The future of live music might still be a big question mark, but local musicians aren't merely sitting on their hands during quarantine: A lot of them are finding a way to connect with their fans and putting out new material, even without the benefit of physical congregation. Here's a batch of some of our favorite new releases from the past month, and there will no doubt be more in the coming weeks.…

Put pictures of 1975-era Aerosmith and 1995-era Guided By Voices next to each other and you probably wouldn’t think the bands have anything in common.…

The Buzz Bin HERE'S THE BEEF…

We've known that Hamilton was going to be part of the 2020-21 STCU Best of Broadway season for a while, but now we finally know the exact dates, as well as the rest of the featured shows for the season. Granted, the whole world has changed since WestCoast Entertainment announced Hamilton was coming to town back when they announced their 2019-20 season — a season that's been roiled, along with the rest of our lives, by the coronavirus pandemic.…

THE SHOW WILL GO ON…

Another First Friday is here, and you can correctly assume that it will be all online once again. The May 1 Virtual First Friday is from 10 am to midnight.…

ON INLANDER.COM WORLD: Roughly two weeks after Canada's deadliest mass shooting, Prime Minister Justin Trudeau introduced an immediate ban on what he called “military-style assault weapons.”…

Northern Quest Resort & Casino is set to reopen Tuesday, albeit with strict social-distancing and other safety protocols in place, becoming the second regional casino to reopen after closures caused by the coronavirus. Resort officials expect a crowd due to pent-up interest in the community for getting out of the house (not to mention Cinco de Mayo).…

ON INLANDER.COM NATION: Even as U.S. President Donald Trump urges states to reopen their economies, his own administration projects that the death toll from COVID-19 will spike to 3,000 people per day.…

Cops are hackers now, too.…

The Buzz Bin VAMPY VIBES…

By Patricia Cohen and Tiffany Hsu The New York Times Company…

Designology Interiors' Deanna Goguen has three bathrooms in her South Hill-area home, each with its own personality.…

Never before has an issue of Health & Home been produced and delivered in such a strange and scary time.…

The Inlander is a community newspaper covering news, politics, events, happy hour, everything that's happening today, things to do on the weekend, in Spokane, Coeur d'Alene, the greater Inland Northwest and beyond.

The Showcase celebrity golf tournament attracts big-time athletes and pop stars each year.…

[IMAGE-1] It's not surprising the most popular destinations for Inlander readers in North Spokane involve shopping — NorthTown Mall and the Garland District were the top vote-getters in this year's poll — but looking at the overall results, one quickly realizes the region north of the river has a lot going on. Riverside State Park and the Little Spokane River were popular picks, too, along with Mt. Spokane Ski & Snowboard Park; clearly people love to get outside up north in between their trips to Bon Bon or Buffalo Wild Wings.…

Best Athlete KILLIAN TILLIE, GONZAGA BASKETBALL…

[IMAGE-1] Anticipation for the show by West Coast rap legend Snoop Dogg was clearly high (pun totally intended), since he sold out his gig at Northern Quest Resort & Casino so quickly that they added a second night. All told, Mr. D-O-Double-G sold darn near 10,000 tickets to his two shows that, combined, had him on stage for roughly two hours.…

AMC River Park Square…

For people who love playing, a day on the worst possible golf course is better than any day not swinging the clubs.…

One great thing about seeing "oldies" acts on tour is the vivid reminder you get that groups in the old days really knew how to serve their fans. Take the Commodores, for example, a group with a 52-year-history that swung by Northern Quest Resort & Casino Thursday night.…

By Michael D. Shear and Sarah Mervosh WASHINGTON — President Donald Trump on Friday openly encouraged right-wing protests of social distancing restrictions in states with stay-at-home orders, a day after announcing guidelines for how the nation’s governors should carry out an orderly reopening of their communities on their own timetables.…

Yesterday, Spokane Mayor Nadine Woodward and other local leaders urged Gov. Jay Inslee to allow Spokane County to open on a different schedule than the rest of the state.  Inslee, however, wouldn't budge.…

Last week, the New York Times dropped a terrifying story: Asian Giant Hornets, or "murder hornets" as more J. Jonah Jameson-esque researchers like to call them, have been identified in Western Washington. These insects can grow up to 2 inches long, can rip the heads off an entire hive of honeybees in a matter of hours, and have dagger-like stingers that pierce beekeeper suits to deliver a sting that sears like molten acid.…

The invention concerns a new process for the preparation of crystalline form of agomelatine from a solution of agomelatine in a solvent, characterized in that the agomelatine is crystallized by instantaneous precipitation from said solution, at a temperature equal to or below −10° C.

