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Test strip coupled Cas12a-assisted signal amplification strategy for sensitive detection of uracil-DNA glycosylase

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Lab Chip, 2024, 24,1987-1995
DOI: 10.1039/D4LC00096J, Paper
Bin Guo, Chong Hu, Zeping Yang, Chu Tang, Chuanxian Zhang, Fu Wang
In this study, we employed Cas12a protein and enzyme-assisted cycle amplification technology with a test strip to establish a precise platform for the detection of UDG enzyme.
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Wearable intelligent sweat platform for SERS-AI diagnosis of gout

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Lab Chip, 2024, 24,1996-2004
DOI: 10.1039/D3LC01094E, Paper
Zhaoxian Chen, Wei Wang, Hao Tian, Wenrou Yu, Yu Niu, Xueli Zheng, Shihong Liu, Li Wang, Yingzhou Huang
A wearable intelligent SERS platform enables the sensitive detection of UA (0.1 μM) in sweat for AI diagnosis of gout.
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A flexible electrode Array for genetic transfection of different layers of the retina by electroporation

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Lab Chip, 2024, 24,1957-1964
DOI: 10.1039/D3LC01014G, Paper
Yu Zhang, Tao Peng, Yu Ge, Mengda Li, Chendi Li, Jiyu Xi, Zixi Li, Zewen Wei, Yuntao Hu
Stratified delivery into specific retinal layers was realized by a flexible electrode array that exhibited high compatibility with surgical procedures.
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Confining calcium oxalate crystal growth in a carbonated apatite-coated microfluidic channel to better understand the role of Randall's plaque in kidney stone formation

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Lab Chip, 2024, 24,2017-2024
DOI: 10.1039/D3LC01050C, Paper
Samantha Bourg, Karol Rakotozandriny, Ivan T. Lucas, Emmanuel Letavernier, Christian Bonhomme, Florence Babonneau, Ali Abou-Hassan
The successful formation of a carbonated apatite coating inside a micrometer channel is described, which was used to investigate its role on the formation of calcium oxalate crystals in the context of kidney stones.
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A microfluidic chip for sustained oxygen gradient formation in the intestine ex vivo

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Lab Chip, 2024, 24,1918-1929
DOI: 10.1039/D3LC00793F, Paper
Lauren M. Delong, Colby E. Witt, Madison Pennell, Ashley E. Ross
Here, we have developed a 3D printed microfluidic device capable of oxygen gradient formation within intestinal tissue slices ex vivo. The device is open-welled and compatible with external electrochemical recording during tissue analysis.
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Microfluidic impedance cytometry with flat-end cylindrical electrodes for accurate and fast analysis of marine microalgae

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Lab Chip, 2024, 24,2058-2068
DOI: 10.1039/D3LC00942D, Paper
Xiaoming Chen, Mo Shen, Shun Liu, Chungang Wu, Liangliang Sun, Zhipeng Song, Jishun Shi, Yulong Yuan, Yong Zhao
We develop a novel microfluidic impedance cytometer for analysis of marine microalgae by inserting ground flat-end cylindrical electrodes into microchannels.
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Comparison between dynamic versus static models and real-time monitoring of neuronal dysfunction in an amyloid-β induced neuronal toxic model on a chip platform

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Lab Chip, 2024, 24,1887-1902
DOI: 10.1039/D3LC00507K, Paper
Open Access
Chu-Chun Liang, Po-Yen Chen, Nien-Che Liu, I-Chi Lee
A 3D neural spheroid-based system with an interstitial level of flow for simulating the brain microenvironment toward a dynamic amyloid-β induced neuronal toxic model was established. A real-time impedance recording was used to monitor the neural network formation and disconnection.
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SeParate: multiway fluorescence-activated droplet sorting based on integration of serial and parallel triaging concepts

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Lab Chip, 2024, 24,2107-2121
DOI: 10.1039/D3LC01075A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Wannes Verbist, Jolien Breukers, Sapna Sharma, Iene Rutten, Hans Gerstmans, Lotte Coelmont, Francesco Dal Dosso, Kai Dallmeier, Jeroen Lammertyn
A novel platform, called SeParate, enabling accurate multiplex droplet sorting by integrating serial and parallel sorting principles for three model systems with increasing complexity and intra-subpopulation variation in fluorescence intensities.
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Recent developments and future perspectives of microfluidics and smart technologies in wearable devices

