Fault Current Limiters (FCL) provide protection for upstream and/or downstream devices in electric power grids. Conventional FCL require the use of expensive conductors and liquid or gas cryogen handling. Disclosed embodiments describe FCL systems and devices that use lower cost superconductors, require no liquid cryogen, and are fast cycling. These improved FCL can sustain many sequential faults and require less time to clear faults while avoiding the use of liquid cryogen. Disclosed embodiments describe a FCL with a superconductor and cladding cooled to cryogenic temperatures; these are connected in parallel with a second resistor across two nodes in a circuit. According to disclosed embodiments, the resistance of the superconducting components and its sheath in the fault mode are sufficiently high to minimize energy deposition within the cryogenic system, minimizing recovery time. A scheme for intermediate heat storage also is described which allows a useful compromise between conductor length enabled energy minimization and allowable number of sequential faults to enable an overall system design which is affordable, and yet allows conduction cooled (cryogen free) systems which have fast recovery and allows for multiple sequential faults.

The present disclosure relates to a superconducting rotating electrical machine and a manufacturing method for a high temperature superconducting film thereof. The superconducting rotating electrical machine includes a stator, and a rotor rotatable with respect to the stator, the rotor having a rotary shaft and a rotor winding. Here, the rotor winding includes tubes disposed on a circumference of the rotary shaft and each forming a passage for a cooling fluid therein, superconducting wires accommodated within the tubes, and a cooling fluid flowing through the inside of the tubes. This configuration may allow for direct heat exchange between the superconducting wires and a refrigerant, resulting in improvement of heat exchange efficiencies of the superconducting wires.

Techniques for protecting a superconducting (SC) article are disclosed. The techniques may be realized as an apparatus for protecting a superconducting (SC) article. The apparatus may comprise a porous sleeve configured to fit around the superconducting (SC) article. The porous sleeve may be made of non-conductive, dielectric material.

Methods, apparatus, and computer programs for simulating the source of sound are provided. One method includes operations for determining a location in space of the head of a user utilizing face recognition of images of the user. Further, the method includes an operation for determining a sound for two speakers, and an operation for determining an emanating location in space for the sound, each speaker being associated with one ear of the user. The acoustic signals for each speaker are established based on the location in space of the head, the sound, the emanating location in space, and the auditory characteristics of the user. In addition, the acoustic signals are transmitted to the two speakers. When the acoustic signals are played by the two speakers, the acoustic signals simulate that the sound originated at the emanating location in space.

Computer-implemented systems and methods are provided for suggesting emoticons for insertion into text based on an analysis of sentiment in the text. An example method includes: determining a first sentiment of text in a text field; selecting first text from the text field in proximity to a current position of an input cursor in the text field; identifying one or more candidate emoticons wherein each candidate emoticon is associated with a respective score indicating relevance to the first text and the first sentiment based on, at least, historical user selections of emoticons for insertion in proximity to respective second text having a respective second sentiment; providing one or more candidate emoticons having respective highest scores for user selection; and receiving user selection of one or more of the provided emoticons and inserting the selected emoticons into the text field at the current position of the input cursor.

Alert event notifications may be provided by: displaying a first user interface layer including at least one user interface element configured to provide an alert event notification; displaying a second user interface layer such that at least a portion of the second user interface layer overlays the at least one user interface element configured to provide an alert event notification; detecting an alert event; and at least partially displaying the at least one user interface element configured to provide an alert event notification in an area where the at least a portion of the second user interface layer overlays the at least one user interface element configured to provide an alert event notification.

A system for translating user motion into multiple object responses of an on-screen object based on user interaction of an application executing on a computing device is provided. User motion data is received from a capture device from one or more users. The user motion data corresponds to user interaction with an on-screen object presented in the application. The on-screen object corresponds to an object other than an on-screen representation of a user that is displayed by the computing device. The user motion data is automatically translated into multiple object responses of the on-screen object. The multiple object responses of the on-screen object are simultaneously displayed to the users.

A method and apparatus to mark-up an electronic document (i.e., a second electronic document) that is superimposed on a first electronic document keeping the first electronic document unchanged. The second electronic document is optionally viewed concurrently with the first electronic document. The second electronic document is capable of being viewed or modified using different application programs so long as the different application programs process the format used by the second electronic document. The second electronic document is saved as a separate document independent of the first electronic document.

