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Quantitatively controllable fluid flows with ballpoint-pen-printed patterns for programmable photo-paper-based microfluidic devices

Lab Chip, 2020, 20,1601-1611
DOI: 10.1039/D0LC00115E, Paper
Veasna Soum, Sooyong Park, Albertus Ivan Brilian, Jae-Youl Choi, Yongwoo Lee, Wonjung Kim, Oh-Sun Kwon, Kwanwoo Shin
A precise, simple, and inexpensive method for controlling fluid flow in a photo-paper-based microfluidic device was reported.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Monitoring the two-dimensional concentration profile of toluene vapors by using polymer-stabilized nematic liquid crystals in microchannels

Lab Chip, 2020, 20,1687-1693
DOI: 10.1039/C9LC01021A, Paper
Zongdai Liu, Dan Luo, Kun-Lin Yang
The concentration of toluene vapor is obtained based on polymer-stabilized liquid crystals by viewing a colourful gamut under a polarized optical microscope.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery

Lab Chip, 2020, 20,1562-1576
DOI: 10.1039/D0LC00121J, Paper
Open Access
Nicola Di Trani, Antonia Silvestri, Antons Sizovs, Yu Wang, Donald R. Erm, Danilo Demarchi, Xuewu Liu, Alessandro Grattoni
Control of molecular diffusion through nanofluidic channels using electrostatic gating.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Hybrid paper and 3D-printed microfluidic device for electrochemical detection of Ag nanoparticle labels

Lab Chip, 2020, 20,1648-1657
DOI: 10.1039/D0LC00276C, Paper
Charuksha Walgama, Michael P. Nguyen, Lisa M. Boatner, Ian Richards, Richard M. Crooks
A hybrid paper/plastic microfluidic device for detection of Ag nanoparticle labels at concentrations as low as 12 pM.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selective cell propagation via micropatterning of a thermally-activated hydrogel

Lab Chip, 2020, 20,1544-1553
DOI: 10.1039/C9LC01230C, Communication
Jeffrey C. Y. Chiu, Joyce A. Teodoro, Jeong Hyun Lee, Kerryn Matthews, Simon P. Duffy, Hongshen Ma
Inverse gelation of methylcellulose enables hydrogel micropatterning to selectively propagate cells identified by microscopy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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In-flow measurement of cell–cell adhesion using oscillatory inertial microfluidics

Lab Chip, 2020, 20,1612-1620
DOI: 10.1039/D0LC00089B, Paper
Baris R. Mutlu, Taronish Dubash, Claudius Dietsche, Avanish Mishra, Arzu Ozbey, Kevin Keim, Jon F. Edd, Daniel A. Haber, Shyamala Maheswaran, Mehmet Toner
Cell–cell adhesion strength of freely suspended cell clusters can be measured using an oscillatory inertial microfluidic system.
The content of this RSS Feed (c) The Royal Society of Chemistry




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3-Step flow focusing enables multidirectional imaging of bioparticles for imaging flow cytometry

Lab Chip, 2020, 20,1676-1686
DOI: 10.1039/D0LC00244E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Andreas Kleiber, Anuradha Ramoji, Günter Mayer, Ute Neugebauer, Jürgen Popp, Thomas Henkel
The control of the focus plane allows multi-directional imaging flow cytometry.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Matrix density drives 3D organotypic lymphatic vessel activation in a microfluidic model of the breast tumor microenvironment

Lab Chip, 2020, 20,1586-1600
DOI: 10.1039/D0LC00099J, Paper
Karina M. Lugo-Cintrón, José M. Ayuso, Bridget R. White, Paul M. Harari, Suzanne M. Ponik, David J. Beebe, Max M. Gong, María Virumbrales-Muñoz
Lymphatic organotypic in vitro model allows the examination of components of the tumor microenvironment (e.g., ECM density, cancer cells) in lymphatic vessel biology in the context of cancer, providing insights into potential therapeutic targets.
The content of this RSS Feed (c) The Royal Society of Chemistry




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High-sensitivity microliter blood pressure sensors based on patterned micro-nanostructure arrays

Lab Chip, 2020, 20,1554-1561
DOI: 10.1039/D0LC00063A, Communication
Nianzuo Yu, Yongshun Liu, Bai Ji, Shuli Wang, Yunyun Chen, Tianmeng Sun, Junhu Zhang, Bai Yang
Blood pressure sensors are proposed to measure the value of central venous pressure, and diagnose the severity of hypertension, hypotension and arterial thrombosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




y

Acoustic erythrocytometer for mechanically probing cell viscoelasticity

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC00999J, Paper
Open Access
A. Link, T. Franke
Novel microfluidic platform to determine the viscoelastic fingerprint of a red blood cell population using surface acoustic waves.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Particle/cell separation using sheath-free deterministic lateral displacement arrays with inertially focused single straight input

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00354A, Paper
Naotomo Tottori, Takasi Nisisako
We propose sheath-free microfluidic deterministic lateral displacement devices with inertially focused single straight input.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A high-throughput system combining microfluidic hydrogel droplets with deep learning for screening the antisolvent-crystallization conditions of active pharmaceutical ingredient

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00153H, Paper
Zhening Su, Jinxu He, Peipei Zhou, Lu Huang, Jianhua Zhou
Crystallization of active pharmaceutical ingredients (APIs) is a crucial process in the pharmaceutical industry due to its great impact in drug efficacy. However, conventional approaches for screening the optimal crystallization...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evaluation of intercellular communication between breast cancer cells and adipose-derived stem cells via passive diffusion in a two-layer microfluidic device

