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Nations League: England bounce back to down Finland

England enjoyed a 3-1 victory over Finland thanks to goals from Jack Grealish, Trent Alexander-Arnold and Declan Rice.




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PIX: Real Madrid's stunning comeback!

Real Madrid fought back from two goals down as Vinicius Jr grabbed a hat-trick in a thrilling 5-2 win over visitors Borussia Dortmund in the Champions League.




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PIX: Fenerbache's Mourinho sees red as Man Utd draw

IMAGES from the Europa League matches played on Thursday




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Israel rescues soccer fans attacked in Amsterdam

An eyewitness captured a video verified by Reuters showing a group of men running near Amsterdam central station, chasing and assaulting other men, as police sirens sounded.




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No energy for outdoor vacations




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Sonata Software secures multi-year deal from Fortune 500 manufacturing company

The client is partnering with Sonata Software to modernise its operations and deliver a homogenous, unified user experience at scale




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Infosys unveils small language models built on NVIDIA AI stack

The collaboration leverages NVIDIA AI and Infosys Topaz offerings for scaling enterprise AI




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Indian online gaming sector faces money laundering threat, warns report

The sector employs around one lakh people and has the potential to to create 2,50,000 jobs by 2025




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Mangaluru Technovanza unveils roadmap for ‘Silicon Beach of India’

The event organised by Karnataka Digital Economy Mission brought together industry leaders, start-up founders, students and other stakeholders to explore the technology and entrepreneurship landscape in coastal Karnataka




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India should manufacture its own AI systems: Nvidia’s Jensen Huang

In an interaction with media in Mumbai, Huang said, “Manufacture your own AI. You should not outsource, you should not export data to import intelligence. Don’t wait to jump into this one 20 years later. Enter this one at Ground Zero.”




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Cyient acquires 27.3% stake in Azimuth AI

The investment aligns with India’s initiatives to boost domestic semiconductor innovation and follows Cyient’s establishment of a fully owned semiconductor subsidiary in July 2024




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Having a data backup is not enough. You should store it at multiple places: Veeam

This rule involves maintaining three copies of data, stored on two different types of storage media, with one copy located offsite




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Full impact of tariff hike to flow through current quarter: Gopal Vittal

Vittal, Managing Director and Chief Executive Officer, Airtel, said there is room for further hikes as the average revenue per user levels in India were still much lower than in smaller countries in the region




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Cognizant’s Synapse skilling initiative impacts 275,000 individuals in its first year

The rapid progress of Synapse comes at a time when there is a growing desire from organisations to train and redevelop talent




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Sealy expands global reach with new manufacturing facility in India

The new factory will produce Sealy’s premium mattresses, including the Posturepedic range, for the domestic market




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Progress targets $1 billion revenue with acquisition; expands Bangalore team

The ShareFile business the company is acquiring generates approximately $240 million in revenue




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Posidex Technologies eyes US, Middle-East, APAC expansion

“This strategic rebrand aligns with our target to bring our solutions to high-growth international markets, strengthening its position as a leader in customer data management and technology innovation”




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CCI approves acquisition of STT GDC by Ruby Asia and Singtel

This approval comes with certain voluntary commitments that the parties must adhere to




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Centre writes to Wikipedia over complaints of inaccuracies, biases

Sources said the Information and Broadcasting ministry has sent a notice to Wikipedia regarding complaints that it has received about alleged inaccuracies and bias of information on the site




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Tessolve to acquire German chip design company for up to ₹400 crore

It will expand Tessolve’s European operations by adding four delivery locations across Germany and the Netherlands, including a specialized ADAS and imaging centre-of-excellence lab




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Cyient DLM secures 16-year aerospace contract with Honeywell 

The shares of Cyient DLM Limited were trading at ₹644.85 up by ₹11.80 or 1.86 per cent on the NSE today at 1.40 pm




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OpenAI's ChatGPT back up after brief outage

Outage tracking website Downdetector.com said ChatGPT's services were down for about half an hour, affecting over 19,403 users as of 7:13 p.m. ET (0013 GMT on Saturday)