The present invention generally relates to processes for the enzymatic production of a phosphinothricin product or precursor thereof from a nitrile-containing substrate.

The present invention relates to novel isocyanate and isothiocyanate compounds, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans and animals. The novel isocyanate and isothiocyanate compounds are distinguished, as compared with the known isocyanate and isothiocyanate compounds, by improved therapeutical breadth, i.e. fewer side effects while having high anti-tumor activity.

A process for producing a purified O-(2,6-dichloro-4-methylphenyl)-O,O-dimethyl phosphorothioate, the process comprising: the first step of bringing a crude O-(2,6-dichloro-4-methylphenyl)-O,O-dimethyl phosphorothioate into contact with an acid; andthe second step of recovering the purified O-(2,6-dichloro-4-methylphenyl)-O,O-dimethyl phosphorothioate from the mixture obtained in the first step.

A method for transmitting blocks of data in data packets from a first device on a network to a second device on the network comprising the steps of, providing a File Transmitter Application in communication with the first device, which File Transmitter Application is adapted to control the transmission of the blocks of data in data packets on the network, including the timing of the commencement of the transmission of the data blocks on the network, providing a File Receiver Application in communication with the second device and in communication with the File Transmitter Application, which File Receiver Application is adapted to transmit Acknowledgment data to the File Transmitter Application relating to the receipt of data blocks received at the second device, commencing the transmission of a first data block from the first device to the second device, by way of the network and commencing the transmission of the second data block from the first device to the second device, by way of the network.

A system, method, and computer-readable medium are disclosed for realizing server management functionalities in the absence of a routable Internet Protocol (IP) network address of a remote access controller (RAC). A first device, which is operatively coupled to a link-local network, generates a Multicast Domain Name System (mDNS) IP multicast query message, which it then sends to a second device on the link-local network. In response, the second device, which comprises a RAC, returns its link-local IP address to the first device.

In a computer-implemented method of generating event notifications, in-home data is received. The in-home data and environment data (e.g., weather, law enforcement, etc.) is generated by, or based on information generated by, a device located at a residence of an individual, and is analyzed to determine whether it is indicative of an event that should be reported to one or more neighboring residences and/or businesses. If the data is indicative of such an event, a notification is generated and transmitted to the relevant residences and/or businesses.

A CPU executes a communication partner search process for searching for a communication partner (another game machine). The CPU confirms received data content. If identification information included in the received data matches, application identification information saved in a wireless communication module is compared with application identification information included in the received data. When the pieces of application identification information match, a notice that another game machine having exchange data corresponding to the matched application identification information is found is given to a main body. Then, giving/receiving of exchange data is executed to/from another game machine.

A method of transferring data using a Trivial File Transport Protocol (TFTP) includes sending first request packet from client to server, first request packet requesting that first file be transferred; transferring first file according to first request packet if first acknowledgement packet is received at client from server indicating that server can accommodate request of first request packet; sending second request packet from client to the server if transfer of first file does not complete successfully, the second request packet including TFTP option indicating that transfer of first file be retried beginning at first block after final block that was successfully transferred in response to first request packet; and retrying transfer of first file according to second request packet if second acknowledgement packet is received at client from server indicating that server can accommodate request of second request packet.

In order to allow a single user registered on a single local host or other machine to access multiple shared resources on a remote host, an aliasing mechanism is employed so that multiple concurrent connections can be established by the user to a single remote host, with each connection using a different identity. Each connection can therefore be used to access a different shared resource on the remote host. In some illustrative examples, a user's identifier such as his or her machine log-in identification may be associated with two or more resource sharing aliases. As a result, two or more resource sharing sessions can be established by the user with a single remote host, with each of the sessions using a different one of the aliases. The resource sharing sessions are usually established in accordance with a resource sharing protocol such as the Server Block Message (SBM) protocol.

A calendar watch includes a central date indicator (4). The indicator is united with a crown wheel (9) comprising teeth (11) forming a circular crown (12) arranged to be perpendicular to a face (13) of said wheel. The teeth (12) are driven by a finger (14) rotating in a plane intersecting said crown in its height. The finger is united with a date driving wheel (15). The invention permits easy transformation of a watch having its date display in a dial aperture to a watch having a date indicator rotating about the center of the movement.

