A reversible folio for a tablet computer has a tablet shell with a cavity removably receiving the tablet computer. A keyboard is pivotally and removably coupled to the tablet shell. A channel is pivotally coupled to an edge of the keyboard. An interior of the channel removably receives the proximal edge of the tablet shell, and has a profile mating with a profile of the tablet shell. The channel and proximal edge have first and second symmetrical magnet arrays, respectively. The proximal edge of the tablet shell physically mates with the channel of the keyboard, and the second magnet array of the tablet shell magnetically mates with the first magnet array of the channel, in both a first orientation and an opposite second orientation.

An apparatus and system for housing a device include a housing that is configured such that a device may be fitted within the housing and thereby be protected, such as from shocks and/or liquid. The housing may include top and bottom members that may be removably coupled together so as to form the housing. Each top and bottom member optionally includes front and back surfaces surrounded by a perimeter. The perimeter is defined by proximal and distal ends as well as opposing sides. The top and bottom members may include respective clasping mechanisms that extend along the perimeter of the top and bottom members. The clasping mechanisms are configured for coupling the top and bottom members with one another thereby sealing the housing, for instance, in a shock-proof and/or water tight seal.

An ultra removable booklet with label for application to media is described. The booklet with label includes a release liner, an ultra removable adhesive layer, a paper stock layer, a booklet, an adhesive layer, and a clear plastic cover layer. The clear plastic cover layer has the adhesive layer applied to a bottom surface thereof and the bottom surface is positioned over the booklet. The booklet is positioned over the paper stock. The ultra removable adhesive layer is attached to the lower surface of the paper stock. The release liner is applied to the ultra removable adhesive layer. A process for forming an ultra removable booklet with label for application to media is also described.

A communications device may include a near-field communication (NFC) circuit device, and a radio frequency (RF) signal blocking member adhesively coupled with the NFC device. The RF signal blocking member may be configured to block RF signal communication by the NFC device while coupled therewith. The RF signal blocking member may comprise an electrical conductor. In accordance with an example, the RF signal blocking member may comprise a frangible layer. In another example, a pressure sensitive adhesive layer may be included for adhesively securing the RF signal blocking member with the NFC device.

A method for producing a continuous web of printed material for use in creating mailpieces. The continuous web has a width and a length, the length comprised of a series of attached sheets. The series of attached sheets are comprising envelope sheets and rectangular content pages. The content pages are rectangular in shape and may be oriented relative to the envelope sheets in a number of different configurations. In some configurations, two sets of content pages and/or envelope sheets can be printed across the width of the web. Sheets for forming business return envelopes may be printed in series with the content pages and envelope sheets. BREs may include individualized return addresses. A control code may be printed on one or more of the sheets for a given mailpiece, providing information for controlling assembly of the mailpiece. Two sets of sheets may be printed across the width of the web by printing content pages onto the continuous web such that two end-to-end content pages are printed across the width of the web. Positioning of mail content pages and envelope sheets for a given mailpiece may be optimized based on respective processing times determined for the system.

An inside leaflet of a book is provided which is bond-bound with pages of the book to provide an advertisement. The inside leaflet includes an advertisement printed part and a binding part. Catchphrases or illustrations for advertisement are printed on at least one side of the advertisement printed part. The binding part is configured to be bound with the pages along an edge of the inside leaflet such that the binding part has less binding portions than those of the pages in order to leave no traces or marks when the inside leaflet is detached from the book. Accordingly, since the inside leaflet is able to be bound to pages of various kinds of books and easily removed from the books without leaving any traces or marks in the books, the inside leaflet contributes to extension of the application range of advertisements and improvement of advertisement efficiency.

A binding system for binding a set of media sheets, including first and second binder pieces, each including an end cap, a retainer, a cylinder and a connection mechanism. The retainer has an arc-shaped cross-section having an associated arc angle thereby providing an opening slot that extends along a length of the retainer. The retainer and the cylinder are connected to the end cap such that the cylinder is positioned within the retainer. The binder pieces are adapted to bind the set of sheets of media by inserting the set of media sheets into the first and second binder pieces such that the media sheets are wrapped around the cylinders and extend out of the opening slots in the retainers, and engaging the connection mechanisms to connect the first and second binder pieces together.

