hi Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD90044H, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki FujiiTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00645C, Research ArticleGeetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra BorahVirtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi Novel benzenesulfonamides containing a dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00617H, Research ArticleAida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü BeydemirIn this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00450G, Review ArticleShikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan DwivediThiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00579A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-BrocetaA ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00621F, Research ArticleChunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei MaoA series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00555D, Research ArticleShenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong LiuThe continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00373J, Research ArticleYongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian ZhangThe mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00626G, Research ArticleAleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan VeerappanLipidation modulates the Gram-selective antibacterial activity of QPyNATh.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00495G, Research ArticleYakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez TumerNew isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00601A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza GainaNew meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi 3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00597J, Research ArticleAlbert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken WittSomatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi A practical guide for the assay-dependent characterisation of irreversible inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00707G, Review ArticleLavleen K. Mader, Jessica E. Borean, Jeffrey W. KeillorKinetic evaluations for assay dependent characterization of irreversible inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
hi Four schools and a college in Tiruchi receive hoax bomb threats By www.thehindu.com Published On :: Tue, 05 Nov 2024 14:34:30 +0530 Three schools declared a holiday on Tuesday as a precautionary measure Full Article Tiruchirapalli
hi Changes in train services notified due to demolition of old bridge near Tiruchi junction By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:30:53 +0530 Full Article Tiruchirapalli
hi Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:44:09 +0530 Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago Full Article Tamil Nadu
hi Frequent traffic snarls pose hardship to motorists in Tiruchi By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:45:36 +0530 It is common to see vehicles lining up for a long distance from the traffic signal near Cauvery bridge to Anna Statue. Full Article Tiruchirapalli
hi Doctor assaulted inside Tiruchi ESI Hospital By www.thehindu.com Published On :: Tue, 05 Nov 2024 18:29:04 +0530 Full Article Tiruchirapalli
hi Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents By www.thehindu.com Published On :: Tue, 05 Nov 2024 21:04:51 +0530 Full Article Tiruchirapalli
hi Tiruchi Today (November 7, 2024) By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:16:44 +0530 Full Article Tiruchirapalli
hi Duo arrested for possession of banned tobacco products worth ₹3 lakh in Tiruchi By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:23:30 +0530 Full Article Tiruchirapalli
hi Ensure time-bound implementation of development schemes, says Thirumavalavan By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:29:00 +0530 Full Article Tiruchirapalli
hi Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation By www.thehindu.com Published On :: Wed, 06 Nov 2024 19:30:58 +0530 Full Article Tiruchirapalli
hi Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district By www.thehindu.com Published On :: Thu, 07 Nov 2024 18:48:04 +0530 Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects Full Article Tiruchirapalli
hi Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:10:58 +0530 About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive Full Article Tiruchirapalli
hi Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival By www.thehindu.com Published On :: Fri, 08 Nov 2024 07:51:25 +0530 Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base Full Article Tiruchirapalli
hi Power shutdown in parts of Tiruchi on November 9 By www.thehindu.com Published On :: Fri, 08 Nov 2024 17:45:18 +0530 Full Article Tiruchirapalli
hi Consultant to be appointed soon to design Kalaignar grand library in Tiruchi By www.thehindu.com Published On :: Fri, 08 Nov 2024 18:41:18 +0530 The centre will offer translation, services for persons with disabilities and children, training and mentorship programmes, besides hosting monthly literary events Full Article Tiruchirapalli
hi High-level committee formed to facilitate clearances for companies that signed MoU, says Minister By www.thehindu.com Published On :: Fri, 08 Nov 2024 18:56:40 +0530 Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa Full Article Tiruchirapalli
hi NTK chief Seeman booked for alleged ‘derogatory remarks’ against Karunanidhi By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:03:53 +0530 Full Article Tiruchirapalli
hi Advanced baggage handling system introduced in Tiruchi airport By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:01:36 +0530 Full Article Tiruchirapalli
hi Man attempts to end life, kills his wife and daughter By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:03:18 +0530 Full Article Tiruchirapalli
hi Tiruchi Corporation office expansion plan witnesses more delay By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:22:07 +0530 Full Article Tiruchirapalli
