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Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage

RSC Med. Chem., 2024, 15,3597-3608
DOI: 10.1039/D4MD00378K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. Jenkins
In silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00450G, Review Article
Shikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan Dwivedi
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00579A, Research Article
Open Access
Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-Broceta
A ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00619D, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott
25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00495G, Research Article
Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez Tumer
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Four schools and a college in Tiruchi receive hoax bomb threats

Three schools declared a holiday on Tuesday as a precautionary measure




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Changes in train services notified due to demolition of old bridge near Tiruchi junction




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Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan

Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago




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50 new primary health centres to be opened in State soon: Minister




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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents




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Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation




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Plea to include ‘panneer karumbu’ in Pongal gift hamper




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Urban Primary Health Centre stuck in cramped, temporary facility




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Deputy CM releases commemorative flag of Bharat Scouts and Guides




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Railways using treated water from its STP for maintaining green spaces

The treated water is stored in an overhead tank and used in gardens at the two railway rest houses meant for officers at Kallukuzhi near Tiruchi Railway Junction




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Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival

Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base




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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa




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Fishermen seek healthcare and cold storage facilities




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EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy




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AIADMK ready to join hands with like-minded parties to defeat DMK: Palaniswami




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542: Breaking Up with CSS-in-JS, Mastodon, and Stories on the Web

We're talking CSS-in-JS, Token CSS, Matuzo being suspended from Twitter, trying out Mastodon, testing out stable diffusion, stories on the web, and Jake Albaugh's new social network.




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543: Zach Leatherman on Eleventy, Mastodon, Twitter, and is-land

Zach Leatherman talks with us about what's new with Eleventy, setting up on Mastodon, what's happened with Twitter, and is-land.




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551: PlanetScale with Iheanyi Ekechukwu and Mike Coutermarsh

Iheanyi Ekechukwu and Mike Coutermarsh talk about PlanetScale, what Vitess is, if PlanetScale is for both side and big projects, what read only regions are, what schema changes are, and how PlanetScale compares to other projects.




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555: React Documentary, Front of the Front End, Fast Fallacy, and Best Practices

Reacting to the React.js documentary, is there still jobs for front of the front end anymore? The fast fallacy in frameworks, best practices, dealing with too much or too little isolation, and AI test generation.




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557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life

When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life.




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567: Full Stack Dev, Load Bearing Developer, and Being Zod Curious

What do you do if your computer dies? Chris applies to work at Luro, Dave applies at CodePen, Dave's Zod curious, TypeScript, sorting out a 10MB blog post, and how much do you miss jQuery?




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569: Apple’s Web Apps, Meta Quest and Vision Pro, and Missing Sticky Headers

How do you point out things in a UI? Are Arc Boosts the end of the web? What do you think of VR and AR / Vision Pro and Meta Quest? And what do you do when the sticky header goes missing?




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571: Searching vs AI, Getting Designers to Play Nice, and Web Components

Do you listen at 2x? Do Chris and Dave sound weird at normal speed IRL? How searching compares to using AI, chatbots kind of suck at context, getting a designer to work with developers at an agency, what happened to content visibility, and how to best build a design system using web components.




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573: Google Reader, Sticky and Overflow, and Figma Thoughts

Chris breaks out his banjo, some thoughts on making music vs recording music, what happened to Google Reader and social reading, what black box properties can't Dave or Chris remember, follow up for dev teams communicating with designers, and what's Adobe going to do about Figma?




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581: DevRel, Musical Mics, Social Sharing, and 100 Years of WordPress

Dave calls a quick Luro branding meeting, some thoughts on DevRel, Chris tries to figure out musical instrument mics, follow up on WordPress from a previous episode, Chris' journey through the social graph options, 100 year hosting with WordPress, and the introduction of a new segment: Happy Project Share Time.




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589: CSS Functions, Read It Later, Making Money in Business, and More

A quick bit of union news follow up, CSS function round up, Read It Later inside Feedbin, fun uses for a Stream Deck+, how to turn up the money dial in your own business, and having the audacity to call yourself a publisher.




