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want to do good know how to shoot a semiautomatic handgun v




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well, you know they are a liar




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how to become a great writer




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New Engineering X Pandemic Preparedness programme to support global innovation and knowledge sharing




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How to Stay Safe on the Internet, Part 2: Take Canaries Into the Data Mine

More than any other factor, it is our asset that determines our adversary. For most of us, our asset is the corpus of sensitive personal details used for online transactions. This all comes down to how much data an adversary can glean from you, and how thoroughly it can analyze it. If your data passes through some software or hardware, its developer or maintainer enjoys some measure of control.




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How to Fix Your Phone or Tablet's Broken Screen

Cracked or broken mobile device screens can be costly to fix, but a few inexpensive DIY strategies can eliminate a repair shop visit and salvage your tablet or phone. It is relatively easy and cheap to replace the glass on a phone once you get the hang of it. Tablets are a bit more involved because of the larger size and added components. Tools might require an additional monetary outlay.




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How to Stay Safe on the Internet, Part 3: Drive the Black Hatters Mad

Like conventional criminals, criminal hackers choose easy, lucrative targets. One group in the crosshairs is made up of companies that have data on millions of users, such as private sector entities with a Web presence. Why go after one user at a time when data is collected in one place? Criminal hackers also like to hunt small organizations that have modest capital but weak information security.




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Red Hat's Virtual Summit Crowds Hint at Future Conference Models

In what could be a trial run for more of the same, Red Hat last week held a first-ever virtual technical summit to spread the word about its latest cloud tech offerings. CEO Paul Cormier welcomed online viewers to the conference, which attracted more than 80,000 virtual attendees. The company made several key announcements during the online gathering and highlighted customer innovations.




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How AI Can Improve Customer Retention

Customer attrition and churn are not new problems. Anyone who has spent time in the sales world has heard statistics around the cost of acquiring a new customer. It can be five to 25 times more expensive to acquire a new customer than to retain an existing one. Improving customer retention by just 5 percent can increase profits by 25-95 percent, depending on your industry and company size.




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Merchants Now Can List Products on Google Shopping for Free

Merchants soon will be able to sell products on Google Shopping at no charge. Previously, they had to pay per click, but the cost was not fixed. There was no minimum, but they had to set a maximum for ad spend and Google would stop displaying their ads once the maximum was reached. Starting next week, search results on the Google Shopping tab will consist primarily of free product listings.




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4 Things You Need to Know for Successful Enterprise CRM Integration

The enterprise IT environment is complex. Many systems, technologies and practices developed at various times coexist in the same world. With expectations for technological advancements at their peak, we're tasked with enabling these systems to work together harmoniously to support the continuous sharing of information. Systems and data must connect as if all information were native to each.




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How to Adapt Your Customer Service When Crisis Strikes

Customer service doesn't have to suffer while your company goes through a difficult transition. In fact, 78 percent of consumers said they stopped doing business with a company because of poor customer service. Now is the time to show your most valuable buyers how you'll keep them informed, updated and respected throughout this crisis by adapting your practices to the moment.




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Steve Kornacki: How we know Clarence Thomas did it




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You Don't Know Jack Soo




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The Cat in the Hat Knows a Lot About That!




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Not In Our Town





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Exiting low inflation traps by "consensus": nominal wages and price stability

Exiting low inflation traps by "consensus": nominal wages and price stability - Speech by Luiz A Pereira da Silva and Benoît Mojon, based on the keynote speech at the Eighth High-level Policy Dialogue between the Eurosystem and Latin American Central Banks, Cartagena de Indias, Colombia, 28-29 November 2019.




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Bold steps to pump coronavirus rescue funds down the last mile

Op-ed by Agustín Carstens published in the Financial Times on 29 March 2020.




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[~20.8 MB mp3] The 'Worm' That Could Bring Down The Internet

Story: As many as 12 million computers worldwide have been infected with a highly encrypted computer worm called Conficker. Writer Mark Bowden details how Conficker was discovered, how it works, and the ongoing programming battle to bring down Conficker in his book Worm: The First Digital World War.




