ac Stereoselective Synthesis of gem-Dihalopiperidines via Halo-Aza-Prins Cyclization Reaction: Access to Piperidin-4-ones and Pyridines By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00338A, PaperAnil Kumar Saikia, Surjya Kumar Bora, Subhamoy Biswas, Bipin Kumar BeheraAn efficient methodology for the synthesis of 4,4-dihalopiperidine derivatives has been developed from N-(3-halobut-3-en-1-yl)-4-methylbenzenesulfonamide and aldehyde catalyzed by In(OTf)3 in excellent yields. The reaction involves an initial formation of six...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Covalently linked thieno[2,3-b]thiophene-fullerene dimers: synthesis and physical characterization By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,2978-2984DOI: 10.1039/D4OB00027G, PaperAbdulrahman M. Alazemi, Mohammad H. BinSabt, Hamad M. Al-Matar, Alan L. Balch, Mona A. ShalabyLinked thieno[2,3-b]thiophene-fullerene Dimers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Recent advances in spirocyclization of maleimides via transition-metal catalyzed C–H activation By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,2916-2947DOI: 10.1039/D3OB01904G, Review ArticleSwadhin Swaraj Acharya, Sagarika Patra, Rojalini Maharana, Manaswini Dash, Liza Mama Barad, Bibhuti Bhusan ParidaIn recent years, the maleimide scaffold has received a great deal of attention in C–H activation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Vinylogous and stereoselective domino synthesis of pyrano[2,3-c]pyrroles from alkylidene meldrum's acids By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,2948-2952DOI: 10.1039/D4OB00233D, CommunicationMariia Savchuk, Giang Vo-Thanh, Sylvain Oudeyer, Hélène Beucher, Jean-François BrièreAn expeditious diatereoselective synthesis of pyrano[2,3-c]pyrroles thanks to a domino Vinylogous aza-Michael-Aldol-Cyclocondensation (aza-VMAC) reaction to alkylidene Meldrum's acid derivatives.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermal stability and yield By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,3009-3018DOI: 10.1039/D4OB00211C, PaperYu-Ke Cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo ZhengA single-point mutation of 7α-HSDH achieved the highest activity and synergistically improved substrate tolerance, thermal stability, cofactor affinity, and conversion rate.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Expanding the scope of the successive ring expansion strategy for macrocycle and medium-sized ring synthesis: unreactive and reactive lactams By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,2985-2991DOI: 10.1039/D4OB00285G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Zhongzhen Yang, Marion Arnoux, Damien Hazelard, Owen R. Hughes, Joe Nabarro, Adrian C. Whitwood, Martin A. Fascione, Christopher D. Spicer, Philippe Compain, William P. UnsworthNew Successive Ring Expansion (SuRE) protocols are described for use on unreactive lactams, as well as iminosugar derived lactams.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Photogenerated chlorine radicals activate C(sp3)–H bonds of alkylbenzenes to access quinazolinones By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,2968-2973DOI: 10.1039/D4OB00129J, CommunicationXin-Yao Pan, Gui-Xia Sun, Fang-Ping Huang, Wen-Jian Qin, Qing-Hu Teng, Kai WangAn Fe-catalyzed visible-light induced condensation of alkylbenzenes with anthranilamides has been developed.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Stereoselective synthesis of (R)- and (S)-1,2-diazetidine-3-carboxylic acid derivatives for peptidomimetics By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,2974-2977DOI: 10.1039/D4OB00278D, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Matthew Nutter, Henry Stone, Michael Shipman, Stefan RoesnerStereoselective synthesis of both enantiomers of orthogonally protected 1,2-diazetidine-3-carboxylic acid (aAze) from homochiral glycidol and its application in peptidomimetics.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Direct access to pyrrole anhydrides via oxidative self-coupling of pyrrole carboxaldehydes By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, 22,3045-3052DOI: 10.1039/D4OB00052H, PaperSurabhi Panday, Tapas Maity, Pratibha Bhatti, Joydev K. LahaAn elegant synthesis of pyrrole-2-carboxylic acid anhydrides from pyrrole-2-carboxaldehydes using TBAI as a catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant is described herein.