A process for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines comprising (1) providing a mixture of 1,3-cyanocyclohexane carboxaldehyde and/or 1,4-cyanocyclohexane carboxaldehyde; (2) contacting said mixture with a metal carbonate based solid bed or a weak base anion exchange resin bed at a temperature from 15 to 40 ° C. for a period of at least 1 minute; (3) thereby treating said mixture, wherein said treated mixture has a pH in the range of 6 to 9; (4) feeding said treated mixture, hydrogen, and ammonia into a continuous reductive amination reactor system; (6) contacting said treated mixture, hydrogen, and ammonia with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature from 80 ° C. to 160 ° C. and a pressure from 700 to 3500 psig; (7) thereby producing one or more cycloaliphatic diamines is provided.

Biocidal compositions and their use in aqueous media, such as metalworking fluids, the compositions comprising a biocidal agent; and a non-biocidal primary amino alcohol compound of the formula (I); wherein R1, R2, R3, R4, and R5 are as defined herein.

Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; wherein R3 is selected from the group consisting of hydrogen or lower alkyl having 1 to 6 carbon atoms, R4 is selected from the group consisting of hydrogen, straight or branched chain alkyl having from one to six carbon atoms, phenyl, alkaryl, or arylalkyl; and b) reacting the intermediate product of step a) with a polyalkylene polyamine.

A modeling framework for evaluating the impact of weather conditions on farming and harvest operations applies real-time, field-level weather data and forecasts of meteorological and climatological conditions together with user-provided and/or observed feedback of a present state of a harvest-related condition to agronomic models and to generate a plurality of harvest advisory outputs for precision agriculture. A harvest advisory model simulates and predicts the impacts of this weather information and user-provided and/or observed feedback in one or more physical, empirical, or artificial intelligence models of precision agriculture to analyze crops, plants, soils, and resulting agricultural commodities, and provides harvest advisory outputs to a diagnostic support tool for users to enhance farming and harvest decision-making, whether by providing pre-, post-, or in situ-harvest operations and crop analyzes.

The current application is directed to monitoring subsystems, and monitoring methods incorporated within the monitoring subsystems, that monitor operation of devices and systems in order to identify normal states and to quickly determine when a device or system transitions from a normal state to an abnormal state. The methods and monitoring components to which the current application is directed employ self-organizing maps and moving-average self-organizing maps to both characterize normal system behavior and to identify transitions to abnormal system behaviors.

A method for performing relational analysis of parsed input is employed to create a visual map of knowledge information. A title, header or subject line for an input item of information is parsed into syntactical components of at least a subject component and any predicate component(s) relationally linked as topic and subtopics. A search of topics and subtopics is carried out for each parsed component. If a match is found, then the parsed component is taken as a chosen topic/subtopic label. If no match is found, then the parsed component is formatted as a new entry in the knowledge map. A translation function for translating topics and subtopics from an original language into one or more target languages is enabled by user request or indicated user preference for display on a generated visual map of knowledge information.

A method of forming a product from an oil feedstock, such as a biodiesel product, and a heterogeneous catalyst system used to form said product is disclosed. This catalyst system, which has a high tolerance for the presence of water and free fatty acids (FFA) in the oil feedstock, may simultaneously catalyze both the esterification of FAA and the transesterification of triglycerides present in the oil feedstock. The catalyst system is comprised of a mixture of zinc oxide and a second metal oxide. The zinc oxide includes a mixture of amorphous zinc oxide and zinc oxide nanocrystals, the zinc nanocrystals having a mean grain size between about 20 and 80 nanometers with at least one of the nanocrystals including a mesopore having a diameter of about 5 to 15 nanometers. Preferably, the second metal oxide is a lanthanum oxide, the lanthanum oxide being selected as one from the group of La2CO5, LaOOH, and combinations or mixtures thereof.

