection of Mycoplasma pneumoniae

By pubs.rsc.org
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00341A, Paper
Huiqing Wang, Yang Li, Lin Tian, Xinyi Li, Qian Gao, Yaru Liu, Cuiping Ma, Qing Wang, Chao Shi
An urgent need for a concise and rapid detection method for Mycoplasma pneumoniae is required due to its severe impact on human’s health. To meet such a need, this study...
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A novel fluorescent probe with a large Stokes shift for colorimetric and selective detection of cysteine in water, milk, cucumber, pear and tomato

By pubs.rsc.org
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Anal. Methods, 2024, 16,2322-2329
DOI: 10.1039/D3AY02322B, Paper
Lin Luo, Ranran Guo, Lianjie Wang, Xixi Song, Zhao Wang, Junliang Wu
A novel fluorescent probe for colorimetric and selective detection of cysteine was efficiently constructed through a simple and mild reaction conditions. Probe 2 displays a linear response to Cys concentrations (0–30 μM), low detection limit (0.89 μM), large Stoke shift (125 nm).
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Dual-functional porphyrinic zirconium-based metal–organic framework for the fluorescent sensing of histidine enantiomers and Hg2+

By pubs.rsc.org
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Anal. Methods, 2024, 16,2386-2399
DOI: 10.1039/D3AY02241B, Paper
Shili Qin, Fanshu Meng, Fenglong Jin, Xidi Xu, Ming Zhao, Hongtao Chu, Lidi Gao, Shuren Liu
L-Cys/PCN-222 as a novel and dual-functional fluorescent sensor was developed. It not only showed a higher chiral fluorescent recognition of L-histidine but also performed as a visual sensor for Hg2+ in actual surface water.
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Fe3+-induced luminescence quenching in carbon dots – mechanism unveiled

By pubs.rsc.org
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Anal. Methods, 2024, 16,2349-2358
DOI: 10.1039/D3AY02202A, Paper
Varsha Raveendran P.T., Anjali C., Renuka Neeroli Kizhakayil
Luminescence quenching in carbon dots with an increase in Fe3+ concentration and the quantitative variation in luminescence intensity with added ferric ions.
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On-chip light sheet illumination for nanoparticle tracking in microfluidic channels

By pubs.rsc.org
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Anal. Methods, 2024, 16,2229-2240
DOI: 10.1039/D3AY02290K, Communication
Théo Travers, Gaétan Delhaye, Martinus H. V. Werts, Denis Gindre, Matthieu Loumaigne
A simple and inexpensive method is presented to efficiently integrate light sheet illumination in a microfluidic chip for dark-field microscopic tracking and sizing of nanoparticles.
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An immunochromatographic strip sensor for rapid and sensitive detection of candesartan, olmesartan medoxomil, and irbesartan in herbal beverages

By pubs.rsc.org
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Anal. Methods, 2024, 16,2359-2367
DOI: 10.1039/D4AY00151F, Paper
Dingyu Li, Aihong Wu, Liqiang Liu, Hua Kuang, Chuanlai Xu, Xiaoling Wu
Sartans, as a class of antihypertensive drugs, pose a threat to human health when illegally added to herbal beverages.
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A highly sensitive and selective fluorescent biosensor for breast cancer derived exosomes using click reaction of azide–CD63 aptamer and alkyne-polymer dots

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00146J, Paper
Dumei Ma, Yiting Luo, Xiaoya Zhang, Zehu Xie, Yinghua Yan, Chuan-Fan Ding
A fluorescence method based on Cu-triggered click reaction of azide modified CD63 aptamer and alkyne capped Pdots was developed for breast cancer derived exosome detection.
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Analysis of brominide disinfection by-products in aquaculture water using ultra-high-performance liquid chromatography–quadrupole–time-of-flight mass spectrometry

By pubs.rsc.org
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00396A, Paper
Weimin Yang, Yi Zhang, Jilong Huang, Xing Yang, Ning Jiang
Background: Halogenic disinfectants have been shown to produce toxic and carcinogenic disinfection by-products (DBPs) during water disinfection. Dibromohydantoin (DBDMH) is a commonly used water disinfectant in aquaculture. Aquaculture water has...
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The preparation of a boronate affinity-based controlled oriented imprinting coating on a silica nanoparticle surface for the separation and purification of shikimic acid in herbal medicine

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00219A, Paper
Yumin Yang, Daojin Li, Bingqian Liu
Shikimic acid (SA) is one of the most effective drugs against the A (H1N1) virus and has high medicinal value.
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A highly selective probe engineered to detect polarity and distinguish normal cells and tumor cells in tissue sections

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00438H, Paper
Sai Zhu, Lixuan Dai, Xiaoli Zhong, Weiying Lin
We have designed a polarity fluorescent probe (DCI-Cou-polar) with high selectivity for diagnosing cancer.
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Monolith stationary phases prepared via cyclic anhydride ring-opening polymerization as tunable platforms for chromatographic applications