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Lab Chip, 2024, 24,1833-1866
DOI: 10.1039/D4LC00089G, Critical Review
Sasikala Apoorva, Nam-Trung Nguyen, Kamalalayam Rajan Sreejith
Wearable devices are increasingly popular in health monitoring, diagnosis, and drug delivery. Advances allow real-time analysis of biofluids like sweat, tears, saliva, wound fluid, and urine.
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Droplet microfluidic system for high throughput and passive selection of bacteria producing biosurfactants

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Lab Chip, 2024, 24,1947-1956
DOI: 10.1039/D3LC00656E, Paper
Open Access
Klaudia Staskiewicz, Maria Dabrowska-Zawada, Lukasz Kozon, Zofia Olszewska, Lukasz Drewniak, Tomasz S. Kaminski
Novel microfluidic technique for functional selection of biosurfactant-producing microorganisms. Single bacterial cells are encapsulated into picoliter droplets for clonal cultivation and passively sorted at high throughput by interfacial tension.
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Next generation microfluidics: fulfilling the promise of lab-on-a-chip technologies

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Lab Chip, 2024, 24,1867-1874
DOI: 10.1039/D3LC00796K, Perspective
Open Access
Umut A. Gurkan, David K. Wood, Dorn Carranza, Luke H. Herbertson, Scott L. Diamond, E. Du, Suvajyoti Guha, Jorge Di Paola, Patrick C. Hines, Ian Papautsky, Sergey S. Shevkoplyas, Nathan J. Sniadecki, Vamsee K. Pamula, Prithu Sundd, Asif Rizwan, Pankaj Qasba, Wilbur A. Lam
In this perspective article, we present the state of the microfluidic field regarding current limitations and propose future directions and new approaches for the field to advance lab-on-a-chip technologies closer to translation and clinical use.
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Tuneable hydrogel patterns in pillarless microfluidic devices

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Lab Chip, 2024, 24,2094-2106
DOI: 10.1039/D3LC01082A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Claudia Olaizola-Rodrigo, Sujey Palma-Florez, Teodora Ranđelović, Clara Bayona, Mehran Ashrafi, Josep Samitier, Anna Lagunas, Mònica Mir, Manuel Doblaré, Ignacio Ochoa, Rosa Monge, Sara Oliván
A novel methodology utilizing plasma surface treatment enables the construction of cell culture chambers featuring abutment-free patterns, facilitating the precise distribution of shear stress.
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A self-assembly and cellular migration based fabrication of high-density 3D tubular constructs of barrier forming membranes

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00006D, Paper
Seyedaydin Jalali, Ponnambalam Ravi Selvaganapathy
A scalable method for creating perfusable 3D tissue constructs using self-assembly is introduced. Unlike conventional cell injection methods, here we leverage cell migration to form tissue barriers of low permeability, mimicking in vivo environments.
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Direct laser writing-enabled 3D printing strategies for microfluidic applications

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00743J, Tutorial Review
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Olivia M. Young, Xin Xu, Sunandita Sarker, Ryan D. Sochol
This Tutorial Review highlights strategies for leveraging the micron-to-submicron-scale additive manufacturing technique, “direct laser writing”, to enable 3D microfluidic technologies.
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Spatially controlled diffusion range of tumor-associated angiogenic factors to develop a tumor model using a microfluidic resistive circuit

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Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00891F, Paper
Yu-Hsiang Hsu, Wen-Chih Yang, Yi-Ting Chen, Che-Yu Lin, Chiou-Fong Yang, Wei-Wen Liu, Subhashree Shivani, Pai-Chi Li
The DC-MPS device uses a velocity V-clamp to create a partition with a steep concentration gradient for simultaneously developing vasculogenic vessels and a tumor. It enables vessel–tumor interaction to develop a tumor model with angiogenic vessels.
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Development of a self-contained microfluidic chip and an internet-of-things-based point-of-care device for automated identification of respiratory viruses