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac BBr3-mediated dearomative spirocyclization of biaryl ynones: facile access to spiro[5.5]dienones By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00274A, CommunicationGaurav Jaiswal, Subhas Chandra PanBBr3 mediated dearomative spirocyclization of biaryl ynones has been reported for the direct synthesis of spiro[5.5]dienones with a tri-substituted double bond.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Exploring the mechanism of the reductive amination of acetophenones via Borch approach: the role of the acid catalyst By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00160E, PaperJoão Pedro Albuquerque Souza, Amanda Krauskopf Jacobs, Leandro Piovan, Renan Borsoi CamposThe energetic viability of several mechanistic variations of the reductive amination of acetophenones via the Borch approach was reexamined through density functional theory calculations. The crucial involvement of the acid...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Dess–Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00240G, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Alexandra R. E. Serre, Vibhu Jha, Adèle Rivault, Leif A. Eriksson, Goreti Ribeiro Morais, Robert A. FalconerHerein we describe the first example of the conversion of the primary alcohol of cytidine into a carboxylic acid by use of the Dess–Martin periodinane oxidising agent.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00272E, PaperBrenno A. D. Neto, Pedro Beck, Arthur Leitão, Yasmin Santana, Jose R. Correa, Carime Vitória da Silva Rodrigues, Daniel Machado, Guilherme Matos, Luciana Machado Ramos, Claudia Cristina Gatto, Carlos Kleber Z. Andrade, Sarah CaldasThis study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00040D, PaperSidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar AhmedDespite the high global prevalence, rheumatoid arthritis lacks a satisfactory treatment.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Discovery of selective monosaccharide receptors via dynamic combinatorial chemistry By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00015C, Communication Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Miguel Alena-Rodriguez, Marcos Fernandez-Villamarin, Ignacio Alfonso, Paula M. MendesAn effective workflow to discover selective saccharide receptors by combining dynamic combinatorial chemistry with isothermal titration calorimetry and NMR.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00302K, CommunicationQiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo ZhaoThe aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac An FeCl3-catalyzed three-component reaction for the synthesis of β-(1,2,3-triazolyl)-ketones using DMF as a one-carbon source By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00207E, CommunicationRuilin Fang, Lei Zheng, Xuyang Chen, Can Wang, Yunfeng ChenFeCl3-catalyzed oxidative condensation of NH-1,2,3-triazoles and aryl methyl ketones and DMF has been reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00167B, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maxim A. Voinov, Nicholas Nunn, Roshan Rana, Atli Davidsson, Alex I. Smirnov, Tatyana I. SmirnovaEPR-based local pH measurements based on changes in rotational dynamics of spin-bearing molecules upon protonation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Facile synthesis of tetrahydroquinoline containing dithiocarbamate derivatives via one-pot sequential multicomponent reaction By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00490F, CommunicationSIDDHARTHA KUMAR SENAPATI, Anit Pal, Animesh DasAn efficient sequential multi-component method for the synthesis of tertrahydroquinoline containing dithiocarbamate has been developed. This reaction involved a boronic acid-catalyzed reduction of quinoline to tertrahydroquinoline, followed by nucleophilic addition...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac New Generation of Highly Reactive Allylborating Agents For Cu(I)-Catalyzed Allylation of Chiral Sulfinylimines By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00291A, PaperMichael S. Alexeev, Tatyana V. Strelkova, Michail M. Ilyin, Jr., Yulia V. Nelyubina, Ivan A. Bespalov, Michael Medvedev, Victor N Khrustalev, Nikolai KuznetsovThe implementation of selective catalytic processes with highly active reagents is an attractive strategy that meets modern principles of sustainable development of chemistry. In the current study, we for the...