Recessed adhesive binding systems. One system can include a plurality of sheets arranged in a stack, each of the plurality of sheets having a front surface, a rear surface, and an exposed edge. At least one of the front surface and the rear surface of each of the plurality sheets can include at least one recessed adhesive positioned adjacent the exposed edge to form an at least partially exposed recessed adhesive, which can be selectively activated. The rear surface of a first sheet in the plurality of sheets can be positioned adjacent the front surface of a second sheet in the plurality of sheets, or vice versa, and the exposed edges of the plurality of sheets can be staggered, such that the exposed edge of the second sheet extends further outwardly from the stack than the exposed edge of the first sheet in the stack.

A binding system for binding a set of media sheets, including a cylinder having an outer diameter and a length, and a retainer fabricated from a flexible material. The retainer has an arc-shaped cross-section having an inner diameter and an associated arc angle thereby providing an opening slot that extends along a length of the retainer. The binding system is adapted to bind the set of media sheets by wrapping the media sheets around the cylinder and inserting the wrapped cylinder into the retainer with the wrapped media sheets extending out of the opening slot in the retainer. The inner diameter of the retainer is less than the sum of the outer diameter of the cylinder and a total thickness of the wrapped media sheets so that the retainer flexes to provide a clamping force to bind the media sheets.

A composition book having a front and back cover and a plurality of pages stitched together wherein the plurality of pages may have hole punches and the front and back cover may have hole punches such as to allow the composition book to fit within a binder and wherein the plurality of pages are perforated such that they may be removed from the composition book.

A wireless communication node (10) dynamically estimates passive intermodulation (PIM) interference coupled into the node's receive path from the transmission of a composite signal through the node's transmit path. The node (10) then cancels the estimated PIM interference in the receive path. In some embodiments, the node dynamically estimates the PIM interference as a function of the composite signal that models PIM interference generation and coupling in the node (10) according to one or more coefficients (30). The coefficients (30) may be determined by transmitting a test signal (34) during a test stage, when the node (10) is not scheduled to receive any signal. Later, when the composite signal (18) is transmitted, the node (10) uses the coefficients (10) to dynamically estimate and cancel the resulting PIM interference.

An amplifier circuit includes an input terminal and an output terminal. A current sinking transistor includes a first conduction terminal coupled to the output terminal and a second conduction terminal coupled to a reference supply node. A voltage sensing circuit has a first input coupled to the input terminal and a second input coupled to the output terminal. An output of the voltage sensing circuit is coupled to the control terminal of the current sinking transistor. The voltage sensing circuit functions to sense a rise in the voltage at the output terminal which exceeds the voltage at the input terminal, and respond thereto by activating the current sinking transistor.

An input receiver circuit including a single-to-differential amplifier and a semiconductor device including the input receiver circuit are disclosed. The input receiver circuit includes a first stage amplifier unit and a second stage amplifier unit. The first stage amplifier unit amplifies a single input signal in a single-to-differential mode to generate a differential output signal, without using a reference voltage. The second stage amplifier unit amplifies the differential output signal in a differential-to-single mode to generate a single output signal.

A TIA circuit and method are provided that merge the automatic gain control function with the bandwidth adjustment function to allow the TIA circuit to operate over a wide dynamic range at multiple data rates. The TIA circuit has an effective resistance that is adjustable for adjusting the gain and the bandwidth of the TIA circuit. The mechanism of the TIA circuit that is used to adjust the effective resistance, and hence the gain and bandwidth of the TIA circuit, is temperature independent, and as such, the performance of the TIA circuit is not affected by temperature variations.

An apparatus is described that includes an audio power amplifier having an input and an output. An alternating-current to direct-current power converter is coupled to the audio power amplifier in a single package to supply power to the audio power amplifier.

A pop-free single-ended output class-D amplifier includes: an input signal generator for generating an input signal; a power supply for supplying input power; a reference voltage generator for generating a reference voltage; a gain-adjustable stage for generating an amplified signal according to the reference voltage and adjusting a gain of the single-ended output class-D amplifier; a pulse width modulation module for outputting a pulse width modulation signal according to the reference voltage, the amplified signal, and the input power; a low-pass filter for low-pass filtering the pulse width modulation signal to generate an output voltage; and a logic controller for generating at least one control signal to control the reference voltage generator, the gain-adjustable stage, and the pulse width modulation module according to the input power, the reference voltage, and the pulse width modulation signal.

Differential power amplifier circuitry includes a differential transistor pair, an input transformer, and biasing circuitry. The base contact of each transistor in the differential transistor pair may be coupled to the input transformer through a coupling capacitor. The coupling capacitors may be designed to resonate with the input transformer about a desired frequency range, thereby passing desirable signals to the differential transistor pair while blocking undesirable signals. The biasing circuitry may include a pair of emitter follower transistors, each coupled at the emitter to the base contact of each one of the transistors in the differential transistor pair and adapted to bias the differential transistor pair to maximize efficiency and stability.