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592: Web Component Therapy, SEO Therapy, and Learning Something New like Swift

Talking web components, progressive enhancement, style-able components, having to pay before you get to see a demo, being annoyed at the business of SEO, and subscriptions vs ads.




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593: Beep & Texts, Tumblr, JavaScript & Web Components, & Cool Blog Post Ideas

Thoughts on smashing all communication messaging apps together, what's happened to Tumblr under Automattic, what the situation is with native web components and JavaScript, and looking at a list of types of blog posts.




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596: The Year of AI, Arc, and Being Mad About the Right Thing

Looking back at the year of AI, using Arc on macOS and now Windows, dreaming of subscriptions, and knowing how to be mad about the right thing.




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598: Jen Simmons on Interop, WebKit Releases, and New CSS Features in Safari

Jen Simmons, Apple Evangelist on the Web Developer Experience team for Safari & Webkit, stops by to talk about what Interop is, and a look ahead at new CSS features in Webkit and Safari such as JPEG XL, masks, a round function, JavaScript improvements, styling form controls, content unblocks, masonry, and more!




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600: Where Will The Web Be 12 Years from Now?

We've got your feedback as well as our thoughts on where we all think the web will be in 2036 - as we celebrate 12 years of ShopTalk Show history, we're looking forward to what's to come with ideas around cookie banners, undo, no more passwords, React, Deno, Node, and Mozilla's future, ChatGPT's thoughts, accessibility, blockchain, VR / AR, hoverboards, P3 color space, indie web, JS bundle sizes, and more!




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602: What Does Accessibility Really Mean?

Voiceover pays us a visit, we talk about what accessibility really means, the difficulty of closing a dialogue element, web components at work, and jQuery 4 is out.




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603: Deno, React Alternatives, and Copilot Concerns with Triple Threat Josh Collinsworth

Josh (or Jsoh) stops by to talk about his work at Deno, recent blog posts on Copilot, why Svelte is awesome and React is not, Apple and PWA, and building word games on the web.




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611: React! TypeScript! Jobification! Drupal!

Dave & Chris and thoughts on career advice that worked 3 years ago but isn't as helpful now, marking tests with ChatGPT, is taking a Drupal job in 2024 a good idea, Chris got #gear sniped, P3 color follow up, the confusing File System APIs, and where did all the lightboxes go?




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615: Dave Goes Windows For Real

Dave's got job news to share, as well as insight into the process of what applying for a job in tech is like in 2024. We also talk about styling, scoping, positioning, and floating UI.




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624: Blogging, In App Browsers are Bad, and Teaching CSS from Scratch

On this epsiode we're talking about the current state of blogging and social media, the polyfill hack, whether in app browsers should be banned, web components and the difficulty of front end web dev, and how we would go about teaching CSS from scratch in 2024.




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629: The Great Divide, Global Design + Web Components, and Job Titles

A bit of follow-up on vibe driven development and JavaScript not causing The Great Divide, writing testing automation, global design systems and web components, could PHP be used for web components, what if view transitions are going to be everywhere, and frontend engineer vs design systems engineer job titles and descriptions.




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631: Dave’s Second Brain Idea, Notion Thoughts, and Google’s LLM in Chrome

Dave's got an idea for a second brain app that's customized to his brain, where we're at with Notion and other notes apps, and accessibility on LLM's in browsers.




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Will real estate recover in 2015?

The top localities that have generated a lot of interest among buyers in Hyderabad are Uppal, Chandanagar, Gachibowli, Kondapur, Kukatpally, Manikonda and Miyapur




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Earth as shelter

Traditionally, people built walls by placing mud mixed with jaggery, grass and such local additives, but today we have scientifically evolved mix with cement and quarry dust.




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Green dream a reality now

Chennai-based green building consultant Sumitra Vasudevan gives tips on how to ensure your home has a low carbon footprint.




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Design to beat the heat

Keeping the air conditioner on for long will only create heat islands, says Sathya Prakash Varanashi




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How a city deals with water

Water flows through streams and channels and forms a distinct part of the urban landscape of Tehran.