The rotating metal rim (19) is equipped with a toothed ring made of synthetic material (23) catch-fastened to the rotatating rim and catch-mounted on the frame (1) or by means of a band. The toothing of the ring (23) cooperates with at least one pawl (9) mounted in a recess of the frame and held in place on the one hand by a foot (11) and on the other hand by the rotating rim itself. The mounting of the unit and the after-sales service are facilitated.

A radio paging selective receiver determines that a received message is unread based on the time difference between the message reception time and the current time being larger that some predetermined value of time, and the paging selective receiver provides an indication of the unread message by displaying the reception time of the unread message in a second fashion which is visibly different from a first fashion normally used to display the current time.

A Redundant Array of Independent Disks (RAID) controller receives new data that is to be written, wherein the new data is indicated in blocks of a first block size. The RAID controller reads old data, and old parity that corresponds to the old data, stored in blocks of a second block size that is larger in size than the first block size. The RAID controller computes new parity based on the new data, the old data, and the old parity. The RAID controller writes the new data and the new parity aligned to the blocks of the second block size, wherein portions of the old data that are not overwritten by the RAID controller are also written to the blocks of the second block size.

A Redundant Array of Independent Disks (RAID) controller receives new data that is to be written, wherein the new data is indicated in blocks of a first block size. The RAID controller reads old data, and old parity that corresponds to the old data, stored in blocks of a second block size that is larger in size than the first block size. The RAID controller computes new parity based on the new data, the old data, and the old parity. The RAID controller writes the new data and the new parity aligned to the blocks of the second block size, wherein portions of the old data that are not overwritten by the RAID controller are also written to the blocks of the second block size.

Systems, methods, and other embodiments associated with a distributed cache coherency protocol are described. According to one embodiment, a method includes receiving a request from a requester for access to one or more memory blocks in a block storage device that is shared by at least two physical computing machines and determining if a caching right to any of the one or more memory blocks has been granted to a different requester. If the caching right has not been granted to the different requester, access is granted to the one or more memory blocks to the requester.

Methods and apparatuses for implementing a system cache with quota-based control. Quotas may be assigned on a group ID basis to each group ID that is assigned to use the system cache. The quota does not reserve space in the system cache, but rather the quota may be used within any way within the system cache. The quota may prevent a given group ID from consuming more than a desired amount of the system cache. Once a group ID's quota has been reached, no additional allocation will be permitted for that group ID. The total amount of allocated quota for all group IDs can exceed the size of system cache, such that the system cache can be oversubscribed. The sticky state can be used to prioritize data retention within the system cache when oversubscription is being used.

A dynamically expandable and contractible fault-tolerant storage system employs a virtual hot spare that is created from unused storage capacity across a plurality of storage devices. This unused storage capacity is available if and when a storage device fails for storage of data recovered from the remaining storage device(s). On an ongoing basis, the storage system may determine the amount of unused storage capacity that would be required for the virtual hot spare (e.g., based on the number of storage devices, the capacities of the various storage devices, the amount of data stored, and the manner in which the data is stored) and generate a signal if additional storage capacity is needed for a virtual hot spare.

The invention discloses a deep-ultraviolet chemically-amplified positive photoresist. The deep-ultraviolet chemically-amplified positive photoresist according to one embodiment of the invention includes a cyclopentenyl pimaric acid, a divinyl ether, a photoacid generator and an organic solvent. The deep-ultraviolet chemically-amplified positive photoresist according to the invention has a good sensitivity and a good transparency.

The polycyclic organic compounds which are substantially transparent for an electromagnetic radiation in the visible spectral range, an anisotropic optical film comprising at least one polycyclic organic compound and a method of producing thereof are disclosed. The polycyclic organic compounds have a general formula (I) wherein A and B are acid groups, n is the number of phenyl rings in the range from 3 to 10; m is 0, 1, 2 or 3; l is 1, 2, or 3, p is 1, 2, 3, 4, 5 or 6, C is a counterion from a list comprising H+, NH+4, Na+, K+, Li+, Cs+, Ca2+, Mg2+, Sr2+, La3+, Zn2+, Zr4+, Ce3+, Y3+, Yb3+, Gd3+, and any combination thereof; k is the number of counterions necessary for compensation of the negative electric charge equal to (−p).

