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Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel benzenesulfonamides containing a dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00617H, Research Article
Aida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü Beydemir
In this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00450G, Review Article
Shikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan Dwivedi
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00579A, Research Article
Open Access
Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-Broceta
A ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.
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Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00621F, Research Article
Chunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei Mao
A series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.
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Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00555D, Research Article
Shenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong Liu
The continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.
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Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00373J, Research Article
YongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian Zhang
The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article
Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00495G, Research Article
Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez Tumer
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
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meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
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3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00597J, Research Article
Albert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken Witt
Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...
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A practical guide for the assay-dependent characterisation of irreversible inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
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Four schools and a college in Tiruchi receive hoax bomb threats

Three schools declared a holiday on Tuesday as a precautionary measure




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Changes in train services notified due to demolition of old bridge near Tiruchi junction




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Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan

Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago




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Frequent traffic snarls pose hardship to motorists in Tiruchi

It is common to see vehicles lining up for a long distance from the traffic signal near Cauvery bridge to Anna Statue.




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Doctor assaulted inside Tiruchi ESI Hospital




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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents




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Tiruchi Today (November 7, 2024)




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Duo arrested for possession of banned tobacco products worth ₹3 lakh in Tiruchi




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Ensure time-bound implementation of development schemes, says Thirumavalavan




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Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation




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Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district

Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects




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Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs

About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive




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Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival

Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base




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Power shutdown in parts of Tiruchi on November 9




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Consultant to be appointed soon to design Kalaignar grand library in Tiruchi

The centre will offer translation, services for persons with disabilities and children, training and mentorship programmes, besides hosting monthly literary events




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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa




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NTK chief Seeman booked for alleged ‘derogatory remarks’ against Karunanidhi




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Advanced baggage handling system introduced in Tiruchi airport




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Man attempts to end life, kills his wife and daughter




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Tiruchi Corporation office expansion plan witnesses more delay




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Lack of signboards indicating bus timings at Chathiram Bus Stand in Tiruchi irks passengers

Passengers also say some buses leave earlier than scheduled or don’t pass certain rural areas, leading to schoolchildren not being able to board on time




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Live Cricket Scores, Cricket News, Analysis, Results & More | The Hindu




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571: Searching vs AI, Getting Designers to Play Nice, and Web Components

Do you listen at 2x? Do Chris and Dave sound weird at normal speed IRL? How searching compares to using AI, chatbots kind of suck at context, getting a designer to work with developers at an agency, what happened to content visibility, and how to best build a design system using web components.




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584: Community, Partnerships, Images, and Astro with Fred K. Schott

Fred K. Schott stops by to talk about building community, open source and sponsorship, building on partnerships in the dev community, WordPress + Astro, view transitions, using Discord for support, and leaking secret Astro Studio details.




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587: Why Ethan Marcotte Thinks Tech Workers Deserve a Union

Ethan Marcotte is here to talk about his new book, You Deserve a Tech Union, and discusses topics such as why we need unions in tech, who gets to be in the union, how unions can help deal with the AI question, union busting, and some arguments against unions.




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592: Web Component Therapy, SEO Therapy, and Learning Something New like Swift

Talking web components, progressive enhancement, style-able components, having to pay before you get to see a demo, being annoyed at the business of SEO, and subscriptions vs ads.




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596: The Year of AI, Arc, and Being Mad About the Right Thing

Looking back at the year of AI, using Arc on macOS and now Windows, dreaming of subscriptions, and knowing how to be mad about the right thing.




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616: Strum Machine with Luke Abbott

Luke Abbott is the creator of Strum Machine, an app that simulates backing tracks by stitching together individual notes, chords, and strums recorded on guitar, standup bass, and mandolin. We talk about what Strum Machine does, why he decided to build it, how bringing on a professional designer helped, pricing thoughts, and the "fun" of building a version on iOS.




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624: Blogging, In App Browsers are Bad, and Teaching CSS from Scratch

On this epsiode we're talking about the current state of blogging and social media, the polyfill hack, whether in app browsers should be banned, web components and the difficulty of front end web dev, and how we would go about teaching CSS from scratch in 2024.




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625: CarTalk, Ownership of A Book Apart, and URL Shorteners

Dave's putting together a platform for his presidential bid and workshops his policies, discussing vehicle options for a family in 2024, Chris and other authors get ownership of their A Book Apart books back, and the ramifications and reasoning behind Google killing a URL shortener.




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628: Tending to RSS Feeds, Code Hike’s Fine Markdown, and Cloudflare R2

Doc told me to travel but there's COVID on the planes, Dave's got a 2x life update, how often do you manage or prune your RSS feed subscriptions, checking in on Code Hike and their fine grained Markdown approach, JavaScript decorators use case, and using Cloudflare R2 for image storage.




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Sunshine cities

Kochi and Thiruvananthapuram are among the 60 cities that have received in principle approval from the Union Ministry of New and Renewable Energy to be developed as Solar Cities, writes K.A. Martin




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Towards healthier living

Invest in a green home for long-term benefits, says Arvind Jain




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Architecture of the senses

A building should have greenery, sound of water flowing, feel of natural stone under the feet, the smell of trees, flowers and fresh mud, and a charming yet sensitive design, feels architect Mona Doctor Pingel. A look by Nandhini Sundar.




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Give high priority to fire safety

In majority of high-rise buildings, power supply distribution and meter panels are located in the basement floors making them vulnerable to fire mishaps, writes Avala Buchi Reddy




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Balrampur Chini hopes success of polylactic acid plant will be sweet

In conversation with Avantika Saraogi, ED, and Stefan Barot, President, Chemicals Division, Balrampur Chini Mills




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Cold plunges, hot saunas, smoothies, and fasting

Fitness regimen on the go