Lab Chip, 2024, 24,1887-1902
DOI: 10.1039/D3LC00507K, Paper

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Chu-Chun Liang, Po-Yen Chen, Nien-Che Liu, I-Chi Lee
A 3D neural spheroid-based system with an interstitial level of flow for simulating the brain microenvironment toward a dynamic amyloid-β induced neuronal toxic model was established. A real-time impedance recording was used to monitor the neural network formation and disconnection.
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Lab Chip, 2024, 24,2107-2121
DOI: 10.1039/D3LC01075A, Paper

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Wannes Verbist, Jolien Breukers, Sapna Sharma, Iene Rutten, Hans Gerstmans, Lotte Coelmont, Francesco Dal Dosso, Kai Dallmeier, Jeroen Lammertyn
A novel platform, called SeParate, enabling accurate multiplex droplet sorting by integrating serial and parallel sorting principles for three model systems with increasing complexity and intra-subpopulation variation in fluorescence intensities.
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Lab Chip, 2024, 24,2039-2048
DOI: 10.1039/D4LC00073K, Paper

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Georgeta Vulpe, Guoyi Liu, Sam Oakley, Guanghao Yang, Arjun Ajith Mohan, Mark Waldron, Sanjiv Sharma
Development of wearable sensing devices for minimally invasive and real time monitoring of physiological information in ambulatory conditions.
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Lab Chip, 2024, 24,2080-2093
DOI: 10.1039/D3LC00838J, Paper

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Katharina Schlünder, Madalena Cipriano, Aline Zbinden, Stefanie Fuchs, Torsten Mayr, Katja Schenke-Layland, Peter Loskill
Pancreatic in vitro models are crucial for research on diseases such as diabetes mellitus. A novel thermoplastic organ-on-chip with integrated real-time read-outs models the complex microphysiological structure and function of the endocrine pancreas.
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Lab Chip, 2024, 24,2025-2038
DOI: 10.1039/D3LC01044A, Paper

Qiyue Luan, Ines Pulido, Angelique Isagirre, Julian Carretero, Jian Zhou, Takeshi Shimamura, Ian Papautsky
Agarose microwell platform for modeling lung carcinoma using patient-derived tissues to decipher cancer associated fibroblast-induced drug resistance.
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Lab Chip, 2024, 24,1947-1956
DOI: 10.1039/D3LC00656E, Paper

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Klaudia Staskiewicz, Maria Dabrowska-Zawada, Lukasz Kozon, Zofia Olszewska, Lukasz Drewniak, Tomasz S. Kaminski
Novel microfluidic technique for functional selection of biosurfactant-producing microorganisms. Single bacterial cells are encapsulated into picoliter droplets for clonal cultivation and passively sorted at high throughput by interfacial tension.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00006D, Paper

Seyedaydin Jalali, Ponnambalam Ravi Selvaganapathy
A scalable method for creating perfusable 3D tissue constructs using self-assembly is introduced. Unlike conventional cell injection methods, here we leverage cell migration to form tissue barriers of low permeability, mimicking in vivo environments.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00743J, Tutorial Review

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Olivia M. Young, Xin Xu, Sunandita Sarker, Ryan D. Sochol
This Tutorial Review highlights strategies for leveraging the micron-to-submicron-scale additive manufacturing technique, “direct laser writing”, to enable 3D microfluidic technologies.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00131A, Paper

Fahima Akther, Hedieh Fallahi, Jun Zhang, Nam-Trung Nguyen, Hang Thu Ta
An atherothrombosis-on-chip model to evaluate thrombosis risk and patient-specific treatment strategy.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC01062G, Paper

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Steven A. Soper, Chathurika Rathnayaka, Indu Chandrasoma, Junseo Choi, Katie Childers, Maximillian Chibuike, Khurshed Akabirov, Farhad Shiri, Adam R Hall, Collin J McKinney, Matthew David Verber, Sunggook Park
We report the generation of ~8 nm dual in-plane pores fabricated in a thermoplastic via nanoimprint lithography (NIL). These pores were connected in series with nanochannels, one of which served...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01061A, Paper