A reagent composition for forming fatty acyl amido surfactants is provided which includes an alkali metal or alkaline earth metal salt of an amino compound; a polyol of molecular weight ranging from 76 to 300; and no more than 10% water.

The current invention describes processes for obtaining of concentrates of esters of eicosapentaenoic acid and docosahexaenoic acid for their use in massive and regular human consumption either as a pharmaceutical ingredient or as a food ingredient, which are characterized by having neutral and stable organoleptic properties, free of side effects, which are typical from marine oils derivatives, and with low content of Persistent Organic Pollutants (POP).

An object of the present invention is to provide a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof and to provide a pharmaceutical agent which contains said compound as an active ingredient and has a highly safe neurotrophic factor-like activity or an alleviating action for side effect induced by administration of anti-cancer agents. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof which is the compound of the present invention is specifically represented by the formula (1): (In the formula, Y is —O—, —NR— or —S—, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group) and has a quite high usefulness as a pharmaceutical agent such as a preventive or therapeutic agent for dementia, Alzheimer's disease, Parkinson's disease, depression, etc., a treating or repairing agent for spinal cord injury.

A process for producing C10-C26 monobranched fatty acids or alkyl esters thereof which includes isomerizing unsaturated C10-C26 fatty acids or alkyl esters thereof in the presence of a catalyst which comprises both a zeolite and a Lewis base. The zeolite can be reused after simple separation from the reaction products without having to regenerate. The process is particularly suitable for producing highly monobranched fatty acids or alkyl esters thereof.

Methods and related systems efficiently and effectively recover a significant amount of valuable, useable oil from byproducts formed during a dry milling process used for producing ethanol. The method may include forming a concentrate from the byproduct and recovering oil from the concentrate. The step of forming the concentrate may comprise evaporating the byproduct using a multi-stage evaporator, as well as recovering the oil before the final stage of the evaporator. Further, the step of recovering oil from the concentrate may comprise using a centrifuge and, in particular, a disk stack centrifuge. Other aspects include related methods and subsystems for recovering oil.

The present application describes modulators of MCP-1 or CCR-2 of formula or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, n, W, X, R1 and R6, are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.

The invention relates compounds of general formula (I) and pharmaceutically acceptable salts and solvates thereof wherein R1 is halogen, vinylene-aryl, substituted aryl, heteroaryl or a benzo[1,3]dioxolil group,W is a group of formula —NH—SO2—R2 or heteroaryl group or NHR3 group where R3 is hydrogen or heteroaryl; and n is 1, 2, 3 or 4. Furthermore, the present invention is directed to pharmaceutical composition containing at least one compound of general formula (I) and/or pharmaceutically acceptable salts or solvates thereof and for the use of them for the preparation of pharmaceutical compositions for the prophylaxis and/or the treatment of protein kinase related, especially CDK9-related diseases e.g. cell proliferative disease, infectious disease, pain, cardiovascular disease and inflammation.

The invention discloses quinoxaline derivatives or salts thereof having PDE9-inhibiting activity and being useful as treating agent of dysuria and the like, which are represented by the formula (I) in the formula, R1 and R2 each independently stands for hydrogen, halogen, alkyl, alkoxy, acyl, amino and the like,R3 stands for alkyl, aryl, saturated carbocyclic group, saturated heterocyclic group, acyl and the like,R4 stands for hydrogen, hydroxy, alkyl or amino,R5 and R8 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkoxy, cyano or nitro,R6 and R7 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, cyano, amino, carbocyclic group, heterocyclic group, COR9 or SO2R9,R9 stands for hydrogen, hydroxy, alkyl, amino, pyrrolidin-1-yl, piperidin-1-yl, pyperazin-1-yl or the like,X stands for S or O, andA1, A2 and A3 each independently stands for N or C.

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain pyridyl-amino-pyrazine carbonitrile compounds that, inter alia, inhibit Checkpoint Kinase 1 (CHK1) kinase function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit CHK1 kinase function, and in the treatment of diseases and conditions that are mediated by CHK1, that are ameliorated by the inhibition of CHK1 kinase function, etc., including proliferative conditions such as cancer, etc., optionally in combination with another agent, for example, (a) a DNA topoisomerase I or II inhibitor; (b) a DNA damaging agent; (c) an antimetabolite or thymidylate synthase (TS) inhibitor; (d) a microtubule targeted agent; and (e) ionizing radiation.