An automatic antenna impedance matching method for a radiofrequency transmission circuit. An impedance matching network is inserted between an amplifier and an antenna. The output current and voltage of the amplifier and their phase difference are measured by a variable measurement impedance, and the complex load impedance of the amplifier is deduced from this; the impedance of the antenna is calculated as a function of this complex impedance and as a function of the known current values of the impedances of the matching network. Starting from the value found for the impedance of the antenna, new values of the matching network are calculated that allow the load to be matched to the nominal impedance of the amplifier. The measurement impedance has a value controllable by the calculation processor according to the application and notably as a function of the operating frequency and of the nominal impedance of the amplifier.

A scan head assembled to a scan arm for an ion implanter and a scan arm using the same are provided, wherein the scan head is capable of micro tilting a work piece and comprises a case, a shaft assembly, an electrostatic chuck, a first driving mechanism and a micro-tilt mechanism. The shaft assembly passes through a first side of the case and has a twist axis. The electrostatic chuck is fastened on a first end of the shaft assembly outside the case for holding the work piece. The first driving mechanism is disposed within the case and capable of driving the shaft assembly and the ESC to rotate about the twist axis. The micro-tilt mechanism is disposed within the case and capable of driving the shaft assembly and the ESC to tilt relative to the case.

An interface between a receptacle body and an insert designed, in particular, as a tool or workpiece insert, comprises a receptacle body (2) having a cylindrical receiving bore (4), which is circumscribed by a first plane surface (6) extending at a right angle to the bore axis and in which a first cone surface (9) is arranged, said first cone surface being coaxial with the bore axis and being arranged so that its tapered end faces toward the plane surface. The insert (3) has a pin (15) that is disposed to be plugged into the receiving bore (4) and is circumscribed by a second plane surface (22). At an axial distance from the second plane surface (22), said pin has a second cone surface (22), the tapered end of said second cone surface being arranged so as to face toward the second plane surface. With the pin (15) inserted in the receiving bore (4), the two plane surfaces are in superimposed contact while the two cone surfaces (9, 22) can be biased relative to each other by limited twisting of the insert relative to the receptacle body.

A pin-and-collet assembly, a longwall shearer comprising a ranging arm attached to a lifting bracket with such assembly, a method for the secure fastening of one piece to another, such as securely fastening the ranging arm to the lifting bracket of a longwall shearer using such assembly as a bushing, and a method for longwall mining of ore, such as trona, using such longwall shearer. This assembly is easy to install, does not have to be tightened during longwall operation of an ore panel, and is also demountable when it is time to stop the longwall mining operation and time to remove/replace the ranging arm for maintenance and/or when the end of the ore panel is reached.

An apparatus of semiconductor process including a chuck and a vacuum source is provided. The chuck has a plurality of holes for holding a semiconductor substrate, and the vacuum source is used for providing vacuum suction through the holes to make the semiconductor substrate be subjected to varied suction intensities according to a warpage level thereof.

A tool holder has a body with a spindle side for fastening the tool holder to a spindle of a machine tool and a tool side for accommodating a tool and has a lubricating media passage from the spindle side to the tool side that contains a lubricating media bush adjustable in the axial direction in the body. The lubricating media bush opens out on the tool side of the body, wherein a guide for the lubricating media hush is provided in the body. The guide contains a fitting section in which the lubricating media bush is adjustably guided, wherein a seal is provided which seals the lubricating media bush relative to the body.

The present invention relates to an apparatus and method for positioning and pressing surgical needle blanks. The apparatus includes a needle blank transferring system which transfers needle blanks between a gripping position and a pressing position. A side press system presses a portion of the needle blank when the blank is in the pressing position, and a gripping member is provided to hold the needle blank at least during the transfer and press operations of the apparatus. The method according to the present invention includes inserting a needle blank into a needle blank gripping member at a gripping position, transferring the needle blank between the gripping position and a pressing position, and pressing a side portion of a body portion of the needle blank with pressing dies.

There is disclosed an apparatus for forming a surgical incision member comprising which includes a first die associated with a base and having a first groove therein for receipt of at least a portion of a needle blank. A second die is mounted for movement on the base between a position remote from the first die and a position adjacent the first die. The second die includes a second groove alignable with the first groove to hold a needle blank therebetween, the first and second dies each having spaced apart channels intersecting the first and second grooves. A notching die is provided and is mounted for movement within at the channels so as to engage and notch an edge of the needle blank contained within the first and second grooves. The apparatus also includes structure for curving a needle blank contained within the first and second grooves. A method of forming a surgical incision member is also disclosed, and a surgical incision member blank.