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Cross Recruitment of Domain-Selective Cortical Representations Enables Flexible Semantic Knowledge

Knowledge about objects encompasses not only their prototypical features but also complex, atypical, semantic knowledge (e.g., "Pizza was invented in Naples"). This fMRI study of male and female human participants combines univariate and multivariate analyses to consider the cortical representation of this more complex semantic knowledge. Using the categories of food, people, and places, this study investigates whether access to spatially related geographic semantic knowledge (1) involves the same domain-selective neural representations involved in access to prototypical taste knowledge about food; and (2) elicits activation of neural representations classically linked to places when this geographic knowledge is accessed about food and people. In three experiments using word stimuli, domain-relevant and atypical conceptual access for the categories food, people, and places were assessed. Results uncover two principles of semantic representation: food-selective representations in the left insula continue to be recruited when prototypical taste knowledge is task-irrelevant and under conditions of high cognitive demand; access to geographic knowledge for food and people categories involves the additional recruitment of classically place-selective parahippocampal gyrus, retrosplenial complex, and transverse occipital sulcus. These findings underscore the importance of object category in the representation of a broad range of knowledge, while showing how the cross recruitment of specialized representations may endow the considerable flexibility of our complex semantic knowledge.

SIGNIFICANCE STATEMENT We know not only stereotypical things about objects (an apple is round, graspable, edible) but can also flexibly combine typical and atypical features to form complex concepts (the metaphorical role an apple plays in Judeo-Christian belief). In this fMRI study, we observe that, when atypical geographic knowledge is accessed about food dishes, domain-selective sensorimotor-related cortical representations continue to be recruited, but that regions classically associated with place perception are additionally engaged. This interplay between categorically driven representations, linked to the object being accessed, and the flexible recruitment of semantic stores linked to the content being accessed, provides a potential mechanism for the broad representational repertoire of our semantic system.




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Nestin Selectively Facilitates the Phosphorylation of the Lissencephaly-Linked Protein Doublecortin (DCX) by cdk5/p35 to Regulate Growth Cone Morphology and Sema3a Sensitivity in Developing Neurons

Nestin, an intermediate filament protein widely used as a marker of neural progenitors, was recently found to be expressed transiently in developing cortical neurons in culture and in developing mouse cortex. In young cortical cultures, nestin regulates axonal growth cone morphology. In addition, nestin, which is known to bind the neuronal cdk5/p35 kinase, affects responses to axon guidance cues upstream of cdk5, specifically, to Sema3a. Changes in growth cone morphology require rearrangements of cytoskeletal networks, and changes in microtubules and actin filaments are well studied. In contrast, the roles of intermediate filament proteins in this process are poorly understood, even in cultured neurons. Here, we investigate the molecular mechanism by which nestin affects growth cone morphology and Sema3a sensitivity. We find that nestin selectively facilitates the phosphorylation of the lissencephaly-linked protein doublecortin (DCX) by cdk5/p35, but the phosphorylation of other cdk5 substrates is not affected by nestin. We uncover that this substrate selectivity is based on the ability of nestin to interact with DCX, but not with other cdk5 substrates. Nestin thus creates a selective scaffold for DCX with activated cdk5/p35. Last, we use cortical cultures derived from Dcx KO mice to show that the effects of nestin on growth cone morphology and on Sema3a sensitivity are DCX-dependent, thus suggesting a functional role for the DCX-nestin complex in neurons. We propose that nestin changes growth cone behavior by regulating the intracellular kinase signaling environment in developing neurons. The sex of animal subjects is unknown.

SIGNIFICANCE STATEMENT Nestin, an intermediate filament protein highly expressed in neural progenitors, was recently identified in developing neurons where it regulates growth cone morphology and responsiveness to the guidance cue Sema3a. Changes in growth cone morphology require rearrangements of cytoskeletal networks, but the roles of intermediate filaments in this process are poorly understood. We now report that nestin selectively facilitates phosphorylation of the lissencephaly-linked doublecortin (DCX) by cdk5/p35, but the phosphorylation of other cdk5 substrates is not affected. This substrate selectivity is based on preferential scaffolding of DCX, cdk5, and p35 by nestin. Additionally, we demonstrate a functional role for the DCX-nestin complex in neurons. We propose that nestin changes growth cone behavior by regulating intracellular kinase signaling in developing neurons.




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Help families in the Philippines rebuild their lives – Donate Now!!!

FAO is working to help typhoon-affected farmers to ensure the next harvests in 2014 – You can help as well. Philippine farmers need urgent assistance  to avoid a double tragedy befalling rural survivors of Typhoon Haiyan. The typhoon hit just as farmers were beginning a new planting season, and FAO estimates that over one million farmers have been affected and hundreds of [...]