Open Access

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Felix Reichel, Ruchi Goswami, Salvatore Girardo, Jochen Guck
We use hyperbolic microchannels to create a flow field with linearly increasing velocity, leading to a constant tensile stress to probe the viscoelastic properties of cells. We verify our approach on oil droplets and polyacrylamide beads.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01101A, Paper

Wei Wang, Jaime de la Fuente Diez, Nicolas Delsuc, Juan Peng, Riccardo Spezia, Rodolphe Vuilleumier, Yong Chen
A new method uses piezoelectric and microfluidic tuning to study vibrational polaritons in liquids under flow. This enables modifying cavity length adjustments and flexibility in experimental setups.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC00854A, Paper

Lu Xin, Xi Xiao, Wen Xiao, Ran Peng, Hao Wang, Feng Pan
The incidence of urothelial carcinoma continue to rise annually, particularly among the elderly. Prompt diagnosis and treatment can significantly enhance patient survival and quality of life. Urine cytology remains a...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00165F, Paper

Xiaoming Chen, Shun Liu, Mo Shen, Jishun Shi, Chungang Wu, Zhipeng Song, Yong Zhao
We develop a microfluidic device with closed right-angle bipolar electrodes to realize dielectrophoretic characterization and selection of non-spherical flagellate algae.
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Lab Chip, 2024, 24,2176-2192
DOI: 10.1039/D3LC00912B, Paper

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Priscilla Delgado, C. Alessandra Luna, Anjana Dissanayaka, Oluwamayokun Oshinowo, Jesse J. Waggoner, Sara Schley, Todd Fernandez, David R. Myers
This activity enables students to construct geometrically complex microfluidics at their desk with no specialized equipment. It can be easily transported, and helped students significantly improve their understanding of miniaturization science.
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Lab Chip, 2024, 24,2193-2201
DOI: 10.1039/D3LC00979C, Paper

Bingbing Zhang, Jinxin Fu, Maohua Du, Kai Jin, Qi Huang, Jiahao Li, Dongping Wang, Siyi Hu, Jinhua Li, Hanbin Ma
Advancing active-matrix digital microfluidics through polar coordinates for precise concentration gradients. Demonstrated with chip photography, concentration gradient solution demo, and efficiency comparison.
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Lab Chip, 2024, 24,2262-2271
DOI: 10.1039/D4LC00055B, Paper

Kawin Khachornsakkul, Ruben Del-Rio-Ruiz, Lita Chheang, Wenxin Zeng, Sameer Sonkusale
A carbon dots and dopamine-imprinted polymer was immobilized onto a distance-based paper channel for simultaneous detection of three cytokine biomarkers without requiring expensive reagents and instruments.
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Lab Chip, 2024, 24,2202-2207
DOI: 10.1039/D4LC00014E, Paper

Matthew S. Viglione, Aubrianna Saxton, Dawson Downs, Adam T. Woolley, Kenneth A. Christensen, Pam M. Van Ry, Gregory P. Nordin
A new 3D printing method allows for fabrication of porous membranes with 7 μm pores. A device mimicking an organ-on-a-chip design is fabricated and seeded with living cells, demonstrating potential for diverse biological and mechanical applications.
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Lab Chip, 2024, 24,2358-2359
DOI: 10.1039/D4LC90026J, Correction

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Lei Mou, Kalpana Mandal, Marvin Magan Mecwan, Ana Lopez Hernandez, Surjendu Maity, Saurabh Sharma, Rondinelli Donizetti Herculano, Satoru Kawakita, Vadim Jucaud, Mehmet Remzi Dokmeci, Ali Khademhosseini
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Lab Chip, 2024, 24,2272-2279
DOI: 10.1039/D3LC01079A, Paper