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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00251B, Paper
Ahmad Aqel, Ayman Ghafr, A. Yacine Badjah-Hadj-Ahmed, Zeid Abdullah ALOthman
Polymer monolithic stationary phases were prepared based on a cyclic anhydride as a reactive and tunable platform via ring-opening post-polymerization using primary amines; octadecylamine and benzylamine. The characterization techniques indicated...
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QR codes for security in vehicles

By www.thehindubusinessline.com
Published On :: Tue, 03 Sep 2013 16:32:33 +0530


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Third front: On the expanding nature of the conflict in West Asia

By www.thehindu.com
Published On :: Wed, 18 Sep 2024 00:10:00 +0530

Israel’s fighting three enemy militias at once highlights the pressing need for a ceasefire


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A fair share: On the concerns of high performing States

By www.thehindu.com
Published On :: Thu, 19 Sep 2024 00:10:00 +0530

The Sixteenth Finance Commission must address the concerns of high-performing States


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 Milestones and U-turns: On the government in its third term

By www.thehindu.com
Published On :: Fri, 20 Sep 2024 00:20:00 +0530

The optics of the 100-day mark cannot conceal changed dynamics for the BJP


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It is an offence: On Supreme Court clarification on online content on child sex abuse

By www.thehindu.com
Published On :: Wed, 25 Sep 2024 00:10:00 +0530

Court has done well to clarify law on online content showing child sex abuse


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​Embattled CM: On Karnataka Chief Minister Siddaramaiah

By www.thehindu.com
Published On :: Fri, 27 Sep 2024 00:20:00 +0530

Anti-graft moves should not be overshadowed by political motive


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​Delay and bail: On former Tamil Nadu Minister V. Senthilbalaji’s case

By www.thehindu.com
Published On :: Sat, 28 Sep 2024 00:20:00 +0530

Senthilbalaji’s release on bail was overdue, but he should not be made a Minister


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A learning curve: On the PM Internship Scheme

By www.thehindu.com
Published On :: Mon, 07 Oct 2024 00:15:00 +0530

The outcomes of the PM Internship Scheme’s pilot project need monitoring


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Culture and society: On upholding Section 6A of the Citizenship Act

By www.thehindu.com
Published On :: Tue, 22 Oct 2024 00:30:00 +0530

Supreme Court of India verdict on citizenship law for Assam helps avoid fresh problems


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​Over the borderline: On the India-China deal 

By www.thehindu.com
Published On :: Wed, 23 Oct 2024 00:20:00 +0530

The agreement between India and China opens new opportunities  


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Why Abhishek Missed Aishwarya's Birthday

By www.rediff.com
Published On ::

When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher.


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The Woman Who Lost Everything

By www.rediff.com
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When the landslide hit, Sruthi's house was washed away, along with its inhabitants.


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Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00660G, Review Article
Shutang Li, Jinfei Yang
As research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.
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Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies

By pubs.rsc.org
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RSC Med. Chem., 2024, 15,3507-3528
DOI: 10.1039/D4MD00417E, Research Article
Yuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan Pan
In continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.
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The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif

By pubs.rsc.org
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RSC Med. Chem., 2024, 15,3576-3596
DOI: 10.1039/D4MD00438H, Research Article
Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang Chen
Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.
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Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3469-3476
DOI: 10.1039/D4MD00422A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
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Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3433-3443
DOI: 10.1039/D4MD00468J, Research Article
Meijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing Li
A synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.
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Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024)

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3371-3394
DOI: 10.1039/D4MD00384E, Review Article
Debasis Das, Lingzhi Xie, Jian Hong
Prospects of novel fourth-generation EGFR-TKIs overcoming C797S-mediated resistance in non-small cell lung cancer.
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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
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Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3597-3608
DOI: 10.1039/D4MD00378K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. Jenkins
In silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.
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Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3616-3624
DOI: 10.1039/D4MD00306C, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. Sheldrake
Cyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.
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A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00517A, Research Article
Open Access
Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
A novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.
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Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article
Open Access
Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00471J, Research Article
Poorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar Shrivastava
Screening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.
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Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00608A, Research Article
Sunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo Mathew
A total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.
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Synthesis and evaluation of tetrahydropyrrolo[1,2-a]quinolin-1(2H)-ones as new tubulin polymerization inhibitors

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00541D, Research Article
Mikhail N. Anisimov, Maksim A. Boichenko, Vitaly V. Shorokhov, Julia N. Borzunova, Marina Janibekova, Vadim V. Mustyatsa, Ilya A. Lifshits, Andrey Yu. Plodukhin, Ivan A. Andreev, Nina K. Ratmanova, Sergey S. Zhokhov, Elena A. Tarasenko, Daria A. Ipatova, Alexander R. Pisarev, Ivan A. Vorobjev, Igor V. Trushkov, Olga A. Ivanova, Nikita B. Gudimchuk
New 1,5-disubstituted pyrrolidin-2-ones 1, 2 and 5-aryl-3,3a,4,5-tetrahydropyrrolo[1,2-a]quinoline-1(2H)-ones 3 were explored as inhibitors of tubulin polymerization.
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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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