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Customers no longer reluctant to adopt AI, says Hitachi Vantara’s Hemant Tiwari

Even non-tech companies have AI requirements. If you’re manufacturing a transformer, a train engine, or a jet engine, AI goes into making them efficient: Tiwari




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AI adoption: 74% companies struggle to achieve and scale value, says BCG

Report to assess firms’ AI maturity is based on a survey of 1,000 CxOs and senior executives from over 20 sectors, spanning 59 countries




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Roaches to the rescue

YW storyteller contest: We were flooded with stories for the YW Storyteller contest announced on June 24. Here are some of the entries that almost made it… Congratulations!




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Can we take action?

Bankei’s meditation classes had run into a problem. Somebody was stealing! What could they do?




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Rack your brains

YW storyteller contest: We were flooded with stories for the YW Storyteller contest announced on June 24. Here are some entries that almost made it.




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Prank attack

YW storyteller contest: We were flooded with stories for the YW Storyteller contest announced on June 24. Here are some of the entries that almost made it.. Congratulations!




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Payback time!

YW storyteller contest: We were flooded with stories for the YW Storyteller contest announced on June 24. Here are some of the entries that almost made it… Congratulations!




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Back in time

Pallavi and Prakash are entrusted with the task of cleaning up the attic on a rainy day. What they find is treasure beyond compare.




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On a space odyssey

Ice Age: Collision Course”, the fifth in the Ice Age series, releases today across the country. Join Scrat as he explores space and enjoy his adventures.




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Teach and learn

Rinki’s mother worried about her daughter not revising her lessons. But Mother knew how to get her to study and have fun at the same time.




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The Substitute Teacher: A sudden disappearance

No warning and no goodbyes... was this how VI C wanted the ST chapter to end?




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A crocodile in a palace?

Taran and his family explore the Kanika palace in the Bhitarkarnika National Park.




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Synthesis of 3,5-disubstituted isoxazoles by domino reductive Nef reaction/cyclization of β-nitroenones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00232F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Muhammad Ehtisham Ibraheem Khan, Tomas Lighuen Cassini, Marino Petrini, Alessandro Palmieri
β-Nitroenones were converted into 3,5-disubstituted isoxazoles via a domino reaction promoted by tin(II) dichloride. The protocol efficiently works under both microwave and flow conditions.
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Siloxane-containing phosphine (oxide) ligands for enhanced catalytic activity of cobalt complexes for hydrosilylation reactions

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00333K, Paper
Peng Liu, Jiajian Peng, Ying Bai, Jiayun Li
A series of siloxane-containing phosphine (oxide) ligands have been designed and synthesized.
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A water mediated multicomponent reaction for the synthesis of novel spirooxindole derivatives and their antifungal activity

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00256C, Paper
Min Zhang, Liang Shi, Li Chen, Zhengyu Liu, Ting Zhao, Chunyin Zhu, Liuqing Yang
A total of 27 novel spirooxindoles were synthesized through a water mediated three-component reaction of isatin, 4-aminocoumarin, and 1,3-cyclodicarbonyl compounds. Several compounds showed excellent antifungal activity against Physalospora piricola.
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New 2-pyridone-based donor–acceptor dyes: the effect of the donor group position, type of π-linker and acid–base characteristics of the medium on the photophysical properties

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00177J, Paper
Saveliy P. Sorokin, Mikhail Yu. Ievlev, Oleg V. Ershov
Synthesis of a series of new donor–acceptor dyes based on 2-pyridone and the study of the effect of the position of the donor group, the type of π-linker and the acid–base characteristics of the medium on their photophysical properties.
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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
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Kinetic resolution of 1,1'-binaphthyl-2,2'-diamine derivatives by chiral calcium phosphate-catalyzed acylation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00355A, Paper
Tatsuhiro Uchikura, Yuki Kanno, Yukino Fukuda, Mikoto Sato, Takahiko Akiyama
Chiral calcium phosphate-catalyzed kinetic resolution of BINAM derivatives.
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Rapid in situ generation of 2-(halomethyl)-5-phenylfuran and nucleophilic addition in a microflow reactor