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Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00933E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Huynh Quoc Nguyen, Van Dan Nguyen, Vu Minh Phan, Tae Seok Seo
The COVID-19 pandemic greatly impacted the in vitro diagnostic market, leading to the development of new technologies such as point-of-care testing (POCT), multiplex testing, and digital health platforms.
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Microfluidic Particle Counter Visualizing Mucosal Antibody Levels against SARS-CoV-2 in the Upper Respiratory Tract for Rapid Evaluation of Immune Protection

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Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00118D, Paper
Open Access
Jiaheng Li, Lok Ting CHU, Hogi Hartanto, Guihuan Guo, Lu LIU, Jianpeng WU, Minghui Wu, Chenyu Cui, Gaobo Wang, Wengang LIU, Hoi Kwan Kwong, Siying WU, Ting-Hsuan Chen
Mucosal antibodies at the upper respiratory tract are the earliest and most critical responders to prevent respiratory infections, providing an indication to rapidly evaluate immune protection. Here, we report a...
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Detection and Identification of Single Ribonucleotide Monophosphates using a Dual In-Plane Nanopore Sensor Made from a Thermoplastic via Replication

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Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC01062G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Steven A. Soper, Chathurika Rathnayaka, Indu Chandrasoma, Junseo Choi, Katie Childers, Maximillian Chibuike, Khurshed Akabirov, Farhad Shiri, Adam R Hall, Collin J McKinney, Matthew David Verber, Sunggook Park
We report the generation of ~8 nm dual in-plane pores fabricated in a thermoplastic via nanoimprint lithography (NIL). These pores were connected in series with nanochannels, one of which served...
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High-throughput viscoelastic characterization of cells in hyperbolic microchannels

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01061A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Felix Reichel, Ruchi Goswami, Salvatore Girardo, Jochen Guck
We use hyperbolic microchannels to create a flow field with linearly increasing velocity, leading to a constant tensile stress to probe the viscoelastic properties of cells. We verify our approach on oil droplets and polyacrylamide beads.
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Piezoelectric and microfluidic tuning of an infrared cavity for vibrational polariton studies

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01101A, Paper
Wei Wang, Jaime de la Fuente Diez, Nicolas Delsuc, Juan Peng, Riccardo Spezia, Rodolphe Vuilleumier, Yong Chen
A new method uses piezoelectric and microfluidic tuning to study vibrational polaritons in liquids under flow. This enables modifying cavity length adjustments and flexibility in experimental setups.
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Operando scanning electron microscopy platform for in situ imaging of fluid evolution in nanoporous shale

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Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC01066J, Paper
Open Access
Artur Davletshin, Wen Song
Fluid-solid interactions in nanoporous materials underlie processes fundamental to nature and the engineered environment, including the thermochemical transformation of argillaceous materials during high-level nuclear waste disposal. Operando fluid-solid resolution at...
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Dielectrophoretic characterization and selection of non-spherical flagellate algae in parallel channels with right-angle bipolar electrodes

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00165F, Paper
Xiaoming Chen, Shun Liu, Mo Shen, Jishun Shi, Chungang Wu, Zhipeng Song, Yong Zhao
We develop a microfluidic device with closed right-angle bipolar electrodes to realize dielectrophoretic characterization and selection of non-spherical flagellate algae.
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An economical in-class sticker microfluidic activity develops student expertise in microscale physics and device manufacturing

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Lab Chip, 2024, 24,2176-2192
DOI: 10.1039/D3LC00912B, Paper
Open Access
Priscilla Delgado, C. Alessandra Luna, Anjana Dissanayaka, Oluwamayokun Oshinowo, Jesse J. Waggoner, Sara Schley, Todd Fernandez, David R. Myers
This activity enables students to construct geometrically complex microfluidics at their desk with no specialized equipment. It can be easily transported, and helped students significantly improve their understanding of miniaturization science.
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Polar coordinate active-matrix digital microfluidics for high-resolution concentration gradient generation

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Lab Chip, 2024, 24,2193-2201
DOI: 10.1039/D3LC00979C, Paper
Bingbing Zhang, Jinxin Fu, Maohua Du, Kai Jin, Qi Huang, Jiahao Li, Dongping Wang, Siyi Hu, Jinhua Li, Hanbin Ma
Advancing active-matrix digital microfluidics through polar coordinates for precise concentration gradients. Demonstrated with chip photography, concentration gradient solution demo, and efficiency comparison.
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Synthesis and photocatalytic property of Au–TiO2 nanocomposites with controlled morphologies in microfluidic chips

