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Kaempferol derivatives isolated from Lens culinaris Medik. reduce DNA damage induced by etoposide in peripheral blood mononuclear cells

Toxicol. Res., 2019, 8,896-907
DOI: 10.1039/C9TX00176J, Paper
Magdalena Kluska, Michał Juszczak, Daniel Wysokiński, Jerzy Żuchowski, Anna Stochmal, Katarzyna Woźniak
Bioactive compounds isolated from plants are considered to be attractive candidates for cancer therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use” by D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489

Toxicol. Res., 2019, 8,1057-1058
DOI: 10.1039/C9TX00158A, Comment
Michael E. Mullins, Mark C. Yarema, Marco L. A. Sivilotti, Margaret Thompson, D. Adam Algren, Michael C. Beuhler, Christopher P. Holstege
We point out an acetylcysteine protocol that a previous article (D. N. Bateman and J. W. Dear, Toxicol. Res., 2019, 8, 489–498) overlooked.
The content of this RSS Feed (c) The Royal Society of Chemistry




c

Characteristic synergistic cytotoxic effects toward cells in graphene oxide dressing with cadmium and copper ions

Toxicol. Res., 2019, 8,908-917
DOI: 10.1039/C9TX00146H, Paper
Yiyang Dong, Yulin Chang, Haidi Gao, Victoria Arantza León Anchustegui, Qiang Yu, Haifang Wang, Jia-Hui Liu, Shihui Wang
Cadmium ions exerted synergistic toxic effects with graphene oxide on Hela cells.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ex vivo toxicological evaluation of experimental anticancer gold(I) complexes with lansoprazole-type ligands

Toxicol. Res., 2019, 8,885-895
DOI: 10.1039/C9TX00149B, Paper
Natalia Estrada-Ortiz, Elena Lopez-Gonzales, Ben Woods, Stefan Stürup, Inge A. M. de Graaf, Geny M. M. Groothuis, Angela Casini
Novel experimental anticancer gold-based compounds were studied for their mechanisms of toxicity in healthy rat kidney and liver tissues, using the Precision Cut Tissue Slices (PCTS) technique.
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c

Gynura divaricata ameliorates hepatic insulin resistance by modulating insulin signalling, maintaining glycolipid homeostasis and reducing inflammation in type 2 diabetic mice

Toxicol. Res., 2019, 8,928-938
DOI: 10.1039/C9TX00191C, Paper
Xuan Dong, Shu-Xiang Zhao, Bing-Qing Xu, Yu-Qing Zhang
Oral lyophilized powder of Gynura divaricata, an edible medicinal plant, can alleviate both hyperglycaemia and hepatic insulin resistance in type 2 diabetic mice.
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c

Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress

Toxicol. Res., 2019, 8,918-927
DOI: 10.1039/C9TX00186G, Paper
Li Pang, Ping Deng, Yi-dan Liang, Jing-yu Qian, Li-Chuan Wu, Ling-ling Yang, Zheng-ping Yu, Zhou Zhou
α-Lipoic acid antagonizes paraquat toxicity.
The content of this RSS Feed (c) The Royal Society of Chemistry




c

Thyroid endocrine status and biochemical stress responses in adult male Wistar rats chronically exposed to pristine polystyrene nanoplastics

Toxicol. Res., 2019, 8,953-963
DOI: 10.1039/C9TX00147F, Paper
Fatemeh Amereh, Akbar Eslami, Simin Fazelipour, Mohammad Rafiee, Mohammad Ismail Zibaii, Mohammad Babaei
At this time, little is known about the long-term effects of micro(nano)plastics on public health. In the present study, early warning signs of thyroid endocrine disruption were noticed in adult Wistar rats from the ingestion of virgin polystyrene nanoparticles.
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Environmental distribution of the neurotoxin L-BMAA in Paenibacillus species

Toxicol. Res., 2019, 8,781-783
DOI: 10.1039/C9TX00203K, Viewpoint
Peter B. Nunn, Geoffrey A. Codd
The neurotoxic amino acid, 3-N-methyl-2,3-diaminopropanoic acid (BMAA), known in plants of the genus Cycas and in aquatic cyanobacteria and other organisms, is a component of antibiotic peptides in two species of Paenibacillus.
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Reply to the ‘Comment on “Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use”’ by M. E. Mullins, M. C. Yarema, M. L. A. Sivilotti, M. Thompson, D. A. Algren, M. C. Beuhler and C. P. Holstege, Toxicol. Res., 2019, 8, DOI: 10.1039/C9T