Huilan Hu, Jiaqi Tian, Rui Shu, Huihui Liu, Shaochi Wang, Xuechi Yin, Jianlong Wang, Daohong Zhang
A lateral flow immunoassay (LFIA) is developed for enzyme-catalyzed double-reading determination of clenbuterol (CLE) through the direct electrostatic adsorption of ultra-small copper–gold bimetallic enzyme mimics (USCGs) and monoclonal antibodies.
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Lab Chip, 2024, 24,2287-2297
DOI: 10.1039/D3LC00866E, Paper

Arata Tsuchida, Taikopaul Kaneko, Kaori Nishikawa, Mayu Kawasaki, Ryuji Yokokawa, Hirofumi Shintaku
We introduce a simple integrated analysis method that links cellular phenotypic behaviour with single-cell RNA sequencing by utilizing a combination of optical indices from cells and hydrogel beads.
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Lab Chip, 2024, 24,2298-2305
DOI: 10.1039/D3LC00730H, Paper

Mahdi Samadi Khezri, Mohammad Reza Housaindokht, Mojtaba Firouzi
A volumetric bar-chart chip (V-chip) is a microfluidic device based on distance-based quantitative measurement that visualizes analyte concentration without the need for apparatus or data processing.
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Lab Chip, 2024, 24,2306-2316
DOI: 10.1039/D3LC01045G, Paper

Sabah H. Al-Jaf, Sameera Sh. Mohammed Ameen, Khalid M. Omer
On-site monitoring of ions in drinking water is essential for safeguarding public health, ensuring high water quality, and preserving the ecological balance of aquatic ecosystems.
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Lab Chip, 2024, 24,2208-2223
DOI: 10.1039/D3LC01055D, Paper

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Jungseub Lee, Sangmin Jung, Hye Kyoung Hong, Hyeonsu Jo, Stephen Rhee, Ye-Lin Jeong, Jihoon Ko, Yong Beom Cho, Noo Li Jeon
VT-MAP, a novel in vitro platform, offers better physiological reflection through the vascularized organoid. This advancement supports drug assessment with deeper insights into cancer biology through correlation between morphology and drug effects.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01052J, Paper

Wenxin Wang, Yiyuan Liu, Zhikai Yao, Dengbo Chen, Yue Tang, Jingwei Cui, Jiangjiang Zhang, Hong Liu, Zikai Hao
A depression-on-gut-chip (DoGC) is prepared and enables extended co-culture of aerobic human intestinal epithelial cells and anaerobic gut microbiota, and allows direct study of interactions between human gut microbiota and depression.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC00941F, Paper

Shizheng Zhou, Tianhui Chen, Edgar S. Fu, Liuyong Shi, Teng Zhou, Hong YAN
The composition of species and the physiological status of microalgal cells serve as significant indicators for monitoring marine environments. Symbiotic with corals, Symbiodiniacea are more sensitive to the environmental response....
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00105B, Critical Review

Shanqing Huang, Weixiong Shi, Shiyu Li, Qian Fan, Chaoyong Yang, Jiao Cao, Lingling Wu
Cells are the fundamental building blocks of living systems, exhibiting significant heterogeneity. The transcriptome connects the cellular genotype and phenotype, and profiling single-cell transcriptome is critical for uncovering distinct cell...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00985H, Paper

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Nan Jia, Tianyang Deng, Charles Larouche, Tigran Galstian, André Bégin-Drolet, Jesse Greener
We report a flow sensitive birefringent in-channel chitosan micromembrane. Using a simple cross-polarizer and a calibration curve, the membrane functions as a flow rate meter, which also works as a feedback element for a flow control system.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC01125A, Paper

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Houda Shafique, Vahid Karamzadeh, Geunyong Kim, Molly L. Shen, Yonatan Morocz, Ahmad Sohrabi Kashani, David Juncker
The fabrication of microfluidic devices has progressed from cleanroom manufacturing to replica molding in polymers, and more recently to direct manufacturing by subtractive (e.g., laser machining) and additive (e.g., 3D...
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00149D, Paper

Sunil Shrestha, Vinod Kumar Reddy Lekkala, Prabha Acharya, Soo-Yeon Kang, Manav Goud Vanga, Moo-Yeal Lee
Human liver organoids (HLOs) hold significant potential for recapitulating the architecture and function of liver tissues in vivo. However, conventional culture methos of HLOs, forming Matrigel domes in 6-/24-well plates,...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00163J, Paper