The invention describes new structures of the nucleotide conjugates (nuc-macromolecules) comprising at lease one nucleotide moiety coupled to at least one macromolecular compound via a short linker. These conjugates can be used as substrates for various kinds of polymerizing enzymes in the enzymatic synthesis of nucleic acids. In particular, these compounds can be used for labeling nucleic acids.

An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.

This invention relates to a process for preparing an oligonucleotide 5'-triphosphate. The process comprises the steps of: (a) synthesizing an oligonucleotide having a 5' hydroxyl moiety; (b) reacting the 5' hydroxyl moiety with a reagent of formula I: to convert the 5' hydroxyl moiety to a 5'-H-phosphonate, wherein R1 and R2 are each independently selected from the group consisting of haloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, and substituted heterocycle, acyl, phosphoryl, substituted alkyl acyl, substituted heteroalkyl acyl, substituted aryl acyl or substituted heteroaryl acyl, substituted alkyl phosphoryl, substituted heteroalkyl acyl, substituted aryl phosphoryl, and substituted heteroaryl phosphoryl; (c) activating the H-phosphonate of step (b) by reacting the H-phosphonate with a silylating agent, a halogenated oxidizing agent, a nitrogen-containing heteroaryl, or a combination thereof, to form an activated H-phosphonate; and (d) treating the oligonucleotide having an activated H-phosphonate from step (c) with a poly(alkylammonium)pyrophosphate.

The invention refers to polynucleotides selected from the group consisting of a) polynucleotides encoding for the polypeptide RBM20 comprising a P638L mutation for a human polypeptide RBM20, or a P641L mutation for a rat polypeptide RBM20, b) polynucleotides with a reverse complementary sequence of the polynucleotide of a) above, and c) polynucleotides with an identity at least 50% to a polynucleotide of a) or b) above.

RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.

The present invention relates to the field of cardiology. More specifically, the present invention provides methods and compositions for inducing proliferation of cardiomyocytes. In a specific embodiment, a method for inducing proliferation of cardiomyocytes comprises the step of administering an effective amount of an ALMS1 inhibitor.

The present disclosure provides reagents that can be used to label synthetic oligonucleotides with rhodamine dyes or dye networks that contain rhodamine dyes.

A system and method for low-cost, fault tolerant, EMI robust data communications, particularly for an EV environment. A data communications method, including a) enabling a transmission of a wake signal from a host to a remote client through an isolator disposed at the remote client when the wake signal is asserted from the host at a host-portion of the isolator concurrent with a periodic enablement of a client-portion of the isolator by the remote client; and thereafter b) transmitting the wake signal from the host to the remote client through the isolator; c) controlling enablement of the client-portion responsive to the wake signal transmitted through the isolator; and thereafter d) disabling the transmission by deassertion of the wake signal at the host.

A system, methods and server for monitoring health and safety of individuals in a population and sending alert notifications when exceptions are detected include comparing biometric data obtained from the individuals to a biometric model generated for the individual through computer-learning methods. Biometric data may be gathered by wireless biometric sensor devices which transmit biometric data to receiver devices, which relay the biometric data to a server. The biometric model may be maintained in the server and include nominal and threshold biometric parameters for each individual based on biometric sensor data gathered or analyzed over a period of time. An alert may be issued by the server when an individual's biometric data is outside a threshold in the biometric model. The transmitted alert may depend upon the nature of the exception, user settings and past notification experience. Alerts may be escalated when not answered within defined durations.

Embodiments include a fiducial deployment system and method for use thereof. A fiducial may include one or more protuberances configured to engage one or more slots in a needle of the system. The needle may be configured to deliver a plurality of fiducials to a target location in serial fashion, one at a time. In certain embodiments, echogenic placement of fiducials may present certain advantages.

A system for facilitating remote medical diagnosis and consultation of heart disease for a patient, the system comprising: a diagnostic device for performing Electrocardiography on the patient, a network device in communication with the diagnostic device via wired or wireless communication links, a software program pre-installed in the network device, a server located remotely, wherein during operation, the patient activates the diagnostic device which will perform Electrocardiography on the patient, the diagnostic device receives diagnostic data and transmits the diagnostic data to the network device, the software program transmit the diagnostic data to over a network to a server which a physician have access to, and based on the diagnostic data gathered by the server and some additional medical data, the physician can review the patient's health condition and offer an appropriate feedback and diagnosis for the patient.