Toxicol. Res., 2019, 8,1059-1059
DOI: 10.1039/C9TX00216B, Comment
Open Access
D. Nicholas Bateman, James W. Dear
Mullins et al. made a comment on our article (DOI: 10.1039/C9TX00002J) stating they noticed the omission of the one-bag, standard concentration protocol which is shared by several centers in North America when we discussed IV acetylcysteine protocols.
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Biogenic Aspergillus tubingensis silver nanoparticles’ in vitro effects on human umbilical vein endothelial cells, normal human fibroblasts, HEPG2, and Galleria mellonella

Toxicol. Res., 2019, 8,789-801
DOI: 10.1039/C9TX00091G, Paper
Cristiane Angélica Ottoni, Durvanei Augusto Maria, Priscila Jane Romano de Oliveira Gonçalves, Welington Luiz de Araújo, Ana Olívia de Souza
Biogenic silver nanoparticles are ecofriendly and offers valuable possibilities of applications in several industrial areas.
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Cadmium telluride quantum dot-exposed human bronchial epithelial cells: a further study of the cellular response by proteomics

Toxicol. Res., 2019, 8,994-1001
DOI: 10.1039/C9TX00126C, Paper
Yan-Ming Xu, Heng Wee Tan, Wei Zheng, Zhan-Ling Liang, Fei-Yuan Yu, Dan-Dan Wu, Yue Yao, Qiu-Hua Zhong, Rui Yan, Andy T. Y. Lau
A comparative proteome analysis was conducted to identify global changes in the protein expression profiles of cadmium telluride quantum dot-exposed human bronchial epithelial BEAS-2B cells.
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Synergistic antioxidant capacity of CsNPs and CurNPs against cytotoxicity, genotoxicity and pro-inflammatory mediators induced by hydroxyapatite nanoparticles in male rats

Toxicol. Res., 2019, 8,939-952
DOI: 10.1039/C9TX00221A, Paper
Israa F. Mosa, Mokhtar Youssef, Maher Kamel, Osama F. Mosa, Yasser Helmy
Due to their dynamic characteristics, hydroxyapatite nanoparticles (HAP-NPs) have been employed numerous times in nanomedicine and in tissue engineering, particularly as diagnostic and therapeutic agents.
The content of this RSS Feed (c) The Royal Society of Chemistry




c

Innovative models for in vitro detection of seizure

Toxicol. Res., 2019, 8,784-788
DOI: 10.1039/C9TX00210C, Review Article
Kimberly L. Rockley, Ruth A. Roberts, Michael J. Morton
New technologies offer the opportunity to screen for seizure liability in vitro, avoiding costly failures in preclinical and clinical development.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Novel evaluation of sevoflurane anesthetic exposure on the testicular germ cells of neonatal male mice

Toxicol. Res., 2019, 8,988-993
DOI: 10.1039/C9TX00193J, Paper
Ali Raza Ebrahim Soltani, Abdolmohammad Kajbafzadeh, Maryam Ezzati, Zahra Ebrahim Soltani, Navid Hosseinifar, Anahid Maleki, Maryam Nezhad Sistani
Inhalatory anesthetics may impact spermatogenesis and sexual behavior.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Cigarette smoke inhalation aggravates diabetic kidney injury in rats

Toxicol. Res., 2019, 8,964-971
DOI: 10.1039/C9TX00201D, Paper
Songling Jiang, Do Van Quan, Jae Hyuck Sung, Moo-Yeol Lee, Hunjoo Ha
Four weeks of exposure to cigarette smoke aggravated the progression of diabetic kidney injury including inflammation, fibrosis, and oxidative stress.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Mice with a Sertoli cell-specific knockout of the Ctr1 gene exhibit a reduced sensitivity to cisplatin-induced testicular germ cell apoptosis

Toxicol. Res., 2019, 8,972-978
DOI: 10.1039/C9TX00142E, Paper
Open Access
Rashin Ghaffari, John H. Richburg
Exposure to the chemotherapeutic agent cis-diamminedichloroplatinum(II) (cDDP) is well known to instigate acute and prolonged testicular injury in male patients.
The content of this RSS Feed (c) The Royal Society of Chemistry




c

Effects of moderate red wine on cardiovascular risk factors in diabetics: a systematic review and meta-analysis of randomized controlled trials

Toxicol. Res., 2019, 8,979-987
DOI: 10.1039/C9TX00227H, Paper
Saavia Alice Naame, Decheng Li, Ruixue Huang
Diabetes mellitus is of major public health concerns; its incidence is continuously increasing.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Methanol extract of Iphiona aucheri ameliorates CCl4 induced hepatic injuries by regulation of genes in rats