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Yujia Li, Yingqi Kong, Yubing Hu, Yixuan Li, Rica Asrosa, Wenyu Zhang, Buddha Deka Boruah, Ali K. Yetisen, Andrew Davenport, Tung-Chun Lee, Bing Li
A safe, accurate, and reliable sensing platform for urinary biomarkers analysis of urinary biomarkers is clinically important for the early detection and monitoring of the progression of chronic kidney disease (CKD), as it has become one of the world's most prevalent non-communicable diseases.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00075G, Paper

Abdul Basit Zia, Justin Farrell, Ian G. Foulds
The paper demonstrates an adaptation of a 3D printer (Prusa Mini+) with novel modules to develop a droplet generation system that generates combinatorial droplets from a standard 96 well plate....
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC90040E, Correction

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Olivia M. Young, Xin Xu, Sunandita Sarker, Ryan D. Sochol
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00009A, Paper

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Bastián Carnero, Yago Radziunas-Salinas, Bruno K. Rodiño-Janeiro, Sylvana Varela Ballesta, M. Teresa Flores-Arias
The proposed hybrid technique for passive straight micromixer manufacturing by combining pulsed laser ablation and stereolithographic 3D printing.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00193A, Paper

Marti Z. Hua, Shenmiao Li, M. S. Roopesh, Xiaonan Lu
A QD-MIP based microfluidic device to detect mycotoxin in food.
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React. Chem. Eng., 2024, Advance Article
DOI: 10.1039/D4RE00203B, Paper

Xi-Bao Zhang, Yin-Ning Zhou, Hao Chen, Zheng-Hong Luo, Liyang Zhou, Guojun Yu, Wenwu Liu, Shiping Zhu
A reactor's heat transfer efficiency can be significantly enhanced and the fluid temperature uniformity can be controlled through introducing cooling water in the agitator and regulating the flow ratio of cooling water in the agitator and jacket.
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React. Chem. Eng., 2024, Advance Article
DOI: 10.1039/D4RE00307A, Paper

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J. M. Jimenez-Martin, M. El Tawil-Lucas, C. García-Jerez, J. Moreno, A. García, B. Hernández, J. Iglesias
Two operational regions in the transformation of hexoses have been revealed by experimental and kinetic analysis: glycosidation and retroaldol cleavage at low and high temperatures, respectively.
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React. Chem. Eng., 2024, 9,2868-2881
DOI: 10.1039/D4RE00168K, Paper

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Tim Delrieux, Shweta Sharma, Florian Maurer, Paolo Dolcet, Maximilian Lausch, Anna Zimina, Camilo Cárdenas, Patrick Lott, Maria Casapu, Thomas Lennon Sheppard, Jan-Dierk Grunwaldt
This work presents a fast and non-invasive photo-based channel analysis approach, which helps to screen and understand the effects of different coating parameters on the activity of noble metal-based oxidation catalyst coated on a ceramic cordierite.
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React. Chem. Eng., 2024, 9,2925-2937
DOI: 10.1039/D4RE00271G, Paper

Nicolás Salas, Justin López, Carlos A. Arango
Effect of permutations σ_12,0 and σ₂₁ on graph G₂.
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React. Chem. Eng., 2024, 9,2892-2901
DOI: 10.1039/D4RE00269E, Paper

Yujue Du, Wende Hu, Yunlei Chen, Chuanming Wang, Weimin Yang
The Lewis acid sites in ZSM-5 zeolite involving Co, Ni, and Cu cations were computationally studied on the stability and the PDH catalytic activity.
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React. Chem. Eng., 2024, 9,2994-3002
DOI: 10.1039/D4RE00265B, Paper