There is disclosed an apparatus and a method for progressively forming high strength surgical needles from bulk needle stock material. The apparatus generally includes a series of progressive needle processing stations. A first series of needle processing stations removes material from needle stock material to rough form needle blanks attached to a carrier strip while a second series of processing stations refine the rough formed needle blanks attached to the strip into the desired surgical needles. The disclosed method generally includes the steps of gutting needle stock material to rough form needle blanks attached to a carrier strip and progressively coining the rough formed blanks into surgical needles. Finally, there is disclosed a high bend strength surgical needle formed on the disclosed apparatus or by the disclosed method. Preferably, the surgical needle is a surgical incision member having a predetermined radius of curvature and an optimized conical radius at the tips.

An apparatus for forming armed sutures has a swaging station for receiving, holding and swaging needles that are deposited therein. A linear motor drives a suture insertion gripper, which pulls suture from a supply reel and inserts a cut end thereof into a needle held in the swaging station. A ganged needle transfer assembly with a plurality of spaced needle gripper units carries needles along a line substantially at right angles to the suture line and transfers them to and from the swaging station and other needle processing stations. A precisor orients needles prior to placement in the swaging station and a pull test assembly tests armed sutures in both destructive and non-destructive modes. Both ends of the production line may be automated, e.g., by robots which load and offload needles prior to and after swaging, respectively. The apparatus is capable of forming double armed sutures by using a rotatable mount for the suture insertion gripper and a secondary, loop gripper. A suture transfer gripper extending up to the suture from a multi-tiered stack of slide tables. The suture transfer gripper cooperates with the suture insertion and loop grippers to hold the suture during cutting, insertion and transfer to the pull test apparatus and thereby protects the suture during processing.

A method of actuating an assembly of a transmission, with which are associated a plurality of actuators with whose help the assembly can in principle be actuated, such that out of the actuators available in principle for actuation, a control unit selects at least one actuator for the actual actuation and activates the selected actuator with an output signal in such manner that a status parameter of the actuated assembly corresponds to or follows a control-side nominal value, such that out of the actuators available in principle for actuating the assembly, the control unit selects at least one actuator for the actual actuation of the assembly in such manner that, for all the actuators available in principle for actuating the assembly over the operating life of the transmission, the extent of their utilization is approximately uniform.

Method of indicating the position of a hydraulically actuated armature, comprising an adjust cylinder for actuating the armature, connected by at least one pressure medium line to an adjustment valve through which the pressure medium line can be switched between pressure-causing forward flow and pressure-less backward flow, wherein the flow through the pressure medium line is converted into a number of electric pulses and the number of pulses reflecting the flow is processed in a program in an indicator unit such that the number of pulses occurring in a predetermined adjustment travel when the flow in the pressure medium line is pressure-less is calculated as being the same adjustment travel as when the pressure medium line is switched to be the pressure line.

A control force transmission arrangement for an aircraft is provided. A transmission device has a first and a second force transmission point, and a coupling unit disposed between them. The coupling unit has a first and a second side element and a connecting element. The first and the second side elements are each connected to the first force transmission point and to the connecting element. At least the first side element has an element for altering the length of the side element. The second force transmission point is provided on the connecting element and is adjustable at least between a first and a second position.

An electronic controller for a variable ratio transmission and an electronically controllable variable ratio transmission including a variator or other CVT are described herein. The electronic controller can be configured to receive input signals indicative of parameters associated with an engine coupled to the transmission. The electronic controller can also receive one or more control inputs. The electronic controller can determine an active range and an active variator mode based on the input signals and control inputs. The electronic controller can control a final drive ratio of the variable ratio transmission by controlling one or more electronic solenoids that control the ratios of one or more portions of the variable ratio transmission.

A thin film of a low-thermionic-work-function material is maintained on the cathode of a device for producing a high-current, low-pressure gas discharge by means of sputter deposition from an auxiliary electrode. The auxiliary electrode includes a surface with a low-work-function material, such as thorium, uranium, plutonium or one of the rare earth elements, facing the cathode but at a disposition and electrical potential so as to extract ions from the gas discharge and sputter the low-work-function material onto the cathode. By continuously replenishing the cathode film, high thermionic emissions and ion plasmas can be realized and maintained over extended operating periods.