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00358F, Paper
Open Access
Yuma Matsuura, Shinichiro Fuse
Various 2,5-disubstituted furans were synthesized via 5-substituted 2-halomethylfurans using microflow technology.
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Selective recognition between aromatics and aliphatics by cage-shaped borates supported by a machine learning approach

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00408F, Paper
Open Access
Yuya Tsutsui, Issei Yanaka, Kazuhiro Takeda, Masaru Kondo, Shinobu Takizawa, Ryosuke Kojima, Akihito Konishi, Makoto Yasuda
Exploration of a Lewis acid with high selectivity for hydrocarbon moieties is assisted by a machine learning approach. Molecular polarizability is an essential factor, leading to design guidelines for Lewis acid catalysts with dispersion forces.
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Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00304G, Paper
Michela Eleuteri, Jenny Desantis, Gabriele Cruciani, Raimondo Germani, Laura Goracci
Selective degradation of disease-causing proteins using proteolysis targeting chimeras (PROTACs) has gained great attention, thanks to its several advantages over traditional therapeutic modalities.
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Electrochemical and photochemical reaction of isatins: a decade update

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00202D, Review Article
Nandini M. Gotgi, J. Saurab Jain, Rita Pal, Debashis Ghosh
This review presents all the recent reports on electro- and photochemical reactions of isatins over the last decade.
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A rhodium-catalyzed cascade C–H activation/annulation strategy for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00193A, Paper
Yinsong Wu, Guanghao Shi, Yanan Liu, Yangzilin Kong, Mengdi Wu, Demao Wang, Xiaobing Wu, Yongjia Shang, Xinwei He
We have developed a cascade annulation strategy triggered by rhodium(III)-catalyzed C–H activation for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines from free NH-sulfoximines with maleimides under mild conditions.
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Rh(III)-catalysed C-H annulation of cis-stilbene acids with 2-diazo-1,3-diketones: A facile access to 6,7-dihydrobenzofuran-4(5H)-one and α-pyrone scaffolds

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00151F, Paper
Shankaraiah Nagula, Mary Sravani Galla, Nandini B. Kale, Akshay Kumawat, Darshana Bora
An efficient Rh(III)-catalysed C-H functionalization, tandem annulation of cis-stilbene acids using 2-diazo-1,3-diketones was devised. The protocol has solely afforded 6,7-dihydrobenzofuran-4(5H)-ones using alicyclic diazocarbonyls via decarbonylation and α-pyrones with aliphatic diazo...
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Synthesis of Asp-based lactam cyclic peptides using an amide-bonded diaminodiacid to prevent aspartimide formation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00472H, Communication
Wen-Jie Li, Jun-You Chen, Hui-Xia Zhu, Yi-Ming Li, Yang Xu
A diaminodiacid (DADA) containing an amide bond can be used in Fmoc solid-phase peptide synthesis (SPPS) of an Asp-based lactam cyclic peptide with no aspartimide formation.
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Friedel–Crafts reactions for biomolecular chemistry

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00406J, Review Article
Open Access
Jun Ohata
This review demonstrates advances in Friedel–Crafts alkylation and acylation reactions in a variety of biomolecular chemistry fields.
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Electrochemical nickel-catalyzed cross-coupling of glycosyl thiols with preactivated phenols and ketones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00442F, Communication
Fuxin Li, Hui Liu, Wanyu Xing, Qingju Zhang, Liming Wang
Here we report an efficient electrochemical nickel-catalyzed cross-coupling reaction for the synthesis of S-glycosides from preactivated phenols and ketones.
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Total synthesis of diplofuranone A and diapolic acid A

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00433G, Communication
Dattatraya H. Dethe, Vimlesh Kumar, Nagabhushana C. Beeralingappa
The first and concise syntheses of the anticancer agent diplofuranone A and the fatty acid-derived metabolite diapolic acid A have been demonstrated using easily accessible and commercially available starting materials.
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