Toxicol. Res., 2019, 8,815-832
DOI: 10.1039/C9TX00157C, Paper
Jawaid Ahmed Zai, Muhammad Rashid Khan, Zaib un Nisa Mughal, Riffat Batool, Irum Naz, Sonia Maryam, Zartash Zahra
Alteration in expression of ER stress associated genes, inflammatory genes and antioxidant biochemical induced with CCl4 in liver of rats were restored towards the control rats by co-administration of methanol extract of Iphiona aucheri to rats.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Astilbin attenuates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB pathway

Toxicol. Res., 2019, 8,1002-1008
DOI: 10.1039/C9TX00222G, Paper
Jing Li, Zhaowei Gu, Yue Liu, Yu Wang, Min Zhao
Ischemic stroke is the second most common cause of death worldwide and cerebral ischemia/reperfusion (I/R) injury also leads to serious tissue damage.
The content of this RSS Feed (c) The Royal Society of Chemistry




c

Astaxanthin reduces perfluorooctanoic acid cytotoxicity in Saccharomyces cerevisiae

Toxicol. Res., 2019, 8,1009-1015
DOI: 10.1039/C9TX00215D, Paper
S. J. Sudharshan, Raghavendra Tirupathi, Madhu Dyavaiah
Perfluorooctanoic acid (PFA) has been identified as an environmental contaminant of high concern for human health.
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Nanoparticle induced barrier function assessment at liquid–liquid and air–liquid interface in novel human lung epithelia cell lines

Toxicol. Res., 2019, 8,1016-1027
DOI: 10.1039/C9TX00179D, Paper
Open Access
Lars Leibrock, Sandra Wagener, Ajay Vikram Singh, Peter Laux, Andreas Luch
To answer questions about nanoparticle toxicity, translocation and biokinetics following inhalation exposure, in vitro models should have functional barrier properties to mimic the in vivo situation as closely as possible.
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Application of the direct peptide reactivity assay (DPRA) to inorganic compounds: a case study of platinum species

Toxicol. Res., 2019, 8,802-814
DOI: 10.1039/C9TX00242A, Paper
Jocelyn D. C. Hemming, Mark Hosford, Martin M. Shafer
The in chemico Direct Peptide Reactivity Assay (DPRA) was developed as a non-animal, relatively high throughput, screening tool for skin sensitization potential.
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Phytochemicals protect L02 cells against hepatotoxicity induced by emodin via the Nrf2 signaling pathway

Toxicol. Res., 2019, 8,1028-1034
DOI: 10.1039/C9TX00220K, Paper
Yan Yan, Kang Wang, Xu Tang, Jun-feng Gao, Bin-yu Wen
Dihydromyricetin (DMY), hyperoside and silybin are phytochemicals that belong to a class called flavonoids, and they have been used in liver protection pharmaceutical preparations, but the specific mechanism of these chemicals is still unclarified.
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Benzoquinone alters the lipid homeostasis in Saccharomyces cerevisiae

Toxicol. Res., 2019, 8,1035-1041
DOI: 10.1039/C9TX00139E, Paper
Abhishek Raj, Vasanthi Nachiappan
BQ exposure inhibited cell growth, increased the ROS-mediated apoptosis, and altered the phospholipids that resulted in membrane proliferation.
The content of this RSS Feed (c) The Royal Society of Chemistry




c

Cytotoxic effect of silica nanoparticles against hepatocellular carcinoma cells through necroptosis induction

Toxicol. Res., 2019, 8,1042-1049
DOI: 10.1039/C9TX00240E, Paper
Yuexiang Niu, Engong Tang, Qingan Zhang
Hepatocellular carcinoma (HCC) is a common cancer that affects people worldwide with high morbidity and mortality, and its resistance to current chemotherapeutic drugs is a serious concern.
The content of this RSS Feed (c) The Royal Society of Chemistry




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The protective effect of thymoquinone on tert-butylhydroquinone induced cytotoxicity in human umbilical vein endothelial cells

Toxicol. Res., 2019, 8,1050-1056
DOI: 10.1039/C9TX00235A, Paper
Zahra Karimi, Maryam Ghaffari, Jafar Ezzati Nazhad Dolatabadi, Parvin Dehghan
2-tert-Butyl-4-hydroquinone (TBHQ) is used for inhibition of oxidative rancidity in the food industry.
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c