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00315B, PaperShoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang HuangA series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Regioselective synthesis of 4-arylamino-1,2-naphthoquinones in eutectogel as a confined reaction medium using LED light By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00140K, CommunicationR. Vara Prasad, Yogendra Kumar, R. Arun Kumar, Tohira Banoo, Subbiah NagarajanThe use of a simple carbohydrate-derived eutectogel facilitating a LED-light-induced regioselective synthesis of 4-arylamino-1,2-naphthoquinones in good yields is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00363B, PaperSi-Yu Wang, Chu Liu, Wei Yang, Zhong-Ying Tian, Lin Yuan, Long-Yong XieA three-component cascade reaction of quinoxalinones, alkynes and AgSCF3 toward complete E-selective SCF3-containing 3-alkenylquinoxalinones was developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Advance ArticleDOI: 10.1039/D4OB00479E, CommunicationCao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh NguyenA cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac K2CO3-Mediated (3+3-1) Annulation of 1,3-Acetonedicarboxylates with 2-Fluoro-1-nitroarenes: Synthesis of Indoles By pubs.rsc.org Published On :: Org. Biomol. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4OB00488D, PaperMeng-Yang Chang, Chin-Huey Ho, Hsing-Yin ChenThe K2CO3-mediated one-pot reaction of 1,3-acetonedicarboxylates with 2 equiv. of substituted 2-fluoro-1-nitrobenzenes has been developed to synthesize various 2,3-dicarboxylate indoles via a tandem (3 + 3 − 1) annulation pathway....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Updates to the service worker cache API By developers.google.com Published On :: Thu, 03 Sep 2015 00:00:00 +0000 Full Article
ac A time when hijackings were dime-a-dozen in the US By www.thehindubusinessline.com Published On :: Sun, 27 Jun 2021 13:07:20 +0530 Unthinkable in today’s hyper-security post-9/11 environment, forced diversions were commonplace in the ’60s Full Article Flight Plan
ac Pandemic: Contactless technology on an overdrive By www.thehindubusinessline.com Published On :: Sun, 19 Sep 2021 15:50:25 +0530 As demand for travel rises, industry must meet it while ensuring passenger safety Full Article Logistics
ac Those magnificent flying machines By www.thehindubusinessline.com Published On :: Sun, 26 Dec 2021 18:12:38 +0530 The aviation industry’s roller-coaster ride Full Article Flight Plan
ac Making a comeback By www.thehindubusinessline.com Published On :: Sun, 20 Feb 2022 22:00:00 +0530 The aviation industry has proved its resilience by standing strong, despite an unprecedented economic crisis Full Article Flight Plan
ac No turning back By www.thehindubusinessline.com Published On :: Sun, 20 Mar 2022 21:57:00 +0530 If no action is taken, aviation’s contribution towards greenhouse gas emissions will increase Full Article Flight Plan
ac Corporate travel is unlikely to reach pre-Covid levels By www.thehindubusinessline.com Published On :: Sun, 03 Apr 2022 18:42:20 +0530 However, with offices opening up, many airlines are seeing increased demand with an uptick for premium cabins Full Article Flight Plan
ac Domestic airline industry may face a rejig By www.thehindubusinessline.com Published On :: Sun, 17 Apr 2022 20:18:03 +0530 The pandemic laid bare fault-lines within India’s airlines Full Article Flight Plan
ac The art of avoiding accidents in air By www.thehindubusinessline.com Published On :: Sun, 10 Jul 2022 16:52:28 +0530 Flying distance may vary based on flight phases, altitudes and regions Full Article Flight Plan
ac Embraer expects capacity dynamics to tilt demand in its favour By www.thehindubusinessline.com Published On :: Sun, 18 Sep 2022 21:00:00 +0530 The plane maker’s current foray attempts to shed the tentativeness that overshadowed its earlier endeavours Full Article Flight Plan
ac Apple AirPods Pro’s new hearing aid feature could help people face a problem they’d rather ignore By www.thehindu.com Published On :: Tue, 29 Oct 2024 08:47:33 +0530 Millions who could benefit from hearing aids have never tried them, but the Apple AirPods could change this Full Article Technology
ac Google’s moneymaking machine still pumping out massive profits despite multiple threats By www.thehindu.com Published On :: Wed, 30 Oct 2024 08:18:51 +0530 Google is still thriving while the company navigates through a pivotal shift to artificial intelligence and battles regulators trying to topple its internet empire Full Article Technology