An information processing method includes the following steps: applying a pattern matching process on the body motion signal information, and extracting rhythm cycle candidate waves which are rhythm cycle candidates related to the rhythmic motion; performing −1 or more times integration on the body motion signal information to obtain a motion trajectory, and performing coarse-graining on the motion trajectory to produce an auxiliary wave; superimposing the rhythm cycle candidate waves which are extracted in the process of extracting the cycle candidate waves, on the obtained auxiliary wave, and selecting a cycle of a rhythm cycle candidate wave which has a peak in the auxiliary wave, as a true cycle; and finally obtaining a result of the processing.

The invention relates to improved process for the preparation of fesoterodine and its pharmaceutically acceptable salt, specifically fesoterodine fumarate of formula (1). The invention relates to solid state forms of a novel salt of fesoterodine and process for the preparation thereof. The invention also relates to highly pure fesoterodine fumarate substantially free of impurity X at RRT 1.37. The invention also provides solid particles of pure fesoterodine fumarate wherein 90 volume-percent of the particles (D90) have a size of higher than 200 microns.

A method of labeling a sulfenic acid (—SOH) group of a cysteine residue in a protein; or peptide, comprises contacting said protein or peptide with a beta-ketoester to covalently couple said beta-ketoester to said cysteine residue and form a beta-ketoester-labeled cysteine residue in said protein or peptide.

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

A combination of a substrate selected from silicon, silicon carbide or a metal and a grapheme precursor having the following properties: (a) an aromatic structure that forms the basis of the graphene structure, said aromatic structure being selected from the group consisting of: benzene, naphthalene, pyrene, anthracene, chrysene, coronene, and phenanthrene, or a cyclic or acyclic structures which can be converted to aromatic structures and (b) functional groups that can react with each other to form additional aromatic structures.

A silane compound having a secondary amino group protected with a specific silyl group is useful as silane coupling agent, resin additive, textile treating agent, surface treating agent, paint additive, and adhesive.

The present invention relates to photochromic materials that include one or more indeno-fused naphthopyrans that have particular groups at the 7, 11, and 13 positions thereof, and at the position alpha to the oxygen of the pyran ring thereof. With some embodiments, hydrogen or an alkoxy group is bonded to the 7 position, an optionally substituted phenyl is bonded to the 11 position, two alkyl groups are bonded to the 13 position, and two optionally substituted phenyl groups are bonded to the position alpha to the oxygen of the pyran ring of the indeno-fused naphthopyran compound. The 13 position of the indeno-fused naphthopyrans is free of ether groups in which an ether oxygen is bonded to the 13 position, and hydroxyl. The present invention also relates to photochromic articles and compositions that include such indeno-fused naphthopyrans.

Described herein are compounds generally comprising an indeno[2',3':3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles. Also described herein are methods for preparing certain photochromic compounds, compositions, and articles.

The present invention relates to new salts of 6-(propyl-(2-thiophen-2-ylethyl)amino)tetralin-1-ol(rotigotine), their use as a medicament, for example for the treatment of CNS disorders like Parkinson Disease, RLS, fibromyalgia and/or depression, in particular through electromotive administration. The present invention relates to pharmaceutical formulations suitable for iontophoresis that provide enhanced iontophoretic delivery of rotigotine to at least one target tissue. The formulations are further characterized by good to excellent solubility of the salts in aqueous solutions.

The present invention provides a method for manufacturing artemisinin and its congeners from cyclohexenone as a starting material.

Disclosed is a photosensitive resin composition for a color filter and a color filter using the same. The photosensitive resin composition for a color filter includes (A) a dye-polymer composite including a structural unit derived from the compound represented by the following Chemical Formula 1, wherein each substituent is the same as defined in the detailed description; (B) an acryl-based photopolymerizable monomer; (C) a photopolymerization initiator; and (D) a solvent.

Disclosed is a photosensitive resin composition for a color filter including (A) a dye-polymer composite wherein the dye includes a repeating unit derived from a compound represented by the following Chemical Formula 1, wherein in Chemical Formula 1, each substituent is the same as defined in the detailed description; (B) a binder resin; (C) a photopolymerizable monomer; (D) a photopolymerization initiator; and (E) a solvent.