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Download the free “Quinoa in the kitchen” book and try out new recipes!

Once known as “the gold of the Incas,” quinoa has been one of the world’s neglected crops but is currently becoming more and more popular. For centuries, quinoa remained a hidden treasure grown almost exclusively by indigenous communities in the Andean heights. Lately, quinoa has been growing in popularity with foodies and health-conscious consumers around the world. It was even [...]




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Learn how cash transfer programmes improve lives in sub-Saharan Africa and share the infographics

Did you know that cash transfer (CT) programmes in countries of the sub-Saharan Africa actually have a significant impact? In Malawi, these programmes helped families invest in agricultural equipment and livestock to produce their own food and reduce levels of negative coping strategies, like begging and school drop-outs. In Kenya, secondary school attendance rose by 9 percent and access to [...]




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Learn how good food can improve your health

Have you ever wondered if you are getting adequate nutrients from the food you eat? It is a common misconception that malnutrition means not getting enough food. This is, however, incorrect! People who take in insufficient food can be malnourished, but also those who consume too much face the same risks. Malnutrition is defined as “An abnormal physiological condition caused by [...]




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Empowerment is key to eradicating hunger

Global food security largely depends on smallholder family farms where in many regions of the world women play a crucial role as both producers and providers of food. Studies show that when women and other rural poor have better access to resources, the benefits are far-reaching. Families are healthier, more children attend school, agricultural productivity improves, incomes increase, and rural communities [...]




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7 things you should know about FAO and the Post-2015 development agenda

As FAO launches dedicated webpages on post-2015, here are seven things to know about the process and how FAO is playing its part. 7 - Post-2015 development agenda - The name refers to the process through which Member States agree on a new global development framework to succeed the Millennium Development Goals (MDGs), eight goals that followed the UN Millennium Declaration [...]




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Plant a seed, grow a garden, change a life!

‘‘—the first 1000 days are a critical window in a child’s development, but let’s not forget this child on day 1,001.’’ School nutrition programmes help to address the +1,001 day gap. Today, perceptions of school gardens are changing in response to increasingly urgent needs for greater food security, environmental protection, more secure livelihoods and better nutrition. School gardens have new multiple [...]




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The growing role of fish in feeding the world

People have never consumed so much fish or depended so greatly on the sector for their well-being as they do today. Did you know?  Fish is one of the most-traded food commodities worldwide, worth almost US$130 billion in 2012 – a figure that will probably continue to increase. World per capita apparent fish consumption increased from an average of 9.9 kg in the [...]




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Blue growth - unlocking the potential of seas and oceans

Today’s fisheries sector hosts a multibillion dollar industry that is a vital source of food and nutrition, employment, trade, economic wellbeing and recreation. What is blue growth? The concept of a "blue economy" came out of the 2012 Rio+20 Conference and emphasizes conservation and sustainable management, based on the premise that healthy ocean ecosystems are more productive and a must for sustainable [...]




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Top 5 need-to-knows about Conservation Agriculture

In the face of changing weather driven by climate change and the increasing demand for food, Conservation Agriculture (CA) aims to achieve sustainable and profitable agriculture and improve farmers’ livelihoods. Here are five things you need to know. 1. CA observes three main principles that you should remember Direct seeding involves growing crops without mechanical seedbed preparation and with minimal soil disturbance [...]




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How much do you know about Farmer Field Schools

Farmer field schools (FFS) are essentially schools without walls that introduce new technological innovations while building on indigenous knowledge. In FFS, farmers are the experts. Key features and principles of the FFS approach – TRUE or FALSE? The FFS approach allows farmers to learn through testing changes in a controlled, group-based environment TRUE:  Discovery-based learning is an essential part of the FFS as [...]




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Have you ever wondered how #hunger is measured?

In the year 2000, the UN Member States set the eight Millennium Development Goals. One of the most ambitious was to eradicate extreme poverty and hunger. As part of this goal, the United Nations General Assembly set a target to halve the proportion of people who suffer from hunger by 2015.  But have you ever wondered how hunger is measured in [...]




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Quiz: how well do you know your fruits?

They are delicious, they are nutritious and they make your mouth water.  If you know your apples from your oranges, then pit your wits against our fruit quiz. You will need to guess where different fruits come from, where they are most popular and how good they are for you. Let’s get started. 1. Which country is the biggest producer of dates? A.    [...]