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Lab Chip, 2024, 24,2253-2261
DOI: 10.1039/D3LC01053H, Paper
Ziran Ye, Ping Lu, Yiben Chen, Zhixian Xu, Haixia Huang, Mingjia Zhi, Zi Ang Chen, Bo Yan
We present an efficient approach for the consecutive synthesis of Au–TiO2 nanocomposites with controlled morphologies in a microfluidic chip.
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Deep learning-enabled detection of rare circulating tumor cell clusters in whole blood using label-free, flow cytometry

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Lab Chip, 2024, 24,2237-2252
DOI: 10.1039/D3LC00694H, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilay Vora, Prashant Shekar, Taras Hanulia, Michael Esmail, Abani Patra, Irene Georgakoudi
We present a deep-learning enabled, label-free flow cytometry platform for identifying circulating tumor cell clusters in whole blood based on the endogenous scattering detected at three wavelengths. The method has potential for in vivo translation.
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High-throughput 3D microfluidic chip for generation of concentration gradients and mixture combinations

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Lab Chip, 2024, 24,2280-2286
DOI: 10.1039/D3LC00822C, Paper
Mingwei Zhao, Jing Yang, Zhenqing Li, Yuan Zeng, Chunxian Tao, Bo Dai, Dawei Zhang, Yoshinori Yamaguchi
Concentration gradient generation and mixed combinations of multiple solutions are of great value in the field of biomedical research.
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Distance-based paper analytical device for multiplexed quantification of cytokine biomarkers using carbon dots integrated with molecularly imprinted polymer

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Lab Chip, 2024, 24,2262-2271
DOI: 10.1039/D4LC00055B, Paper
Kawin Khachornsakkul, Ruben Del-Rio-Ruiz, Lita Chheang, Wenxin Zeng, Sameer Sonkusale
A carbon dots and dopamine-imprinted polymer was immobilized onto a distance-based paper channel for simultaneous detection of three cytokine biomarkers without requiring expensive reagents and instruments.
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Effect of in-plane and out-of-plane bifurcated microfluidic channels on the flow of aggregating red blood cells

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Lab Chip, 2024, 24,2317-2326
DOI: 10.1039/D4LC00151F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Amirreza Gholivand, Olivera Korculanin, Knut Dahlhoff, Mehrnaz Babaki, Timo Dickscheid, Minne Paul Lettinga
Taking microfluidics to the third dimension causes scrambling of memory effects in blood flow due to out-of-plane vessel structures.
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A cheaper substitute for HRP: ultra-small Cu–Au bimetallic enzyme mimics with infinitesimal steric hindrance to promote catalytic lateral flow immunodetection of clenbuterol

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Lab Chip, 2024, 24,2272-2279
DOI: 10.1039/D3LC01079A, Paper
Huilan Hu, Jiaqi Tian, Rui Shu, Huihui Liu, Shaochi Wang, Xuechi Yin, Jianlong Wang, Daohong Zhang
A lateral flow immunoassay (LFIA) is developed for enzyme-catalyzed double-reading determination of clenbuterol (CLE) through the direct electrostatic adsorption of ultra-small copper–gold bimetallic enzyme mimics (USCGs) and monoclonal antibodies.
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A microfluidic model to study the effects of arrhythmic flows on endothelial cells

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Lab Chip, 2024, 24,2347-2357
DOI: 10.1039/D3LC00834G, Paper
Austin Lai, Adam Hawke, Mokhaled Mohammed, Peter Thurgood, Gianmarco Concilia, Karlheinz Peter, Khashayar Khoshmanesh, Sara Baratchi
We created a versatile microfluidic system for studying the effect of arrhythmic flow patterns on endothelial cells in vitro. This system provides unique opportunities to identify the molecular machineries that control endothelial biology in response to arrhythmia.
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Development of wafer-scale multifunctional nanophotonic neural probes for brain activity mapping