An improved control system for controlling the position of an upper electrode in a carbon arc lamp. The system has a pulley with a line thereover, and a solenoid core is attached to one end of the line and is movable vertically in a solenoid coil connected in the circuit for supplying discharge current to the electrodes, and a control rod clutch is connected to the other end of the line which normally grasps and holds an electrode control rod on the lower end of which is mounted the upper electrode of the lamp. A balancing weight is provided on the core to balance the weight of the control rod clutch and electrode and a shield is provided around the solenoid coil to shield the arc between the electrodes from the magnetic field of the solenoid coil.

A carbon exchanging system for a carbon-arc weather resistance testing apparatus having a carbon drive system including a reversible motor for automatically moving upper and lower arc producing carbons toward and away from each other along a vertical line for keeping the discharge current and voltage substantially constant. The carbon exchanging system has remotely operable upper and lower carbon chucks for holding the upper and lower carbons, a carbon replacing device having a remotely operable exchanging chuck and a drive for moving the exchanging chuck along a path of movement toward and away from the upper and lower carbon chucks when they are in position on the vertical line, a shifting device for shifting the carbon drive system and the carbon replacing means relative to each other for moving the upper and lower chucks and the exchanging chuck laterally relative to the vertical line, a carbon supply adjacent the path of movement of the exchanging chuck for holding replacement carbons and moving them into position opposite a position of the exchanging chuck along the path, and a moving device for moving the exchanging chuck and the carbon supply relative to each other in a direction toward and away from each other. The system can also include a control device for automatically controlling the operation thereof.

A method and apparatus are disclosed for efficient endothermic processing of liquids and the precipitation of dissolved elements and chemical compounds. Improvements over prior systems include system layout, components and modes of operation of the system. Applications of the system include destruction of toxic wastes and sewage treatment, precipitation of chemical compounds and elements including metals from solution (brine, sea water, industrial waste), sterilization and water purification, catalytic formation of chemical compounds, and processing of hydrocarbons.

Graphite and/or carbon surfaces are coated with a titanium nitride coating by exposing the substrate to electric arc thermal spray process wherein titanium wire as the source of titanium and nitrogen is used as the propelling (atomizing) gas.

A geared motor actuator having a simplified mechanical structure for driving a closing part, such as a vehicle window, moved as far as at least one end position by an electric motor (MO) via a gear (G), preferably a worm gear. Shortly before the end position is reached, switch-off of the electric motor (MO) is performed in accordance with a control device (ST). The gear (G) is drive-connected to an output driver of the closing part without any damping means. The worm wheel (4) of the worm gear, being a solid, integral component that is preferably injection-molded from plastic, is preferably designed to include the output driver as part of the integral component, and provided with a drive pinion (4.1).

An auxiliary lighting system for a high-intensity discharge lamp. In one embodiment, the auxiliary lighting system has an auxiliary light source, an HID lamp status circuit having an input for connection to a status signal representative of the operational state of a high-intensity discharge lamp wherein the HID lamp status circuit determines whether the status signal meets predetermined signal criteria, a switch circuit having a first state that effects application of a voltage source to the auxiliary light source, and a second state that isolates the voltage source from the auxiliary light source, and a control circuit responsive to the HID lamp status circuit for controlling the switch circuit. The control circuit has a first state when the HID lamp status circuit determines that the status signal meets the predetermined signal criteria and a second state when the HID lamp status circuit determines that the status signal does not meet the predetermined signal criteria. When the control circuit is in the first state, the control circuit outputs a control signal for input into the switch circuit that configures the switch circuit into the first state. When the control circuit is in the second state, the control circuit outputs a control signal for input into the switch circuit that configures the switch circuit into the second state.

Methods and devices are disclosed for identifying objects over a surface and for tracking the position of said objects in relation to the sensing surface. The methods include the steps of providing an array of electrodes or coils that generating electromagnetic radiation having a individual characteristic frequencies of oscillation. Objects in proximity to the sensing surface(s) couple electromagnetically to the array of electrodes or coils, which then alters the characteristic frequency of one or more elements in the array. By monitoring the individual frequency shifts among the array elements, one or more objects in proximity to the surface can be sensed and identified. Quantitative identification and enhanced detection of the objects is achieved through the use of electromagnetic markers affixed or embedded in the objects in specified geometric patterns. In addition, a method is presented for scanning the sensing array, through the use of a second layer of electrodes that selectively mask or modulate the sensing field.