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How much do you know about the awesomeness of forests?

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Digging deep in the year of soil – ten Twitter accounts to follow

We took a look around and put together a list of  Twitter accounts to keep you informed about what is happening in the world of soils.  Here are, in alphabetical order, ten voices on twitter you should follow for the latest on soils: @agriculturesnet The AgriCultures Network shares knowledge on small-scale family farming and agroecology. With agroecology we can build soils for life! http://t.co/pN62odtLt9 [...]




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Whittling down instances of child labour in agriculture

“Children subjected to child labour need our support and action so they can enjoy their right to education and health and become productive farmers and workers as adults to escape poverty and hunger.” - José Graziano da Silva, FAO Director- General  Child labour is not unique to a particular country, ethnicity, culture, or ideology. Today, there are about 100 million boys [...]




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How berry knowledgeable are you?

Ripe, juicy, and practically begging to be eaten, berries are a spring and summer treat that make your mouth water. To celebrate the pinnacle of berry season, we gathered some facts and figures and are challenging you to see how far your berry knowledge really goes. 




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7 rules-of-thumb to follow in aquaponics

From a media bed unit start-up in Bangkok to a fully developed 120 households deep water culture (DWC) unit in Ethiopia, aquaponics is showcasing its true potential to produce sustainable food anytime, anywhere. A marriage between aquaculture (raising aquatic animals such as fish, snails or prawns in tanks) and hydroponics (cultivating plants in water), aquaponics is a ‘clean and green’ [...]




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Quiz - How much do you know about FAO?

As we celebrate our 70-year anniversary, find out how much you know about the work that FAO is doing around the world. Answer these 7 questions and help us fight hunger by becoming an ambassador of FAO!




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Let the countdown to the International Year of Pulses begin!

10: EtymologyThe word pulse originates directly from the Latin puls meaning "thick gruel, porridge, mush.” 9: Pulses vs legumes, what’s the difference?The term "legume" refers to the plants whose fruit is enclosed in a pod. Pulses are a subgroup of the legume family, but the term “pulse” refers only to the dried seed. Dried beans, lentils and peas are the most commonly known and consumed types [...]




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Farming systems that ‘Save and Grow' – in pictures

Maize, rice and wheat are fundamental to world food security. We must safeguard production in the world’s grain belts and rice bowls, and increase yields in countries where production has to substantially improve as populations grow. Climate change adds new pressures on cereals, including rising temperatures and a higher incidence of pests, diseases, droughts and floods. FAO’s model of ecosystem-based agriculture, [...]




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10 questions - How much do you know about forests and water?

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Spotlight: How do pulses contribute to a sustainable world?

Pulses are being celebrated in 2016 all over the world since they are nutritious, suited for use in a variety of dishes, easy on the budget  and good for the health of the soil. From food security and nutrition to ensuring biodiversity and mitigating the effects of climate change, pulses contribute to sustainable development. Here is how.  1.     Nutritional benefits of pulses   Pulses [...]




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The power of pollinators: why more bees means better food

What do cucumbers, mustard, almonds and alfalfa have in common? On the surface it appears to be very little. However, there is one thing they do share: They all owe their existence to the service of bees. There is more to the tiny striped helper than sweet honey and a painful sting. For millennia, it has carried out its service [...]




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All about bananas: things you should know about the tropical fruit

Banana split, banana muffins, banana bread, banana pudding, banana pancakes – whether plain, cooked, baked or fried, bananas are among the most widely consumed fruits on the planet. However, how much do we really know about this most produced and exported fruit? Here are 11 interesting facts you should know about bananas: Based on written references discovered in Sanskrit around the year [...]




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Empowering women to end hunger and poverty

In the varied and vital roles they play – as farmers, farm workers, entrepreneurs, caregivers and community leaders – rural women form the backbone of rural societies. Almost everywhere, they make crucial contributions to food production, food processing and marketing. Indeed, because women produce, process and prepare much of the food available, they are critical to the food security of [...]




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10 questions – How much do you know about forests and energy?

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7 reasons why we need to act now to #SaveOurOcean

The oceans have it all: from microscopic life to the largest animal that has ever lived on Earth, from the colourless to the shimmering, from the frozen to the boiling and from the sunlit to the mysterious dark of the deepest parts of the planet. Oceans are an essential component of the Earth's ecosystem -- a source of biodiversity, food, and [...]