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Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00931A, Perspective
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Fu Der Chen, Ankita Sharma, David A. Roszko, Tianyuan Xue, Xin Mu, Xianshu Luo, Hongyao Chua, Patrick Guo-Qiang Lo, Wesley D. Sacher, Joyce K. S. Poon
We explore the development of multifunctional nanophotonic neural probes, integrating microelectrodes, optical emitters, and microfluidic channels for multimodal brain mapping.
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A novel ratiometric design of microfluidic paper-based analytical device for the simultaneous detection of Cu2+ and Fe3+ in drinking water using a fluorescent MOF@tetracycline nanocomposite

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Published On ::

Lab Chip, 2024, 24,2306-2316
DOI: 10.1039/D3LC01045G, Paper
Sabah H. Al-Jaf, Sameera Sh. Mohammed Ameen, Khalid M. Omer
On-site monitoring of ions in drinking water is essential for safeguarding public health, ensuring high water quality, and preserving the ecological balance of aquatic ecosystems.
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Investigation of air bubble behaviour after gas embolism events induced in a microfluidic network mimicking microvasculature

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00087K, Paper
Mohammad Mahdi Mardanpour, Ayyappasamy Sudalaiyadum Perumal, Zahra Mahmoodi, Karine Baassiri, Gala Montiel-Rubies, Kenneth M. LeDez, Dan V. Nicolau
This study conducted in vitro experimentation using microvascular tissue-like structures to examine the dynamics of interfacial forces leading to gas bubble cessation, with the objective of providing a medical guideline for preventing gas embolism.
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Integrated high performance microfluidic organic analysis instrument for planetary and space exploration

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00012A, Paper
Anna L. Butterworth, Matin Golozar, Zachary Estlack, Jeremy McCauley, Richard A. Mathies, Jungkyu Kim
This work presents the design, fabrication, and automation of our space flight-format microfabricated sample processing and capillary electrophoresis analysis instrument.
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A microfluidic-based gut-on-a-chip model containing the gut microbiota of patients with depression reveals physiological characteristics similar to depression

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Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01052J, Paper
Wenxin Wang, Yiyuan Liu, Zhikai Yao, Dengbo Chen, Yue Tang, Jingwei Cui, Jiangjiang Zhang, Hong Liu, Zikai Hao
A depression-on-gut-chip (DoGC) is prepared and enables extended co-culture of aerobic human intestinal epithelial cells and anaerobic gut microbiota, and allows direct study of interactions between human gut microbiota and depression.
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Study on the hemodynamic effects of different pulsatile working modes of a rotary blood pump using a microfluidic platform that realizes in vitro cell culture effectively

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00159A, Paper
Lixue Liang, Xueying Wang, Dong Chen, Palaniappan Sethu, Guruprasad A. Giridharan, Yanxia Wang, Yu Wang, Kai-Rong Qin
The best pulsation frequency mode of the RBP would be one that changes every 2–3 times of the cardiac cycle. The proposed in vitro microfluidic model could provide an effective platform to select the best working mode of the RBP for heart failure.
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Multiplex nanozymatic biosensing of Salmonella on a finger-actuated microfluidic chip

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Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00291A, Paper
Nana Jin, Fan Jiang, Fengzhen Yang, Ying Ding, Ming Liao, Yanbin Li, Jianhan Lin
A colorimetric biosensor was elaboratively designed for fast, sensitive and multiplex bacterial detection on a single microfluidic chip using immune magnetic nanobeads for specific bacterial separation, immune gold@platinum palladium nanoparticles...
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Rocking- and diffusion-based culture of tumor spheroids-on-a-chip

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Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01116J, Paper
Duomei Tian, Zheng Mao, Li Wang, Xiaochen Huang, Wei Wang, Haoyue Luo, Juan Peng, Yong Chen
Tumor spheroids are cultured in hydrogel microwells with a gravity driven medium flow underneath the membrane on-a-chip. The rocking system is pumpless, powered with a rechargeable battery, and programmable with a built-in microprocess.
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A microfluidic microalgae detection system for cellular physiological response based on object detection algorithm

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Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC00941F, Paper
Shizheng Zhou, Tianhui Chen, Edgar S. Fu, Liuyong Shi, Teng Zhou, Hong YAN
The composition of species and the physiological status of microalgal cells serve as significant indicators for monitoring marine environments. Symbiotic with corals, Symbiodiniacea are more sensitive to the environmental response....
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Microflow sensing and control using an in-channel birefringent biomembrane