hi Lack of signboards indicating bus timings at Chathiram Bus Stand in Tiruchi irks passengers By www.thehindu.com Published On :: Mon, 11 Nov 2024 17:08:51 +0530 Passengers also say some buses leave earlier than scheduled or don’t pass certain rural areas, leading to schoolchildren not being able to board on time Full Article Tiruchirapalli
hi Live Cricket Scores, Cricket News, Analysis, Results & More | The Hindu By www.thehindu.com Published On :: Full Article
hi 571: Searching vs AI, Getting Designers to Play Nice, and Web Components By shoptalkshow.com Published On :: Mon, 26 Jun 2023 09:00:02 +0000 Do you listen at 2x? Do Chris and Dave sound weird at normal speed IRL? How searching compares to using AI, chatbots kind of suck at context, getting a designer to work with developers at an agency, what happened to content visibility, and how to best build a design system using web components. Full Article All Episodes AI chatgpt Web Components
hi 584: Community, Partnerships, Images, and Astro with Fred K. Schott By shoptalkshow.com Published On :: Mon, 25 Sep 2023 07:02:00 +0000 Fred K. Schott stops by to talk about building community, open source and sponsorship, building on partnerships in the dev community, WordPress + Astro, view transitions, using Discord for support, and leaking secret Astro Studio details. Full Article All Episodes Astro Community
hi 587: Why Ethan Marcotte Thinks Tech Workers Deserve a Union By shoptalkshow.com Published On :: Mon, 16 Oct 2023 08:04:08 +0000 Ethan Marcotte is here to talk about his new book, You Deserve a Tech Union, and discusses topics such as why we need unions in tech, who gets to be in the union, how unions can help deal with the AI question, union busting, and some arguments against unions. Full Article All Episodes employees union
hi 592: Web Component Therapy, SEO Therapy, and Learning Something New like Swift By shoptalkshow.com Published On :: Mon, 20 Nov 2023 08:30:40 +0000 Talking web components, progressive enhancement, style-able components, having to pay before you get to see a demo, being annoyed at the business of SEO, and subscriptions vs ads. Full Article All Episodes markdown SEO Web Components
hi 596: The Year of AI, Arc, and Being Mad About the Right Thing By shoptalkshow.com Published On :: Mon, 18 Dec 2023 09:03:32 +0000 Looking back at the year of AI, using Arc on macOS and now Windows, dreaming of subscriptions, and knowing how to be mad about the right thing. Full Article All Episodes arc OpenAI web3
hi 616: Strum Machine with Luke Abbott By shoptalkshow.com Published On :: Mon, 20 May 2024 08:09:58 +0000 Luke Abbott is the creator of Strum Machine, an app that simulates backing tracks by stitching together individual notes, chords, and strums recorded on guitar, standup bass, and mandolin. We talk about what Strum Machine does, why he decided to build it, how bringing on a professional designer helped, pricing thoughts, and the "fun" of building a version on iOS. Full Article All Episodes app banjo music
hi 624: Blogging, In App Browsers are Bad, and Teaching CSS from Scratch By shoptalkshow.com Published On :: Mon, 15 Jul 2024 08:37:37 +0000 On this epsiode we're talking about the current state of blogging and social media, the polyfill hack, whether in app browsers should be banned, web components and the difficulty of front end web dev, and how we would go about teaching CSS from scratch in 2024. Full Article All Episodes Blogging CSS Education polyfill
hi 625: CarTalk, Ownership of A Book Apart, and URL Shorteners By shoptalkshow.com Published On :: Mon, 22 Jul 2024 18:28:00 +0000 Dave's putting together a platform for his presidential bid and workshops his policies, discussing vehicle options for a family in 2024, Chris and other authors get ownership of their A Book Apart books back, and the ramifications and reasoning behind Google killing a URL shortener. Full Article All Episodes books cartalk urls
hi 628: Tending to RSS Feeds, Code Hike’s Fine Markdown, and Cloudflare R2 By shoptalkshow.com Published On :: Mon, 12 Aug 2024 07:04:48 +0000 Doc told me to travel but there's COVID on the planes, Dave's got a 2x life update, how often do you manage or prune your RSS feed subscriptions, checking in on Code Hike and their fine grained Markdown approach, JavaScript decorators use case, and using Cloudflare R2 for image storage. Full Article All Episodes Cloudflare covid-19 dogs markdown R2 rss
hi Sunshine cities By www.thehindu.com Published On :: Fri, 26 Dec 2014 17:19:51 +0530 Kochi and Thiruvananthapuram are among the 60 cities that have received in principle approval from the Union Ministry of New and Renewable Energy to be developed as Solar Cities, writes K.A. Martin Full Article Green Living
hi Towards healthier living By www.thehindu.com Published On :: Fri, 19 Jun 2015 22:23:02 +0530 Invest in a green home for long-term benefits, says Arvind Jain Full Article Property Plus
hi Architecture of the senses By www.thehindu.com Published On :: Fri, 11 Sep 2015 22:10:45 +0530 A building should have greenery, sound of water flowing, feel of natural stone under the feet, the smell of trees, flowers and fresh mud, and a charming yet sensitive design, feels architect Mona Doctor Pingel. A look by Nandhini Sundar. Full Article Green Living
hi Give high priority to fire safety By www.thehindu.com Published On :: Fri, 08 Jan 2016 16:39:57 +0530 In majority of high-rise buildings, power supply distribution and meter panels are located in the basement floors making them vulnerable to fire mishaps, writes Avala Buchi Reddy Full Article Property Plus
hi Balrampur Chini hopes success of polylactic acid plant will be sweet By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 20:46:00 +0530 In conversation with Avantika Saraogi, ED, and Stefan Barot, President, Chemicals Division, Balrampur Chini Mills Full Article Corporate File
hi Cold plunges, hot saunas, smoothies, and fasting By www.thehindubusinessline.com Published On :: Sun, 06 Oct 2024 21:49:00 +0530 Fitness regimen on the go Full Article Pulse