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00142B, Paper
Sharif M. Rahman, Joshua M. Campbell, Rachael N. Coates, Katie M. Render, C. Ethan Byrne, Elizabeth C. Martin, Adam T. Melvin
Breast cancer cells co-cultured with adipose-derived stem cells (ASCs) in a microfluidic device exhibited enhanced growth, a more aggressive morphology and polarization towards the ASCs, and increased drug resistance.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A Web-based Automated Machine Learning Platform to Analyze Liquid Biopsy Data

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00096E, Paper
Hanfei Shen, Tony Liu, Jesse Cui, Piyush Borole, Ari Benjamin, Konrad Kording, David Issadore
Liquid biopsy (LB) technologies continue to improve in sensitivity, specificity, and multiplexing and can measure an ever growing library of disease biomarkers. However, clinical interpretation of the increasingly large sets...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Liquid-liquid-liquid three-phase microsystem: hybrid slug flow-laminar flow

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00292E, Communication
Tao Wang, Cong Xu
Liquid-liquid-liquid three-phase microfluidics provides abundant flow patterns and attractive characteristics that substantially extend the applications of liquid-liquid two-phase microfluidics. Although the manipulation of stable interfaces between adjacent liquid phases is...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Picoliter Agar Droplet Breakup in Microfluidics Meets Microbiology Application: Numerical and Experimental Approaches

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00300J, Paper
Asmaa Khater, Osama Abdelrehim, Mehdi Mohammadi, Milad Azarmanesh, Mohsen Jonmaleki, Razieh Salahandish, AbdulMajeed Mohamad, Amir Sanati Nezhad
Droplet microfluidics has provided lab-on-a-chip platforms with the capability of bacteria encapsulation in biomaterials, controlled culture environment, and live monitoring of growth and proliferation. The droplets are mainly generated from...
The content of this RSS Feed (c) The Royal Society of Chemistry




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PM Narendra Modi’s day at the Red Fort through 10 Express photos




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Express newslist: Updates on Draft National Encryption Policy, beef ban and other stories




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Express newslist: Secret letter on Netaji, Bombay HC verdict on sedition and other updates




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Express News list: Hardik surfaces after disappearance, prosecution seeks death penalty for 8 in Mumbai blasts case




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Express Newslist: Mumbai blasts convict’s confession, India’s reply to Pak at UN, Mahesh Sharma on Dadri lynching




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Dadri lynching: Akhlaq’s son fights for life, Muslims live in fear, politicians home in




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Express Newslist: MHA’s ‘zero tolerance’ on Dadri Lynching, jawans killed in Kupwara encounter, Khurshid Mahmud Kasuri’s new book,




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Bihar pre-poll survey: Advantage BJP as state gets ready for elections




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Here are the 33 writers who returned their Sahitya Akademi awards




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7th Pay Commission recommendations: All you need to know




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What is Panama Papers? Here is everything you need to know




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Today’s top news: Pinarayi to swear-in as Kerala CM, UP Governor on Bajrang Dal camp and more




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[ASAP] Comparing Cryo-EM Reconstructions and Validating Atomic Model Fit Using Difference Maps

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01103




y

[ASAP] Computational Protocol for Assessing the Optimal Pixel Size to Improve the Accuracy of Single-particle Cryo-electron Microscopy Maps

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01107




y

[ASAP] SPREAD: A Fully Automated Toolkit for Single-Particle Cryogenic Electron Microscopy Data 3D Reconstruction with Image-Network-Aided Orientation Assignment

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01099




y

[ASAP] POLARIS: Path of Least Action Analysis on Energy Landscapes

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01108




y

[ASAP] What Will Computational Modeling Approaches Have to Say in the Era of Atomistic Cryo-EM Data?

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00123




y

[ASAP] Need for Cross-Validation of Single Particle Cryo-EM

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01121




y

[ASAP] Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01073




y

[ASAP] What Could Go Wrong? A Practical Guide to Single-Particle Cryo-EM: From Biochemistry to Atomic Models

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01178




y

[ASAP] Structural Biology in the Multi-Omics Era

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01164




y

[ASAP] Will Cryo-Electron Microscopy Shift the Current Paradigm in Protein Structure Prediction?

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00177




y

[ASAP] Correction of Missing-Wedge Artifacts in Filamentous Tomograms by Template-Based Constrained Deconvolution

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01111




y

[ASAP] Retrospect and Prospect of Single Particle Cryo-Electron Microscopy: The Class of Integral Membrane Proteins as an Example

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01015




y

[ASAP] Modeling of a 14 kDa RUVBL2-Binding Domain with Medium Resolution Cryo-EM Density

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01095




y

[ASAP] MAINMASTseg: Automated Map Segmentation Method for Cryo-EM Density Maps with Symmetry

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01110




y

[ASAP] Flexible Fitting of Small Molecules into Electron Microscopy Maps Using Molecular Dynamics Simulations with Neural Network Potentials

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01167




y

[ASAP] Simulation-Based Methods for Model Building and Refinement in Cryoelectron Microscopy

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00087




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[ASAP] Propagation of Conformational Coordinates Across Angular Space in Mapping the Continuum of States from Cryo-EM Data by Manifold Embedding

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01115




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[ASAP] Cylindrical Similarity Measurement for Helices in Medium-Resolution Cryo-Electron Microscopy Density Maps

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00010




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[ASAP] Cov_FB3D: A De Novo Covalent Drug Design Protocol Integrating the BA-SAMP Strategy and Machine-Learning-Based Synthetic Tractability Evaluation

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01197




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[ASAP] Live Analysis and Reconstruction of Single-Particle Cryo-Electron Microscopy Data with CryoFLARE

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01102




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[ASAP] Exploring Conformational Space with Thermal Fluctuations Obtained by Normal-Mode Analysis

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.9b01136




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[ASAP] The Synthesizability of Molecules Proposed by Generative Models

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00174