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Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00985H, Paper
Open Access
Nan Jia, Tianyang Deng, Charles Larouche, Tigran Galstian, André Bégin-Drolet, Jesse Greener
We report a flow sensitive birefringent in-channel chitosan micromembrane. Using a simple cross-polarizer and a calibration curve, the membrane functions as a flow rate meter, which also works as a feedback element for a flow control system.
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High-resolution low-cost LCD 3D printing for microfluidic and organ-on-a-chip devices

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Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC01125A, Paper
Open Access
Houda Shafique, Vahid Karamzadeh, Geunyong Kim, Molly L. Shen, Yonatan Morocz, Ahmad Sohrabi Kashani, David Juncker
The fabrication of microfluidic devices has progressed from cleanroom manufacturing to replica molding in polymers, and more recently to direct manufacturing by subtractive (e.g., laser machining) and additive (e.g., 3D...
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Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting

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Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00149D, Paper
Sunil Shrestha, Vinod Kumar Reddy Lekkala, Prabha Acharya, Soo-Yeon Kang, Manav Goud Vanga, Moo-Yeal Lee
Human liver organoids (HLOs) hold significant potential for recapitulating the architecture and function of liver tissues in vivo. However, conventional culture methos of HLOs, forming Matrigel domes in 6-/24-well plates,...
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A point-of-care testing platform for on-site identification of genetically modified crops

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00040D, Paper
Yangyang Wang, Furui Yang, Yingyi Fu, Xin He, Haowei Tian, Lili Yang, Mengxi Wu, Jijuan Cao, Junshan Liu
To fulfil the urgent needs of on-site testing, we develop a point-of-care testing platform that is able to identify 12 types of GM crops in less than 40 minutes without using laboratory settings.
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A paper-based dual functional biosensor for safe and user-friendly point-of-care urine analysis

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00163J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yujia Li, Yingqi Kong, Yubing Hu, Yixuan Li, Rica Asrosa, Wenyu Zhang, Buddha Deka Boruah, Ali K. Yetisen, Andrew Davenport, Tung-Chun Lee, Bing Li
A safe, accurate, and reliable sensing platform for urinary biomarkers analysis of urinary biomarkers is clinically important for the early detection and monitoring of the progression of chronic kidney disease (CKD), as it has become one of the world's most prevalent non-communicable diseases.
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Portable platform for leukocyte extraction from blood using sheath-free microfluidic DLD

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00132J, Paper
Oriana G. Chavez-Pineda, Roberto Rodriguez-Moncayo, Alan M. Gonzalez-Suarez, Pablo E. Guevara-Pantoja, Jose L. Maravillas-Montero, Jose L. Garcia-Cordero
A microfluidic platform isolates leukocytes from blood efficiently, offering diagnostic and immunotherapeutic potential. Enhanced by a handheld pressure controller, it enables near-patient testing and integration with downstream assays.
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Automated Dynamic Inlet Microfluidics System: 3D Printer Adaptation for Cost-Effective, Low Volume, On-Demand Multi-Analyte Droplet Generator

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Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00075G, Paper
Abdul Basit Zia, Justin Farrell, Ian G. Foulds
The paper demonstrates an adaptation of a 3D printer (Prusa Mini+) with novel modules to develop a droplet generation system that generates combinatorial droplets from a standard 96 well plate....
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Correction: Direct laser writing-enabled 3D printing strategies for microfluidic applications

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Olivia M. Young, Xin Xu, Sunandita Sarker, Ryan D. Sochol
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Development of a microfluidic device to enrich and detect zearalenone in food using quantum dot-embedded molecularly imprinted polymers

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00193A, Paper
Marti Z. Hua, Shenmiao Li, M. S. Roopesh, Xiaonan Lu
A QD-MIP based microfluidic device to detect mycotoxin in food.
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Drug testing of monodisperse arrays of live microdissected tumors using a valved multiwell microfluidic platform

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00016A, Paper
Ethan J. Lockhart, Lisa F. Horowitz, Adán Rodríguez, Songli Zhu, Tran Nguyen, Mehdi Mehrabi, Taranjit S. Gujral, Albert Folch
A microfluidic platform was developed that hydrodynamically traps microdissected cuboids for selective drug treatments and isolates conditions with thermoplastic valves.
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