ac OpenAI builds first chip with Broadcom and TSMC, scales back foundry ambition By www.thehindu.com Published On :: Wed, 30 Oct 2024 08:32:52 +0530 OpenAI is working with Broadcom and TSMC to build its first in-house chip designed to support its artificial intelligence systems, per sources Full Article Technology
ac Crypto firm Consensys to cut 20% of workforce amid macroeconomic, regulatory headwinds By www.thehindu.com Published On :: Wed, 30 Oct 2024 11:42:41 +0530 The crypto firm added that elevated interest rates, inflationary pressures, and tightening liquidity have created a more “cautious macroeconomic environment” Full Article Technology
ac Chinese researchers develop AI model for military use on back of Meta's Llama By www.thehindu.com Published On :: Fri, 01 Nov 2024 09:59:35 +0530 ChatBIT was fine-tuned and "optimised for dialogue and question-answering tasks in the military field", the paper said Full Article Technology
ac I Didn’t Realize How Much I Rely on GitHub Codespaces Until This week By htmlcssjavascript.com Published On :: Wed, 10 Apr 2024 16:15:24 +0000 How much do I rely on GitHub Codespaces for open source development? Super double-plus much. I can illustrate exactly how much with one short anecdote. Gulp 5 was recently released and I created several PRs across repos in the H5BP organization to update Gulp across the board. I missed one issue with the encoding of […] Full Article HTML JavaScript github h5bp
ac WHO to evacuate 1,000 Gazan women, children for urgent medical care By www.thehindu.com Published On :: Mon, 21 Oct 2024 16:02:57 +0530 Last week, U.N. investigators said Israel was deliberately targeting health facilities in Gaza, and killing and torturing medical personnel there, accusing the country of "crimes against humanity". Full Article Health
ac Dietary restriction or good genes: new study tries to unpack which has greater impact on lifespan By www.thehindu.com Published On :: Mon, 21 Oct 2024 16:50:20 +0530 If we know that genetics and lifestyle affect how long you live, which one is more important? And how do they interact? Full Article Health
ac High cataract rate among elderly in Mucherla, Meerkhanpet of Rangareddy district, says survey By www.thehindu.com Published On :: Tue, 22 Oct 2024 10:05:07 +0530 HHF’s screening of 200 patients in Mucherla and Meerkhanpet found that 21% had senile cataracts, 18% had immature cataracts, and 15% had refractive errors Full Article Telangana
ac Rapid assessment of pulse polio campaign shows high vaccine coverage, highlights gaps in Chennai By www.thehindu.com Published On :: Tue, 22 Oct 2024 15:41:02 +0530 Chennai accounted for nearly 21% of the non-vaccinated children, highlighting the gaps in an urban area and the need for targeted community outreach Full Article Chennai
ac Acute Flaccid Paralysis surveillance as a crucial defence against polio in India | Explained By www.thehindu.com Published On :: Wed, 23 Oct 2024 14:26:23 +0530 India needs to continue efforts to maintain its polio-free status, and AFP surveillance has to remain a cornerstone of its strategy Full Article Health
ac Over 77 per cent of India’s children lack WHO-suggested diversity in diet, study finds By www.thehindu.com Published On :: Wed, 23 Oct 2024 16:38:03 +0530 The states of Uttar Pradesh, Rajasthan, Gujarat, Maharashtra and Madhya Pradesh reported the highest levels of inadequate diversity in children's diets -- all above 80 per cent -- while Sikkim and Meghalaya were the only two to report an under-50 per cent prevalence Full Article Health
ac WHO says ‘intense bombardment’ halts Gaza polio vaccinations By www.thehindu.com Published On :: Wed, 23 Oct 2024 16:50:34 +0530 The U.N. health body said it had been “compelled to postpone” the bid to give 119,279 children in northern Gaza a second vaccine dose due to the escalating violence Full Article Health
ac Trachoma eliminated as a public health problem in India; what next? By www.thehindu.com Published On :: Fri, 25 Oct 2024 06:00:00 +0530 The achievement marks a significant public health victory and has profound economic implications. Trachoma’s impact, through blindness and visual impairment, results in an estimated economic loss of $2.9 to 5.3 billion annually due to reduced productivity Full Article Health
ac Drugs regulator finds 49 samples not of standard quality, manufacturers asked to withdraw their products By www.thehindu.com Published On :: Sat, 26 Oct 2024 03:00:00 +0530 Four spurious drugs were also found and action has been initiated against the makers, the DCGI said Full Article Health