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Adrian Ioan Dudu, Csaba Paizs, Monica Ioana Toşa
In this study, the synthesis of aroma esters by the direct esterfication of carboxylic acids with aromatic alcohols mediated by lipase B from Candida antarctica encapsulated in a sol–gel matrix in a solvent-free system is presented.
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React. Chem. Eng., 2024, 9,2830-2845
DOI: 10.1039/D4RE00263F, Review Article

Guo Xiaoying, Bao Yuanyuan, Li Wei, Zhao Siqin, Huang Chao
With the current global economy developing at a rapid pace, research into lithium-ion batteries has become a focal point in many major areas.
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React. Chem. Eng., 2024, 9,2984-2993
DOI: 10.1039/D4RE00127C, Paper

Leon Hennecke, Lucas Schaare, Mirko Skiborowski, Andreas Liese
This study presents an automated reactor platform for the identification of enzyme kinetic models using model-based design of experiments on the example of the reduction of NAD⁺ by formate dehydrogenase from Candida boidinii.
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React. Chem. Eng., 2024, 9,2846-2862
DOI: 10.1039/D4RE00259H, Review Article

Fuyu Jiao, Saif Al Ghafri, Keelan T. O'Neill, Paul S. Stanwix, Guinevere M. Sellner, Einar O. Fridjonsson, Neil Robinson, Eric F. May, Michael L. Johns
This work reviews ortho–para hydrogen conversion data for various types of catalysts at cryogenic temperatures and evaluates different reaction kinetic expressions employed to describe these experimental data.
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React. Chem. Eng., 2024, 9,3003-3015
DOI: 10.1039/D4RE00202D, Paper

Riska Rachmantyo, Afif Akmal Afkauni, Ricky Reinaldo, Lei Zhang, Arramel Arramel, Muhammad Danang Birowosuto, Arie Wibowo, Hermawan Judawisastra
This study shows that a narrower band gap TiO₂, namely black TiO₂, can be prepared using NaBH₄ as a reducing material and microwave heating, which is a faster, greener, and simpler method than the existing method using furnace heating.
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React. Chem. Eng., 2024, 9,3016-3028
DOI: 10.1039/D4RE00313F, Paper

Junnan Wang, Wei Zhan, Yating Li, Ting Wang, Chengxiang He, Chunying Zhu, Youguang Ma, Taotao Fu
The oxidation of glyoxal by nitric acid to glyoxylic acid is a complex process with parallel and consecutive side reactions.
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React. Chem. Eng., 2024, 9,2863-2867
DOI: 10.1039/D4RE00277F, Communication

Daichi Noda, Wanyu Shi, Aiga Yamada, Zizhen Liu, Motohiro Tagaya
Promotion of the immobilization of cationic porphyrin on Eu(III) ion-doped hydroxyapatite nanoparticles through citric acid as the bonding layer was achieved.
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React. Chem. Eng., 2024, Advance Article
DOI: 10.1039/D4RE00406J, Paper

Judith Cabello-Romero, Román Torres-Lubián, Javier Francisco Enríquez-Medrano, Adrián Ochoa-Terán, Jesús Jara-Cortés, Iván Zapata-González
Transesterification of 2-(diethylamino)ethyl methacrylate (DEAEMA) with methanol leads to the formation of methyl methacrylate (MMA) and amino alcohol. This reaction significantly affects DEAEMA polymerization giving rise to poly(DEAEMA-co-MMA).
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React. Chem. Eng., 2024, Advance Article
DOI: 10.1039/D4RE00432A, Paper

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Theodoros Papalas, Andy N. Antzaras, Angeliki A. Lemonidou
MgO promoted with molten alkali salts and CaCO₃ displayed efficient CO₂ capture activity in a fixed bed reactor, attaining 75% CO₂ removal at 275 °C and stable cyclic performance, with the promoters providing an alternative carbonation mechanism.
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React. Chem. Eng., 2024, Advance Article
DOI: 10.1039/D4RE00414K, Paper

Naoto Tsubouchi, Momone Yoshizawa, Javzandogole Bud, Yuuki Mochizuki
The main objective of this study was to investigate the removal of gaseous Hg⁰ from the residue obtained during the chlorination of rice husk char to recover silica.
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