b A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3795-3799DOI: 10.1039/D4MD00458B, Research ArticleKazuya Matsuo, Takashi Kikukawa, Tomonori Waku, Akio Kobori, Nobuyuki TamaokiA photoswitchable centromere-associated protein E (CENP-E) inhibitor based on the 4-methylaminoazobenzene photoswitch is reported, which is characterized with cis–trans photoisomerization with blue-green light and fast thermal relaxation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3728-3745DOI: 10.1039/D4MD00476K, Research ArticleVincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien FortinNew water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3837-3852DOI: 10.1039/D4MD00426D, Research ArticleAbdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. BednarskiStructure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safetyThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3800-3816DOI: 10.1039/D4MD00585F, Research ArticleMarwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-KarmalawyNovel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3853-3861DOI: 10.1039/D4MD00165F, Research ArticleJiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang LiuThe synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3746-3758DOI: 10.1039/D4MD00122B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong LiWe designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3695-3703DOI: 10.1039/D4MD00546E, Research ArticleMiyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke DemizuA novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00661E, Review ArticleAvijit Kumar DasThe detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
b Supreme Court stays order for CBI probe into sexual assault of minor in Chennai By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:07:47 +0530 Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre Full Article Tamil Nadu
b Amaran is a film about a soldier’s life, nothing more: Seeman By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:55:42 +0530 Full Article Tamil Nadu
b AIADMK will not form an alliance with BJP in 2026 polls, reiterates Palaniswami By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:30:55 +0530 “During the Lok Sabha election, it was said at the party headquarters and in press bytes that the AIADMK will not have alliance with the BJP in the [2026] Assembly election,” he said Full Article Tamil Nadu
b T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:15:58 +0530 It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students Full Article Tamil Nadu
b IIT-M students develop robot for O.P. Jindal university’s Constitution Museum By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:27 +0530 It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says Full Article Tamil Nadu
b Four Swedish companies, including IKEA, looking to set up base in Tamil Nadu: Swedish Ambassador to India By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:56:01 +0530 There are 70 Swedish companies in Tamil Nadu, employing about 25,000 people. But we want to do more, says Jan Thesleff Full Article Tamil Nadu
b Delhi airport sees seven flight diversions owing to bad weather By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:39:37 +0530 The IMD reported that very dense fog began forming at around 5.30 a.m., resulting in a thick haze over various parts of Delhi Full Article Delhi
b DUSU election results to be announced on November 21 By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:18:26 +0530 The counting of votes for both the central panel and college representatives will begin at 8:30 a.m. on November 21 at the DU Conference Centre Full Article Delhi
b Delhi High Court upholds ban on two-wheelers on Expressways By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:18:26 +0530 Two-wheelers, three-wheelers, and other slow-moving vehicles, such as tractors, are prohibited as per the Gazette Notifications dated June 14, 2018, and January 15, 2021 Full Article Delhi
b Delhi’s air quality turns ‘severe’ for first time this season: CPCB By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:52:21 +0530 According to Central Pollution Control Board data, Delhi’s air quality reaches ‘severe’ levels with AQI of 418 Full Article Delhi
b SBI, HDFC Bank, ICICI Bank figure in RBI’s 2024 list of Domestic Systemically Important Banks (D-SIBs) By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:00:14 +0530 Higher D-SIB surcharge fixed for SBI and HDFC Bank, will be applicable from April 01, 2025 Full Article Business
b U.S. oil industry urges Trump to ditch Biden climate policies By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:27:45 +0530 Full Article Business
b Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:16:07 +0530 Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year. Full Article Business
b SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:49:14 +0530 Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities Full Article Mangaluru
b Mangaluru Junction - CSMT Superfast Express to get LHB coaches in March 2025 By www.thehindu.com Published On :: Wed, 13 Nov 2024 14:25:17 +0530 Train No. 12133 Mumbai CSMT-Mangaluru Junction Superfast Express will get an LHB rake from March 1 while its pairing service, Train No. 12134 Mangaluru Junction-Mumbai CSMT Superfast Express, will get an LHB rake from March 2 Full Article Mangaluru
b Free and fair inquiry sought into death of snakebite victim in Srikakulam district By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:10:47 +0530 Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident Full Article Andhra Pradesh
b Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:25:35 +0530 P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches Full Article Andhra Pradesh
b SEIL Energy bags seven awards from QCFI By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:35:31 +0530 Full Article Andhra Pradesh
b Centre’s nod sought for Vizag Metro, MA&UD Minister informs A.P. Assembly By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:55:45 +0530 The revised cost estimate stands at ₹17,232 crore; the project is initially proposed to come up in two phases with four corridors spanning a total length of 76 km Full Article Andhra Pradesh
b Water supply from Pampa Reservoir to be paused this rabi By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:59:48 +0530 IAB makes decision to allow reservoir gate repairs and aqueduct construction works; water to affected lands to be supplied from the Eastern Godavari Delta, Pithapuram Branch Canal and Yeleru Reservoir instead Full Article Andhra Pradesh
b Andhra Pradesh Budget reflects aspirations of all sections of people, say legislators By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:10:11 +0530 It has given impetus to the developmental goals outlined in the NDA’s election manifesto, say MLAs on the first day of discussion Full Article Andhra Pradesh
b PAG report points out Andhra Pradesh govt.’s failure to disclose quantum of off-budget borrowings in Budget By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:19:16 +0530 Principal amount outstanding in 2019-20 was ₹67,171 crore, and it touched ₹1,54,797 crore in 2023-24, says the PAG report released by the I&PR Department Full Article Andhra Pradesh
b RLDA invites bids for commercial land use in Tirupati railway station By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:29:31 +0530 The station is being developed on a massive scale, providing commuting area on the southern side, in view of the crammed locality on the northern side Full Article Andhra Pradesh
b 117 applications received at Kuppam’s first ‘Praja Darbar’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:37:24 +0530 Full Article Andhra Pradesh
b Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:25:39 +0530 Full Article Andhra Pradesh
b Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:30:39 +0530 Full Article Andhra Pradesh
b Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 11:31:53 +0530 The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling Full Article News
b GlobalLogic opens delivery centre in Hyderabad to spread wings, ramp up hiring in Telangana By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:21:21 +0530 The company will consider spreading wings to one more such location, in addition to Mahbubnagar where it has about 350 employees Full Article Hyderabad
b IMD forecasts onset of winter in Telangana by November-end By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:22:39 +0530 Full Article Telangana
b Vikarabad attack: Former BRS MLA Narender Reddy taken into custody for questioning By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:17:51 +0530 He was picked up near his residence when he stepped out for a morning walk Full Article Telangana
b Over 2,300 kilograms of drugs incinerated by Cyberabad police By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:02:00 +0530 The wide range of drugs were seized from 155 cases registered under the NDPS Act Full Article Hyderabad
b Hyderabad to get regional centre of Indian Institute of Creative Technology By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:34:11 +0530 All activities are going to start quickly. The facility in Hyderabad will be set up in the IMAGE Tower, said Secretary, Union Ministry of Information and Broadcasting Full Article Hyderabad
b Missile Exhibition Centre inaugurated at DRDL By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:10:16 +0530 Full Article Telangana
b Hyderabad Airport wins global recognition for digital innovations By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:14:32 +0530 Full Article Hyderabad
b Metro Rail services to be extended to Medchal and other parts of northern Hyderabad under Phase-III: Telangana CM By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:18:36 +0530 Full Article Hyderabad
b Prasar Bharati OTT launch, private FM stations for small towns on cards By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:29:11 +0530 Full Article Hyderabad
b Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:50:51 +0530 GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations Full Article Health