A method of compressing a character by determining an overall code specific to the character comprising the steps of: a) grouping the characters in terms of a common behaviour pattern;b) where the number of characters within that group is odd, creating a two new groups of character, one new group containing just one character and the other new group containing the remaining characters;c) for each new group from of step b) said groups from step a) which have an even number of characters, assigning a group specific code d) where there is more than one character in the group referred to in step c) assigning a character identifier code to identify an individual character within the group, e) the overall character code comprising of the cocatenated group specific and identifier codes.

An indirectly heated cathode C1 comprises a heater 1, a double coil 2, a mesh member 3, and a metal oxide 10. An electrical insulating layer 4 is formed on the surface of heater 1. Heater 1 is inserted into and positioned at the inner side of double coil 2. Mesh member 3 is disposed along the length direction of double coil 2 at the outer side of double coil 2. Double coil 2 is grounded by being connected to the ground terminal of heater 1 via a lead rod 7. Metal oxide 10 is held by double coil 2 and disposed to be in contact with mesh member 3. Metal oxide 10 and mesh member 3 are exposed to the outer side of indirectly heated electrode C1 so that the surface of metal oxide 10 and the surface of mesh member 3 make up a discharge surface and mesh member 3 is in contact with the surface part of metal oxide 10.

In general, this disclosure describes techniques for changing a sampling frequency of a digital signal. In particular, the techniques provide a more accurate way to determining a relative timing between a desired output sample and a corresponding input sample using a non-approximated integer representation of the relative timing. The relative timing between the desired output sample and corresponding input sample may be represented using a first component that identifies a latest input sample of the digital signal used to generate intermediate samples, a second component that identifies an intermediate sample, and a third component that identifies a timing difference between the desired output sample and the intermediate sample. Each of the components may be recursively updated using non-approximated integer values.

A bridge for crossing a passage of a navigation channel includes a section in the form of a single span, which may be displaced by vertical translation between a base position spanning the passage, in which the span rests on fixed support sections of the bridge, and a raised position, for opening the passage, and a support structure for the span on displacement of the span, and a drive for lifting the span. The bridge has only one support structure, with the drive, located on one side of the passage to be spanned.

A system that encodes a sequence of integers using a variable-length compression technique is described. During operation, the system scans the sequence of integers and observes the sizes of the integers to determine a threshold value K from the observed sizes. For a given integer which is N bits in length, if N−K is greater than or equal to zero, the system generates a tag for the encoded integer which comprises a sequence of N−K zeros followed by a one, and generates a set of remaining bits for the encoded integer as a sequence of the N bits which make up the integer. Otherwise, if N−K is less than zero, the system generates a tag for the encoded integer as a single one, and generates a set of remaining bits for the encoded integer by padding the N bits which make up the integer with zeros so that the set of remaining bits is K bits in length.

An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be fully consumed followed by the linking conductive base material of the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity disabling activity in the device. A visual indicator may be provided allowing a wearer to monitor the state of reaction of the linking area.

An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be fully consumed followed by the linking conductive base material of the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity disabling activity in the device. A visual indicator may be provided allowing a wearer to monitor the state of reaction of the linking area.

This disclosure relates to a micro manipulator having a simple structure and having high possibility of recording a biological signal of a neuron at a desired position by improving positioning resolution of an electrode disposed adjacent to a subject's brain neuron or an electrode holder attached with the electrode. The micro manipulator according to the disclosure includes: a motor which includes a shaft and a vibration portion; a mobile which is connected to the shaft so as to be movable along the shaft; and a frame which supports the motor, wherein an electrode is connected to the mobile in a direction parallel to a longitudinal direction of the shaft, and wherein when the mobile moves linearly in accordance with a vibration of the shaft due to the vibration portion, the electrode moves linearly.

There are provided an apparatus and a method for manufacturing a vitreous silica crucible which can prevent the deterioration of the inner surface property in the manufacturing process of a vitreous silica crucible. The apparatus includes a mold defining an outer shape of a vitreous silica crucible, and an arc discharge unit having electrodes and a power-supply unit, wherein each of the electrodes includes a tip end directed to the mold, the other end opposite to the tip end, and a bent portion provided between the tip end and the other end.

Provided herein are methods of treating a proliferative disease in a subject, comprising administering to the subject a therapeutically effective amount of AC220 and a nucleoside analog, a topoisomerase inhibitor or an anthracycline, or a combination thereof.

Method and apparatus for tri-axially aligning, folding, trimming and edge stitching a cloth sheet particularly adapted for making pockets for garments.