Formaldehyde-free binder compositions are described that include an aldehyde or ketone, a nitrogen-containing salt of an inorganic acid, and an acidic compound. The acidic compound may be an organic acid, such as maleic acid or citric acid among others. The acidic compound is supplied in quantities that lower the pH of the binder composition to about 5 or less. The binder compositions may be used in methods of binding fiberglass and the resulting fiberglass products have an improved tensile strength due to the addition of the acidic compound.

Non water-soluble polymers with a comb structure and a (meth)acrylic skeleton on which are grafted side chains containing at least one hydrophobic monomer of the styrene or (meth)acrylic ester type on C1 to C4, and at least one hydroxy or methoxy polylakylene glycol monomer. The levels of monomers are such that the polymer is amphiphilic because it is both rich in hydrophobic monomer and polylakylene glycol monomer. These products, used in paper coating dispersions, enable an increase in their Brookfield™ viscosity, a reduction in their ACAV viscosity, and an improvement in their water retention, which makes them particularly well suited for dry extract and/or high deposit speed coatings.

Titanocenes containing two 5-membered cyclodienyl groups, for example cyclopentadienyl, and one or two 6-membered carbocyclic or 5- or 6-membered heterocyclic aromatic rings which are substituted by a fluorine atom in at least one of the two ortho-positions to the titanium-carbon bond and contain, as a further substituent, unsubstituted or substituted 1-pyrryl, are suitable as photoinitiators for radiation-induced polymerization of ethylenically unsaturated compounds.

A platinum complex having the following formula (I) is disclosed, ##STR1## wherein R1 and R2 may be the same or different and each independently represents a methyl group or an ethyl group, and the configuration of 1,2-diaminocyclohexane is either cis-, trans-l-, trans-d-, or trans-dl-.The compound possess excellent antitumor activity with a high therapeutic index and abundant water solubility, and thus are effective as an antitumor agent.

The invention relates 6-acyl-(6H)-dibenz[c,e][1,2]oxaphosphorin-6-oxides of the formula ##STR1## wherein each of R1, R2 and R3 may be present one or more times and R1, R2 and R3 represent halogen having an atomic number of from 9 to 35, alkyl or alkoxy each having from 1 to 6 carbon atoms and wherein Ar represents an aromatic hydrocarbon group having from 6 to 10 carbon atoms.The invention further relates to a process for the preparation of the afore-mentioned compounds and polymerizable compositions containing them as an essential ingredient as a photo-initiator. Finally the invention relates to 6-alkoxy-(6H)-dibenz[c,e][1,2]oxaphosphorin of the formula II ##STR2## wherein each of R1 and R2 may be present once or more times and R1 and R2 represent halogen having an atomic number of from 9 to 35, alkyl or alkoxy each having from 1 to 6 carbon atoms, at least one R1 being, however, halogen and wherein R4 represents alkyl having from 1 to 6 carbon atoms.

The present invention relates to novel heterocycle-substituted diphosphonic acids, and the pharmaceutically-acceptable salts and esters thereof, in which the diphosphonate-substituted carbon atom moiety is attached to a carbon atom in a nitrogen-containing six membered ring heterocycle, preferably a piperidine ring. The heterocycle-substituted diphosphonic acid compounds have the general structure: ##STR1## wherein Z is a nitrogen-containing six membered ring heterocycle moiety selected from piperidinyl, diazinyl and triazinyl; m, n and m+n are from 0 to 10; Q is a covalent bond or a moiety selected from oxygen, sulfur or nitrogen; and R1, R2, R3 and R4 are substituent groups.The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention.

Curable organopolysiloxane compositions comprising a platinum catalyst selected from the group consisting of (PR23)2 Pt(--C.tbd.C--R3)2 (III), (R22 P--R4 --PR22)Pt(--C.tbd.C--R3)2 (IV)and H--C.tbd.C--R5 --C.tbd.C--[--Pt(PR23)2 --C.tbd.C--R5 --C.tbd.C--]e --H (V)where R2, R3, R4, R5 and e are as defined in claim 1.

This invention relates to a composition comprising antimony trifluoride and silica, a method for the preparation of said composition and use of said composition as a catalyst in a process for the oxidation of cyclohexanone to ε-caprolactone.