Central Board of Direct Taxes amends Rule 44G of Income-tax Rules 1962

It also states that if a resolution is arrived, the same shall be communicated to the assessee, who shall communicate his acceptance or non-acceptance within 30 days




c

AIIB extends $500 mn loan to India to deal with coronavirus crisis

The bank's board of directors has approved a loan to India to strengthen the preparedness of the country's national health system




c

India's credit profile to face further pressure due to Covid-19: Moody's

Moody's rating on the government of India is Baa2 with negative outlook




c

Franklin Templeton issues apology to Sebi for global chief's remarks

Stung by the comments made by the global chief, market regulator on Thursday issued a press release defending the new rules it introduced in October last year




c

SC's struggles with 'unruly horse' of public policy in foreign awards

The Nafed-Alimenta judgment shows it might perhaps be time for Parliament to intervene and clarify the notion of public policy in the context of foreign arbitral awards




c

US Federal Reserve won't take rates negative, say fund managers, economists

Fed funds futures, which are a gauge of where markets expect the Fed's benchmark overnight lending rate to be, are now pricing in a slightly negative rate environment beginning in December




c

Nomura predicts Indian GDP to contract by 5.2% in FY21, more rate cuts

Analysts at Goldman Sachs expect the Indian economy to contract 0.4 per cent in FY21 versus consensus median 2.7 per cent




c

Only 13% of industrial units resume ops after Odisha eases lockdown

Micro units in the state have not been able to resume operations to catch up with their larger peers




c

Export contraction in April could surpass March's steep 25-year decline

Major forex earning sectors cite lack of labour, funds and key supplies




c

Vizag gas leak: NGT orders LG Polymers to deposit Rs 50 cr pending probe

NGT bench set up fact-finding committee, to be headed by former AP High Court judge




c

Gujarat eases labour laws, offers land to firms shifting base from China

The state government also offered land and infrastructure for companies and projects that were looking to shift base from China to other destinations




c

CBDT orders tax officials to not issue scrutiny notices to taxpayers

Move comes after a group of IRS created panic and tax policy uncertainty




c

Govt must work to revive consumption, not worry about rating: Rahul Gandhi

Congress wants lockdown lifted across country on May 18, save hotspots; Gandhi urges Centre to make citizens 'psychologically' prepared to for lockdown exit




c

Govt hikes borrowing limit by over 50% to Rs 12 trn as virus grips economy

Sources say the Centre has asked RBI to do whatever to keep yields in check, which may result in massive secondary market bond purchases




c

Country's first round-the-clock solar power tender closes at Rs 2.9/unit

The project developer will have the option of building a hybrid plant with wind and hydro power or have energy storage systems




c

HC orders closure of Liquor shops in Tamil Nadu, allows online sales

The opening of shops in districts, except Chennai on May 7, has resulted in people thronging the outlets without maintaining social distancing norms




c

Lockdown period not to be counted for determining residency of NRIs: CBDT

There were apprehensions that this extended stay could lead to these individuals becoming Indian residents as per Section 6 of the Income Tax Act




c

Working closely with states on labour reforms to help industry: Centre

The Confederation of Indian Industry (CII) suggested to the Labour Ministry to "direct workers to join back to their workplace" by issuing a circular




c

Covid-19 lockdown effect: Every second Indian now on internet in cities

The data released by Nielsen and the Broadcast Audience Research Council (BARC) shows that internet usage has grown sharply in cities over the last one month, touching 54 per cent




c

Additional borrowing to widen fiscal deficit, but help govt perk up economy

He did not think that the move will crowd out borrowings of the private sector, saying demand of the government and the private sector are not contradictory in these circumstances




c

FM to discuss credit flow to NBFCs, businesses with banks on Monday

The FM will take stock of the credit sanction and disbursement by the banks since March 1, 2020, and the Covid-19-related emergency credit lines opened by the lenders




c

Sitharaman launches two exchanges to take on offshore currency market

The launch comes amid the world's most expansive coronavirus lockdown, which has crippled businesses and hurt trading volumes in the country's financial markets.




c

Covid-19: Relief for NRIs, foreign visitors as tax residency rules eased

The government imposed a lockdown on March 24 and is yet to open up travel, including international flights.




c

Ministry of Defence inks Rs 1,200 cr contract to boost electronics sector

The deal, Modernisation of Air Field Infrastructure Phase 2 (MAFI-2), follows from an earlier contract, called MAFI-1, which TPSED won in 2011 to upgrade 30 IAF airfields.